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Items: 1 to 50 of 114

1.

Ergothioneine stands out from hercynine in the reaction with singlet oxygen: Resistance to glutathione and TRIS in the generation of specific products indicates high reactivity.

Stoffels C, Oumari M, Perrou A, Termath A, Schlundt W, Schmalz HG, Schäfer M, Wewer V, Metzger S, Schömig E, Gründemann D.

Free Radic Biol Med. 2017 Dec;113:385-394. doi: 10.1016/j.freeradbiomed.2017.10.372. Epub 2017 Oct 23.

PMID:
29074402
2.

Control measures following a case of imported Lassa fever from Togo, North Rhine Westphalia, Germany, 2016.

Lehmann C, Kochanek M, Abdulla D, Becker S, Böll B, Bunte A, Cadar D, Dormann A, Eickmann M, Emmerich P, Feldt T, Frank C, Fries J, Gabriel M, Goetsch U, Gottschalk R, Günther S, Hallek M, Häussinger D, Herzog C, Jensen B, Kolibay F, Krakau M, Langebartels G, Rieger T, Schaade L, Schmidt-Chanasit J, Schömig E, Schüttfort G, Shimabukuro-Vornhagen A, von Bergwelt-Baildon M, Wieland U, Wiesmüller G, Wolf T, Fätkenheuer G.

Euro Surveill. 2017 Sep;22(39). doi: 10.2807/1560-7917.ES.2017.22.39.17-00088.

3.

A novel mode of operation of SLC22A11: Membrane insertion of estrone sulfate versus translocation of uric acid and glutamate.

Skwara P, Schömig E, Gründemann D.

Biochem Pharmacol. 2017 Mar 15;128:74-82. doi: 10.1016/j.bcp.2016.12.020. Epub 2016 Dec 25.

PMID:
28027879
4.

Knockout of the ergothioneine transporter ETT in zebrafish results in increased 8-oxoguanine levels.

Pfeiffer C, Bach M, Bauer T, Campos da Ponte J, Schömig E, Gründemann D.

Free Radic Biol Med. 2015 Jun;83:178-85. doi: 10.1016/j.freeradbiomed.2015.02.026. Epub 2015 Mar 5.

PMID:
25746775
5.

SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct.

Schulz C, Fork C, Bauer T, Golz S, Geerts A, Schömig E, Gründemann D.

Biochem J. 2014 Jan 15;457(2):243-51. doi: 10.1042/BJ20130654.

PMID:
24147638
6.

Benzoic acid and specific 2-oxo acids activate hepatic efflux of glutamate at OAT2.

Pfennig T, Herrmann B, Bauer T, Schömig E, Gründemann D.

Biochim Biophys Acta. 2013 Feb;1828(2):491-8. doi: 10.1016/j.bbamem.2012.08.026. Epub 2012 Sep 7.

7.

Organic cation transporters OCT1 and OCT2 determine the accumulation of lamivudine in CD4 cells of HIV-infected patients.

Jung N, Lehmann C, Rubbert A, Schömig E, Fätkenheuer G, Hartmann P, Taubert D.

Infection. 2013 Apr;41(2):379-85. doi: 10.1007/s15010-012-0308-8. Epub 2012 Aug 9.

PMID:
22875535
8.

Paramount levels of ergothioneine transporter SLC22A4 mRNA in boar seminal vesicles and cross-species analysis of ergothioneine and glutathione in seminal plasma.

Nikodemus D, Lazic D, Bach M, Bauer T, Pfeiffer C, Wiltzer L, Lain E, Schömig E, Gründemann D.

J Physiol Pharmacol. 2011 Aug;62(4):411-9.

9.

OAT2 catalyses efflux of glutamate and uptake of orotic acid.

Fork C, Bauer T, Golz S, Geerts A, Weiland J, Del Turco D, Schömig E, Gründemann D.

Biochem J. 2011 Jun 1;436(2):305-12. doi: 10.1042/BJ20101904.

PMID:
21446918
10.

Paraoxonase-1 is a major determinant of clopidogrel efficacy.

Bouman HJ, Schömig E, van Werkum JW, Velder J, Hackeng CM, Hirschhäuser C, Waldmann C, Schmalz HG, ten Berg JM, Taubert D.

Nat Med. 2011 Jan;17(1):110-6. doi: 10.1038/nm.2281. Epub 2010 Dec 19. Erratum in: Nat Med. 2011 Sep;17(9):1153.

PMID:
21170047
11.

Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients?

Jetter A, Fätkenheuer G, Frank D, Klaassen T, Seeringer A, Doroshyenko O, Kirchheiner J, Hein W, Schömig E, Fuhr U, Wyen C.

Antivir Ther. 2010;15(7):975-83. doi: 10.3851/IMP1648.

12.

Substrate discrimination by ergothioneine transporter SLC22A4 and carnitine transporter SLC22A5: gain-of-function by interchange of selected amino acids.

Bacher P, Giersiefer S, Bach M, Fork C, Schömig E, Gründemann D.

Biochim Biophys Acta. 2009 Dec;1788(12):2594-602. doi: 10.1016/j.bbamem.2009.09.019. Epub 2009 Oct 6.

13.

Uptake of mIBG and catecholamines in noradrenaline- and organic cation transporter-expressing cells: potential use of corticosterone for a preferred uptake in neuroblastoma- and pheochromocytoma cells.

Bayer M, Kuçi Z, Schömig E, Gründemann D, Dittmann H, Handgretinger R, Bruchelt G.

Nucl Med Biol. 2009 Apr;36(3):287-94. doi: 10.1016/j.nucmedbio.2008.12.010.

PMID:
19324274
14.

Decreased anxiety in mice lacking the organic cation transporter 3.

Wultsch T, Grimberg G, Schmitt A, Painsipp E, Wetzstein H, Breitenkamp AF, Gründemann D, Schömig E, Lesch KP, Gerlach M, Reif A.

J Neural Transm (Vienna). 2009 Jun;116(6):689-97. doi: 10.1007/s00702-009-0205-1. Epub 2009 Mar 11.

PMID:
19280114
15.

In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans.

Doroshyenko O, Fuhr U, Kunz D, Frank D, Kinzig M, Jetter A, Reith Y, Lazar A, Taubert D, Kirchheiner J, Baum M, Eisenbrand G, Berger FI, Bertow D, Berkessel A, Sörgel F, Schömig E, Tomalik-Scharte D.

Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):433-43. doi: 10.1158/1055-9965.EPI-08-0832. Epub 2009 Feb 3.

16.

Increased ergothioneine tissue concentrations in carriers of the Crohn's disease risk-associated 503F variant of the organic cation transporter OCTN1.

Taubert D, Jung N, Goeser T, Schömig E.

Gut. 2009 Feb;58(2):312-4. doi: 10.1136/gut.2008.164418. No abstract available.

PMID:
19136526
17.

The carnitine transporter SLC22A5 is not a general drug transporter, but it efficiently translocates mildronate.

Grigat S, Fork C, Bach M, Golz S, Geerts A, Schömig E, Gründemann D.

Drug Metab Dispos. 2009 Feb;37(2):330-7. doi: 10.1124/dmd.108.023929. Epub 2008 Nov 3.

PMID:
18981167
18.

Acute and chronic cannabinoid treatment differentially affects recognition memory and social behavior in pubertal and adult rats.

Schneider M, Schömig E, Leweke FM.

Addict Biol. 2008 Sep;13(3-4):345-57. doi: 10.1111/j.1369-1600.2008.00117.x.

PMID:
18782382
19.

Impaired bioavailability of clopidogrel in patients with a ST-segment elevation myocardial infarction.

Heestermans AA, van Werkum JW, Taubert D, Seesing TH, von Beckerath N, Hackeng CM, Schömig E, Verheugt FW, ten Berg JM.

Thromb Res. 2008;122(6):776-81. doi: 10.1016/j.thromres.2008.01.021. Epub 2008 May 1. No abstract available.

PMID:
18455217
20.

Simultaneous fitting of real-time PCR data with efficiency of amplification modeled as Gaussian function of target fluorescence.

Batsch A, Noetel A, Fork C, Urban A, Lazic D, Lucas T, Pietsch J, Lazar A, Schömig E, Gründemann D.

BMC Bioinformatics. 2008 Feb 12;9:95. doi: 10.1186/1471-2105-9-95.

21.

Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients.

Wyen C, Fuhr U, Frank D, Aarnoutse RE, Klaassen T, Lazar A, Seeringer A, Doroshyenko O, Kirchheiner JC, Abdulrazik F, Schmeisser N, Lehmann C, Hein W, Schömig E, Burger DM, Fätkenheuer G, Jetter A.

Clin Pharmacol Ther. 2008 Jul;84(1):75-82. doi: 10.1038/sj.clpt.6100452. Epub 2008 Jan 9.

22.

Rapid detection of the DPYD IVS14+1G>A mutation for screening patients to prevent fluorouracil-related toxicity.

Lazar A, Gründemann D, Schömig E.

Mol Diagn Ther. 2007;11(5):341; author reply 341-2. No abstract available.

PMID:
17963423
23.

Dietary sources and antioxidant effects of ergothioneine.

Ey J, Schömig E, Taubert D.

J Agric Food Chem. 2007 Aug 8;55(16):6466-74. Epub 2007 Jul 6.

PMID:
17616140
24.

Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial.

Taubert D, Roesen R, Lehmann C, Jung N, Schömig E.

JAMA. 2007 Jul 4;298(1):49-60.

PMID:
17609490
25.

Probing the substrate specificity of the ergothioneine transporter with methimazole, hercynine, and organic cations.

Grigat S, Harlfinger S, Pal S, Striebinger R, Golz S, Geerts A, Lazar A, Schömig E, Gründemann D.

Biochem Pharmacol. 2007 Jul 15;74(2):309-16. Epub 2007 Apr 22.

PMID:
17532304
26.

Novel mutations of the extraneuronal monoamine transporter gene in children and adolescents with obsessive-compulsive disorder.

Lazar A, Walitza S, Jetter A, Gerlach M, Warnke A, Herpertz-Dahlmann B, Gründemann D, Grimberg G, Schulz E, Remschmidt H, Wewetzer C, Schömig E.

Int J Neuropsychopharmacol. 2008 Feb;11(1):35-48. Epub 2007 May 4.

PMID:
17477885
28.

Effect of cocoa and tea intake on blood pressure: a meta-analysis.

Taubert D, Roesen R, Schömig E.

Arch Intern Med. 2007 Apr 9;167(7):626-34.

PMID:
17420419
29.

Fast set-up of doxycycline-inducible protein expression in human cell lines with a single plasmid based on Epstein-Barr virus replication and the simple tetracycline repressor.

Bach M, Grigat S, Pawlik B, Fork C, Utermöhlen O, Pal S, Banczyk D, Lazar A, Schömig E, Gründemann D.

FEBS J. 2007 Feb;274(3):783-90.

30.

Determination of anandamide and other fatty acyl ethanolamides in human serum by electrospray tandem mass spectrometry.

Schreiber D, Harlfinger S, Nolden BM, Gerth CW, Jaehde U, Schömig E, Klosterkötter J, Giuffrida A, Astarita G, Piomelli D, Markus Leweke F.

Anal Biochem. 2007 Feb 15;361(2):162-8. Epub 2006 Dec 20.

31.

Impact of P-glycoprotein on clopidogrel absorption.

Taubert D, von Beckerath N, Grimberg G, Lazar A, Jung N, Goeser T, Kastrati A, Schömig A, Schömig E.

Clin Pharmacol Ther. 2006 Nov;80(5):486-501.

PMID:
17112805
32.

Association of rheumatoid arthritis with ergothioneine levels in red blood cells: a case control study.

Taubert D, Lazar A, Grimberg G, Jung N, Rubbert A, Delank KS, Perniok A, Erdmann E, Schömig E.

J Rheumatol. 2006 Nov;33(11):2139-45.

PMID:
17086603
33.

Lower prevalence of the OCT2 Ser270 allele in patients with essential hypertension.

Lazar A, Zimmermann T, Koch W, Gründemann D, Schömig A, Kastrati A, Schömig E.

Clin Exp Hypertens. 2006 Oct;28(7):645-53.

PMID:
17060063
34.

Contribution of allelic variations in transporters to the phenotype of drug response.

Kirchheiner J, Gründemann D, Schömig E.

J Psychopharmacol. 2006 Jul;20(4 Suppl):27-32. Review.

PMID:
16785267
35.

Extraneuronal monoamine transporter and organic cation transporters 1 and 2: a review of transport efficiency.

Schömig E, Lazar A, Gründemann D.

Handb Exp Pharmacol. 2006;(175):151-80. Review.

PMID:
16722235
36.

Clopidogrel resistance caused by a failure to metabolize clopidogrel into its metabolites.

Heestermans AA, van Werkum JW, Schömig E, ten Berg JM, Taubert D.

J Thromb Haemost. 2006 May;4(5):1143-5. No abstract available.

37.

Toxicokinetics of acrylamide in humans after ingestion of a defined dose in a test meal to improve risk assessment for acrylamide carcinogenicity.

Fuhr U, Boettcher MI, Kinzig-Schippers M, Weyer A, Jetter A, Lazar A, Taubert D, Tomalik-Scharte D, Pournara P, Jakob V, Harlfinger S, Klaassen T, Berkessel A, Angerer J, Sörgel F, Schömig E.

Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):266-71.

38.

The garlic ingredient diallyl sulfide inhibits cytochrome P450 2E1 dependent bioactivation of acrylamide to glycidamide.

Taubert D, Glöckner R, Müller D, Schömig E.

Toxicol Lett. 2006 Jun 20;164(1):1-5. Epub 2005 Dec 7.

PMID:
16337756
40.

Are organic cation transporters capable of transporting prostaglandins?

Harlfinger S, Fork C, Lazar A, Schömig E, Gründemann D.

Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):125-30. Epub 2005 Oct 7.

PMID:
16211406
41.

The CYP2C9 genotype does not influence sildenafil pharmacokinetics in healthy volunteers.

Jetter A, Lazar A, Schömig E, Fuhr U, Kinzig-Schippers M, Sörgel F.

Clin Pharmacol Ther. 2005 Oct;78(4):441-3. No abstract available.

PMID:
16198665
42.

Functional role of the 503F variant of the organic cation transporter OCTN1 in Crohn's disease.

Taubert D, Grimberg G, Jung N, Rubbert A, Schömig E.

Gut. 2005 Oct;54(10):1505-6. No abstract available.

43.

Tannic acid in plant dust causes airway obstruction.

Taubert D, Grimberg G, Schömig E.

Thorax. 2005 Sep;60(9):789-91. No abstract available.

44.

A patient with stent thrombosis, clopidogrel-resistance and failure to metabolize clopidogrel to its active metabolite.

von Beckerath N, Taubert D, Pogatsa-Murray G, Wieczorek A, Schömig E, Schömig A, Kastrati A.

Thromb Haemost. 2005 Apr;93(4):789-91. No abstract available.

PMID:
15841329
45.

Discovery of the ergothioneine transporter.

Gründemann D, Harlfinger S, Golz S, Geerts A, Lazar A, Berkels R, Jung N, Rubbert A, Schömig E.

Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5256-61. Epub 2005 Mar 28.

46.

Acute effects of glucose and insulin on vascular endothelium.

Taubert D, Rosenkranz A, Berkels R, Roesen R, Schömig E.

Diabetologia. 2004 Dec;47(12):2059-71. Epub 2004 Dec 15.

PMID:
15662548
47.

Multiple organ failure due to 5-fluorouracil chemotherapy in a patient with a rare dihydropyrimidine dehydrogenase gene variant.

Lazar A, Mau-Holzmann UA, Kolb H, Reichenmiller HE, Riess O, Schömig E.

Onkologie. 2004 Dec;27(6):559-62.

PMID:
15591715
48.

Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action.

Taubert D, Berkels R, Grosser N, Schröder H, Gründemann D, Schömig E.

Br J Pharmacol. 2004 Sep;143(1):159-65. Epub 2004 Aug 2.

49.

Pharmacokinetics of clopidogrel after administration of a high loading dose.

Taubert D, Kastrati A, Harlfinger S, Gorchakova O, Lazar A, von Beckerath N, Schömig A, Schömig E.

Thromb Haemost. 2004 Aug;92(2):311-6.

PMID:
15269827
50.

Influence of processing parameters on acrylamide formation during frying of potatoes.

Taubert D, Harlfinger S, Henkes L, Berkels R, Schömig E.

J Agric Food Chem. 2004 May 5;52(9):2735-9.

PMID:
15113184

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