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Items: 1 to 50 of 99

1.

Delta-aminolevulinic acid synthase 2 expression in combination with iron as modifiers of disease severity in erythropoietic protoporphyria.

Barman-Aksözen J, Halloy F, Iyer PS, Schümperli D, Minder AE, Hall J, Minder EI, Schneider-Yin X.

Mol Genet Metab. 2019 Nov;128(3):304-308. doi: 10.1016/j.ymgme.2019.04.013. Epub 2019 May 2.

2.

Positive cofactor 4 (PC4) contributes to the regulation of replication-dependent canonical histone gene expression.

Brzek A, Cichocka M, Dolata J, Juzwa W, Schümperli D, Raczynska KD.

BMC Mol Biol. 2018 Jul 27;19(1):9. doi: 10.1186/s12867-018-0110-y.

3.

Modeling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice.

Barman-Aksözen J, C Wiek P, Bansode VB, Koentgen F, Trüb J, Pelczar P, Cinelli P, Schneider-Yin X, Schümperli D, Minder EI.

Dis Model Mech. 2017 Mar 1;10(3):225-233. doi: 10.1242/dmm.027755. Epub 2017 Jan 12.

4.

Synthesis and cellular activity of stereochemically-pure 2'-O-(2-methoxyethyl)-phosphorothioate oligonucleotides.

Li M, Lightfoot HL, Halloy F, Malinowska AL, Berk C, Behera A, Schümperli D, Hall J.

Chem Commun (Camb). 2017 Jan 3;53(3):541-544. doi: 10.1039/c6cc08473g.

PMID:
27966701
5.

Somatic Therapy of a Mouse SMA Model with a U7 snRNA Gene Correcting SMN2 Splicing.

Odermatt P, Trüb J, Furrer L, Fricker R, Marti A, Schümperli D.

Mol Ther. 2016 Oct;24(10):1797-1805. doi: 10.1038/mt.2016.152. Epub 2016 Jul 26.

6.

Rudolf Weber (1922-2015): a driving force in the transition of developmental biology into a molecular and cellular science.

Schümperli D.

Dev Genes Evol. 2016 Mar;226(2):65-7. doi: 10.1007/s00427-016-0532-9. Epub 2016 Feb 27. No abstract available.

PMID:
26922058
7.

Cycling in the nucleus: regulation of RNA 3' processing and nuclear organization of replication-dependent histone genes.

Romeo V, Schümperli D.

Curr Opin Cell Biol. 2016 Jun;40:23-31. doi: 10.1016/j.ceb.2016.01.015. Epub 2016 Feb 16. Review.

8.

Central and peripheral defects in motor units of the diaphragm of spinal muscular atrophy mice.

Neve A, Trüb J, Saxena S, Schümperli D.

Mol Cell Neurosci. 2016 Jan;70:30-41. doi: 10.1016/j.mcn.2015.11.007. Epub 2015 Nov 24.

9.

FUS/TLS contributes to replication-dependent histone gene expression by interaction with U7 snRNPs and histone-specific transcription factors.

Raczynska KD, Ruepp MD, Brzek A, Reber S, Romeo V, Rindlisbacher B, Heller M, Szweykowska-Kulinska Z, Jarmolowski A, Schümperli D.

Nucleic Acids Res. 2015 Nov 16;43(20):9711-28. doi: 10.1093/nar/gkv794. Epub 2015 Aug 6.

10.

Splicing changes in SMA mouse motoneurons and SMN-depleted neuroblastoma cells: evidence for involvement of splicing regulatory proteins.

Huo Q, Kayikci M, Odermatt P, Meyer K, Michels O, Saxena S, Ule J, Schümperli D.

RNA Biol. 2014;11(11):1430-46. doi: 10.1080/15476286.2014.996494.

11.

A large animal model of spinal muscular atrophy and correction of phenotype.

Duque SI, Arnold WD, Odermatt P, Li X, Porensky PN, Schmelzer L, Meyer K, Kolb SJ, Schümperli D, Kaspar BK, Burghes AH.

Ann Neurol. 2015 Mar;77(3):399-414. doi: 10.1002/ana.24332. Epub 2015 Feb 9.

12.

CstF64: cell cycle regulation and functional role in 3' end processing of replication-dependent histone mRNAs.

Romeo V, Griesbach E, Schümperli D.

Mol Cell Biol. 2014 Dec 1;34(23):4272-84. doi: 10.1128/MCB.00791-14. Epub 2014 Sep 29.

13.
14.

Antisense genes to induce exon inclusion.

Nlend RN, Schümperli D.

Methods Mol Biol. 2012;867:325-47. doi: 10.1007/978-1-61779-767-5_21.

PMID:
22454071
15.

mRNA 3' end processing and more--multiple functions of mammalian cleavage factor I-68.

Ruepp MD, Schümperli D, Barabino SM.

Wiley Interdiscip Rev RNA. 2011 Jan-Feb;2(1):79-91. doi: 10.1002/wrna.35. Review.

PMID:
21956970
16.

Improving gene silencing of siRNAs via tricyclo-DNA modification.

Ittig D, Luisier S, Weiler J, Schümperli D, Leumann CJ.

Artif DNA PNA XNA. 2010 Jul;1(1):9-16.

17.

Editorial on alternative splicing and disease.

Barta A, Schümperli D.

RNA Biol. 2010 Jul-Aug;7(4):388-9. No abstract available.

PMID:
21140604
18.

Interactions of CstF-64, CstF-77, and symplekin: implications on localisation and function.

Ruepp MD, Schweingruber C, Kleinschmidt N, Schümperli D.

Mol Biol Cell. 2011 Jan 1;22(1):91-104. doi: 10.1091/mbc.E10-06-0543. Epub 2010 Nov 30.

19.

Ultrastructural changes in diaphragm neuromuscular junctions in a severe mouse model for Spinal Muscular Atrophy and their prevention by bifunctional U7 snRNA correcting SMN2 splicing.

Voigt T, Meyer K, Baum O, Schümperli D.

Neuromuscul Disord. 2010 Nov;20(11):744-52. doi: 10.1016/j.nmd.2010.06.010. Epub 2010 Sep 15.

PMID:
20832308
20.

The 68 kDa subunit of mammalian cleavage factor I interacts with the U7 small nuclear ribonucleoprotein and participates in 3'-end processing of animal histone mRNAs.

Ruepp MD, Vivarelli S, Pillai RS, Kleinschmidt N, Azzouz TN, Barabino SM, Schümperli D.

Nucleic Acids Res. 2010 Nov;38(21):7637-50. doi: 10.1093/nar/gkq613. Epub 2010 Jul 15.

21.

Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop.

Matulis G, Sanderson JP, Lissin NM, Asparuhova MB, Bommineni GR, Schümperli D, Schmidt RR, Villiger PM, Jakobsen BK, Gadola SD.

PLoS Biol. 2010 Jun 22;8(6):e1000402. doi: 10.1371/journal.pbio.1000402.

22.

Repair of pre-mRNA splicing: prospects for a therapy for spinal muscular atrophy.

Nlend Nlend R, Meyer K, Schümperli D.

RNA Biol. 2010 Jul-Aug;7(4):430-40. Epub 2010 Jul 1. Review.

23.

Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export.

Ruepp MD, Aringhieri C, Vivarelli S, Cardinale S, Paro S, Schümperli D, Barabino SM.

Mol Biol Cell. 2009 Dec;20(24):5211-23. doi: 10.1091/mbc.E09-05-0389.

24.

Rescue of a severe mouse model for spinal muscular atrophy by U7 snRNA-mediated splicing modulation.

Meyer K, Marquis J, Trüb J, Nlend Nlend R, Verp S, Ruepp MD, Imboden H, Barde I, Trono D, Schümperli D.

Hum Mol Genet. 2009 Feb 1;18(3):546-55. doi: 10.1093/hmg/ddn382. Epub 2008 Nov 13.

PMID:
19010792
25.

Tc-DNA modified siRNA.

Ittig D, Schümperli D, Leumann CJ.

Nucleic Acids Symp Ser (Oxf). 2008;(52):501-2. doi: 10.1093/nass/nrn254.

PMID:
18776473
26.

Doxycycline-controlled splicing modulation by regulated antisense U7 snRNA expression cassettes.

Marquis J, Kämpfer SS, Angehrn L, Schümperli D.

Gene Ther. 2009 Jan;16(1):70-7. doi: 10.1038/gt.2008.138. Epub 2008 Aug 14.

PMID:
18701908
27.

Development and characterization of a triple combination gene therapy vector inhibiting HIV-1 multiplication.

Asparuhova MB, Barde I, Trono D, Schranz K, Schümperli D.

J Gene Med. 2008 Oct;10(10):1059-70. doi: 10.1002/jgm.1238.

PMID:
18642399
28.

Spinal muscular atrophy: position and functional importance of the branch site preceding SMN exon 7.

Scholl R, Marquis J, Meyer K, Schümperli D.

RNA Biol. 2007 Jan-Mar;4(1):34-7. Epub 2007 May 30.

PMID:
17585203
29.

Spinal muscular atrophy: SMN2 pre-mRNA splicing corrected by a U7 snRNA derivative carrying a splicing enhancer sequence.

Marquis J, Meyer K, Angehrn L, Kämpfer SS, Rothen-Rutishauser B, Schümperli D.

Mol Ther. 2007 Aug;15(8):1479-86. Epub 2007 Jun 5.

30.

Inhibition of HIV-1 multiplication by a modified U7 snRNA inducing Tat and Rev exon skipping.

Asparuhova MB, Marti G, Liu S, Serhan F, Trono D, Schümperli D.

J Gene Med. 2007 May;9(5):323-34.

PMID:
17474072
31.

Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.

Azzouz TN, Pillai RS, Däpp C, Chari A, Meister G, Kambach C, Fischer U, Schümperli D.

J Biol Chem. 2005 Oct 14;280(41):34435-40. Epub 2005 Aug 8.

32.

The C-terminal domain of coilin interacts with Sm proteins and U snRNPs.

Xu H, Pillai RS, Azzouz TN, Shpargel KB, Kambach C, Hebert MD, Schümperli D, Matera AG.

Chromosoma. 2005 Aug;114(3):155-66. Epub 2005 Jul 8.

33.

The stem-loop binding protein stimulates histone translation at an early step in the initiation pathway.

Gorgoni B, Andrews S, Schaller A, Schümperli D, Gray NK, Müller B.

RNA. 2005 Jul;11(7):1030-42.

35.

The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ribonucleoprotein.

Schümperli D, Pillai RS.

Cell Mol Life Sci. 2004 Oct;61(19-20):2560-70. Review.

PMID:
15526162
36.

Inhibition of HIV-1 multiplication by antisense U7 snRNAs and siRNAs targeting cyclophilin A.

Liu S, Asparuhova M, Brondani V, Ziekau I, Klimkait T, Schümperli D.

Nucleic Acids Res. 2004 Jul 14;32(12):3752-9. Print 2004.

37.

Nuclear antisense effects in cyclophilin A pre-mRNA splicing by oligonucleotides: a comparison of tricyclo-DNA with LNA.

Ittig D, Liu S, Renneberg D, Schümperli D, Leumann CJ.

Nucleic Acids Res. 2004 Jan 15;32(1):346-53. Print 2004.

38.
39.

Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing.

Pillai RS, Grimmler M, Meister G, Will CL, Lührmann R, Fischer U, Schümperli D.

Genes Dev. 2003 Sep 15;17(18):2321-33.

40.

U7 snRNAs induce correction of mutated dystrophin pre-mRNA by exon skipping.

Brun C, Suter D, Pauli C, Dunant P, Lochmüller H, Burgunder JM, Schümperli D, Weis J.

Cell Mol Life Sci. 2003 Mar;60(3):557-66.

PMID:
12737315
41.

Antisense properties of tricyclo-DNA.

Renneberg D, Bouliong E, Reber U, Schümperli D, Leumann CJ.

Nucleic Acids Res. 2002 Jul 1;30(13):2751-7.

42.

Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression.

Zanier K, Luyten I, Crombie C, Muller B, Schümperli D, Linge JP, Nilges M, Sattler M.

RNA. 2002 Jan;8(1):29-46.

44.

Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein.

Pillai RS, Will CL, Lührmann R, Schümperli D, Müller B.

EMBO J. 2001 Oct 1;20(19):5470-9.

46.

Positive and negative mutant selection in the human histone hairpin-binding protein using the yeast three-hybrid system.

Martin F, Michel F, Zenklusen D, Müller B, Schümperli D.

Nucleic Acids Res. 2000 Apr 1;28(7):1594-603.

47.

Double-target antisense U7 snRNAs promote efficient skipping of an aberrant exon in three human beta-thalassemic mutations.

Suter D, Tomasini R, Reber U, Gorman L, Kole R, Schümperli D.

Hum Mol Genet. 1999 Dec;8(13):2415-23.

48.

Sensitivity of splice sites to antisense oligonucleotides in vivo.

Sierakowska H, Sambade MJ, Schümperli D, Kole R.

RNA. 1999 Mar;5(3):369-77.

49.

A 5'-3' exonuclease activity involved in forming the 3' products of histone pre-mRNA processing in vitro.

Walther TN, Wittop Koning TH, Schümperli D, Müller B.

RNA. 1998 Sep;4(9):1034-46.

50.

The U7 snRNP and the hairpin binding protein: Key players in histone mRNA metabolism.

Müller B, Schümperli D.

Semin Cell Dev Biol. 1997 Dec;8(6):567-76.

PMID:
9642171

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