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Items: 18


Of Mice, Dogs, Pigs, and Men: Choosing the Appropriate Model for Immuno-Oncology Research.

Overgaard NH, Fan TM, Schachtschneider KM, Principe DR, Schook LB, Jungersen G.

ILAR J. 2018 Nov 22. doi: 10.1093/ilar/ily014. [Epub ahead of print]


Utilization of Genomics and Functional Genomics to Inform Clinical Decisions in IR.

Schachtschneider KM, Gaba RC.

J Vasc Interv Radiol. 2018 Aug;29(8):1117-1121. doi: 10.1016/j.jvir.2018.03.015. Review. No abstract available.


Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β+ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules.

Overgaard NH, Principe DR, Schachtschneider KM, Jakobsen JT, Rund LA, Grippo PJ, Schook LB, Jungersen G.

Front Immunol. 2018 Jun 7;9:1301. doi: 10.3389/fimmu.2018.01301. eCollection 2018.


Characterization of an Inducible Alcoholic Liver Fibrosis Model for Hepatocellular Carcinoma Investigation in a Transgenic Porcine Tumorigenic Platform.

Gaba RC, Mendoza-Elias N, Regan DP, Garcia KD, Lokken RP, Schwind RM, Eichner M, Thomas FM, Rund LA, Schook LB, Schachtschneider KM.

J Vasc Interv Radiol. 2018 Aug;29(8):1194-1202.e1. doi: 10.1016/j.jvir.2018.03.007. Epub 2018 Jun 7.


The Oncopig Cancer Model as a Complementary Tool for Phenotypic Drug Discovery.

Segatto NV, Remião MH, Schachtschneider KM, Seixas FK, Schook LB, Collares T.

Front Pharmacol. 2017 Dec 5;8:894. doi: 10.3389/fphar.2017.00894. eCollection 2017. Review.


A validated, transitional and translational porcine model of hepatocellular carcinoma.

Schachtschneider KM, Schwind RM, Darfour-Oduro KA, De AK, Rund LA, Singh K, Principe DR, Guzman G, Ray CE Jr, Ozer H, Gaba RC, Schook LB.

Oncotarget. 2017 Jun 29;8(38):63620-63634. doi: 10.18632/oncotarget.18872. eCollection 2017 Sep 8.


The Oncopig Cancer Model: An Innovative Large Animal Translational Oncology Platform.

Schachtschneider KM, Schwind RM, Newson J, Kinachtchouk N, Rizko M, Mendoza-Elias N, Grippo P, Principe DR, Park A, Overgaard NH, Jungersen G, Garcia KD, Maker AV, Rund LA, Ozer H, Gaba RC, Schook LB.

Front Oncol. 2017 Aug 23;7:190. doi: 10.3389/fonc.2017.00190. eCollection 2017. Review.


Oncopig Soft-Tissue Sarcomas Recapitulate Key Transcriptional Features of Human Sarcomas.

Schachtschneider KM, Liu Y, Mäkeläinen S, Madsen O, Rund LA, Groenen MAM, Schook LB.

Sci Rep. 2017 Jun 1;7(1):2624. doi: 10.1038/s41598-017-02912-9.


Impact of neonatal iron deficiency on hippocampal DNA methylation and gene transcription in a porcine biomedical model of cognitive development.

Schachtschneider KM, Liu Y, Rund LA, Madsen O, Johnson RW, Groenen MA, Schook LB.

BMC Genomics. 2016 Nov 3;17(1):856.


Gene and transposable element methylation in great tit (Parus major) brain and blood.

Derks MF, Schachtschneider KM, Madsen O, Schijlen E, Verhoeven KJ, van Oers K.

BMC Genomics. 2016 May 4;17:332. doi: 10.1186/s12864-016-2653-y.


Peripheral viral infection induced microglial sensome genes and enhanced microglial cell activity in the hippocampus of neonatal piglets.

Ji P, Schachtschneider KM, Schook LB, Walker FR, Johnson RW.

Brain Behav Immun. 2016 May;54:243-251. doi: 10.1016/j.bbi.2016.02.010. Epub 2016 Feb 9.


Evolutionary signals of selection on cognition from the great tit genome and methylome.

Laine VN, Gossmann TI, Schachtschneider KM, Garroway CJ, Madsen O, Verhoeven KJ, de Jager V, Megens HJ, Warren WC, Minx P, Crooijmans RP, Corcoran P; Great Tit HapMap Consortium, Sheldon BC, Slate J, Zeng K, van Oers K, Visser ME, Groenen MA.

Nat Commun. 2016 Jan 25;7:10474. doi: 10.1038/ncomms10474.


Adult porcine genome-wide DNA methylation patterns support pigs as a biomedical model.

Schachtschneider KM, Madsen O, Park C, Rund LA, Groenen MA, Schook LB.

BMC Genomics. 2015 Oct 5;16:743. doi: 10.1186/s12864-015-1938-x.


Genome-wide analysis of DNA methylation in pigs using reduced representation bisulfite sequencing.

Choi M, Lee J, Le MT, Nguyen DT, Park S, Soundrarajan N, Schachtschneider KM, Kim J, Park JK, Kim JH, Park C.

DNA Res. 2015 Oct;22(5):343-55. doi: 10.1093/dnares/dsv017. Epub 2015 Sep 10.


A Genetic Porcine Model of Cancer.

Schook LB, Collares TV, Hu W, Liang Y, Rodrigues FM, Rund LA, Schachtschneider KM, Seixas FK, Singh K, Wells KD, Walters EM, Prather RS, Counter CM.

PLoS One. 2015 Jul 1;10(7):e0128864. doi: 10.1371/journal.pone.0128864. eCollection 2015.


Unraveling the swine genome: implications for human health.

Schook LB, Collares TV, Darfour-Oduro KA, De AK, Rund LA, Schachtschneider KM, Seixas FK.

Annu Rev Anim Biosci. 2015;3:219-44. doi: 10.1146/annurev-animal-022114-110815. Review.


Identification of differentially expressed genes in breast muscle and skin fat of postnatal Pekin duck.

Xu T, Gu L, Schachtschneider KM, Liu X, Huang W, Xie M, Hou S.

PLoS One. 2014 Sep 29;9(9):e107574. doi: 10.1371/journal.pone.0107574. eCollection 2014.


Modulation of systemic immune responses through commensal gastrointestinal microbiota.

Schachtschneider KM, Yeoman CJ, Isaacson RE, White BA, Schook LB, Pieters M.

PLoS One. 2013;8(1):e53969. doi: 10.1371/journal.pone.0053969. Epub 2013 Jan 11.

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