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Items: 8

1.

Fungicidal Potency and Mechanisms of θ-Defensins against Multidrug-Resistant Candida Species.

Basso V, Garcia A, Tran DQ, Schaal JB, Tran P, Ngole D, Aqeel Y, Tongaonkar P, Ouellette AJ, Selsted ME.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00111-18. doi: 10.1128/AAC.00111-18. Print 2018 Jun.

2.

Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α-converting enzyme.

Schaal JB, Maretzky T, Tran DQ, Tran PA, Tongaonkar P, Blobel CP, Ouellette AJ, Selsted ME.

J Biol Chem. 2018 Feb 23;293(8):2725-2734. doi: 10.1074/jbc.RA117.000793. Epub 2018 Jan 9.

3.

Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide.

Schaal JB, Tran DQ, Subramanian A, Patel R, Laragione T, Roberts KD, Trinh K, Tongaonkar P, Tran PA, Minond D, Fields GB, Beringer P, Ouellette AJ, Gulko PS, Selsted ME.

PLoS One. 2017 Nov 16;12(11):e0187868. doi: 10.1371/journal.pone.0187868. eCollection 2017.

4.

Rhesus θ-Defensin-1 Attenuates Endotoxin-induced Acute Lung Injury by Inhibiting Proinflammatory Cytokines and Neutrophil Recruitment.

Jayne JG, Bensman TJ, Schaal JB, Park AYJ, Kimura E, Tran D, Selsted ME, Beringer PM.

Am J Respir Cell Mol Biol. 2018 Mar;58(3):310-319. doi: 10.1165/rcmb.2016-0428OC.

5.

Efficacy of Rhesus Theta-Defensin-1 in Experimental Models of Pseudomonas aeruginosa Lung Infection and Inflammation.

Bensman TJ, Jayne JG, Sun M, Kimura E, Meinert J, Wang JC, Schaal JB, Tran D, Rao AP, Akbari O, Selsted ME, Beringer PM.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00154-17. doi: 10.1128/AAC.00154-17. Print 2017 Aug.

6.

Rhesus macaque θ-defensin RTD-1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF-κB and MAPK pathways.

Tongaonkar P, Trinh KK, Schaal JB, Tran D, Gulko PS, Ouellette AJ, Selsted ME.

J Leukoc Biol. 2015 Dec;98(6):1061-70. doi: 10.1189/jlb.3A0315-102R. Epub 2015 Aug 12.

7.

Killing of staphylococci by θ-defensins involves membrane impairment and activation of autolytic enzymes.

Wilmes M, Stockem M, Bierbaum G, Schlag M, Götz F, Tran DQ, Schaal JB, Ouellette AJ, Selsted ME, Sahl HG.

Antibiotics (Basel). 2014;3(4):617-31. doi: 10.3390/antibiotics3040617.

8.

Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis.

Schaal JB, Tran D, Tran P, Ösapay G, Trinh K, Roberts KD, Brasky KM, Tongaonkar P, Ouellette AJ, Selsted ME.

PLoS One. 2012;7(12):e51337. doi: 10.1371/journal.pone.0051337. Epub 2012 Dec 6.

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