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Items: 1 to 50 of 101

1.

On the biophysics and kinetics of toehold-mediated DNA strand displacement.

Srinivas N, Ouldridge TE, Sulc P, Schaeffer JM, Yurke B, Louis AA, Doye JP, Winfree E.

Nucleic Acids Res. 2013 Dec;41(22):10641-58. doi: 10.1093/nar/gkt801. Epub 2013 Sep 9.

2.

Using vacuum-assisted suspension to manage residual limb wounds in persons with transtibial amputation: a case series.

Hoskins RD, Sutton EE, Kinor D, Schaeffer JM, Fatone S.

Prosthet Orthot Int. 2014 Feb;38(1):68-74. doi: 10.1177/0309364613487547. Epub 2013 May 17.

PMID:
23685916
3.

Bisphenol A and other compounds in human saliva and urine associated with the placement of composite restorations.

Kingman A, Hyman J, Masten SA, Jayaram B, Smith C, Eichmiller F, Arnold MC, Wong PA, Schaeffer JM, Solanki S, Dunn WJ.

J Am Dent Assoc. 2012 Dec;143(12):1292-302.

PMID:
23204083
4.

Somatostatin receptor subtypes 2 and 5 mediate inhibition of egg yolk-induced gall bladder emptying in mice.

Kaczmarek P, Singh V, Cashen DE, Yang L, Berk S, Pasternak A, Xiong Y, Shen DM, Hutchins SM, Chapman K, Wiedenmann B, Schaeffer JM, Strowski MZ.

Neurogastroenterol Motil. 2010 Feb;22(2):204-9, e66. doi: 10.1111/j.1365-2982.2009.01407.x. Epub 2009 Sep 15.

PMID:
19754922
5.

Control of rat tail skin temperature regulation by estrogen receptor-beta selective ligand.

Opas EE, Scafonas A, Nantermet PV, Wilkening RR, Birzin ET, Wilkinson H, Colwell LF, Schaeffer JM, Towler DA, Rodan GA, Schmidt A.

Maturitas. 2009 Sep 20;64(1):46-51. doi: 10.1016/j.maturitas.2009.07.007. Epub 2009 Aug 12.

PMID:
19679413
6.

Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha.

Dykstra KD, Guo L, Birzin ET, Chan W, Yang YT, Hayes EC, DaSilva CA, Pai LY, Mosley RT, Kraker B, Fitzgerald PM, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML.

Bioorg Med Chem Lett. 2007 Apr 15;17(8):2322-8. Epub 2007 Jan 25.

PMID:
17289385
7.

Antidiabetic activity of a highly potent and selective nonpeptide somatostatin receptor subtype-2 agonist.

Strowski MZ, Cashen DE, Birzin ET, Yang L, Singh V, Jacks TM, Nowak KW, Rohrer SP, Patchett AA, Smith RG, Schaeffer JM.

Endocrinology. 2006 Oct;147(10):4664-73. Epub 2006 Jul 20.

PMID:
16857751
8.

The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands.

Wilkening RR, Ratcliffe RW, Tynebor EC, Wildonger KJ, Fried AK, Hammond ML, Mosley RT, Fitzgerald PM, Sharma N, McKeever BM, Nilsson S, Carlquist M, Thorsell A, Locco L, Katz R, Frisch K, Birzin ET, Wilkinson HA, Mitra S, Cai S, Hayes EC, Schaeffer JM, Rohrer SP.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3489-94. Epub 2006 May 2.

PMID:
16632357
9.

11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice.

Hermanowski-Vosatka A, Balkovec JM, Cheng K, Chen HY, Hernandez M, Koo GC, Le Grand CB, Li Z, Metzger JM, Mundt SS, Noonan H, Nunes CN, Olson SH, Pikounis B, Ren N, Robertson N, Schaeffer JM, Shah K, Springer MS, Strack AM, Strowski M, Wu K, Wu T, Xiao J, Zhang BB, Wright SD, Thieringer R.

J Exp Med. 2005 Aug 15;202(4):517-27.

10.

Adamantyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.

Olson S, Aster SD, Brown K, Carbin L, Graham DW, Hermanowski-Vosatka A, LeGrand CB, Mundt SS, Robbins MA, Schaeffer JM, Slossberg LH, Szymonifka MJ, Thieringer R, Wright SD, Balkovec JM.

Bioorg Med Chem Lett. 2005 Oct 1;15(19):4359-62.

PMID:
16039856
11.

Estrogen receptor ligands. Part 13: Dihydrobenzoxathiin SERAMs with an optimized antagonist side chain.

Blizzard TA, DiNinno F, Chen HY, Kim S, Wu JY, Chan W, Birzin ET, Yang YT, Pai LY, Hayes EC, DaSilva CA, Rohrer SP, Schaeffer JM, Hammond ML.

Bioorg Med Chem Lett. 2005 Sep 1;15(17):3912-6.

PMID:
15993065
12.

Estrogen receptor-beta regulates tryptophan hydroxylase-1 expression in the murine midbrain raphe.

Gundlah C, Alves SE, Clark JA, Pai LY, Schaeffer JM, Rohrer SP.

Biol Psychiatry. 2005 Apr 15;57(8):938-42.

PMID:
15820717
13.

Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.

Tan Q, Blizzard TA, Morgan JD 2nd, Birzin ET, Chan W, Yang YT, Pai LY, Hayes EC, DaSilva CA, Warrier S, Yudkovitz J, Wilkinson HA, Sharma N, Fitzgerald PM, Li S, Colwell L, Fisher JE, Adamski S, Reszka AA, Kimmel D, DiNinno F, Rohrer SP, Freedman LP, Schaeffer JM, Hammond ML.

Bioorg Med Chem Lett. 2005 Mar 15;15(6):1675-81.

PMID:
15745820
14.

Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans.

Liu J, Birzin ET, Chan W, Yang YT, Pai LY, Dasilva C, Hayes EC, Mosley RT, Dininno F, Rohrer SP, Schaeffer JM, Hammond ML.

Bioorg Med Chem Lett. 2005 Feb 1;15(3):715-8.

PMID:
15664843
15.

17 Beta-estradiol-induced antidepressant-like effect in the forced swim test is absent in estrogen receptor-beta knockout (BERKO) mice.

Rocha BA, Fleischer R, Schaeffer JM, Rohrer SP, Hickey GJ.

Psychopharmacology (Berl). 2005 May;179(3):637-43. Epub 2005 Jan 6.

PMID:
15645223
16.

Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.

Blizzard TA, Dininno F, Morgan JD 2nd, Chen HY, Wu JY, Kim S, Chan W, Birzin ET, Yang YT, Pai LY, Fitzgerald PM, Sharma N, Li Y, Zhang Z, Hayes EC, Dasilva CA, Tang W, Rohrer SP, Schaeffer JM, Hammond ML.

Bioorg Med Chem Lett. 2005 Jan 3;15(1):107-13.

PMID:
15582421
17.

Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains.

Blizzard TA, DiNinno F, Morgan JD 2nd, Wu JY, Chen HY, Kim S, Chan W, Birzin ET, Yang YT, Pai LY, Zhang Z, Hayes EC, DaSilva CA, Tang W, Rohrer SP, Schaeffer JM, Hammond ML.

Bioorg Med Chem Lett. 2004 Aug 2;14(15):3865-8.

PMID:
15225686
18.

Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains.

Blizzard TA, DiNinno F, Morgan JD 2nd, Chen HY, Wu JY, Gude C, Kim S, Chan W, Birzin ET, Tien Yang Y, Pai LY, Zhang Z, Hayes EC, DaSilva CA, Tang W, Rohrer SP, Schaeffer JM, Hammond ML.

Bioorg Med Chem Lett. 2004 Aug 2;14(15):3861-4.

PMID:
15225685
19.

Estrogen receptor ligands. Part 6: Synthesis and binding affinity of dihydrobenzodithiins.

Tan Q, Birzin ET, Chan W, Yang YT, Pai LY, Hayes EC, DaSilva CA, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML.

Bioorg Med Chem Lett. 2004 Jul 16;14(14):3753-5.

PMID:
15203156
20.

Estrogen receptor ligands. Part 5: The SAR of dihydrobenzoxathiins containing modified basic side chains.

Tan Q, Birzin ET, Chan W, Tien Yang Y, Pai LY, Hayes EC, DaSilva CA, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML.

Bioorg Med Chem Lett. 2004 Jul 16;14(14):3747-51.

PMID:
15203155
21.

Distinct effects of the antiestrogen Faslodex on the stability of estrogen receptors-alpha and -beta in the breast cancer cell line MCF-7.

Peekhaus NT, Chang T, Hayes EC, Wilkinson HA, Mitra SW, Schaeffer JM, Rohrer SP.

J Mol Endocrinol. 2004 Jun;32(3):987-95.

PMID:
15171727
22.

Estrogen receptor ligands. Part 4: The SAR of the syn-dihydrobenzoxathiin SERAMs.

Kim S, Wu J, Chen HY, Birzin ET, Chan W, Yang YT, Colwell L, Li S, Dahllund J, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML.

Bioorg Med Chem Lett. 2004 Jun 7;14(11):2741-5.

PMID:
15125925
23.

Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs.

Chen HY, Kim S, Wu JY, Birzin ET, Chan W, Yang YT, Dahllund J, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML.

Bioorg Med Chem Lett. 2004 May 17;14(10):2551-4.

PMID:
15109649
24.

A beta-lactamase-dependent Gal4-estrogen receptor beta transactivation assay for the ultra-high throughput screening of estrogen receptor beta agonists in a 3456-well format.

Peekhaus NT, Ferrer M, Chang T, Kornienko O, Schneeweis JE, Smith TS, Hoffman I, Mitnaul LJ, Chin J, Fischer PA, Blizzard TA, Birzin ET, Chan W, Inglese J, Strulovici B, Rohrer SP, Schaeffer JM.

Assay Drug Dev Technol. 2003 Dec;1(6):789-800.

PMID:
15090225
25.

Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators.

Kim S, Wu JY, Birzin ET, Frisch K, Chan W, Pai LY, Yang YT, Mosley RT, Fitzgerald PM, Sharma N, Dahllund J, Thorsell AG, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML.

J Med Chem. 2004 Apr 22;47(9):2171-5.

PMID:
15084115
26.

Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity.

Chen HY, Dykstra KD, Birzin ET, Frisch K, Chan W, Yang YT, Mosley RT, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML.

Bioorg Med Chem Lett. 2004 Mar 22;14(6):1417-21.

PMID:
15006374
27.

Immunolocalization of estrogen receptor beta in the mouse brain: comparison with estrogen receptor alpha.

Mitra SW, Hoskin E, Yudkovitz J, Pear L, Wilkinson HA, Hayashi S, Pfaff DW, Ogawa S, Rohrer SP, Schaeffer JM, McEwen BS, Alves SE.

Endocrinology. 2003 May;144(5):2055-67. Erratum in: Endocrinology. 2003 Jul;144(7):2844.

PMID:
12697714
28.

Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis.

Strowski MZ, Kohler M, Chen HY, Trumbauer ME, Li Z, Szalkowski D, Gopal-Truter S, Fisher JK, Schaeffer JM, Blake AD, Zhang BB, Wilkinson HA.

Mol Endocrinol. 2003 Jan;17(1):93-106.

PMID:
12511609
29.

Somatostatin receptor subtypes 2 and 5 inhibit corticotropin-releasing hormone-stimulated adrenocorticotropin secretion from AtT-20 cells.

Strowski MZ, Dashkevicz MP, Parmar RM, Wilkinson H, Kohler M, Schaeffer JM, Blake AD.

Neuroendocrinology. 2002 Jun;75(6):339-46.

PMID:
12065886
30.

The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate.

Cui J, Heard TS, Yu J, Lo JL, Huang L, Li Y, Schaeffer JM, Wright SD.

J Biol Chem. 2002 Jul 19;277(29):25963-9. Epub 2002 May 9.

31.

Identification and characterization of a functionally distinct form of human estrogen receptor beta.

Wilkinson HA, Dahllund J, Liu H, Yudkovitz J, Cai SJ, Nilsson S, Schaeffer JM, Mitra SW.

Endocrinology. 2002 Apr;143(4):1558-61.

PMID:
11897716
32.

A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor.

DeVita RJ, Walsh TF, Young JR, Jiang J, Ujjainwalla F, Toupence RB, Parikh M, Huang SX, Fair JA, Goulet MT, Wyvratt MJ, Lo JL, Ren N, Yudkovitz JB, Yang YT, Cheng K, Cui J, Mount G, Rohrer SP, Schaeffer JM, Rhodes L, Drisko JE, McGowan E, MacIntyre DE, Vincent S, Carlin JR, Cameron J, Smith RG.

J Med Chem. 2001 Mar 15;44(6):917-22.

PMID:
11300873
33.

Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists.

Zhou C, Guo L, Morriello G, Pasternak A, Pan Y, Rohrer SP, Birzin ET, Huskey SE, Jacks T, Schleim KD, Cheng K, Schaeffer JM, Patchett AA, Yang L.

Bioorg Med Chem Lett. 2001 Feb 12;11(3):415-7.

PMID:
11212124
34.

Identification and characterization of subtype selective somatostatin receptor agonists.

Rohrer SP, Schaeffer JM.

J Physiol Paris. 2000 May-Aug;94(3-4):211-5.

PMID:
11087999
35.

Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.

Dawson GR, Wafford KA, Smith A, Marshall GR, Bayley PJ, Schaeffer JM, Meinke PT, McKernan RM.

J Pharmacol Exp Ther. 2000 Dec;295(3):1051-60.

PMID:
11082440
36.

Identification of Phe313 of the gonadotropin-releasing hormone (GnRH) receptor as a site critical for the binding of nonpeptide GnRH antagonists.

Cui J, Smith RG, Mount GR, Lo JL, Yu J, Walsh TF, Singh SB, DeVita RJ, Goulet MT, Schaeffer JM, Cheng K.

Mol Endocrinol. 2000 May;14(5):671-81.

PMID:
10809231
37.

A combinatorial approach toward the discovery of non-peptide, subtype-selective somatostatin receptor ligands.

Berk SC, Rohrer SP, Degrado SJ, Birzin ET, Mosley RT, Hutchins SM, Pasternak A, Schaeffer JM, Underwood DJ, Chapman KT.

J Comb Chem. 1999 Sep-Oct;1(5):388-96.

PMID:
10748735
38.

Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues.

Ye Z, Gao Y, Bakshi RK, Chen MH, Rohrer SP, Feighner SD, Pong SS, Howard AD, Blake A, Birzin ET, Locco L, Parmar RM, Chan WW, Schaeffer JM, Smith RG, Patchett AA, Nargund RP.

Bioorg Med Chem Lett. 2000 Jan 3;10(1):5-8.

PMID:
10636230
39.
40.

Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor.

Smith LE, Shen W, Perruzzi C, Soker S, Kinose F, Xu X, Robinson G, Driver S, Bischoff J, Zhang B, Schaeffer JM, Senger DR.

Nat Med. 1999 Dec;5(12):1390-5.

PMID:
10581081
41.

Nonpeptidyl somatostatin agonists demonstrate that sst2 and sst5 inhibit stimulated growth hormone secretion from rat anterior pituitary cells.

Parmar RM, Chan WW, Dashkevicz M, Hayes EC, Rohrer SP, Smith RG, Schaeffer JM, Blake AD.

Biochem Biophys Res Commun. 1999 Sep 24;263(2):276-80.

PMID:
10491284
42.

Colocalization of somatostatin receptor sst5 and insulin in rat pancreatic beta-cells.

Mitra SW, Mezey E, Hunyady B, Chamberlain L, Hayes E, Foor F, Wang Y, Schonbrunn A, Schaeffer JM.

Endocrinology. 1999 Aug;140(8):3790-6.

PMID:
10433240
43.

Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization.

Pasternak A, Pan Y, Marino D, Sanderson PE, Mosley R, Rohrer SP, Birzin ET, Huskey SE, Jacks T, Schleim KD, Cheng K, Schaeffer JM, Patchett AA, Yang L.

Bioorg Med Chem Lett. 1999 Feb 8;9(3):491-6.

PMID:
10091708
44.

Picrotoxin blockade of invertebrate glutamate-gated chloride channels: subunit dependence and evidence for binding within the pore.

Etter A, Cully DF, Liu KK, Reiss B, Vassilatis DK, Schaeffer JM, Arena JP.

J Neurochem. 1999 Jan;72(1):318-26.

45.

Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.

Rohrer SP, Birzin ET, Mosley RT, Berk SC, Hutchins SM, Shen DM, Xiong Y, Hayes EC, Parmar RM, Foor F, Mitra SW, Degrado SJ, Shu M, Klopp JM, Cai SJ, Blake A, Chan WW, Pasternak A, Yang L, Patchett AA, Smith RG, Chapman KT, Schaeffer JM.

Science. 1998 Oct 23;282(5389):737-40. Erratum in: Science 1998 Nov 27;282(5394):1646.

46.

Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer.

Zhou G, Cummings R, Li Y, Mitra S, Wilkinson HA, Elbrecht A, Hermes JD, Schaeffer JM, Smith RG, Moller DE.

Mol Endocrinol. 1998 Oct;12(10):1594-604.

PMID:
9773982
47.

Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2.

Yang L, Berk SC, Rohrer SP, Mosley RT, Guo L, Underwood DJ, Arison BH, Birzin ET, Hayes EC, Mitra SW, Parmar RM, Cheng K, Wu TJ, Butler BS, Foor F, Pasternak A, Pan Y, Silva M, Freidinger RM, Smith RG, Chapman K, Schaeffer JM, Patchett AA.

Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10836-41.

48.

High basal gastric acid secretion in somatostatin receptor subtype 2 knockout mice.

Martinez V, Curi AP, Torkian B, Schaeffer JM, Wilkinson HA, Walsh JH, Taché Y.

Gastroenterology. 1998 Jun;114(6):1125-32.

PMID:
9609748
49.

Genetic and biochemical evidence for a novel avermectin-sensitive chloride channel in Caenorhabditis elegans. Isolation and characterization.

Vassilatis DK, Arena JP, Plasterk RH, Wilkinson HA, Schaeffer JM, Cully DF, Van der Ploeg LH.

J Biol Chem. 1997 Dec 26;272(52):33167-74.

50.

Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons.

Zheng H, Bailey A, Jiang MH, Honda K, Chen HY, Trumbauer ME, Van der Ploeg LH, Schaeffer JM, Leng G, Smith RG.

Mol Endocrinol. 1997 Oct;11(11):1709-17.

PMID:
9328352

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