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Host plant-related genomic differentiation in the European cherry fruit fly, Rhagoletis cerasi.

Bakovic V, Schuler H, Schebeck M, Feder JL, Stauffer C, Ragland GJ.

Mol Ecol. 2019 Oct;28(20):4648-4666. doi: 10.1111/mec.15239. Epub 2019 Oct 13.


Geographic and Ecological Dimensions of Host Plant-Associated Genetic Differentiation and Speciation in the Rhagoletis cingulata (Diptera: Tephritidae) Sibling Species Group.

Doellman MM, Schuler H, Jean GS, Hood GR, Egan SP, Powell THQ, Glover MM, Bruzzese DJ, Smith JJ, Yee WL, Goughnour RB, Rull J, Aluja M, Feder JL.

Insects. 2019 Aug 29;10(9). pii: E275. doi: 10.3390/insects10090275.


Correction to "Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors".

Thorsell AG, Ekblad T, Karlberg T, Löw M, Pinto AF, Trésaugues L, Moche M, Cohen MS, Schüler H.

J Med Chem. 2019 Jun 27;62(12):5922. doi: 10.1021/acs.jmedchem.9b00852. Epub 2019 Jun 19. No abstract available.


Dynamics of an Ongoing Wolbachia Spread in the European Cherry Fruit Fly, Rhagoletis cerasi (Diptera: Tephritidae).

Schebeck M, Feldkirchner L, Stauffer C, Schuler H.

Insects. 2019 Jun 14;10(6). pii: E172. doi: 10.3390/insects10060172.


The Apennines as a cryptic Pleistocene refugium of the bark beetle Pityogenes chalcographus (Coleoptera: Curculionidae).

Schebeck M, Schuler H, Einramhof B, Avtzis DN, Dowle EJ, Faccoli M, Battisti A, Ragland GJ, Stauffer C, Bertheau C.

Biol J Linn Soc Lond. 2019 May 31;127(1):24-33. doi: 10.1093/biolinnean/blz012. Epub 2019 Apr 5.


A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes.

Yuen LH, Dana S, Liu Y, Bloom SI, Thorsell AG, Neri D, Donato AJ, Kireev D, Schüler H, Franzini RM.

J Am Chem Soc. 2019 Apr 3;141(13):5169-5181. doi: 10.1021/jacs.8b08039. Epub 2019 Mar 19.


The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell-derived sensory neurons of erythromelalgia patients.

Meents JE, Bressan E, Sontag S, Foerster A, Hautvast P, Rösseler C, Hampl M, Schüler H, Goetzke R, Le TKC, Kleggetveit IP, Le Cann K, Kerth C, Rush AM, Rogers M, Kohl Z, Schmelz M, Wagner W, Jørum E, Namer B, Winner B, Zenke M, Lampert A.

Pain. 2019 Jun;160(6):1327-1341. doi: 10.1097/j.pain.0000000000001511.


Next-generation sequencing of 32 genes associated with hereditary aortopathies and related disorders of connective tissue in a cohort of 199 patients.

Renner S, Schüler H, Alawi M, Kolbe V, Rybczynski M, Woitschach R, Sheikhzadeh S, Stark VC, Olfe J, Roser E, Seggewies FS, Mahlmann A, Hempel M, Hartmann MJ, Hillebrand M, Wieczorek D, Volk AE, Kloth K, Koch-Hogrebe M, Abou Jamra R, Mitter D, Altmüller J, Wey-Fabrizius A, Petersen C, Rau I, Borck G, Kubisch C, Mir TS, von Kodolitsch Y, Kutsche K, Rosenberger G.

Genet Med. 2019 Aug;21(8):1832-1841. doi: 10.1038/s41436-019-0435-z. Epub 2019 Jan 24.


Target-Enriched Endosymbiont Sequencing (TEEseq): A New High-Throughput Sequencing Approach Applied to the Comprehensive Characterization of Endosymbionts.

Schuler H, Lopez JA, Doellman MM, Hood GR, Egan SP, Feder JL.

Methods Mol Biol. 2019;1858:195-212. doi: 10.1007/978-1-4939-8775-7_14.


A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity.

Kirby IT, Kojic A, Arnold MR, Thorsell AG, Karlberg T, Vermehren-Schmaedick A, Sreenivasan R, Schultz C, Schüler H, Cohen MS.

Cell Chem Biol. 2018 Dec 20;25(12):1547-1553.e12. doi: 10.1016/j.chembiol.2018.09.011. Epub 2018 Oct 18.


Correction to 'Spatial spread of Wolbachia in Rhagoletis cerasi populations'.

Bakovic V, Schebeck M, Telschow A, Stauffer C, Schuler H.

Biol Lett. 2018 Oct 10;14(10). pii: 20180683. doi: 10.1098/rsbl.2018.0683. No abstract available.


Pleistocene climate cycling and host plant association shaped the demographic history of the bark beetle Pityogenes chalcographus.

Schebeck M, Dowle EJ, Schuler H, Avtzis DN, Bertheau C, Feder JL, Ragland GJ, Stauffer C.

Sci Rep. 2018 Sep 21;8(1):14207. doi: 10.1038/s41598-018-32617-6.


14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface.

Karlberg T, Hornyak P, Pinto AF, Milanova S, Ebrahimi M, Lindberg M, Püllen N, Nordström A, Löverli E, Caraballo R, Wong EV, Näreoja K, Thorsell AG, Elofsson M, De La Cruz EM, Björkegren C, Schüler H.

Nat Commun. 2018 Sep 17;9(1):3785. doi: 10.1038/s41467-018-06194-1.


Current and potential future role of PSMA-PET in patients with castration-resistant prostate cancer.

Fankhauser CD, Poyet C, Kroeze SGC, Kranzbühler B, Schüler HIG, Guckenberger M, Kaufmann PA, Hermanns T, Burger IA.

World J Urol. 2019 Mar;37(3):457-467. doi: 10.1007/s00345-018-2408-2. Epub 2018 Jul 20. Review.


A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition.

Favalli N, Biendl S, Hartmann M, Piazzi J, Sladojevich F, Gräslund S, Brown PJ, Näreoja K, Schüler H, Scheuermann J, Franzini R, Neri D.

ChemMedChem. 2018 Jul 6;13(13):1303-1307. doi: 10.1002/cmdc.201800193. Epub 2018 Jun 1.


In response: "A novel cause of rebreathing carbon dioxide related to removed CLIC-seal on the Dräger Apollo© Anesthesia Machine" from B. Nikman et al. in this issue of JCMC.

Schüler HU, Goldbeck B, Karchner D.

J Clin Monit Comput. 2019 Apr;33(2):353-355. doi: 10.1007/s10877-018-0162-z. Epub 2018 May 31. No abstract available.


Spatial spread of Wolbachia in Rhagoletis cerasi populations.

Bakovic V, Schebeck M, Telschow A, Stauffer C, Schuler H.

Biol Lett. 2018 May;14(5). pii: 20180161. doi: 10.1098/rsbl.2018.0161. Erratum in: Biol Lett. 2018 Oct 10;14(10):.


Genomic Differentiation during Speciation-with-Gene-Flow: Comparing Geographic and Host-Related Variation in Divergent Life History Adaptation in Rhagoletis pomonella.

Doellman MM, Ragland GJ, Hood GR, Meyers PJ, Egan SP, Powell THQ, Lazorchak P, Glover MM, Tait C, Schuler H, Hahn DA, Berlocher SH, Smith JJ, Nosil P, Feder JL.

Genes (Basel). 2018 May 18;9(5). pii: E262. doi: 10.3390/genes9050262.


Reproductive Manipulators in the Bark Beetle Pityogenes chalcographus (Coleoptera: Curculionidae)-The Role of Cardinium, Rickettsia, Spiroplasma, and Wolbachia.

Schebeck M, Feldkirchner L, Marín B, Krumböck S, Schuler H, Stauffer C.

J Insect Sci. 2018 May 1;18(3). doi: 10.1093/jisesa/iey044.


Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14.

Holechek J, Lease R, Thorsell AG, Karlberg T, McCadden C, Grant R, Keen A, Callahan E, Schüler H, Ferraris D.

Bioorg Med Chem Lett. 2018 Jun 15;28(11):2050-2054. doi: 10.1016/j.bmcl.2018.04.056. Epub 2018 May 3.


Diversity and distribution of Wolbachia in relation to geography, host plant affiliation and life cycle of a heterogonic gall wasp.

Schuler H, Egan SP, Hood GR, Busbee RW, Driscoe AL, Ott JR.

BMC Evol Biol. 2018 Mar 27;18(1):37. doi: 10.1186/s12862-018-1151-z.


Ocular manifestation in Marfan syndrome: corneal biomechanical properties relate to increased systemic score points.

Scheibenberger D, Frings A, Steinberg J, Schüler H, Druchkiv V, Katz T, von Kodolitsch Y, Linke S.

Graefes Arch Clin Exp Ophthalmol. 2018 Jun;256(6):1159-1163. doi: 10.1007/s00417-018-3946-4. Epub 2018 Mar 10.


Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol.

Ekblad T, Verheugd P, Lindgren AE, Nyman T, Elofsson M, Schüler H.

SLAS Discov. 2018 Apr;23(4):353-362. doi: 10.1177/2472555217750870. Epub 2018 Jan 9.


Warfarin anticoagulation in acute type A aortic dissection survivors (WATAS).

von Kodolitsch Y, Wilson O, Schüler H, Larena-Avellaneda A, Kölbel T, Wipper S, Rohlffs F, Behrendt C, Debus ES, Brickwedel J, Girdauskas E, Detter C, Bernhardt AM, Berger J, Blankenberg S, Reichenspurner H, Ghazy T, Matschke K, Hoffmann RT, Weiss N, Mahlmann A.

Cardiovasc Diagn Ther. 2017 Dec;7(6):559-571. doi: 10.21037/cdt.2017.07.01.


Structure-activity relationships for inhibitors of Pseudomonas aeruginosa exoenzyme S ADP-ribosyltransferase activity.

Saleeb M, Sundin C, Aglar Ö, Pinto AF, Ebrahimi M, Forsberg Å, Schüler H, Elofsson M.

Eur J Med Chem. 2018 Jan 1;143:568-576. doi: 10.1016/j.ejmech.2017.11.036. Epub 2017 Nov 21.


Diagnostic accuracy study of routine echocardiography for bicuspid aortic valve: a retrospective study and meta-analysis.

Hillebrand M, Koschyk D, Ter Hark P, Schüler H, Rybczynski M, Berger J, Gulati A, Bernhardt AM, Detter C, Girdauskas E, Blankenberg S, von Kodolitsch Y.

Cardiovasc Diagn Ther. 2017 Aug;7(4):367-379. doi: 10.21037/cdt.2017.05.03.


Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14.

Upton K, Meyers M, Thorsell AG, Karlberg T, Holechek J, Lease R, Schey G, Wolf E, Lucente A, Schüler H, Ferraris D.

Bioorg Med Chem Lett. 2017 Jul 1;27(13):2907-2911. doi: 10.1016/j.bmcl.2017.04.089. Epub 2017 Apr 29.


Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells.

Sontag S, Förster M, Qin J, Wanek P, Mitzka S, Schüler HM, Koschmieder S, Rose-John S, Seré K, Zenke M.

Stem Cells. 2017 Apr;35(4):898-908. doi: 10.1002/stem.2565. Epub 2017 Feb 1.


Wolbachia in Parasitoids Attacking Native European and Introduced Eastern Cherry Fruit Flies in Europe.

Schuler H, Kern P, Arthofer W, Vogt H, Fischer M, Stauffer C, Riegler M.

Environ Entomol. 2016 Dec;45(6):1424-1431. doi: 10.1093/ee/nvw137. Epub 2016 Oct 15.


Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.

Thorsell AG, Ekblad T, Karlberg T, Löw M, Pinto AF, Trésaugues L, Moche M, Cohen MS, Schüler H.

J Med Chem. 2017 Feb 23;60(4):1262-1271. doi: 10.1021/acs.jmedchem.6b00990. Epub 2016 Dec 21. Erratum in: J Med Chem. 2019 Jun 27;62(12):5922.


Small Molecule Microarray Based Discovery of PARP14 Inhibitors.

Peng B, Thorsell AG, Karlberg T, Schüler H, Yao SQ.

Angew Chem Int Ed Engl. 2017 Jan 2;56(1):248-253. doi: 10.1002/anie.201609655. Epub 2016 Dec 5.


The role of the multidisciplinary health care team in the management of patients with Marfan syndrome.

von Kodolitsch Y, Rybczynski M, Vogler M, Mir TS, Schüler H, Kutsche K, Rosenberger G, Detter C, Bernhardt AM, Larena-Avellaneda A, Kölbel T, Debus ES, Schroeder M, Linke SJ, Fuisting B, Napp B, Kammal AL, Püschel K, Bannas P, Hoffmann BA, Gessler N, Vahle-Hinz E, Kahl-Nieke B, Thomalla G, Weiler-Normann C, Ohm G, Neumann S, Benninghoven D, Blankenberg S, Pyeritz RE.

J Multidiscip Healthc. 2016 Nov 3;9:587-614. eCollection 2016. Review.


Economic and care considerations of Marfan syndrome.

Blankart CR, Milstein R, Rybczynski M, Schüler H, von Kodolitsch Y.

Expert Rev Pharmacoecon Outcomes Res. 2016 Oct;16(5):591-598. Epub 2016 Oct 6. Review.


Wolbachia endosymbionts in haplodiploid and diploid scolytine beetles (Coleoptera: Curculionidae: Scolytinae).

Kawasaki Y, Schuler H, Stauffer C, Lakatos F, Kajimura H.

Environ Microbiol Rep. 2016 Oct;8(5):680-688. doi: 10.1111/1758-2229.12425. Epub 2016 Jul 14.


Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis.

Kouznetsova E, Kanno T, Karlberg T, Thorsell AG, Wisniewska M, Kursula P, Sjögren C, Schüler H.

Structure. 2016 May 3;24(5):789-796. doi: 10.1016/j.str.2016.03.021. Epub 2016 Apr 21.


DNA binding to SMC ATPases-trapped for release.

Schüler H, Sjögren C.

EMBO J. 2016 Apr 1;35(7):703-5. doi: 10.15252/embj.201694210. Epub 2016 Mar 11.


Identification of Inhibitors of Pseudomonas aeruginosa Exotoxin-S ADP-Ribosyltransferase Activity.

Pinto AF, Ebrahimi M, Saleeb M, Forsberg Å, Elofsson M, Schüler H.

J Biomol Screen. 2016 Jul;21(6):590-5. doi: 10.1177/1087057116629923. Epub 2016 Feb 5.


The hitchhiker's guide to Europe: the infection dynamics of an ongoing Wolbachia invasion and mitochondrial selective sweep in Rhagoletis cerasi.

Schuler H, Köppler K, Daxböck-Horvath S, Rasool B, Krumböck S, Schwarz D, Hoffmeister TS, Schlick-Steiner BC, Steiner FM, Telschow A, Stauffer C, Arthofer W, Riegler M.

Mol Ecol. 2016 Apr;25(7):1595-609. doi: 10.1111/mec.13571. Epub 2016 Mar 15.


Mitral valve prolapse syndrome and MASS phenotype: Stability of aortic dilatation but progression of mitral valve prolapse.

Rippe M, De Backer J, Kutsche K, Mosquera LM, Schüler H, Rybczynski M, Bernhardt AM, Keyser B, Hillebrand M, Mir TS, Berger J, Blankenberg S, Koschyk D, von Kodolitsch Y.

Int J Cardiol Heart Vasc. 2016 Jan 21;10:39-46. doi: 10.1016/j.ijcha.2016.01.002. eCollection 2016 Mar.


Sirtuins are Unaffected by PARP Inhibitors Containing Planar Nicotinamide Bioisosteres.

Ekblad T, Schüler H.

Chem Biol Drug Des. 2016 Mar;87(3):478-82. doi: 10.1111/cbdd.12680. Epub 2015 Nov 26.


Perspectives on the revised Ghent criteria for the diagnosis of Marfan syndrome.

von Kodolitsch Y, De Backer J, Schüler H, Bannas P, Behzadi C, Bernhardt AM, Hillebrand M, Fuisting B, Sheikhzadeh S, Rybczynski M, Kölbel T, Püschel K, Blankenberg S, Robinson PN.

Appl Clin Genet. 2015 Jun 16;8:137-55. doi: 10.2147/TACG.S60472. eCollection 2015. Review.


Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library.

Samain F, Ekblad T, Mikutis G, Zhong N, Zimmermann M, Nauer A, Bajic D, Decurtins W, Scheuermann J, Brown PJ, Hall J, Gräslund S, Schüler H, Neri D, Franzini RM.

J Med Chem. 2015 Jun 25;58(12):5143-9. doi: 10.1021/acs.jmedchem.5b00432. Epub 2015 Jun 10.


Towards small molecule inhibitors of mono-ADP-ribosyltransferases.

Ekblad T, Lindgren AE, Andersson CD, Caraballo R, Thorsell AG, Karlberg T, Spjut S, Linusson A, Schüler H, Elofsson M.

Eur J Med Chem. 2015 May 5;95:546-51. doi: 10.1016/j.ejmech.2015.03.067. Epub 2015 Apr 1.


Identification of structure-activity relationships from screening a structurally compact DNA-encoded chemical library.

Franzini RM, Ekblad T, Zhong N, Wichert M, Decurtins W, Nauer A, Zimmermann M, Samain F, Scheuermann J, Brown PJ, Hall J, Gräslund S, Schüler H, Neri D.

Angew Chem Int Ed Engl. 2015 Mar 23;54(13):3927-31. doi: 10.1002/anie.201410736. Epub 2015 Feb 3.


Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein.

Karlberg T, Klepsch M, Thorsell AG, Andersson CD, Linusson A, Schüler H.

J Biol Chem. 2015 Mar 20;290(12):7336-44. doi: 10.1074/jbc.M114.630160. Epub 2015 Jan 29.


Pivotal and distinct role for Plasmodium actin capping protein alpha during blood infection of the malaria parasite.

Ganter M, Rizopoulos Z, Schüler H, Matuschewski K.

Mol Microbiol. 2015 Apr;96(1):84-94. doi: 10.1111/mmi.12922. Epub 2015 Jan 30.


The main pulmonary artery in adults: a controlled multicenter study with assessment of echocardiographic reference values, and the frequency of dilatation and aneurysm in Marfan syndrome.

Sheikhzadeh S, De Backer J, Gorgan NR, Rybczynski M, Hillebrand M, Schüler H, Bernhardt AM, Koschyk D, Bannas P, Keyser B, Mortensen K, Radke RM, Mir TS, Kölbel T, Robinson PN, Schmidtke J, Berger J, Blankenberg S, von Kodolitsch Y.

Orphanet J Rare Dis. 2014 Dec 10;9:203. doi: 10.1186/s13023-014-0203-8.


Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family.

Pinto AF, Schüler H.

Curr Top Microbiol Immunol. 2015;384:153-66. Review.


Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors.

Liscio P, Carotti A, Asciutti S, Karlberg T, Bellocchi D, Llacuna L, Macchiarulo A, Aaronson SA, Schüler H, Pellicciari R, Camaioni E.

J Med Chem. 2014 Mar 27;57(6):2807-12. doi: 10.1021/jm401356t. Epub 2014 Feb 24.


Interruption of Onchocerca volvulus transmission in Northern Venezuela.

Convit J, Schuler H, Borges R, Olivero V, Domínguez-Vázquez A, Frontado H, Grillet ME.

Parasit Vectors. 2013 Oct 7;6(1):289. doi: 10.1186/1756-3305-6-289.

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