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Items: 42


CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment.

Drummond RA, Swamydas M, Oikonomou V, Zhai B, Dambuza IM, Schaefer BC, Bohrer AC, Mayer-Barber KD, Lira SA, Iwakura Y, Filler SG, Brown GD, Hube B, Naglik JR, Hohl TM, Lionakis MS.

Nat Immunol. 2019 May;20(5):559-570. doi: 10.1038/s41590-019-0377-2. Epub 2019 Apr 17.


Enhanced Autophagy Contributes to Reduced Viral Infection in Black Flying Fox Cells.

Laing ED, Sterling SL, Weir DL, Beauregard CR, Smith IL, Larsen SE, Wang LF, Snow AL, Schaefer BC, Broder CC.

Viruses. 2019 Mar 14;11(3). pii: E260. doi: 10.3390/v11030260.


T Cell Receptor Activation of NF-κB in Effector T Cells: Visualizing Signaling Events Within and Beyond the Cytoplasmic Domain of the Immunological Synapse.

Traver MK, Paul S, Schaefer BC.

Methods Mol Biol. 2017;1584:101-127. doi: 10.1007/978-1-4939-6881-7_8.


Salsalate treatment following traumatic brain injury reduces inflammation and promotes a neuroprotective and neurogenic transcriptional response with concomitant functional recovery.

Lagraoui M, Sukumar G, Latoche JR, Maynard SK, Dalgard CL, Schaefer BC.

Brain Behav Immun. 2017 Mar;61:96-109. doi: 10.1016/j.bbi.2016.12.005. Epub 2016 Dec 7.


Visualizing TCR-induced POLKADOTS formation and NF-κB activation in the D10 T-cell clone and mouse primary effector T cells.

Paul S, Schaefer BC.

Methods Mol Biol. 2015;1280:219-38. doi: 10.1007/978-1-4939-2422-6_12.


T cell receptor signals to NF-κB are transmitted by a cytosolic p62-Bcl10-Malt1-IKK signalosome.

Paul S, Traver MK, Kashyap AK, Washington MA, Latoche JR, Schaefer BC.

Sci Signal. 2014 May 13;7(325):ra45. doi: 10.1126/scisignal.2004882.


A new look at T cell receptor signaling to nuclear factor-κB.

Paul S, Schaefer BC.

Trends Immunol. 2013 Jun;34(6):269-81. doi: 10.1016/ Epub 2013 Mar 7. Review.


Controlled cortical impact and craniotomy induce strikingly similar profiles of inflammatory gene expression, but with distinct kinetics.

Lagraoui M, Latoche JR, Cartwright NG, Sukumar G, Dalgard CL, Schaefer BC.

Front Neurol. 2012 Oct 31;3:155. doi: 10.3389/fneur.2012.00155. eCollection 2012.


Selective autophagy regulates T cell activation.

Paul S, Schaefer BC.

Autophagy. 2012 Nov;8(11):1690-2. doi: 10.4161/auto.21581. Epub 2012 Aug 9.


Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB.

Paul S, Kashyap AK, Jia W, He YW, Schaefer BC.

Immunity. 2012 Jun 29;36(6):947-58. doi: 10.1016/j.immuni.2012.04.008. Epub 2012 May 31.


An active kinase domain is required for retention of PKCθ at the T cell immunological synapse.

Cartwright NG, Kashyap AK, Schaefer BC.

Mol Biol Cell. 2011 Sep;22(18):3491-7. doi: 10.1091/mbc.E10-11-0916. Epub 2011 Jul 27.


Cutting edge: TCR ligation triggers digital activation of NF-kappaB.

Kingeter LM, Paul S, Maynard SK, Cartwright NG, Schaefer BC.

J Immunol. 2010 Oct 15;185(8):4520-4. doi: 10.4049/jimmunol.1001051. Epub 2010 Sep 20.


Blood fluke exploitation of non-cognate CD4+ T cell help to facilitate parasite development.

Lamb EW, Walls CD, Pesce JT, Riner DK, Maynard SK, Crow ET, Wynn TA, Schaefer BC, Davies SJ.

PLoS Pathog. 2010 Apr 29;6(4):e1000892. doi: 10.1371/journal.ppat.1000892.


Malt1 and cIAP2-Malt1 as effectors of NF-kappaB activation: kissing cousins or distant relatives?

Kingeter LM, Schaefer BC.

Cell Signal. 2010 Jan;22(1):9-22. doi: 10.1016/j.cellsig.2009.09.033. Epub 2009 Sep 19. Review.


Multiple protein domains mediate interaction between Bcl10 and MALT1.

Langel FD, Jain NA, Rossman JS, Kingeter LM, Kashyap AK, Schaefer BC.

J Biol Chem. 2008 Nov 21;283(47):32419-31. doi: 10.1074/jbc.M800670200. Epub 2008 Sep 19.


Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways.

Cameron JE, Yin Q, Fewell C, Lacey M, McBride J, Wang X, Lin Z, Schaefer BC, Flemington EK.

J Virol. 2008 Feb;82(4):1946-58. Epub 2007 Dec 5.


POLKADOTS are foci of functional interactions in T-Cell receptor-mediated signaling to NF-kappaB.

Rossman JS, Stoicheva NG, Langel FD, Patterson GH, Lippincott-Schwartz J, Schaefer BC.

Mol Biol Cell. 2006 May;17(5):2166-76. Epub 2006 Feb 22.


Analysis of tumor-associated stromal cells using SCID GFP transgenic mice: contribution of local and bone marrow-derived host cells.

Udagawa T, Puder M, Wood M, Schaefer BC, D'Amato RJ.

FASEB J. 2006 Jan;20(1):95-102.


Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells.

Zhu Y, Swanson BJ, Wang M, Hildeman DA, Schaefer BC, Liu X, Suzuki H, Mihara K, Kappler J, Marrack P.

Proc Natl Acad Sci U S A. 2004 May 18;101(20):7681-6. Epub 2004 May 10.


Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation.

Schaefer BC, Kappler JW, Kupfer A, Marrack P.

Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1004-9. Epub 2004 Jan 14.


Observation of antigen-dependent CD8+ T-cell/ dendritic cell interactions in vivo.

Schaefer BC, Schaefer ML, Kappler JW, Marrack P, Kedl RM.

Cell Immunol. 2001 Dec 15;214(2):110-22.


Cell surface expression of the HIV-1 envelope glycoproteins is directed from intracellular CTLA-4-containing regulated secretory granules.

Miranda LR, Schaefer BC, Kupfer A, Hu Z, Franzusoff A.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8031-6.


T cells down-modulate peptide-MHC complexes on APCs in vivo.

Kedl RM, Schaefer BC, Kappler JW, Marrack P.

Nat Immunol. 2002 Jan;3(1):27-32. Epub 2001 Dec 3.


A novel family of retroviral vectors for the rapid production of complex stable cell lines.

Schaefer BC, Mitchell TC, Kappler JW, Marrack P.

Anal Biochem. 2001 Oct 1;297(1):86-93.


Major histocompatibility complex proteins and TCRs: do they really go together like a horse and carriage?

Marrack P, Bender J, Jordan M, Rees W, Robertson J, Schaefer BC, Kappler J.

J Immunol. 2001 Jul 15;167(2):617-21. No abstract available.


Immunological adjuvants promote activated T cell survival via induction of Bcl-3.

Mitchell TC, Hildeman D, Kedl RM, Teague TK, Schaefer BC, White J, Zhu Y, Kappler J, Marrack P.

Nat Immunol. 2001 May;2(5):397-402.


Homeostasis of alpha beta TCR+ T cells.

Marrack P, Bender J, Hildeman D, Jordan M, Mitchell T, Murakami M, Sakamoto A, Schaefer BC, Swanson B, Kappler J.

Nat Immunol. 2000 Aug;1(2):107-11. Review.


MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway.

Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL.

J Biol Chem. 2001 Feb 16;276(7):5093-100. Epub 2000 Nov 9.


Activation-induced inhibition of interleukin 6-mediated T cell survival and signal transducer and activator of transcription 1 signaling.

Teague TK, Schaefer BC, Hildeman D, Bender J, Mitchell T, Kappler JW, Marrack P.

J Exp Med. 2000 Mar 20;191(6):915-26.


Genomic-scale analysis of gene expression in resting and activated T cells.

Marrack P, Mitchell T, Hildeman D, Kedl R, Teague TK, Bender J, Rees W, Schaefer BC, Kappler J.

Curr Opin Immunol. 2000 Apr;12(2):206-9. Review.


Live cell fluorescence imaging of T cell MEKK2: redistribution and activation in response to antigen stimulation of the T cell receptor.

Schaefer BC, Ware MF, Marrack P, Fanger GR, Kappler JW, Johnson GL, Monks CR.

Immunity. 1999 Oct;11(4):411-21. Erratum in: Immunity 2001 May;14(5):655-6.


Activation changes the spectrum but not the diversity of genes expressed by T cells.

Teague TK, Hildeman D, Kedl RM, Mitchell T, Rees W, Schaefer BC, Bender J, Kappler J, Marrack P.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12691-6.


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