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Items: 6

1.

FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer.

Weiss A, Adler F, Buhles A, Stamm C, Fairhurst RA, Kiffe M, Sterker D, Centeleghe M, Wartmann M, Kinyamu-Akunda J, Schadt HS, Couttet P, Wolf A, Wang Y, Barzaghi-Rinaudo P, Murakami M, Kauffmann A, Knoepfel T, Buschmann N, Leblanc C, Mah R, Furet P, Blank J, Hofmann F, Sellers WR, Graus Porta D.

Mol Cancer Ther. 2019 Dec;18(12):2194-2206. doi: 10.1158/1535-7163.MCT-18-1291. Epub 2019 Aug 13.

PMID:
31409633
2.

Bile Acid Sequestration by Cholestyramine Mitigates FGFR4 Inhibition-Induced ALT Elevation.

Schadt HS, Wolf A, Mahl JA, Wuersch K, Couttet P, Schwald M, Fischer A, Lienard M, Emotte C, Teng CH, Skuba E, Richardson TA, Manenti L, Weiss A, Graus Porta D, Fairhurst RA, Kullak-Ublick GA, Chibout SD, Pognan F, Kluwe W, Kinyamu-Akunda J.

Toxicol Sci. 2018 May 1;163(1):265-278. doi: 10.1093/toxsci/kfy031.

PMID:
29432567
3.

Bile acids in drug induced liver injury: Key players and surrogate markers.

Schadt HS, Wolf A, Pognan F, Chibout SD, Merz M, Kullak-Ublick GA.

Clin Res Hepatol Gastroenterol. 2016 Jun;40(3):257-266. doi: 10.1016/j.clinre.2015.12.017. Epub 2016 Feb 10. Review.

4.
5.

2-Amino-2-deoxyisochorismate is a key intermediate in Bacillus subtilis p-aminobenzoic acid biosynthesis.

Schadt HS, Schadt S, Oldach F, Süssmuth RD.

J Am Chem Soc. 2009 Mar 18;131(10):3481-3. doi: 10.1021/ja809283u.

PMID:
19275258
6.

Action of atrop-abyssomicin C as an inhibitor of 4-amino-4-deoxychorismate synthase PabB.

Keller S, Schadt HS, Ortel I, Süssmuth RD.

Angew Chem Int Ed Engl. 2007;46(43):8284-6. No abstract available.

PMID:
17886307

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