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Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens.

Matsushita T, Sati GC, Kondasinghe N, Pirrone MG, Kato T, Waduge P, Kumar HS, Sanchon AC, Dobosz-Bartoszek M, Shcherbakov D, Juhas M, Hobbie SN, Schrepfer T, Chow CS, Polikanov YS, Schacht J, Vasella A, Böttger EC, Crich D.

J Am Chem Soc. 2019 Mar 13. doi: 10.1021/jacs.9b01693. [Epub ahead of print]


Brain Glutamate, GABA, and Glutamine Levels and Associations with Recent Drinking in Treatment-Naïve Individuals with Alcohol Use Disorder Versus Light Drinkers.

Prisciandaro JJ, Schacht JP, Prescot AP, Renshaw PF, Brown TR, Anton RF.

Alcohol Clin Exp Res. 2019 Feb;43(2):221-226. doi: 10.1111/acer.13931. Epub 2019 Jan 4.


Dissecting the genetics underlying the relationship between protein content and grain yield in a large hybrid wheat population.

Thorwarth P, Liu G, Ebmeyer E, Schacht J, Schachschneider R, Kazman E, Reif JC, Würschum T, Longin CFH.

Theor Appl Genet. 2019 Feb;132(2):489-500. doi: 10.1007/s00122-018-3236-x. Epub 2018 Nov 19.


Investigating a novel fMRI cannabis cue reactivity task in youth.

Karoly HC, Schacht JP, Meredith LR, Jacobus J, Tapert SF, Gray KM, Squeglia LM.

Addict Behav. 2019 Feb;89:20-28. doi: 10.1016/j.addbeh.2018.09.015. Epub 2018 Sep 11.


Assessing ototoxicity due to chronic lead and cadmium intake with and without noise exposure in the mature mouse.

Carlson K, Schacht J, Neitzel RL.

J Toxicol Environ Health A. 2018;81(20):1041-1057. doi: 10.1080/15287394.2018.1521320. Epub 2018 Sep 21.


Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations.

Akbergenov R, Duscha S, Fritz AK, Juskeviciene R, Oishi N, Schmitt K, Shcherbakov D, Teo Y, Boukari H, Freihofer P, Isnard-Petit P, Oettinghaus B, Frank S, Thiam K, Rehrauer H, Westhof E, Schacht J, Eckert A, Wolfer D, Böttger EC.

EMBO Rep. 2018 Nov;19(11). pii: e46193. doi: 10.15252/embr.201846193. Epub 2018 Sep 20.


The dopamine transporter VNTR polymorphism moderates the relationship between acute response to alcohol and future alcohol use disorder symptoms.

Schacht JP, Anton RF, McNamara PJ, Im Y, King AC.

Addict Biol. 2018 Sep 18. doi: 10.1111/adb.12676. [Epub ahead of print]


Parsing Cannabis Exposure and Predisposing Risk Effects: Does Adolescent Cannabis Use Cause Neurocognitive Impairment, or Result From It?

Schacht JP.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Aug;3(8):654-656. doi: 10.1016/j.bpsc.2018.06.005. No abstract available.


Effects of the 1- N-(4-Amino-2 S-hydroxybutyryl) and 6'- N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity, and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics.

Sonousi A, Sarpe VA, Brilkova M, Schacht J, Vasella A, Böttger EC, Crich D.

ACS Infect Dis. 2018 Jul 13;4(7):1114-1120. doi: 10.1021/acsinfecdis.8b00052. Epub 2018 May 10.


Aluminum oxo-fluoride clusters: A first principle investigation of stability, synthetic considerations, and the interaction with water.

Schacht J, Budau JH, Gaston N, Paulus B.

J Comput Chem. 2018 Jul 15;39(19):1208-1214. doi: 10.1002/jcc.25183. Epub 2018 Feb 21.


Nicotine-Use/Smoking Is Associated with the Efficacy of Naltrexone in the Treatment of Alcohol Dependence.

Anton RF, Latham PK, Voronin KE, Randall PK, Book SW, Hoffman M, Schacht JP.

Alcohol Clin Exp Res. 2018 Apr;42(4):751-760. doi: 10.1111/acer.13601. Epub 2018 Feb 12.


Cluster assemblies as superatomic solids: a first principles study of bonding & electronic structure.

Schacht J, Gaston N.

Phys Chem Chem Phys. 2018 Feb 28;20(9):6167-6175. doi: 10.1039/c7cp06755k.


Tetraploid-diploid mosaicism in a patient with pigmentary anomalies of hair and skin: a new dermatologic feature.

Schacht JP, Farnworth E, Hogue J, Rohena L.

Clin Case Rep. 2017 Nov 29;6(1):103-108. doi: 10.1002/ccr3.1114. eCollection 2018 Jan.


Dopaminergic Genetic Variation Influences Aripiprazole Effects on Alcohol Self-Administration and the Neural Response to Alcohol Cues in a Randomized Trial.

Schacht JP, Voronin KE, Randall PK, Anton RF.

Neuropsychopharmacology. 2018 May;43(6):1247-1256. doi: 10.1038/npp.2017.298. Epub 2017 Dec 6.


Earlier alcohol use onset prospectively predicts changes in functional connectivity.

Nguyen-Louie TT, Simmons AN, Squeglia LM, Alejandra Infante M, Schacht JP, Tapert SF.

Psychopharmacology (Berl). 2018 Apr;235(4):1041-1054. doi: 10.1007/s00213-017-4821-4. Epub 2018 Jan 6.


Predictors of Naltrexone Response in a Randomized Trial: Reward-Related Brain Activation, OPRM1 Genotype, and Smoking Status.

Schacht JP, Randall PK, Latham PK, Voronin KE, Book SW, Myrick H, Anton RF.

Neuropsychopharmacology. 2017 Dec;42(13):2654. doi: 10.1038/npp.2017.185.


Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity.

Yang CH, Liu Z, Dong D, Schacht J, Arya D, Sha SH.

Front Cell Neurosci. 2017 Oct 24;11:315. doi: 10.3389/fncel.2017.00315. eCollection 2017.


Superatomic states in nickel clusters: Revising the prospects for transition metal based superatoms.

Gilmour JTA, Hammerschmidt L, Schacht J, Gaston N.

J Chem Phys. 2017 Oct 21;147(15):154307. doi: 10.1063/1.4990814.


HIV Among MSM and Heterosexual Women in the United States: An Ecologic Analysis.

Raymond HF, Al-Tayyib A, Neaigus A, Reilly KH, Braunstein S, Brady KA, Sey E, Risser J, Padget P, Lalota M, Schacht JM, Forrest DW, Macomber K, Griffin V, Higgins E, Robinson WT, Zarwell MC, Opoku J, Magnus M, Kuo I, Burt R, Thiede H, Glick S, Flynn C, German D.

J Acquir Immune Defic Syndr. 2017 Jul 1;75 Suppl 3:S276-S280. doi: 10.1097/QAI.0000000000001422.


Aripiprazole Suppression of Drinking in a Clinical Laboratory Paradigm: Influence of Impulsivity and Self-Control.

Anton RF, Schacht JP, Voronin KE, Randall PK.

Alcohol Clin Exp Res. 2017 Jul;41(7):1370-1380. doi: 10.1111/acer.13417. Epub 2017 Jun 5.


Predictors of Naltrexone Response in a Randomized Trial: Reward-Related Brain Activation, OPRM1 Genotype, and Smoking Status.

Schacht JP, Randall PK, Latham PK, Voronin KE, Book SW, Myrick H, Anton RF.

Neuropsychopharmacology. 2017 Dec;42(13):2640-2653. doi: 10.1038/npp.2017.74. Epub 2017 Apr 14. Erratum in: Neuropsychopharmacology. 2017 Dec;42(13):2654.


Genome-metabolite associations revealed low heritability, high genetic complexity, and causal relations for leaf metabolites in winter wheat (Triticum aestivum).

Matros A, Liu G, Hartmann A, Jiang Y, Zhao Y, Wang H, Ebmeyer E, Korzun V, Schachschneider R, Kazman E, Schacht J, Longin F, Reif JC, Mock HP.

J Exp Bot. 2017 Jan 1;68(3):415-428. doi: 10.1093/jxb/erw441.


Emerging therapeutic interventions against noise-induced hearing loss.

Sha SH, Schacht J.

Expert Opin Investig Drugs. 2017 Jan;26(1):85-96. doi: 10.1080/13543784.2017.1269171. Epub 2016 Dec 14. Review.


From the Superatom Model to a Diverse Array of Super-Elements: A Systematic Study of Dopant Influence on the Electronic Structure of Thiolate-Protected Gold Clusters.

Schacht J, Gaston N.

Chemphyschem. 2016 Oct 18;17(20):3237-3244. doi: 10.1002/cphc.201600684. Epub 2016 Aug 19.


Vestibular dysfunction in the adult CBA/CaJ mouse after lead and cadmium treatment.

Klimpel KE, Lee MY, King WM, Raphael Y, Schacht J, Neitzel RL.

Environ Toxicol. 2017 Mar;32(3):869-876. doi: 10.1002/tox.22286. Epub 2016 Jun 3.


COMT val158met moderation of dopaminergic drug effects on cognitive function: a critical review.

Schacht JP.

Pharmacogenomics J. 2016 Oct;16(5):430-8. doi: 10.1038/tpj.2016.43. Epub 2016 May 31. Review.


Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals.

Boyd SJ, Schacht JP, Prisciandaro JJ, Voronin K, Anton RF.

Alcohol Alcohol. 2016 Sep;51(5):549-54. doi: 10.1093/alcalc/agw024. Epub 2016 Apr 26.


Associations Between Recent Heavy Drinking and Dorsal Anterior Cingulate N-Acetylaspartate and Glutamate Concentrations in Non-Treatment-Seeking Individuals with Alcohol Dependence.

Prisciandaro JJ, Schacht JP, Prescot AP, Renshaw PF, Brown TR, Anton RF.

Alcohol Clin Exp Res. 2016 Mar;40(3):491-6. doi: 10.1111/acer.12977. Epub 2016 Feb 8.


Genome-based establishment of a high-yielding heterotic pattern for hybrid wheat breeding.

Zhao Y, Li Z, Liu G, Jiang Y, Maurer HP, Würschum T, Mock HP, Matros A, Ebmeyer E, Schachschneider R, Kazman E, Schacht J, Gowda M, Longin CF, Reif JC.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15624-9. doi: 10.1073/pnas.1514547112. Epub 2015 Dec 9.


Neural substrates of cue reactivity: association with treatment outcomes and relapse.

Courtney KE, Schacht JP, Hutchison K, Roche DJ, Ray LA.

Addict Biol. 2016 Jan;21(1):3-22. doi: 10.1111/adb.12314. Epub 2015 Oct 4. Review.


Age-related hearing impairment and the triad of acquired hearing loss.

Yang CH, Schrepfer T, Schacht J.

Front Cell Neurosci. 2015 Jul 27;9:276. doi: 10.3389/fncel.2015.00276. eCollection 2015. Review.


Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics.

Shalev M, Rozenberg H, Smolkin B, Nasereddin A, Kopelyanskiy D, Belakhov V, Schrepfer T, Schacht J, Jaffe CL, Adir N, Baasov T.

Nucleic Acids Res. 2015 Sep 30;43(17):8601-13. doi: 10.1093/nar/gkv821. Epub 2015 Aug 11.


XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death.

Oishi N, Duscha S, Boukari H, Meyer M, Xie J, Wei G, Schrepfer T, Roschitzki B, Boettger EC, Schacht J.

Cell Death Dis. 2015 May 14;6:e1763. doi: 10.1038/cddis.2015.108.


Genome-wide association mapping of preharvest sprouting resistance in a diversity panel of European winter wheats.

Albrecht T, Oberforster M, Kempf H, Ramgraber L, Schacht J, Kazman E, Zechner E, Neumayer A, Hartl L, Mohler V.

J Appl Genet. 2015 Aug;56(3):277-85. doi: 10.1007/s13353-015-0286-5. Epub 2015 Apr 30.


Age-related changes in auditory nerve-inner hair cell connections, hair cell numbers, auditory brain stem response and gap detection in UM-HET4 mice.

Altschuler RA, Dolan DF, Halsey K, Kanicki A, Deng N, Martin C, Eberle J, Kohrman DC, Miller RA, Schacht J.

Neuroscience. 2015 Apr 30;292:22-33. doi: 10.1016/j.neuroscience.2015.01.068. Epub 2015 Feb 7.


Disparities in auditory physiology and pathology between C57BL/6J and C57BL/6N substrains.

Kendall A, Schacht J.

Hear Res. 2014 Dec;318:18-22. doi: 10.1016/j.heares.2014.10.005. Epub 2014 Oct 22.


Pharmacologic treatment of alcoholism.

Anton RF, Schacht JP, Book SW.

Handb Clin Neurol. 2014;125:527-42. doi: 10.1016/B978-0-444-62619-6.00030-6. Review.


Applying association mapping and genomic selection to the dissection of key traits in elite European wheat.

Bentley AR, Scutari M, Gosman N, Faure S, Bedford F, Howell P, Cockram J, Rose GA, Barber T, Irigoyen J, Horsnell R, Pumfrey C, Winnie E, Schacht J, Beauchêne K, Praud S, Greenland A, Balding D, Mackay IJ.

Theor Appl Genet. 2014 Dec;127(12):2619-33. doi: 10.1007/s00122-014-2403-y. Epub 2014 Oct 2.


Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.

Duscha S, Boukari H, Shcherbakov D, Salian S, Silva S, Kendall A, Kato T, Akbergenov R, Perez-Fernandez D, Bernet B, Vaddi S, Thommes P, Schacht J, Crich D, Vasella A, Böttger EC.

MBio. 2014 Sep 30;5(5):e01827-14. doi: 10.1128/mBio.01827-14.


Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo.

Oishi N, Kendall A, Schacht J.

Neurosci Lett. 2014 Nov 7;583:65-9. doi: 10.1016/j.neulet.2014.09.028. Epub 2014 Sep 18.


Varenicline effects on drinking, craving and neural reward processing among non-treatment-seeking alcohol-dependent individuals.

Schacht JP, Anton RF, Randall PK, Li X, Henderson S, Myrick H.

Psychopharmacology (Berl). 2014 Sep;231(18):3799-807. doi: 10.1007/s00213-014-3518-1. Epub 2014 Mar 20.


Relatedness severely impacts accuracy of marker-assisted selection for disease resistance in hybrid wheat.

Gowda M, Zhao Y, Würschum T, Longin CF, Miedaner T, Ebmeyer E, Schachschneider R, Kazman E, Schacht J, Martinant JP, Mette MF, Reif JC.

Heredity (Edinb). 2014 May;112(5):552-61. doi: 10.1038/hdy.2013.139. Epub 2013 Dec 18.


Designer aminoglycosides that selectively inhibit cytoplasmic rather than mitochondrial ribosomes show decreased ototoxicity: a strategy for the treatment of genetic diseases.

Shulman E, Belakhov V, Wei G, Kendall A, Meyron-Holtz EG, Ben-Shachar D, Schacht J, Baasov T.

J Biol Chem. 2014 Jan 24;289(4):2318-30. doi: 10.1074/jbc.M113.533588. Epub 2013 Dec 3.


Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor.

Xue X, Mutyam V, Tang L, Biswas S, Du M, Jackson LA, Dai Y, Belakhov V, Shalev M, Chen F, Schacht J, J Bridges R, Baasov T, Hong J, Bedwell DM, Rowe SM.

Am J Respir Cell Mol Biol. 2014 Apr;50(4):805-16. doi: 10.1165/rcmb.2013-0282OC.


Tumor necrosis factor-alpha-mutant mice exhibit high frequency hearing loss.

Oishi N, Chen J, Zheng HW, Hill K, Schacht J, Sha SH.

J Assoc Res Otolaryngol. 2013 Dec;14(6):801-11. doi: 10.1007/s10162-013-0410-3. Epub 2013 Aug 31.


Hybrid wheat: quantitative genetic parameters and consequences for the design of breeding programs.

Longin CF, Gowda M, Mühleisen J, Ebmeyer E, Kazman E, Schachschneider R, Schacht J, Kirchhoff M, Zhao Y, Reif JC.

Theor Appl Genet. 2013 Nov;126(11):2791-801. doi: 10.1007/s00122-013-2172-z. Epub 2013 Aug 4.


Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea.

Chen FQ, Zheng HW, Schacht J, Sha SH.

PLoS One. 2013 Apr 23;8(4):e61999. doi: 10.1371/journal.pone.0061999. Print 2013.


Population structure, genetic diversity and linkage disequilibrium in elite winter wheat assessed with SNP and SSR markers.

Würschum T, Langer SM, Longin CF, Korzun V, Akhunov E, Ebmeyer E, Schachschneider R, Schacht J, Kazman E, Reif JC.

Theor Appl Genet. 2013 Jun;126(6):1477-86. doi: 10.1007/s00122-013-2065-1. Epub 2013 Feb 22.


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