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A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos. Matyskiela ME et al. J Med Chem. (2018)

Plant root-microbe communication in shaping root microbiomes. Lareen A et al. Plant Mol Biol. (2016)

Mechanisms Underlying the Clinical Effects of Apremilast for Psoriasis. Pincelli C et al. J Drugs Dermatol. (2018)

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Items: 1 to 50 of 402


Spebrutinib (CC-292) Affects Markers of B Cell Activation, Chemotaxis, and Osteoclasts in Patients with Rheumatoid Arthritis: Results from a Mechanistic Study.

Schafer PH, Kivitz AJ, Ma J, Korish S, Sutherland D, Li L, Azaryan A, Kosek J, Adams M, Capone L, Hur EM, Hough DR, Ringheim GE.

Rheumatol Ther. 2019 Nov 13. doi: 10.1007/s40744-019-00182-7. [Epub ahead of print]


Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice.

Schafer PH, Adams M, Horan G, Truzzi F, Marconi A, Pincelli C.

Drugs R D. 2019 Oct 9. doi: 10.1007/s40268-019-00284-1. [Epub ahead of print]


Team-Based Intervention to Reduce the Impact of Nonactionable Alarms in an Adult Intensive Care Unit.

Yeh J, Wilson R, Young L, Pahl L, Whitney S, Dellsperger KC, Schafer PE.

J Nurs Care Qual. 2019 Sep 10. doi: 10.1097/NCQ.0000000000000436. [Epub ahead of print]


Negative regulators of plant immunity derived from cinnamyl alcohol dehydrogenases are targeted by multiple Phytophthora Avr3a-like effectors.

Li T, Wang Q, Feng R, Li L, Ding L, Fan G, Li W, Du Y, Zhang M, Huang G, Schäfer P, Meng Y, Tyler BM, Shan W.

New Phytol. 2019 Aug 22. doi: 10.1111/nph.16139. [Epub ahead of print]


Towards New Robust Zn(II) Complexes for the Ring-Opening Polymerization of Lactide Under Industrially Relevant Conditions.

Schäfer PM, Dankhoff K, Rothemund M, Ksiazkiewicz AN, Pich A, Schobert R, Weber B, Herres-Pawlis S.

ChemistryOpen. 2019 Jul 29;8(7):1020-1026. doi: 10.1002/open.201900199. eCollection 2019 Jul.


Heterolepic β-Ketoiminate Zinc Phenoxide Complexes as Efficient Catalysts for the Ring Opening Polymerization of Lactide.

Ghosh S, Schäfer PM, Dittrich D, Scheiper C, Steiniger P, Fink G, Ksiazkiewicz AN, Tjaberings A, Wölper C, Gröschel AH, Pich A, Herres-Pawlis S, Schulz S.

ChemistryOpen. 2019 Jul 4;8(7):951-960. doi: 10.1002/open.201900203. eCollection 2019 Jul.


Better haemodynamic stability under xenon anaesthesia than under isoflurane anaesthesia during partial nephrectomy - a secondary analysis of a randomised controlled trial.

Schäfer P, Fahlenkamp A, Rossaint R, Coburn M, Kowark A.

BMC Anesthesiol. 2019 Jul 9;19(1):125. doi: 10.1186/s12871-019-0799-2.


Markers for Malnutrition and BMI Status in Total Joint Arthroplasty and Pharmaconutrient Therapy.

Sayeed Z, Anoushiravani AA, Simha S, Padela MT, Schafer P, Awad ME, Darwiche HF, Saleh KJ.

JBJS Rev. 2019 May;7(5):e3. doi: 10.2106/JBJS.RVW.18.00056. No abstract available.


[Medical examination: Preparation for ENT specialisation : Part 42].

Schäfer P.

HNO. 2019 Jun;67(6):463-468. doi: 10.1007/s00106-019-0667-x. Review. German. No abstract available.


Regulation of Resource Partitioning Coordinates Nitrogen and Rhizobia Responses and Autoregulation of Nodulation in Medicago truncatula.

Lagunas B, Achom M, Bonyadi-Pour R, Pardal AJ, Richmond BL, Sergaki C, Vázquez S, Schäfer P, Ott S, Hammond J, Gifford ML.

Mol Plant. 2019 Jun 3;12(6):833-846. doi: 10.1016/j.molp.2019.03.014. Epub 2019 Apr 3.


A novel 3D printed radial collimator for x-ray diffraction.

Kowarik S, Bogula L, Boitano S, Carlà F, Pithan H, Schäfer P, Wilming H, Zykov A, Pithan L.

Rev Sci Instrum. 2019 Mar;90(3):035102. doi: 10.1063/1.5063520.


Mapping Polymer Molecular Order in the SEM with Secondary Electron Hyperspectral Imaging.

Masters RC, Stehling N, Abrams KJ, Kumar V, Azzolini M, Pugno NM, Dapor M, Huber A, Schäfer P, Lidzey DG, Rodenburg C.

Adv Sci (Weinh). 2019 Jan 20;6(5):1801752. doi: 10.1002/advs.201801752. eCollection 2019 Mar 6.


Consequences of impaired 1-MDa TIC complex assembly for the abundance and composition of chloroplast high-molecular mass protein complexes.

Schäfer P, Helm S, Köhler D, Agne B, Baginsky S.

PLoS One. 2019 Mar 13;14(3):e0213364. doi: 10.1371/journal.pone.0213364. eCollection 2019.


IL-12/IL-23p40 identified as a downstream target of apremilast in ex vivo models of arthritis.

Kragstrup TW, Adams M, Lomholt S, Nielsen MA, Heftdal LD, Schafer P, Deleuran B.

Ther Adv Musculoskelet Dis. 2019 Feb 22;11:1759720X19828669. doi: 10.1177/1759720X19828669. eCollection 2019.


New Kids in Lactide Polymerization: Highly Active and Robust Iron Guanidine Complexes as Superior Catalysts.

Rittinghaus RD, Schäfer PM, Albrecht P, Conrads C, Hoffmann A, Ksiazkiewicz AN, Bienemann O, Pich A, Herres-Pawlis S.

ChemSusChem. 2019 May 21;12(10):2161-2165. doi: 10.1002/cssc.201900481. Epub 2019 Mar 19.


Tuning a robust system: N,O zinc guanidine catalysts for the ROP of lactide.

Schäfer PM, McKeown P, Fuchs M, Rittinghaus RD, Hermann A, Henkel J, Seidel S, Roitzheim C, Ksiazkiewicz AN, Hoffmann A, Pich A, Jones MD, Herres-Pawlis S.

Dalton Trans. 2019 May 7;48(18):6071-6082. doi: 10.1039/c8dt04938f.


The IASP classification of chronic pain for ICD-11: functioning properties of chronic pain.

Nugraha B, Gutenbrunner C, Barke A, Karst M, Schiller J, Schäfer P, Falter S, Korwisi B, Rief W, Treede RD; IASP Taskforce for the Classification of Chronic Pain.

Pain. 2019 Jan;160(1):88-94. doi: 10.1097/j.pain.0000000000001433. Review.


Advancing research paradigms and pathophysiological pathways in psoriatic arthritis and ankylosing spondylitis: Proceedings of the 2017 Platform for the Exchange of Expertise and Research (PEER) meeting.

Abraham S, Barton A, Eder L, Lim A, McGonagle D, McHugh N, Pennington S, Sengupta R, Siebert S, Bowness P, Schafer PH, Cullen E, FitzGerald O.

Semin Arthritis Rheum. 2019 Jun;48(6):1005-1013. doi: 10.1016/j.semarthrit.2018.10.008. Epub 2018 Oct 15. No abstract available.


Fluidic Patterning of Transparent Polymer Heaters.

Romasanta LJ, Schäfer P, Leng J.

Sci Rep. 2018 Nov 1;8(1):16227. doi: 10.1038/s41598-018-34538-w.


Molecular structure of the substrate-induced thin-film phase of tetracene.

Pithan L, Nabok D, Cocchi C, Beyer P, Duva G, Simbrunner J, Rawle J, Nicklin C, Schäfer P, Draxl C, Schreiber F, Kowarik S.

J Chem Phys. 2018 Oct 14;149(14):144701. doi: 10.1063/1.5043379.


Learning Clinical Hypnosis Wide Awake: Can We Teach Hypnosis Hypnotically?

Sugarman LI, Schafer PM, Alter DS, Reid DB.

Am J Clin Hypn. 2018 Oct;61(2):140-158. doi: 10.1080/00029157.2018.1437710.


Challenges and Approaches in Microbiome Research: From Fundamental to Applied.

Sergaki C, Lagunas B, Lidbury I, Gifford ML, Schäfer P.

Front Plant Sci. 2018 Aug 17;9:1205. doi: 10.3389/fpls.2018.01205. eCollection 2018. Review.


Reconstitution of mammalian cleavage factor II involved in 3' processing of mRNA precursors.

Schäfer P, Tüting C, Schönemann L, Kühn U, Treiber T, Treiber N, Ihling C, Graber A, Keller W, Meister G, Sinz A, Wahle E.

RNA. 2018 Dec;24(12):1721-1737. doi: 10.1261/rna.068056.118. Epub 2018 Aug 23.


The Tetrazole Analogue of the Auxin Indole-3-acetic Acid Binds Preferentially to TIR1 and Not AFB5.

Quareshy M, Prusinska J, Kieffer M, Fukui K, Pardal AJ, Lehmann S, Schafer P, Del Genio CI, Kepinski S, Hayashi K, Marsh A, Napier RM.

ACS Chem Biol. 2018 Sep 21;13(9):2585-2594. doi: 10.1021/acschembio.8b00527. Epub 2018 Sep 6.


Mechanisms Underlying the Clinical Effects of Apremilast for Psoriasis.

Pincelli C, Schafer PH, French LE, Augustin M, Krueger JG.

J Drugs Dermatol. 2018 Aug 1;17(8):835-840. Review.


Apremilast Ameliorates Experimental Arthritis via Suppression of Th1 and Th17 Cells and Enhancement of CD4+Foxp3+ Regulatory T Cells Differentiation.

Chen W, Wang J, Xu Z, Huang F, Qian W, Ma J, Wee HB, Lewis GS, June RR, Schafer PH, Lin J, Zheng SG.

Front Immunol. 2018 Jul 18;9:1662. doi: 10.3389/fimmu.2018.01662. eCollection 2018.


Stevens-Johnson Syndrome: A Challenging Diagnosis.

Davis WD, Schafer PA.

Adv Emerg Nurs J. 2018 Jul/Sep;40(3):176-182. doi: 10.1097/TME.0000000000000197.


Retraction notice to "Synapse loss regulated by matrix metalloproteinases in traumatic brain injury is associated with hypoxia-inducible factor-1α expression" [Brain Res. 1268 (2009) 125-134].

Ding JY, Kreipke CW, Schafer P, Schafer S, Speirs SL, Rafols JA.

Brain Res. 2018 Sep 1;1694:150. doi: 10.1016/j.brainres.2018.06.005. No abstract available.


Cereblon modulator iberdomide induces degradation of the transcription factors Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus.

Schafer PH, Ye Y, Wu L, Kosek J, Ringheim G, Yang Z, Liu L, Thomas M, Palmisano M, Chopra R.

Ann Rheum Dis. 2018 Oct;77(10):1516-1523. doi: 10.1136/annrheumdis-2017-212916. Epub 2018 Jun 26.


Synergistic cytokine effects as apremilast response predictors in patients with psoriasis.

Garcet S, Nograles K, Correa da Rosa J, Schafer PH, Krueger JG.

J Allergy Clin Immunol. 2018 Sep;142(3):1010-1013.e6. doi: 10.1016/j.jaci.2018.05.039. Epub 2018 Jun 21. No abstract available.


Renovascular hypertension: endovascular therapy in complicated aortic Stanford type B dissection.

Cupa J, Hippe HJ, Schäfer P, Frey N, Langer C.

Cardiovasc Diagn Ther. 2018 Apr;8(2):173-175. doi: 10.21037/cdt.2017.11.06.


Author Correction: Asymmetric Suzuki-Miyaura coupling of heterocycles via Rhodium-catalysed allylic arylation of racemates.

Schäfer P, Palacin T, Sidera M, Fletcher SP.

Nat Commun. 2018 May 25;9:16216. doi: 10.1038/ncomms16216.


From water striders to water bugs: the molecular diversity of aquatic Heteroptera (Gerromorpha, Nepomorpha) of Germany based on DNA barcodes.

Havemann N, Gossner MM, Hendrich L, Morinière J, Niedringhaus R, Schäfer P, Raupach MJ.

PeerJ. 2018 May 2;6:e4577. doi: 10.7717/peerj.4577. eCollection 2018.


Preoperative PCR analysis of synovial fluid has limited value for the diagnosis of periprosthetic joint infections of total knee arthroplasties.

Fink B, Steurer M, Hofäcker S, Schäfer P, Sandow D, Schuster P, Oremek D.

Arch Orthop Trauma Surg. 2018 Jun;138(6):871-878. doi: 10.1007/s00402-018-2924-y. Epub 2018 Apr 4.


Impact of spatial organization on a novel auxotrophic interaction among soil microbes.

Jiang X, Zerfaß C, Feng S, Eichmann R, Asally M, Schäfer P, Soyer OS.

ISME J. 2018 Jun;12(6):1443-1456. doi: 10.1038/s41396-018-0095-z. Epub 2018 Mar 23.


Corrigendum: Highly Active N,O Zinc Guanidine Catalysts for the Ring-Opening Polymerization of Lactide.

Schäfer PM, Fuchs M, Ohligschläger A, Rittinghaus R, McKeown P, Akin E, Schmidt M, Hoffmann A, Liauw MA, Jones MD, Herres-Pawlis S.

ChemSusChem. 2017 Dec 8;10(23):4799. doi: 10.1002/cssc.201702066. Epub 2017 Nov 14. No abstract available.


Asymmetric cross-coupling of alkyl, alkenyl and (hetero)aryl nucleophiles with racemic allyl halides.

Schäfer P, Sidera M, Palacin T, Fletcher SP.

Chem Commun (Camb). 2017 Nov 21;53(93):12499-12511. doi: 10.1039/c7cc07151e.


Pomalidomide in Patients with Interstitial Lung Disease due to Systemic Sclerosis: A Phase II, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study.

Hsu VM, Denton CP, Domsic RT, Furst DE, Rischmueller M, Stanislav M, Steen VD, Distler JHW, Korish S, Cooper A, Choi S, Schafer PH, Horan G, Hough DR.

J Rheumatol. 2018 Mar;45(3):405-410. doi: 10.3899/jrheum.161040. Epub 2017 Nov 1.


Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity.

Nakayama Y, Kosek J, Capone L, Hur EM, Schafer PH, Ringheim GE.

J Immunol. 2017 Oct 1;199(7):2388-2407. doi: 10.4049/jimmunol.1601725. Epub 2017 Aug 28.


Retinal cell death dependent reactive proliferative gliosis in the mouse retina.

Sardar Pasha SPB, Münch R, Schäfer P, Oertel P, Sykes AM, Zhu Y, Karl MO.

Sci Rep. 2017 Aug 25;7(1):9517. doi: 10.1038/s41598-017-09743-8.


The powdery mildew-resistant Arabidopsis mlo2 mlo6 mlo12 triple mutant displays altered infection phenotypes with diverse types of phytopathogens.

Acevedo-Garcia J, Gruner K, Reinstädler A, Kemen A, Kemen E, Cao L, Takken FLW, Reitz MU, Schäfer P, O'Connell RJ, Kusch S, Kuhn H, Panstruga R.

Sci Rep. 2017 Aug 24;7(1):9319. doi: 10.1038/s41598-017-07188-7.


Highly Active N,O Zinc Guanidine Catalysts for the Ring-Opening Polymerization of Lactide.

Schäfer PM, Fuchs M, Ohligschläger A, Rittinghaus R, McKeown P, Akin E, Schmidt M, Hoffmann A, Liauw MA, Jones MD, Herres-Pawlis S.

ChemSusChem. 2017 Sep 22;10(18):3547-3556. doi: 10.1002/cssc.201701237. Epub 2017 Sep 19. Erratum in: ChemSusChem. 2017 Dec 8;10 (23 ):4799.


Left ventricular hypertrophy in acute stroke patients with known hypertension.

Bruno A, Brooks DD, Abrams TA, Poorak MD, Gunio D, Kandhal PK, Lakhanpal A, Nagabandi AK, Akinwuntan AE, Looney S, Schafer PE.

Clin Exp Hypertens. 2017;39(6):502-504. doi: 10.1080/10641963.2016.1259328. Epub 2017 Jul 19.


Asymmetric Suzuki-Miyaura coupling of heterocycles via Rhodium-catalysed allylic arylation of racemates.

Schäfer P, Palacin T, Sidera M, Fletcher SP.

Nat Commun. 2017 Jun 13;8:15762. doi: 10.1038/ncomms15762. Erratum in: Nat Commun. 2018 May 25;9:16216.


Safety and Efficacy of Uninterrupted Apixaban Therapy Versus Warfarin During Atrial Fibrillation Ablation.

Shah RR, Pillai A, Schafer P, Meggo D, McElderry T, Plumb V, Yamada T, Kumar V, Doppalapudi H, Gunter A, Pentecost E, Maddox WR.

Am J Cardiol. 2017 Aug 1;120(3):404-407. doi: 10.1016/j.amjcard.2017.04.041. Epub 2017 May 10.


A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.

Matyskiela ME, Zhang W, Man HW, Muller G, Khambatta G, Baculi F, Hickman M, LeBrun L, Pagarigan B, Carmel G, Lu CC, Lu G, Riley M, Satoh Y, Schafer P, Daniel TO, Carmichael J, Cathers BE, Chamberlain PP.

J Med Chem. 2018 Jan 25;61(2):535-542. doi: 10.1021/acs.jmedchem.6b01921. Epub 2017 Apr 20.


Prospective purification and characterization of Müller glia in the mouse retina regeneration assay.

Schäfer P, Karl MO.

Glia. 2017 May;65(5):828-847. doi: 10.1002/glia.23130. Epub 2017 Feb 21.


Chronic Stress and C-Reactive Protein in Mothers During the First Postpartum Year.

Guardino CM, Dunkel Schetter C, Hobel CJ, Gaines Lanzi R, Schafer P, Thorp JM, Shalowitz MU; Community Child Health Network (CCHN).

Psychosom Med. 2017 May;79(4):450-460. doi: 10.1097/PSY.0000000000000424.


Iatrogenic Catheter-Induced Acute Aortic Dissection Type A after Coronary Angiography-A Retrospective Consecutive Case Series.

Huenges K, Dreyer J, Panholzer B, Grothusen C, Renner J, Schäfer P, Freundt M, Schoeneich F, Schöttler J, Rahimi-Barfeh A, Cremer J, Haneya A.

Thorac Cardiovasc Surg. 2017 Mar;65(2):85-89. doi: 10.1055/s-0036-1594290. Epub 2016 Dec 13.


Direct Photoalignment and Optical Patterning of Molecular Thin Films.

Pithan L, Beyer P, Bogula L, Zykov A, Schäfer P, Rawle J, Nicklin C, Opitz A, Kowarik S.

Adv Mater. 2017 Feb;29(6). doi: 10.1002/adma.201604382. Epub 2016 Dec 1.


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