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Items: 15

1.

Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency.

Cushman M, Insaf S, Paul G, Ruell JA, De Clercq E, Schols D, Pannecouque C, Witvrouw M, Schaeffer CA, Turpin JA, Williamson K, Rice WG.

J Med Chem. 1999 May 20;42(10):1767-77.

PMID:
10346929
2.

Synthesis of a cosalane analog with an extended polyanionic pharmacophore conferring enhanced potency as an anti-HIV agent.

Cushman M, Insaf S, Ruell JA, Schaeffer CA, Rice WG.

Bioorg Med Chem Lett. 1998 Apr 7;8(7):833-6.

PMID:
9871550
3.

New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors.

Cushman M, Casimiro-Garcia A, Hejchman E, Ruell JA, Huang M, Schaeffer CA, Williamson K, Rice WG, Buckheit RW Jr.

J Med Chem. 1998 Jun 4;41(12):2076-89.

PMID:
9622549
4.

Inhibition of acute-, latent-, and chronic-phase human immunodeficiency virus type 1 (HIV-1) replication by a bistriazoloacridone analog that selectively inhibits HIV-1 transcription.

Turpin JA, Buckheit RW Jr, Derse D, Hollingshead M, Williamson K, Palamone C, Osterling MC, Hill SA, Graham L, Schaeffer CA, Bu M, Huang M, Cholody WM, Michejda CJ, Rice WG.

Antimicrob Agents Chemother. 1998 Mar;42(3):487-94.

5.

Inhibition of multiple phases of human immunodeficiency virus type 1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteins.

Rice WG, Baker DC, Schaeffer CA, Graham L, Bu M, Terpening S, Clanton D, Schultz R, Bader JP, Buckheit RW Jr, Field L, Singh PK, Turpin JA.

Antimicrob Agents Chemother. 1997 Feb;41(2):419-26.

6.

Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.

Rice WG, Turpin JA, Schaeffer CA, Graham L, Clanton D, Buckheit RW Jr, Zaharevitz D, Summers MF, Wallqvist A, Covell DG.

J Med Chem. 1996 Sep 13;39(19):3606-16.

PMID:
8809151
7.

Inhibitors of human immunodeficiency virus type 1 zinc fingers prevent normal processing of gag precursors and result in the release of noninfectious virus particles.

Turpin JA, Terpening SJ, Schaeffer CA, Yu G, Glover CJ, Felsted RL, Sausville EA, Rice WG.

J Virol. 1996 Sep;70(9):6180-9.

8.

All-atom models for the non-nucleoside binding site of HIV-1 reverse transcriptase complexed with inhibitors: a 3D QSAR approach.

Gussio R, Pattabiraman N, Zaharevitz DW, Kellogg GE, Topol IA, Rice WG, Schaeffer CA, Erickson JW, Burt SK.

J Med Chem. 1996 Apr 12;39(8):1645-50.

PMID:
8648604
9.

Human immunodeficiency virus type-1 (HIV-1) replication is unaffected by human secretory leukocyte protease inhibitor.

Turpin JA, Schaeffer CA, Bu M, Graham L, Buckheit RW Jr, Clanton D, Rice WG.

Antiviral Res. 1996 Mar;29(2-3):269-77.

PMID:
8739605
10.

Inhibitors of HIV nucleocapsid protein zinc fingers as candidates for the treatment of AIDS.

Rice WG, Supko JG, Malspeis L, Buckheit RW Jr, Clanton D, Bu M, Graham L, Schaeffer CA, Turpin JA, Domagala J, Gogliotti R, Bader JP, Halliday SM, Coren L, Sowder RC 2nd, Arthur LO, Henderson LE.

Science. 1995 Nov 17;270(5239):1194-7.

PMID:
7502043
11.

The site of antiviral action of 3-nitrosobenzamide on the infectivity process of human immunodeficiency virus in human lymphocytes.

Rice WG, Schaeffer CA, Graham L, Bu M, McDougal JS, Orloff SL, Villinger F, Young M, Oroszlan S, Fesen MR, et al.

Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9721-4.

12.

Inhibition of the replication of native and 3'-azido-2',3'-dideoxythymidine (AZT)-resistant simian immunodeficiency virus (SIV) by 3-nitrosobenzamide.

Chuang AJ, Killam KF Jr, Chuang RY, Rice WG, Schaeffer CA, Mendeleyev J, Kun E.

FEBS Lett. 1993 Jul 12;326(1-3):140-4.

13.

Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds.

Rice WG, Schaeffer CA, Harten B, Villinger F, South TL, Summers MF, Henderson LE, Bess JW Jr, Arthur LO, McDougal JS, et al.

Nature. 1993 Feb 4;361(6411):473-5.

PMID:
8429889
14.

Induction of endonuclease-mediated apoptosis in tumor cells by C-nitroso-substituted ligands of poly(ADP-ribose) polymerase.

Rice WG, Hillyer CD, Harten B, Schaeffer CA, Dorminy M, Lackey DA 3rd, Kirsten E, Mendeleyev J, Buki KG, Hakam A, et al.

Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7703-7.

15.

Effects of MSH/ACTH 4-10 on the classically-conditioned rabbit nictitating membrane.

Schaeffer CA, Nathanson DC, Cegavske CF, Roemer RA.

Peptides. 1982 Sep-Oct;3(5):715-9.

PMID:
6294629

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