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Interrelationships between ovarian follicles grown in culture and possible mediators.
Sirotkin AV, Florkovičová Koničková I, Schaeffer HJ, Laurincik J, Harrath AH.
Reprod Biol. 2017 Mar;17(1):97-104. doi: 10.1016/j.repbio.2017.01.005. Epub 2017 Feb 2.
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Krueppel-like factor 15 regulates Wnt/β-catenin transcription and controls cardiac progenitor cell fate in the postnatal heart.
Noack C, Zafiriou MP, Schaeffer HJ, Renger A, Pavlova E, Dietz R, Zimmermann WH, Bergmann MW, Zelarayán LC.
EMBO Mol Med. 2012 Sep;4(9):992-1007. doi: 10.1002/emmm.201101043. Epub 2012 Jul 5.
RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility.
Vomastek T, Iwanicki MP, Schaeffer HJ, Tarcsafalvi A, Parsons JT, Weber MJ.
Mol Cell Biol. 2007 Dec;27(23):8296-305. Epub 2007 Oct 1.
Diversin regulates heart formation and gastrulation movements in development.
Moeller H, Jenny A, Schaeffer HJ, Schwarz-Romond T, Mlodzik M, Hammerschmidt M, Birchmeier W.
Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15900-5. Epub 2006 Oct 10.
The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals.
Pullikuth A, McKinnon E, Schaeffer HJ, Catling AD.
Mol Cell Biol. 2005 Jun;25(12):5119-33.
Thrombopoietin regulates proliferation, apoptosis, secretory activity and intracellular messengers in porcine ovarian follicular cells: involvement of protein kinase A.
Sirotkin AV, Sanislo P, Schaeffer HJ, Florkovicová I, Kotwica J, Bulla J, Hetényi L.
J Endocrinol. 2004 Dec;183(3):595-604.
MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling.
Sharma C, Vomastek T, Tarcsafalvi A, Catling AD, Schaeffer HJ, Eblen ST, Weber MJ.
J Cell Biochem. 2005 Mar 1;94(4):708-19.
Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists.
Vomastek T, Schaeffer HJ, Tarcsafalvi A, Smolkin ME, Bissonette EA, Weber MJ.
Proc Natl Acad Sci U S A. 2004 May 4;101(18):6981-6. Epub 2004 Apr 26.
Oxytocin mediates some effects of insulin-like growth factor-I on porcine ovarian follicles.
Sirotkin AV, Florkovicova I, Makarevich AV, Schaeffer HJ, Kotwica J, Marnet PG, Sanislo P.
J Reprod Dev. 2003 Apr;49(2):141-9.
Longitudinal thrombopoietin plasma concentrations in fetuses with alloimmune thrombocytopenia treated with intrauterine PLT transfusions.
Cremer M, Dame C, Schaeffer HJ, Giers G, Bartmann P, Bald R.
Transfusion. 2003 Sep;43(9):1216-22.
The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling.
Schwarz-Romond T, Asbrand C, Bakkers J, Kühl M, Schaeffer HJ, Huelsken J, Behrens J, Hammerschmidt M, Birchmeier W.
Genes Dev. 2002 Aug 15;16(16):2073-84.
Scaffold protein regulation of mitogen-activated protein kinase cascade.
Catling AD, Eblen ST, Schaeffer HJ, Weber MJ.
Methods Enzymol. 2001;332:368-87. No abstract available.
The selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Reproduced from Proc. Natl. Acad. Sci. USA 74, 5716-5720 (1977)
Elion GB, Furman PA, Fyfe JA, de Miranda P, Beauchamp L, Schaeffer HJ.
Rev Med Virol. 1999 Jul;9(3):147-52; discussion 152-3. No abstract available.
Mitogen-activated protein kinases: specific messages from ubiquitous messengers.
Schaeffer HJ, Weber MJ.
Mol Cell Biol. 1999 Apr;19(4):2435-44. Review. No abstract available.
EXG1p, a novel exo-beta1,3-glucanase from the fungus Cochliobolus carbonum, contains a repeated motif present in other proteins that interact with polysaccharides.
Nikolskaya AN, Pitkin JW, Schaeffer HJ, Ahn JH, Walton JD.
Biochim Biophys Acta. 1998 Nov 27;1425(3):632-6.
MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade.
Schaeffer HJ, Catling AD, Eblen ST, Collier LS, Krauss A, Weber MJ.
Science. 1998 Sep 11;281(5383):1668-71.
Insulin-like growth factor binding protein-3 levels during early and late follow-up after surgery in acromegalic patients.
Charalampaki P, Hildebrandt G, Schaeffer HJ, Schönau E, Klug N.
Exp Clin Endocrinol Diabetes. 1998;106(2):130-4.
Direct regulation of mammalian reproductive organs by serotonin and melatonin.
Sirotkin AV, Schaeffer HJ.
J Endocrinol. 1997 Jul;154(1):1-5. Review. No abstract available.
Cloning and sequencing of a cDNA for firefly luciferase from Photuris pennsylvanica.
Ye L, Buck LM, Schaeffer HJ, Leach FR.
Biochim Biophys Acta. 1997 Apr 25;1339(1):39-52.
Elevated levels of insulin-like growth factor (IGF) binding protein-3 in rheumatoid arthritis synovial fluid inhibit stimulation by IGF-I of articular chondrocyte proteoglycan synthesis.
Neidel J, Blum WF, Schaeffer HJ, Schulze M, Schönau E, Lindschau J, Föll J.
Rheumatol Int. 1997;17(1):29-37.
Melatonin and serotonin regulate the release of insulin-like growth factor-I, oxytocin and progesterone by cultured human granulosa cells.
Schaeffer HJ, Sirotkin AV.
Exp Clin Endocrinol Diabetes. 1997;105(2):109-12.
Oxytocin affects the release of steroids, insulin-like growth factor-I, prostaglandin F2alpha and cyclic nucleotides by human granulosa cells in vitro.
Sirotkin AV, Schaeffer HJ, Mlyncek M, Missik J, Bulla J.
Hum Reprod. 1996 Jan;11(1):152-5.
High-dose progesterone infusion in healthy males: evidence against antiglucocorticoid activity of progesterone.
Allolio B, Oremus M, Reincke M, Schaeffer HJ, Winkelmann W, Heck G, Schulte HM.
Eur J Endocrinol. 1995 Dec;133(6):696-700.
A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function.
Catling AD, Schaeffer HJ, Reuter CW, Reddy GR, Weber MJ.
Mol Cell Biol. 1995 Oct;15(10):5214-25.
Identification of enhancer and silencer regions involved in salt-responsive expression of Crassulacean acid metabolism (CAM) genes in the facultative halophyte Mesembryanthemum crystallinum.
Schaeffer HJ, Forstheoefel NR, Cushman JC.
Plant Mol Biol. 1995 May;28(2):205-18.
The release of insulin-like growth factor-I by luteinized human granulosa cells in vitro: regulation by growth hormone, oxytocin, steroids and cAMP-dependent intracellular mechanisms.
Exp Clin Endocrinol Diabetes. 1995;103(6):361-6.
Oxytocin regulates the secretory activity of human granulosa cells in vitro.
Adv Exp Med Biol. 1995;395:549-50. No abstract available.
Melatonin and serotonin directly regulate oxytocin, insulin-like growth factor-I and progesterone secretion by cultured human granulosa cells.
Adv Exp Med Biol. 1995;395:547-8. No abstract available.
[The prognostic significance of cathepsin D in primary breast cancer].
Crombach G, Ingenhorst A, Göhring UJ, Scharl A, Schaeffer HJ, Stützer H, Bolte A.
Geburtshilfe Frauenheilkd. 1994 Oct;54(10):545-51. German.
Cloning and targeted gene disruption of EXG1, encoding exo-beta 1, 3-glucanase, in the phytopathogenic fungus Cochliobolus carbonum.
Schaeffer HJ, Leykam J, Walton JD.
Appl Environ Microbiol. 1994 Feb;60(2):594-8.
Expression of pS2 protein in breast cancer.
Crombach G, Ingenhorst A, Göhring UJ, Scharl A, Neuhaus W, Möbus V, Schaeffer HJ.
Arch Gynecol Obstet. 1993;253(4):183-92.
Aluminum Ions Induce Oat Protoplasts to Produce an Extracellular (1-->3)beta-d-Glucan.
Schaeffer HJ, Walton JD.
Plant Physiol. 1990 Sep;94(1):13-9.
Hypoxic stress inhibits the appearance of wound-response proteins in potato tubers.
Vayda ME, Schaeffer HJ.
Plant Physiol. 1988 Nov;88(3):805-9.
Effect of acyclic pyrimidines related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine on herpesviruses.
Beauchamp LM, Serling BL, Kelsey JE, Biron KK, Collins P, Selway J, Lin JC, Schaeffer HJ.
J Med Chem. 1988 Jan;31(1):144-9.
Purine acyclic nucleosides. 6-Dimethylamino-9-[(2-phenylalanylamido-1-substituted- ethoxy)methyl]purines as candidate antivirals.
Kelley JL, Selway JW, Schaeffer HJ.
J Pharm Sci. 1985 Dec;74(12):1302-4.
Modifications on the heterocyclic base of acyclovir: syntheses and antiviral properties.
Beauchamp LM, Dolmatch BL, Schaeffer HJ, Collins P, Bauer DJ, Keller PM, Fyfe JA.
J Med Chem. 1985 Aug;28(8):982-7.
6-Deoxyacyclovir: a xanthine oxidase-activated prodrug of acyclovir.
Krenitsky TA, Hall WW, de Miranda P, Beauchamp LM, Schaeffer HJ, Whiteman PD.
Proc Natl Acad Sci U S A. 1984 May;81(10):3209-13.
Acyclovir chemistry and spectrum of activity.
Schaeffer HJ.
Am J Med. 1982 Jul 20;73(1A):4-6.
Purine acyclic nucleosides. Nitrogen isosteres of 9-[(2-hydroxyethoxy)methyl]guanine as candidate antivirals.
Kelley JL, Krochmal MP, Schaeffer HJ.
J Med Chem. 1981 Dec;24(12):1528-31.
Enzymatic phosphorylation of acyclic nucleoside analogs and correlations with antiherpetic activities.
Keller PM, Fyfe JA, Beauchamp L, Lubbers CM, Furman PA, Schaeffer HJ, Elion GB.
Biochem Pharmacol. 1981 Nov 15;30(22):3071-7. No abstract available.
Acyclic Puromycin Analogs: 9-[(2-phenylalanylamidoethoxy) methyl] adenine and 9-(3-phenylalanylamidopropyl) adenine.
Kelley JL, Miller CA, Schaeffer HJ.
J Pharm Sci. 1981 Oct;70(10):1169-71. No abstract available.
Pyrimidine acyclic nucleosides, 1-[(2-Hydroxyethoxy)methyl]pyrimidines as candidate antivirals.
Kelley JL, Kelsey JE, Hall WR, Krochmal MP, Schaeffer HJ.
J Med Chem. 1981 Jun;24(6):753-6.
Pyrimidine acyclic nucleosides. 5-Substituted 1-[(2-aminoethoxy)methyl]uracils as candidate antivirals.
J Med Chem. 1981 Apr;24(4):472-4.
[Transvenous cholangiography and percutaneous transhepatic fine needle cholangiography (author's transl)].
Günther R, Georgi M, Schaeffer HJ.
Dtsch Med Wochenschr. 1980 Feb 22;105(8):255-62. German.
9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group.
Schaeffer HJ, Beauchamp L, de Miranda P, Elion GB, Bauer DJ, Collins P.
Nature. 1978 Apr 13;272(5654):583-5.
Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5716-20.
Enzyme inhibitors. 26. Bridging hydrophobic and hydrophilic regions on adenosine deaminase with some 9-(2-hydroxy-3-alkyl)adenines.
Schaeffer HJ, Schwender CF.
J Med Chem. 1974 Jan;17(1):6-8. No abstract available.
Enzyme inhibitors. 25. An equation to calculate the unknown K i from two known values of K i in an R,S, and RS series. Stereoselectivity of inhibition of Adenosine deaminase by (R)-, (S)-, and (RS)-9-(1-hydroxy-2-alkyl and -aralkyl)adenines.
Schaeffer HJ, Johnson RN, Schwartz MA, Schwender CF.
J Med Chem. 1972 May;15(5):456-8. No abstract available.
Enzyme inhibitors XXIV: bridging hydrophobic and hydrophilic regions on adenosine deaminase.
J Pharm Sci. 1971 Aug;60(8):1204-8. No abstract available.
Enzyme inhibitors. 23. Syntheses of 9-(substituted aralkyl)-6-substituted purines as inhibitors of adenosine deaminase.
Schaeffer HJ, Odin E, Bittner S.
J Pharm Sci. 1971 Aug;60(8):1184-8. No abstract available.
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