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Items: 1 to 50 of 205

1.

A SEPT1-based scaffold is required for Golgi integrity and function.

Song K, Gras C, Capin G, Gimber N, Lehmann M, Mohd S, Puchkov D, Rödiger M, Wilhelmi I, Daumke O, Schmoranzer J, Schürmann A, Krauss M.

J Cell Sci. 2019 Feb 1;132(3). pii: jcs225557. doi: 10.1242/jcs.225557.

PMID:
30709970
2.

Insulin-Like Growth Factor Binding Protein 2 (IGFBP-2) and the Risk of Developing Type 2 Diabetes.

Wittenbecher C, Ouni M, Kuxhaus O, Jähnert M, Gottmann P, Teichmann A, Meidtner K, Kriebel J, Grallert H, Pischon T, Boeing H, Schulze MB, Schürmann A.

Diabetes. 2019 Jan;68(1):188-197. doi: 10.2337/db18-0620. Epub 2018 Nov 5.

PMID:
30396904
3.

Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model.

Henkel J, Coleman CD, Schraplau A, Jöhrens K, Weiss TS, Jonas W, Schürmann A, Püschel GP.

Sci Rep. 2018 Oct 31;8(1):16127. doi: 10.1038/s41598-018-34633-y.

4.

Epigenetic regulation of hepatic Dpp4 expression in response to dietary protein.

Saussenthaler S, Ouni M, Baumeier C, Schwerbel K, Gottmann P, Christmann S, Laeger T, Schürmann A.

J Nutr Biochem. 2019 Jan;63:109-116. doi: 10.1016/j.jnutbio.2018.09.025. Epub 2018 Oct 13.

PMID:
30359860
5.

The GTPase ARFRP1 affects lipid droplet protein composition and triglyceride release from intracellular storage of intestinal Caco-2 cells.

Werno MW, Wilhelmi I, Kuropka B, Ebert F, Freund C, Schürmann A.

Biochem Biophys Res Commun. 2018 Nov 17;506(1):259-265. doi: 10.1016/j.bbrc.2018.10.092. Epub 2018 Oct 19.

6.

Two Novel Candidate Genes for Insulin Secretion Identified by Comparative Genomics of Multiple Backcross Mouse Populations.

Schallschmidt T, Lebek S, Altenhofen D, Damen M, Schulte Y, Knebel B, Herwig R, Rasche A, Stermann T, Kamitz A, Hallahan N, Jähnert M, Vogel H, Schürmann A, Chadt A, Al-Hasani H.

Genetics. 2018 Dec;210(4):1527-1542. doi: 10.1534/genetics.118.301578. Epub 2018 Oct 19.

PMID:
30341086
7.

The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans.

Gerst F, Jaghutriz BA, Staiger H, Schulte AM, Lorza-Gil E, Kaiser G, Panse M, Haug S, Heni M, Schütz M, Stadion M, Schürmann A, Marzetta F, Ibberson M, Sipos B, Fend F, Fleming T, Nawroth PP, Königsrainer A, Nadalin S, Wagner S, Peter A, Fritsche A, Richter D, Solimena M, Häring HU, Ullrich S, Wagner R.

J Clin Endocrinol Metab. 2018 Dec 1;103(12):4373-4383. doi: 10.1210/jc.2018-00791.

PMID:
30202879
8.

Effect of adipocyte-derived IGF-I on adipose tissue mass and glucose metabolism in the Berlin Fat Mouse.

Hesse D, Trost J, Schäfer N, Schwerbel K, Hoeflich A, Schürmann A, Brockmann GA.

Growth Factors. 2018 Apr;36(1-2):78-88. doi: 10.1080/08977194.2018.1497621.

PMID:
30196772
9.

Loss of periostin occurs in aging adipose tissue of mice and its genetic ablation impairs adipose tissue lipid metabolism.

Graja A, Garcia-Carrizo F, Jank AM, Gohlke S, Ambrosi TH, Jonas W, Ussar S, Kern M, Schürmann A, Aleksandrova K, Blüher M, Schulz TJ.

Aging Cell. 2018 Oct;17(5):e12810. doi: 10.1111/acel.12810. Epub 2018 Aug 7.

10.

An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation.

Khajavi N, Finan B, Kluth O, Müller TD, Mergler S, Schulz A, Kleinau G, Scheerer P, Schürmann A, Gudermann T, Tschöp MH, Krude H, DiMarchi RD, Biebermann H.

Cell Signal. 2018 Nov;51:13-22. doi: 10.1016/j.cellsig.2018.07.006. Epub 2018 Jul 25.

PMID:
30055232
11.

Diet-Induced Obesity Affects Muscle Regeneration After Murine Blunt Muscle Trauma-A Broad Spectrum Analysis.

Xu P, Werner JU, Milerski S, Hamp CM, Kuzenko T, Jähnert M, Gottmann P, de Roy L, Warnecke D, Abaei A, Palmer A, Huber-Lang M, Dürselen L, Rasche V, Schürmann A, Wabitsch M, Knippschild U.

Front Physiol. 2018 Jun 5;9:674. doi: 10.3389/fphys.2018.00674. eCollection 2018.

12.

A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and Type 2 diabetes.

Vogel H, Kamitz A, Hallahan N, Lebek S, Schallschmidt T, Jonas W, Jähnert M, Gottmann P, Zellner L, Kanzleiter T, Damen M, Altenhofen D, Burkhardt R, Renner S, Dahlhoff M, Wolf E, Müller TD, Blüher M, Joost HG, Chadt A, Al-Hasani H, Schürmann A.

Hum Mol Genet. 2018 Sep 1;27(17):3099-3112. doi: 10.1093/hmg/ddy217.

13.

Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms.

Panse M, Kluth O, Lorza-Gil E, Kaiser G, Mühlbauer E, Schürmann A, Häring HU, Ullrich S, Gerst F.

PLoS One. 2018 May 29;13(5):e0198016. doi: 10.1371/journal.pone.0198016. eCollection 2018.

14.

The novel adipokine WISP1 associates with insulin resistance and impairs insulin action in human myotubes and mouse hepatocytes.

Hörbelt T, Tacke C, Markova M, Herzfeld de Wiza D, Van de Velde F, Bekaert M, Van Nieuwenhove Y, Hornemann S, Rödiger M, Seebeck N, Friedl E, Jonas W, Thoresen GH, Kuss O, Rosenthal A, Lange V, Pfeiffer AFH, Schürmann A, Lapauw B, Rudovich N, Pivovarova O, Ouwens DM.

Diabetologia. 2018 May 12. doi: 10.1007/s00125-018-4636-9. [Epub ahead of print]

PMID:
29754289
15.

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes.

Abderrahmani A, Yengo L, Caiazzo R, Canouil M, Cauchi S, Raverdy V, Plaisance V, Pawlowski V, Lobbens S, Maillet J, Rolland L, Boutry R, Queniat G, Kwapich M, Tenenbaum M, Bricambert J, Saussenthaler S, Anthony E, Jha P, Derop J, Sand O, Rabearivelo I, Leloire A, Pigeyre M, Daujat-Chavanieu M, Gerbal-Chaloin S, Dayeh T, Lassailly G, Mathurin P, Staels B, Auwerx J, Schürmann A, Postic C, Schafmayer C, Hampe J, Bonnefond A, Pattou F, Froguel P.

Diabetes. 2018 Jul;67(7):1310-1321. doi: 10.2337/db17-1539. Epub 2018 May 4.

16.

Insulin sensitivity linked skeletal muscle Nr4a1 DNA methylation is programmed by the maternal diet and modulated by voluntary exercise in mice.

Kasch J, Kanzleiter I, Saussenthaler S, Schürmann A, Keijer J, van Schothorst E, Klaus S, Schumann S.

J Nutr Biochem. 2018 Jul;57:86-92. doi: 10.1016/j.jnutbio.2018.03.015. Epub 2018 Mar 21.

PMID:
29680662
17.

Novel Insights into How Overnutrition Disrupts the Hypothalamic Actions of Leptin.

Fruhwürth S, Vogel H, Schürmann A, Williams KJ.

Front Endocrinol (Lausanne). 2018 Mar 26;9:89. doi: 10.3389/fendo.2018.00089. eCollection 2018. Review.

18.

A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes.

Gottmann P, Ouni M, Saussenthaler S, Roos J, Stirm L, Jähnert M, Kamitz A, Hallahan N, Jonas W, Fritsche A, Häring HU, Staiger H, Blüher M, Fischer-Posovszky P, Vogel H, Schürmann A.

Mol Metab. 2018 May;11:145-159. doi: 10.1016/j.molmet.2018.03.005. Epub 2018 Mar 15.

19.

Dietary carbohydrates impair the protective effect of protein restriction against diabetes in NZO mice used as a model of type 2 diabetes.

Laeger T, Castaño-Martinez T, Werno MW, Japtok L, Baumeier C, Jonas W, Kleuser B, Schürmann A.

Diabetologia. 2018 Jun;61(6):1459-1469. doi: 10.1007/s00125-018-4595-1. Epub 2018 Mar 17.

PMID:
29550873
20.

Increased Ifi202b/IFI16 expression stimulates adipogenesis in mice and humans.

Stadion M, Schwerbel K, Graja A, Baumeier C, Rödiger M, Jonas W, Wolfrum C, Staiger H, Fritsche A, Häring HU, Klöting N, Blüher M, Fischer-Posovszky P, Schulz TJ, Joost HG, Vogel H, Schürmann A.

Diabetologia. 2018 May;61(5):1167-1179. doi: 10.1007/s00125-018-4571-9. Epub 2018 Feb 24.

PMID:
29478099
21.

Comparison of Fatty Acid and Gene Profiles in Skeletal Muscle in Normal and Obese C57BL/6J Mice before and after Blunt Muscle Injury.

Werner JU, Tödter K, Xu P, Lockhart L, Jähnert M, Gottmann P, Schürmann A, Scheja L, Wabitsch M, Knippschild U.

Front Physiol. 2018 Jan 30;9:19. doi: 10.3389/fphys.2018.00019. eCollection 2018.

22.

Animal models of obesity and diabetes mellitus.

Kleinert M, Clemmensen C, Hofmann SM, Moore MC, Renner S, Woods SC, Huypens P, Beckers J, de Angelis MH, Schürmann A, Bakhti M, Klingenspor M, Heiman M, Cherrington AD, Ristow M, Lickert H, Wolf E, Havel PJ, Müller TD, Tschöp MH.

Nat Rev Endocrinol. 2018 Mar;14(3):140-162. doi: 10.1038/nrendo.2017.161. Epub 2018 Jan 19. Review.

PMID:
29348476
23.

Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes.

Rödiger M, Werno MW, Wilhelmi I, Baumeier C, Hesse D, Wettschureck N, Offermanns S, Song K, Krauß M, Schürmann A.

Mol Metab. 2018 Feb;8:167-179. doi: 10.1016/j.molmet.2017.11.011. Epub 2017 Nov 22.

24.

Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease.

Baumeier C, Schlüter L, Saussenthaler S, Laeger T, Rödiger M, Alaze SA, Fritsche L, Häring HU, Stefan N, Fritsche A, Schwenk RW, Schürmann A.

Mol Metab. 2017 Oct;6(10):1254-1263. doi: 10.1016/j.molmet.2017.07.016. Epub 2017 Aug 4.

25.

FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes.

Laeger T, Baumeier C, Wilhelmi I, Würfel J, Kamitz A, Schürmann A.

Diabetologia. 2017 Nov;60(11):2274-2284. doi: 10.1007/s00125-017-4389-x. Epub 2017 Aug 2.

PMID:
28770320
26.

Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.

Ambrosi TH, Scialdone A, Graja A, Gohlke S, Jank AM, Bocian C, Woelk L, Fan H, Logan DW, Schürmann A, Saraiva LR, Schulz TJ.

Cell Stem Cell. 2017 Jun 1;20(6):771-784.e6. doi: 10.1016/j.stem.2017.02.009. Epub 2017 Mar 16.

27.

A vast genomic deletion in the C56BL/6 genome affects different genes within the Ifi200 cluster on chromosome 1 and mediates obesity and insulin resistance.

Vogel H, Jähnert M, Stadion M, Matzke D, Scherneck S, Schürmann A.

BMC Genomics. 2017 Feb 15;18(1):172. doi: 10.1186/s12864-017-3552-6.

28.

A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels.

Wiemerslage L, Islam R, van der Kamp C, Cao H, Olivo G, Ence-Eriksson F, Castillo S, Larsen AL, Bandstein M, Dahlberg LS, Perland E, Gustavsson V, Nilsson J, Vogel H, Schürmann A, Larsson EM, Rask-Andersen M, Benedict C, Schiöth HB.

Int J Obes (Lond). 2017 Jun;41(6):990-994. doi: 10.1038/ijo.2017.43. Epub 2017 Feb 14.

PMID:
28194012
29.

Hepatic DPP4 DNA Methylation Associates With Fatty Liver.

Baumeier C, Saussenthaler S, Kammel A, Jähnert M, Schlüter L, Hesse D, Canouil M, Lobbens S, Caiazzo R, Raverdy V, Pattou F, Nilsson E, Pihlajamäki J, Ling C, Froguel P, Schürmann A, Schwenk RW.

Diabetes. 2017 Jan;66(1):25-35. doi: 10.2337/db15-1716. Epub 2016 Oct 10.

30.

Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival.

Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim ÖA, Sotlar K, Schürmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T.

Elife. 2016 Dec 19;5. pii: e20914. doi: 10.7554/eLife.20914.

31.

Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals.

Benedict C, Vogel H, Jonas W, Woting A, Blaut M, Schürmann A, Cedernaes J.

Mol Metab. 2016 Oct 24;5(12):1175-1186. doi: 10.1016/j.molmet.2016.10.003. eCollection 2016 Dec.

32.

The complete classification of five-dimensional Dirichlet-Voronoi polyhedra of translational lattices.

Dutour Sikirić M, Garber A, Schürmann A, Waldmann C.

Acta Crystallogr A Found Adv. 2016 Nov 1;72(Pt 6):673-683. Epub 2016 Oct 3.

PMID:
27809207
33.

Ring Finger Protein 11 Inhibits Melanocortin 3 and 4 Receptor Signaling.

Müller A, Niederstadt L, Jonas W, Yi CX, Meyer F, Wiedmer P, Fischer J, Grötzinger C, Schürmann A, Tschöp M, Kleinau G, Grüters A, Krude H, Biebermann H.

Front Endocrinol (Lausanne). 2016 Aug 8;7:109. doi: 10.3389/fendo.2016.00109. eCollection 2016.

34.

GLP-1 and estrogen conjugate acts in the supramammillary nucleus to reduce food-reward and body weight.

Vogel H, Wolf S, Rabasa C, Rodriguez-Pacheco F, Babaei CS, Stöber F, Goldschmidt J, DiMarchi RD, Finan B, Tschöp MH, Dickson SL, Schürmann A, Skibicka KP.

Neuropharmacology. 2016 Nov;110(Pt A):396-406. doi: 10.1016/j.neuropharm.2016.07.039. Epub 2016 Aug 2.

35.

High Variability of Insulin Sensitivity in Closely Related Obese Mouse Inbred Strains.

Heise S, Trost J, Arends D, Wirth EK, Schäfer N, Köhrle J, Schürmann A, Brockmann GA.

Exp Clin Endocrinol Diabetes. 2016 Oct;124(9):519-528. Epub 2016 Jul 20.

PMID:
27437914
36.

Postprandial alterations in whole-blood DNA methylation are mediated by changes in white blood cell composition.

Rask-Andersen M, Bringeland N, Nilsson EK, Bandstein M, Olaya Búcaro M, Vogel H, Schürmann A, Hogenkamp PS, Benedict C, Schiöth HB.

Am J Clin Nutr. 2016 Aug;104(2):518-25. doi: 10.3945/ajcn.115.122366. Epub 2016 Jul 6.

PMID:
27385611
37.

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.

Schmidt V, Schulz N, Yan X, Schürmann A, Kempa S, Kern M, Blüher M, Poy MN, Olivecrona G, Willnow TE.

J Clin Invest. 2016 Jul 1;126(7):2706-20. doi: 10.1172/JCI84708. Epub 2016 Jun 20.

38.

Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice.

Kammel A, Saussenthaler S, Jähnert M, Jonas W, Stirm L, Hoeflich A, Staiger H, Fritsche A, Häring HU, Joost HG, Schürmann A, Schwenk RW.

Hum Mol Genet. 2016 Jun 15;25(12):2588-2599. Epub 2016 Apr 28.

39.

Analysis of Genes Involved in Body Weight Regulation by Targeted Re-Sequencing.

Volckmar AL, Han CT, Pütter C, Haas S, Vogel CI, Knoll N, Struve C, Göbel M, Haas K, Herrfurth N, Jarick I, Grallert H, Schürmann A, Al-Hasani H, Hebebrand J, Sauer S, Hinney A.

PLoS One. 2016 Feb 1;11(2):e0147904. doi: 10.1371/journal.pone.0147904. eCollection 2016.

40.

Induction of steatohepatitis (NASH) with insulin resistance in wildtype B6 mice by a western-type diet containing soybean oil and cholesterol.

Henkel J, Coleman CD, Schraplau A, Jӧhrens K, Weber D, Castro JP, Hugo M, Schulz TJ, Krämer S, Schürmann A, Püschel GP.

Mol Med. 2017 May;23:70-82. doi: 10.2119/molmed.2016.00203. Epub 2017 Mar 21.

41.

Identification of novel putative adipomyokines by a cross-species annotation of secretomes and expression profiles.

Schering L, Hoene M, Kanzleiter T, Jähnert M, Wimmers K, Klaus S, Eckel J, Weigert C, Schürmann A, Maak S, Jonas W, Sell H.

Arch Physiol Biochem. 2015;121(5):194-205. doi: 10.3109/13813455.2015.1092044. Epub 2015 Nov 24.

PMID:
26599229
42.

Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity.

Voigt A, Katterle Y, Kahle M, Kluge R, Schürmann A, Joost HG, Klaus S.

Genes Nutr. 2015 Nov;10(6):57. doi: 10.1007/s12263-015-0507-x. Epub 2015 Nov 19.

43.

Understanding the fundamentals of redox mediators in Li-O2 batteries: a case study on nitroxides.

Bergner BJ, Hofmann C, Schürmann A, Schröder D, Peppler K, Schreiner PR, Janek J.

Phys Chem Chem Phys. 2015 Dec 21;17(47):31769-79. doi: 10.1039/c5cp04505c.

PMID:
26563563
44.

Diabetes prevalence in NZO females depends on estrogen action on liver fat content.

Lubura M, Hesse D, Kraemer M, Hallahan N, Schupp M, von Löffelholz C, Kriebel J, Rudovich N, Pfeiffer A, John C, Scheja L, Heeren J, Koliaki C, Roden M, Schürmann A.

Am J Physiol Endocrinol Metab. 2015 Dec 15;309(12):E968-80. doi: 10.1152/ajpendo.00338.2015. Epub 2015 Oct 20.

45.

Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation.

Kluth O, Matzke D, Kamitz A, Jähnert M, Vogel H, Scherneck S, Schulze M, Staiger H, Machicao F, Häring HU, Joost HG, Schürmann A.

PLoS Genet. 2015 Sep 8;11(9):e1005506. doi: 10.1371/journal.pgen.1005506. eCollection 2015 Sep.

46.

Report from a symposium on catalyzing primary and secondary prevention of cancer in India.

Krishnan S, Dhillon PK, Bhadelia A, Schurmann A, Basu P, Bhatla N, Birur P, Colaco R, Dey S, Grover S, Gupta H, Gupta R, Gupta V, Lewis MA, Mehrotra R, McMikel A, Mukherji A, Naik N, Nyblade L, Pati S, Pillai MR, Rajaraman P, Ramesh C, Rath GK, Reithinger R, Sankaranarayanan R, Selvam J, Shanmugam MS, Shridhar K, Siddiqi M, Squiers L, Subramanian S, Travasso SM, Verma Y, Vijayakumar M, Weiner BJ, Reddy KS, Knaul FM.

Cancer Causes Control. 2015 Nov;26(11):1671-84. doi: 10.1007/s10552-015-0637-x. Epub 2015 Sep 3.

47.

JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis.

Tuncay H, Brinkmann BF, Steinbacher T, Schürmann A, Gerke V, Iden S, Ebnet K.

Nat Commun. 2015 Aug 26;6:8128. doi: 10.1038/ncomms9128.

48.

The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice.

Chung B, Stadion M, Schulz N, Jain D, Scherneck S, Joost HG, Schürmann A.

Diabetologia. 2015 Oct;58(10):2403-13. doi: 10.1007/s00125-015-3703-8. Epub 2015 Aug 1.

49.

Exercise training alters DNA methylation patterns in genes related to muscle growth and differentiation in mice.

Kanzleiter T, Jähnert M, Schulze G, Selbig J, Hallahan N, Schwenk RW, Schürmann A.

Am J Physiol Endocrinol Metab. 2015 May 15;308(10):E912-20. doi: 10.1152/ajpendo.00289.2014. Epub 2015 Mar 24.

50.

Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice.

Baumeier C, Kaiser D, Heeren J, Scheja L, John C, Weise C, Eravci M, Lagerpusch M, Schulze G, Joost HG, Schwenk RW, Schürmann A.

Biochim Biophys Acta. 2015 May;1851(5):566-76. doi: 10.1016/j.bbalip.2015.01.013. Epub 2015 Jan 31.

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