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Active DNA demethylation by DNA repair: Facts and uncertainties. Schuermann D et al. DNA Repair (Amst). (2016)

Gadd45a promotes DNA demethylation through TDG. Li Z et al. Nucleic Acids Res. (2015)

Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Weber AR et al. Nat Commun. (2016)

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Tumor Initiation Capacity and Therapy Resistance Are Differential Features of EMT-Related Subpopulations in the NSCLC Cell Line A549.

Tièche CC, Gao Y, Bührer ED, Hobi N, Berezowska SA, Wyler K, Froment L, Weis S, Peng RW, Bruggmann R, Schär P, Amrein MA, Hall SRR, Dorn P, Kocher G, Riether C, Ochsenbein A, Schmid RA, Marti TM.

Neoplasia. 2018 Dec 27;21(2):185-196. doi: 10.1016/j.neo.2018.09.008. [Epub ahead of print]


SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation.

Steinacher R, Barekati Z, Botev P, Kuśnierczyk A, Slupphaug G, Schär P.

EMBO J. 2019 Jan 3;38(1). pii: e99242. doi: 10.15252/embj.201899242. Epub 2018 Dec 6.


ELF-MF exposure affects the robustness of epigenetic programming during granulopoiesis.

Manser M, Sater MR, Schmid CD, Noreen F, Murbach M, Kuster N, Schuermann D, Schär P.

Sci Rep. 2017 Mar 7;7:43345. doi: 10.1038/srep43345.


Active DNA demethylation by DNA repair: Facts and uncertainties.

Schuermann D, Weber AR, Schär P.

DNA Repair (Amst). 2016 Aug;44:92-102. doi: 10.1016/j.dnarep.2016.05.013. Epub 2016 May 16. Review.


Extremely low-frequency magnetic fields and risk of childhood leukemia: A risk assessment by the ARIMMORA consortium.

Schüz J, Dasenbrock C, Ravazzani P, Röösli M, Schär P, Bounds PL, Erdmann F, Borkhardt A, Cobaleda C, Fedrowitz M, Hamnerius Y, Sanchez-Garcia I, Seger R, Schmiegelow K, Ziegelberger G, Capstick M, Manser M, Müller M, Schmid CD, Schürmann D, Struchen B, Kuster N.

Bioelectromagnetics. 2016 Apr;37(3):183-189. doi: 10.1002/bem.21963. Epub 2016 Mar 15.


Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism.

Weber AR, Krawczyk C, Robertson AB, Kuśnierczyk A, Vågbø CB, Schuermann D, Klungland A, Schär P.

Nat Commun. 2016 Mar 2;7:10806. doi: 10.1038/ncomms10806.


Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase.

Liu Y, Duong W, Krawczyk C, Bretschneider N, Borbély G, Varshney M, Zinser C, Schär P, Rüegg J.

Epigenetics Chromatin. 2016 Feb 16;9:7. doi: 10.1186/s13072-016-0055-7. eCollection 2016.


3CAPS - a structural AP-site analogue as a tool to investigate DNA base excision repair.

Schuermann D, Scheidegger SP, Weber AR, Bjørås M, Leumann CJ, Schär P.

Nucleic Acids Res. 2016 Mar 18;44(5):2187-98. doi: 10.1093/nar/gkv1520. Epub 2016 Jan 4.


Gadd45a promotes DNA demethylation through TDG.

Li Z, Gu TP, Weber AR, Shen JZ, Li BZ, Xie ZG, Yin R, Guo F, Liu X, Tang F, Wang H, Schär P, Xu GL.

Nucleic Acids Res. 2015 Apr 30;43(8):3986-97. doi: 10.1093/nar/gkv283. Epub 2015 Apr 6.


Versatile recombinant SUMOylation system for the production of SUMO-modified protein.

Weber AR, Schuermann D, Schär P.

PLoS One. 2014 Jul 9;9(7):e102157. doi: 10.1371/journal.pone.0102157. eCollection 2014.


Modulation of age- and cancer-associated DNA methylation change in the healthy colon by aspirin and lifestyle.

Noreen F, Röösli M, Gaj P, Pietrzak J, Weis S, Urfer P, Regula J, Schär P, Truninger K.

J Natl Cancer Inst. 2014 Jun 28;106(7). pii: dju161. doi: 10.1093/jnci/dju161. Print 2014 Jul.


Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.

Pfaffeneder T, Spada F, Wagner M, Brandmayr C, Laube SK, Eisen D, Truss M, Steinbacher J, Hackner B, Kotljarova O, Schuermann D, Michalakis S, Kosmatchev O, Schiesser S, Steigenberger B, Raddaoui N, Kashiwazaki G, Müller U, Spruijt CG, Vermeulen M, Leonhardt H, Schär P, Müller M, Carell T.

Nat Chem Biol. 2014 Jul;10(7):574-81. doi: 10.1038/nchembio.1532. Epub 2014 May 18.


Reversible Top1 cleavage complexes are stabilized strand-specifically at the ribosomal replication fork barrier and contribute to ribosomal DNA stability.

Krawczyk C, Dion V, Schär P, Fritsch O.

Nucleic Acids Res. 2014 Apr;42(8):4985-95. doi: 10.1093/nar/gku148. Epub 2014 Feb 25.


7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases.

Talhaoui I, Couvé S, Ishchenko AA, Kunz C, Schär P, Saparbaev M.

Nucleic Acids Res. 2013 Jan;41(2):912-23. doi: 10.1093/nar/gks1149. Epub 2012 Dec 2.


ELF exposure system for live cell imaging.

Capstick M, Schär P, Schuermann D, Romann A, Kuster N.

Bioelectromagnetics. 2013 Apr;34(3):231-9. doi: 10.1002/bem.21751. Epub 2012 Nov 1.


Resources for methylome analysis suitable for gene knockout studies of potential epigenome modifiers.

Wilson GA, Dhami P, Feber A, Cortázar D, Suzuki Y, Schulz R, Schär P, Beck S.

Gigascience. 2012 Jul 12;1(1):3. doi: 10.1186/2047-217X-1-3.


DNA glycosylases: in DNA repair and beyond.

Jacobs AL, Schär P.

Chromosoma. 2012 Feb;121(1):1-20. doi: 10.1007/s00412-011-0347-4. Epub 2011 Nov 3. Review.


Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability.

Cortázar D, Kunz C, Selfridge J, Lettieri T, Saito Y, MacDougall E, Wirz A, Schuermann D, Jacobs AL, Siegrist F, Steinacher R, Jiricny J, Bird A, Schär P.

Nature. 2011 Feb 17;470(7334):419-23. doi: 10.1038/nature09672. Epub 2011 Jan 30.


DNA repair and the control of DNA methylation.

Schär P, Fritsch O.

Prog Drug Res. 2011;67:51-68. Review.


DNA ligase 4 stabilizes the ribosomal DNA array upon fork collapse at the replication fork barrier.

Fritsch O, Burkhalter MD, Kais S, Sogo JM, Schär P.

DNA Repair (Amst). 2010 Aug 5;9(8):879-88. doi: 10.1016/j.dnarep.2010.05.003. Epub 2010 Jun 12.


DNA fragmentation in human fibroblasts under extremely low frequency electromagnetic field exposure.

Focke F, Schuermann D, Kuster N, Schär P.

Mutat Res. 2010 Jan 5;683(1-2):74-83. doi: 10.1016/j.mrfmmm.2009.10.012.


Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function.

Messner S, Schuermann D, Altmeyer M, Kassner I, Schmidt D, Schär P, Müller S, Hottiger MO.

FASEB J. 2009 Nov;23(11):3978-89. doi: 10.1096/fj.09-137695. Epub 2009 Jul 21.


Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil.

Kunz C, Focke F, Saito Y, Schuermann D, Lettieri T, Selfridge J, Schär P.

PLoS Biol. 2009 Apr 28;7(4):e91. doi: 10.1371/journal.pbio.1000091.


Diastereoselectivity control of the radical carboazidation of substituted methylenecyclohexanes.

Cren S, Schär P, Renaud P, Schenk K.

J Org Chem. 2009 Apr 17;74(8):2942-6. doi: 10.1021/jo900088x.


DNA Repair in mammalian cells: Mismatched repair: variations on a theme.

Kunz C, Saito Y, Schär P.

Cell Mol Life Sci. 2009 Mar;66(6):1021-38. doi: 10.1007/s00018-009-8739-9. Review.


Normal colorectal mucosa exhibits sex- and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT promoters.

Menigatti M, Truninger K, Gebbers JO, Marbet U, Marra G, Schär P.

Oncogene. 2009 Feb 12;28(6):899-909. doi: 10.1038/onc.2008.444. Epub 2008 Dec 8.


Resource use and outcome in critically ill patients with hematological malignancy: a retrospective cohort study.

Merz TM, Schär P, Bühlmann M, Takala J, Rothen HU.

Crit Care. 2008;12(3):R75. doi: 10.1186/cc6921. Epub 2008 Jun 6.


Cell cycle regulation as a mechanism for functional separation of the apparently redundant uracil DNA glycosylases TDG and UNG2.

Hardeland U, Kunz C, Focke F, Szadkowski M, Schär P.

Nucleic Acids Res. 2007;35(11):3859-67. Epub 2007 May 25.


O6-methylguanine-DNA methyltransferase promoter hypermethylation in colorectal carcinogenesis.

Menigatti M, Pedroni M, Verrone AM, Borghi F, Scarselli A, Benatti P, Losi L, Di Gregorio C, Schär P, Marra G, Ponz de Leon M, Roncucci L.

Oncol Rep. 2007 Jun;17(6):1421-7.


Conserved interactions of the splicing factor Ntr1/Spp382 with proteins involved in DNA double-strand break repair and telomere metabolism.

Herrmann G, Kais S, Hoffbauer J, Shah-Hosseini K, Brüggenolte N, Schober H, Fäsi M, Schär P.

Nucleic Acids Res. 2007;35(7):2321-32. Epub 2007 Mar 27.


The enigmatic thymine DNA glycosylase.

Cortázar D, Kunz C, Saito Y, Steinacher R, Schär P.

DNA Repair (Amst). 2007 Apr 1;6(4):489-504. Epub 2006 Nov 20. Review.


Arginine methylation regulates DNA polymerase beta.

El-Andaloussi N, Valovka T, Toueille M, Steinacher R, Focke F, Gehrig P, Covic M, Hassa PO, Schär P, Hübscher U, Hottiger MO.

Mol Cell. 2006 Apr 7;22(1):51-62.


Total synthesis of the marine alkaloid (+/-)-lepadiformine via a radical carboazidation.

Schär P, Renaud P.

Org Lett. 2006 Apr 13;8(8):1569-71.


T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif.

Lucey MJ, Chen D, Lopez-Garcia J, Hart SM, Phoenix F, Al-Jehani R, Alao JP, White R, Kindle KB, Losson R, Chambon P, Parker MG, Schär P, Heery DM, Buluwela L, Ali S.

Nucleic Acids Res. 2005 Nov 10;33(19):6393-404. Print 2005.


Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae.

Cejka P, Mojas N, Gillet L, Schär P, Jiricny J.

Curr Biol. 2005 Aug 9;15(15):1395-400.


Immunohistochemical analysis reveals high frequency of PMS2 defects in colorectal cancer.

Truninger K, Menigatti M, Luz J, Russell A, Haider R, Gebbers JO, Bannwart F, Yurtsever H, Neuweiler J, Riehle HM, Cattaruzza MS, Heinimann K, Schär P, Jiricny J, Marra G.

Gastroenterology. 2005 May;128(5):1160-71.


Mismatch dependent uracil/thymine-DNA glycosylases excise exocyclic hydroxyethano and hydroxypropano cytosine adducts.

Borys-Brzywczy E, Arczewska KD, Saparbaev M, Hardeland U, Schär P, Kuśmierek JT.

Acta Biochim Pol. 2005;52(1):149-65.


Meiotic recombination: sealing the partnership at the junction.

Kunz C, Schär P.

Curr Biol. 2004 Nov 23;14(22):R962-4. Review.


Lack of mismatch correction facilitates genome evolution in mycobacteria.

Springer B, Sander P, Sedlacek L, Hardt WD, Mizrahi V, Schär P, Böttger EC.

Mol Microbiol. 2004 Sep;53(6):1601-9.


SMC1 coordinates DNA double-strand break repair pathways.

Schär P, Fäsi M, Jessberger R.

Nucleic Acids Res. 2004 Jul 27;32(13):3921-9. Print 2004.


Translesion DNA synthesis: little fingers teach tolerance.

Fleck O, Schär P.

Curr Biol. 2004 May 25;14(10):R389-91. Review.


T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha.

Chen D, Lucey MJ, Phoenix F, Lopez-Garcia J, Hart SM, Losson R, Buluwela L, Coombes RC, Chambon P, Schär P, Ali S.

J Biol Chem. 2003 Oct 3;278(40):38586-92. Epub 2003 Jul 21.


The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs.

Hardeland U, Bentele M, Jiricny J, Schär P.

Nucleic Acids Res. 2003 May 1;31(9):2261-71.


Acetylation regulates the DNA end-trimming activity of DNA polymerase beta.

Hasan S, El-Andaloussi N, Hardeland U, Hassa PO, Bürki C, Imhof R, Schär P, Hottiger MO.

Mol Cell. 2002 Nov;10(5):1213-22.


Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover.

Hardeland U, Steinacher R, Jiricny J, Schär P.

EMBO J. 2002 Mar 15;21(6):1456-64.


NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae.

Valencia M, Bentele M, Vaze MB, Herrmann G, Kraus E, Lee SE, Schär P, Haber JE.

Nature. 2001 Dec 6;414(6864):666-9.


Thymine DNA glycosylase.

Hardeland U, Bentele M, Lettieri T, Steinacher R, Jiricny J, Schär P.

Prog Nucleic Acid Res Mol Biol. 2001;68:235-53. Review.


Biochemical characterization of uracil processing activities in the hyperthermophilic archaeon Pyrobaculum aerophilum.

Sartori AA, Schär P, Fitz-Gibbon S, Miller JH, Jiricny J.

J Biol Chem. 2001 Aug 10;276(32):29979-86. Epub 2001 Jun 8.

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