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Items: 23


Liver-specific Bid silencing inhibits APAP-induced cell death in mice.

Maxa M, Schaeper U, Dames S, Vollmar B, Kuhla A.

Apoptosis. 2019 Dec;24(11-12):934-945. doi: 10.1007/s10495-019-01571-7.


Repin1 deficiency in liver tissue alleviates NAFLD progression in mice.

Abshagen K, Mense L, Fischer F, Liebig M, Schaeper U, Navarro G, Glass Ä, Frank M, Klöting N, Vollmar B.

J Adv Res. 2018 Nov 22;16:99-111. doi: 10.1016/j.jare.2018.11.003. eCollection 2019 Mar.


CLIC4/Arf6 Pathway.

Abdul-Salam VB, Russomanno G, Chien-Nien C, Mahomed AS, Yates LA, Wilkins MR, Zhao L, Gierula M, Dubois O, Schaeper U, Endruschat J, Wojciak-Stothard B.

Circ Res. 2019 Jan 4;124(1):52-65. doi: 10.1161/CIRCRESAHA.118.313705.


Liver-specific Repin1 deficiency impairs transient hepatic steatosis in liver regeneration.

Abshagen K, Degenhardt B, Liebig M, Wendt A, Genz B, Schaeper U, Stumvoll M, Hofmann U, Frank M, Vollmar B, Klöting N.

Sci Rep. 2018 Nov 15;8(1):16858. doi: 10.1038/s41598-018-35325-3.


Therapeutic siRNA targeting endothelial KDR decreases portosystemic collateralization in portal hypertension.

Gallego J, Garcia-Pras E, Mejias M, Pell N, Schaeper U, Fernandez M.

Sci Rep. 2017 Nov 1;7(1):14791. doi: 10.1038/s41598-017-14818-7.


Endoglin in human liver disease and murine models of liver fibrosis-A protective factor against liver fibrosis.

Alsamman M, Sterzer V, Meurer SK, Sahin H, Schaeper U, Kuscuoglu D, Strnad P, Weiskirchen R, Trautwein C, Scholten D.

Liver Int. 2018 May;38(5):858-867. doi: 10.1111/liv.13595. Epub 2017 Oct 23.


Foxf1 siRNA delivery to hepatic stellate cells by DBTC lipoplex formulations ameliorates fibrosis in livers of bile duct ligated mice.

Abshagen K, Brensel M, Genz B, Roth K, Thomas M, Fehring V, Schaeper U, Vollmar B.

Curr Gene Ther. 2015;15(3):215-27.


Liver-specific Fas silencing prevents galactosamine/lipopolysaccharide-induced liver injury.

Kuhla A, Thrum M, Schaeper U, Fehring V, Schulze-Topphoff U, Abshagen K, Vollmar B.

Apoptosis. 2015 Apr;20(4):500-11. doi: 10.1007/s10495-015-1088-2.


Lung-targeted RNA interference against angiopoietin-2 ameliorates multiple organ dysfunction and death in sepsis.

Stiehl T, Thamm K, Kaufmann J, Schaeper U, Kirsch T, Haller H, Santel A, Ghosh CC, Parikh SM, David S.

Crit Care Med. 2014 Oct;42(10):e654-62. doi: 10.1097/CCM.0000000000000524.


Delivery of therapeutic siRNA to the lung endothelium via novel Lipoplex formulation DACC.

Fehring V, Schaeper U, Ahrens K, Santel A, Keil O, Eisermann M, Giese K, Kaufmann J.

Mol Ther. 2014 Apr;22(4):811-20. doi: 10.1038/mt.2013.291. Epub 2014 Jan 6.


Atu027 prevents pulmonary metastasis in experimental and spontaneous mouse metastasis models.

Santel A, Aleku M, Röder N, Möpert K, Durieux B, Janke O, Keil O, Endruschat J, Dames S, Lange C, Eisermann M, Löffler K, Fechtner M, Fisch G, Vank C, Schaeper U, Giese K, Kaufmann J.

Clin Cancer Res. 2010 Nov 15;16(22):5469-80. doi: 10.1158/1078-0432.CCR-10-1994. Epub 2010 Nov 9.


Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression.

Aleku M, Schulz P, Keil O, Santel A, Schaeper U, Dieckhoff B, Janke O, Endruschat J, Durieux B, Röder N, Löffler K, Lange C, Fechtner M, Möpert K, Fisch G, Dames S, Arnold W, Jochims K, Giese K, Wiedenmann B, Scholz A, Kaufmann J.

Cancer Res. 2008 Dec 1;68(23):9788-98. doi: 10.1158/0008-5472.CAN-08-2428.


Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo.

Schaeper U, Vogel R, Chmielowiec J, Huelsken J, Rosario M, Birchmeier W.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15376-81. Epub 2007 Sep 19.


Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors.

van den Akker E, van Dijk T, Parren-van Amelsvoort M, Grossmann KS, Schaeper U, Toney-Earley K, Waltz SE, Löwenberg B, von Lindern M.

Blood. 2004 Jun 15;103(12):4457-65. Epub 2004 Feb 24.


The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif.

Lewitzky M, Kardinal C, Gehring NH, Schmidt EK, Konkol B, Eulitz M, Birchmeier W, Schaeper U, Feller SM.

Oncogene. 2001 Mar 1;20(9):1052-62.


Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL.

Sakkab D, Lewitzky M, Posern G, Schaeper U, Sachs M, Birchmeier W, Feller SM.

J Biol Chem. 2000 Apr 14;275(15):10772-8.


Essential role of Gab1 for signaling by the c-Met receptor in vivo.

Sachs M, Brohmann H, Zechner D, Müller T, Hülsken J, Walther I, Schaeper U, Birchmeier C, Birchmeier W.

J Cell Biol. 2000 Sep 18;150(6):1375-84.


Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.

Schaeper U, Gehring NH, Fuchs KP, Sachs M, Kempkes B, Birchmeier W.

J Cell Biol. 2000 Jun 26;149(7):1419-32.


Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation.

Schaeper U, Boyd JM, Verma S, Uhlmann E, Subramanian T, Chinnadurai G.

Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10467-71. Erratum in: Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14584.


Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins.

Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, D'Sa-Eipper C, Chinnadurai G.

Cell. 1994 Oct 21;79(2):341-51. Erratum in: Cell. 1994 Dec 16;79(6):1121.


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