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Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repair. Mu H et al. DNA Repair (Amst). (2018)

Nucleotide excision repair in eukaryotes. Schärer OD et al. Cold Spring Harb Perspect Biol. (2013)

ERCC1-XPF endonuclease-positioned to cut. Schärer OD et al. EMBO J. (2017)

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Items: 1 to 50 of 80


MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers.

Srinivasan G, Williamson EA, Kong K, Jaiswal AS, Huang G, Kim HS, Schärer O, Zhao W, Burma S, Sung P, Hromas R.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17438-17443. doi: 10.1073/pnas.1903150116. Epub 2019 Aug 8.


Single-molecule visualization reveals the damage search mechanism for the human NER protein XPC-RAD23B.

Cheon NY, Kim HS, Yeo JE, Schärer OD, Lee JY.

Nucleic Acids Res. 2019 Aug 2. pii: gkz629. doi: 10.1093/nar/gkz629. [Epub ahead of print]


Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repair.

Mu H, Geacintov NE, Broyde S, Yeo JE, Schärer OD.

DNA Repair (Amst). 2018 Nov;71:33-42. doi: 10.1016/j.dnarep.2018.08.005. Epub 2018 Aug 23. Review.


Structural mechanism of DNA interstrand cross-link unhooking by the bacterial FAN1 nuclease.

Jin H, Roy U, Lee G, Schärer OD, Cho Y.

J Biol Chem. 2018 Apr 27;293(17):6482-6496. doi: 10.1074/jbc.RA118.002171. Epub 2018 Mar 7.


Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway.

Kato N, Kawasoe Y, Williams H, Coates E, Roy U, Shi Y, Beese LS, Schärer OD, Yan H, Gottesman ME, Takahashi TS, Gautier J.

Cell Rep. 2017 Oct 31;21(5):1375-1385. doi: 10.1016/j.celrep.2017.10.032.


FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.

Thompson EL, Yeo JE, Lee EA, Kan Y, Raghunandan M, Wiek C, Hanenberg H, Schärer OD, Hendrickson EA, Sobeck A.

Nucleic Acids Res. 2017 Nov 16;45(20):11837-11857. doi: 10.1093/nar/gkx847.


ERCC1-XPF endonuclease-positioned to cut.

Schärer OD.

EMBO J. 2017 Jul 14;36(14):1993-1995. doi: 10.15252/embj.201797489. Epub 2017 Jun 28. No abstract available.


Preparation of Stable Nitrogen Mustard DNA Interstrand Cross-Link Analogs for Biochemical and Cell Biological Studies.

Castaño A, Roy U, Schärer OD.

Methods Enzymol. 2017;591:415-431. doi: 10.1016/bs.mie.2017.03.007. Epub 2017 Apr 14.


Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair.

Beagan K, Armstrong RL, Witsell A, Roy U, Renedo N, Baker AE, Schärer OD, McVey M.

PLoS Genet. 2017 May 25;13(5):e1006813. doi: 10.1371/journal.pgen.1006813. eCollection 2017 May.


A new sub-pathway of long-patch base excision repair involving 5' gap formation.

Woodrick J, Gupta S, Camacho S, Parvathaneni S, Choudhury S, Cheema A, Bai Y, Khatkar P, Erkizan HV, Sami F, Su Y, Schärer OD, Sharma S, Roy R.

EMBO J. 2017 Jun 1;36(11):1605-1622. doi: 10.15252/embj.201694920. Epub 2017 Apr 3.


Mutagenicity of a Model DNA-Peptide Cross-Link in Human Cells: Roles of Translesion Synthesis DNA Polymerases.

Pande P, Ji S, Mukherjee S, Schärer OD, Tretyakova NY, Basu AK.

Chem Res Toxicol. 2017 Feb 20;30(2):669-677. doi: 10.1021/acs.chemrestox.6b00397. Epub 2016 Dec 21.


Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases.

Wickramaratne S, Ji S, Mukherjee S, Su Y, Pence MG, Lior-Hoffmann L, Fu I, Broyde S, Guengerich FP, Distefano M, Schärer OD, Sham YY, Tretyakova N.

J Biol Chem. 2016 Nov 4;291(45):23589-23603. Epub 2016 Sep 12.


Involvement of translesion synthesis DNA polymerases in DNA interstrand crosslink repair.

Roy U, Schärer OD.

DNA Repair (Amst). 2016 Aug;44:33-41. doi: 10.1016/j.dnarep.2016.05.004. Epub 2016 May 13. Review.


The structure and duplex context of DNA interstrand crosslinks affects the activity of DNA polymerase η.

Roy U, Mukherjee S, Sharma A, Frank EG, Schärer OD.

Nucleic Acids Res. 2016 Sep 6;44(15):7281-91. doi: 10.1093/nar/gkw485. Epub 2016 Jun 1.


FANCD2-associated nuclease 1, but not exonuclease 1 or flap endonuclease 1, is able to unhook DNA interstrand cross-links in vitro.

Pizzolato J, Mukherjee S, Schärer OD, Jiricny J.

J Biol Chem. 2015 Sep 11;290(37):22602-11. doi: 10.1074/jbc.M115.663666. Epub 2015 Jul 28.


Synthesis of structurally diverse major groove DNA interstrand crosslinks using three different aldehyde precursors.

Mukherjee S, Guainazzi A, Schärer OD.

Nucleic Acids Res. 2014 Jun;42(11):7429-35. doi: 10.1093/nar/gku328. Epub 2014 Apr 29.


Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair.

Hodskinson MR, Silhan J, Crossan GP, Garaycoechea JI, Mukherjee S, Johnson CM, Schärer OD, Patel KJ.

Mol Cell. 2014 May 8;54(3):472-84. doi: 10.1016/j.molcel.2014.03.014. Epub 2014 Apr 10.


FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation.

Guillemette S, Branagan A, Peng M, Dhruva A, Schärer OD, Cantor SB.

Cancer Res. 2014 Feb 1;74(3):932-44. doi: 10.1158/0008-5472.CAN-13-2474. Epub 2013 Dec 18.


Advances in understanding the complex mechanisms of DNA interstrand cross-link repair.

Clauson C, Schärer OD, Niedernhofer L.

Cold Spring Harb Perspect Biol. 2013 Oct 1;5(10):a012732. doi: 10.1101/cshperspect.a012732. Review.


Nucleotide excision repair in eukaryotes.

Schärer OD.

Cold Spring Harb Perspect Biol. 2013 Oct 1;5(10):a012609. doi: 10.1101/cshperspect.a012609. Review.


Synthesis of sequence-specific DNA-protein conjugates via a reductive amination strategy.

Wickramaratne S, Mukherjee S, Villalta PW, Schärer OD, Tretyakova NY.

Bioconjug Chem. 2013 Sep 18;24(9):1496-506. doi: 10.1021/bc400018u. Epub 2013 Aug 16.


Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia.

Bogliolo M, Schuster B, Stoepker C, Derkunt B, Su Y, Raams A, Trujillo JP, Minguillón J, Ramírez MJ, Pujol R, Casado JA, Baños R, Rio P, Knies K, Zúñiga S, Benítez J, Bueren JA, Jaspers NG, Schärer OD, de Winter JP, Schindler D, Surrallés J.

Am J Hum Genet. 2013 May 2;92(5):800-6. doi: 10.1016/j.ajhg.2013.04.002. Epub 2013 Apr 25.


Interconverting conformations of slipped-DNA junctions formed by trinucleotide repeats affect repair outcome.

Slean MM, Reddy K, Wu B, Nichol Edamura K, Kekis M, Nelissen FH, Aspers RL, Tessari M, Schärer OD, Wijmenga SS, Pearson CE.

Biochemistry. 2013 Feb 5;52(5):773-85. doi: 10.1021/bi301369b. Epub 2013 Jan 22.


The efficiencies of damage recognition and excision correlate with duplex destabilization induced by acetylaminofluorene adducts in human nucleotide excision repair.

Yeo JE, Khoo A, Fagbemi AF, Schärer OD.

Chem Res Toxicol. 2012 Nov 19;25(11):2462-8. doi: 10.1021/tx3003033. Epub 2012 Oct 31.


Replication-coupled DNA interstrand cross-link repair in Xenopus egg extracts.

Knipscheer P, Räschle M, Schärer OD, Walter JC.

Methods Mol Biol. 2012;920:221-43. doi: 10.1007/978-1-61779-998-3_16.


Construction of plasmids containing site-specific DNA interstrand cross-links for biochemical and cell biological studies.

Enoiu M, Ho TV, Long DT, Walter JC, Schärer OD.

Methods Mol Biol. 2012;920:203-19. doi: 10.1007/978-1-61779-998-3_15.


Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis.

Enoiu M, Jiricny J, Schärer OD.

Nucleic Acids Res. 2012 Oct;40(18):8953-64. doi: 10.1093/nar/gks670. Epub 2012 Jul 18.


Alkyltransferase-like proteins: brokers dealing with alkylated DNA bases.

Schärer OD.

Mol Cell. 2012 Jul 13;47(1):3-4. doi: 10.1016/j.molcel.2012.06.030.


Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair.

Su Y, Orelli B, Madireddy A, Niedernhofer LJ, Schärer OD.

J Biol Chem. 2012 Jun 22;287(26):21846-55. doi: 10.1074/jbc.M111.337899. Epub 2012 Apr 30.


Synthesis of DNA interstrand cross-links using a photocaged nucleobase.

Hentschel S, Alzeer J, Angelov T, Schärer OD, Luedtke NW.

Angew Chem Int Ed Engl. 2012 Apr 2;51(14):3466-9. doi: 10.1002/anie.201108018. Epub 2012 Feb 17.


Lack of recognition by global-genome nucleotide excision repair accounts for the high mutagenicity and persistence of aristolactam-DNA adducts.

Sidorenko VS, Yeo JE, Bonala RR, Johnson F, Schärer OD, Grollman AP.

Nucleic Acids Res. 2012 Mar;40(6):2494-505. doi: 10.1093/nar/gkr1095. Epub 2011 Nov 25.


Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase.

Fu YV, Yardimci H, Long DT, Ho TV, Guainazzi A, Bermudez VP, Hurwitz J, van Oijen A, Schärer OD, Walter JC.

Cell. 2011 Sep 16;146(6):931-41. doi: 10.1016/j.cell.2011.07.045.


Structure-dependent bypass of DNA interstrand crosslinks by translesion synthesis polymerases.

Ho TV, Guainazzi A, Derkunt SB, Enoiu M, Schärer OD.

Nucleic Acids Res. 2011 Sep 1;39(17):7455-64. doi: 10.1093/nar/gkr448. Epub 2011 Jun 11.


Regulation of endonuclease activity in human nucleotide excision repair.

Fagbemi AF, Orelli B, Schärer OD.

DNA Repair (Amst). 2011 Jul 15;10(7):722-9. doi: 10.1016/j.dnarep.2011.04.022. Epub 2011 May 17. Review.


Synthesis and molecular modeling of a nitrogen mustard DNA interstrand crosslink.

Guainazzi A, Campbell AJ, Angelov T, Simmerling C, Schärer OD.

Chemistry. 2010 Oct 25;16(40):12100-3. doi: 10.1002/chem.201002041. No abstract available.


Using synthetic DNA interstrand crosslinks to elucidate repair pathways and identify new therapeutic targets for cancer chemotherapy.

Guainazzi A, Schärer OD.

Cell Mol Life Sci. 2010 Nov;67(21):3683-97. doi: 10.1007/s00018-010-0492-6. Epub 2010 Aug 21. Review.


Translesion DNA synthesis polymerases in DNA interstrand crosslink repair.

Ho TV, Schärer OD.

Environ Mol Mutagen. 2010 Jul;51(6):552-66. doi: 10.1002/em.20573. Review.


Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients.

Ahmad A, Enzlin JH, Bhagwat NR, Wijgers N, Raams A, Appledoorn E, Theil AF, J Hoeijmakers JH, Vermeulen W, J Jaspers NG, Schärer OD, Niedernhofer LJ.

PLoS Genet. 2010 Mar 5;6(3):e1000871. doi: 10.1371/journal.pgen.1000871.


The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.

Knipscheer P, Räschle M, Smogorzewska A, Enoiu M, Ho TV, Schärer OD, Elledge SJ, Walter JC.

Science. 2009 Dec 18;326(5960):1698-701. doi: 10.1126/science.1182372. Epub 2009 Nov 12.


The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways.

Orelli B, McClendon TB, Tsodikov OV, Ellenberger T, Niedernhofer LJ, Schärer OD.

J Biol Chem. 2010 Feb 5;285(6):3705-12. doi: 10.1074/jbc.M109.067538. Epub 2009 Nov 23.


Coordination of dual incision and repair synthesis in human nucleotide excision repair.

Staresincic L, Fagbemi AF, Enzlin JH, Gourdin AM, Wijgers N, Dunand-Sauthier I, Giglia-Mari G, Clarkson SG, Vermeulen W, Schärer OD.

EMBO J. 2009 Apr 22;28(8):1111-20. doi: 10.1038/emboj.2009.49. Epub 2009 Mar 12.


Wedging out DNA damage.

Schärer OD, Campbell AJ.

Nat Struct Mol Biol. 2009 Feb;16(2):102-4. doi: 10.1038/nsmb0209-102. No abstract available.


XPG: its products and biological roles.

Schärer OD.

Adv Exp Med Biol. 2008;637:83-92. Review.


Generation of DNA interstrand cross-links by post-synthetic reductive amination.

Angelov T, Guainazzi A, Schärer OD.

Org Lett. 2009 Feb 5;11(3):661-4. doi: 10.1021/ol802719a.


Mechanism of replication-coupled DNA interstrand crosslink repair.

Räschle M, Knipscheer P, Enoiu M, Angelov T, Sun J, Griffith JD, Ellenberger TE, Schärer OD, Walter JC.

Cell. 2008 Sep 19;134(6):969-80. doi: 10.1016/j.cell.2008.08.030. Erratum in: Cell.2009 May 29;137(5):972. Knipsheer, Puck [corrected to Knipscheer, Puck].


Interaction of nucleotide excision repair factors XPC-HR23B, XPA, and RPA with damaged DNA.

Krasikova YS, Rechkunova NI, Maltseva EA, Petruseva IO, Silnikov VN, Zatsepin TS, Oretskaya TS, Schärer OD, Lavrik OI.

Biochemistry (Mosc). 2008 Aug;73(8):886-96.


Crosslinking of nucleotide excision repair proteins with DNA containing photoreactive damages.

Maltseva EA, Rechkunova NI, Petruseva IO, Vermeulen W, Schärer OD, Lavrik OI.

Bioorg Chem. 2008 Apr;36(2):77-84. doi: 10.1016/j.bioorg.2007.11.004. Epub 2008 Jan 11.


A molecular basis for damage recognition in eukaryotic nucleotide excision repair.

Schärer OD.

Chembiochem. 2008 Jan 4;9(1):21-3. No abstract available.


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