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A randomized trial of deep-brain stimulation for Parkinson's disease. Deuschl G et al. N Engl J Med. (2006)

Transformations of dimethylsulfide. Kappler U et al. Met Ions Life Sci. (2014)

Tools of pathway reconstruction and production of economically relevant plant secondary metabolites in recombinant microorganisms. Dziggel C et al. Biotechnol J. (2017)

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From bad electrochemical practices to an environmental and waste reducing approach for the generation of active hydrogen evolving electrodes.

Ring L, Pollet B, Chatenet M, Abbou S, Küpper K, Schmidt M, Huck M, Gries A, Steinhart M, Schäfer H.

Angew Chem Int Ed Engl. 2019 Sep 20. doi: 10.1002/anie.201908649. [Epub ahead of print]


NMR-based newborn urine screening for optimized detection of inherited errors of metabolism.

Embade N, Cannet C, Diercks T, Gil-Redondo R, Bruzzone C, Ansó S, Echevarría LR, Ayucar MMM, Collazos L, Lodoso B, Guerra E, Elorriaga IA, Kortajarena MÁ, Legorburu AP, Fang F, Astigarraga I, Schäfer H, Spraul M, Millet O.

Sci Rep. 2019 Sep 10;9(1):13067. doi: 10.1038/s41598-019-49685-x.


Killer on the road?-cells from pancreatic preneoplastic lesions disseminate through pancreatic ducts on their way to cancer.

Schäfer H, Traulsen A, Sebens S.

Hepatobiliary Surg Nutr. 2019 Aug;8(4):392-394. doi: 10.21037/hbsn.2019.06.03. No abstract available.


Short-Term Effects of the Serious Game "Fit, Food, Fun" on Nutritional Knowledge: A Pilot Study among Children and Adolescents.

Holzmann SL, Schäfer H, Groh G, Plecher DA, Klinker G, Schauberger G, Hauner H, Holzapfel C.

Nutrients. 2019 Aug 30;11(9). pii: E2031. doi: 10.3390/nu11092031.


Effect of Repeated Freeze-Thaw Cycles on NMR-Measured Lipoproteins and Metabolites in Biofluids.

Wang F, Debik J, Andreassen T, Euceda LR, Haukaas TH, Cannet C, Schäfer H, Bathen TF, Giskeødegård GF.

J Proteome Res. 2019 Sep 11. doi: 10.1021/acs.jproteome.9b00343. [Epub ahead of print]


explAIner: A Visual Analytics Framework for Interactive and Explainable Machine Learning.

Spinner T, Schlegel U, Schafer H, El-Assady M.

IEEE Trans Vis Comput Graph. 2019 Aug 20. doi: 10.1109/TVCG.2019.2934629. [Epub ahead of print]


Development of an anti-guinea pig CD4 monoclonal antibody for depletion of CD4+ T cells in vivo.

Banasik BN, Perry CL, Keith CA, Bourne N, Schäfer H, Milligan GN.

J Immunol Methods. 2019 Aug 14:112654. doi: 10.1016/j.jim.2019.112654. [Epub ahead of print]


Identification of cross-reactive antibodies for the detection of lymphocytes, myeloid cells and haematopoietic precursors in the naked mole rat.

Shebzukhov Y, Holtze S, Hirseland H, Schäfer H, Radbruch A, Hildebrandt T, Grützkau A.

Eur J Immunol. 2019 Jul 26. doi: 10.1002/eji.201948124. [Epub ahead of print]


Microbial Cycling of Methanethiol.

Schäfer H, Eyice Ö.

Curr Issues Mol Biol. 2019 Jun 5;33:173-182. doi: 10.21775/cimb.033.173. [Epub ahead of print]


[Management of severe COPD].

Schäfer H.

MMW Fortschr Med. 2019 May;161(10):38-42. doi: 10.1007/s15006-019-0555-z. Review. German. No abstract available.


Metastasis of pancreatic cancer: An uninflamed liver micromilieu controls cell growth and cancer stem cell properties by oxidative phosphorylation in pancreatic ductal epithelial cells.

Fabian A, Stegner S, Miarka L, Zimmermann J, Lenk L, Rahn S, Buttlar J, Viol F, Knaack H, Esser D, Schäuble S, Großmann P, Marinos G, Häsler R, Mikulits W, Saur D, Kaleta C, Schäfer H, Sebens S.

Cancer Lett. 2019 Jul 1;453:95-106. doi: 10.1016/j.canlet.2019.03.039. Epub 2019 Mar 28.


Spx, a versatile regulator of the Bacillus subtilis stress response.

Schäfer H, Turgay K.

Curr Genet. 2019 Aug;65(4):871-876. doi: 10.1007/s00294-019-00950-6. Epub 2019 Mar 4. Review.


Towards a systematic understanding of structure-function relationship of dimethylsulfoniopropionate-catabolizing enzymes.

Chen Y, Schäfer H.

Mol Microbiol. 2019 Jun;111(6):1399-1403. doi: 10.1111/mmi.14230. Epub 2019 Apr 2.


Digital Gaming for Nutritional Education: A Survey on Preferences, Motives, and Needs of Children and Adolescents.

Holzmann SL, Dischl F, Schäfer H, Groh G, Hauner H, Holzapfel C.

JMIR Form Res. 2019 Feb 13;3(1):e10284. doi: 10.2196/10284.


A metabolome-wide characterization of the diabetic phenotype in ZDF rats and its reversal by pioglitazone.

Jönsson TJ, Schäfer HL, Herling AW, Brönstrup M.

PLoS One. 2018 Nov 27;13(11):e0207210. doi: 10.1371/journal.pone.0207210. eCollection 2018.


Spx, the central regulator of the heat and oxidative stress response in B. subtilis, can repress transcription of translation-related genes.

Schäfer H, Heinz A, Sudzinová P, Voß M, Hantke I, Krásný L, Turgay K.

Mol Microbiol. 2019 Feb;111(2):514-533. doi: 10.1111/mmi.14171. Epub 2018 Dec 11.


Increased Frequency of Virus Shedding by Herpes Simplex Virus 2-Infected Guinea Pigs in the Absence of CD4+ T Lymphocytes.

Bourne N, Perry CL, Banasik BN, Miller AL, White M, Pyles RB, Schäfer H, Milligan GN.

J Virol. 2019 Feb 5;93(4). pii: e01721-18. doi: 10.1128/JVI.01721-18. Print 2019 Feb 15.


YocM a small heat shock protein can protect Bacillus subtilis cells during salt stress.

Hantke I, Schäfer H, Janczikowski A, Turgay K.

Mol Microbiol. 2019 Feb;111(2):423-440. doi: 10.1111/mmi.14164. Epub 2018 Dec 4.


Metabolite and lipoprotein responses and prediction of weight gain during breast cancer treatment.

Madssen TS, Thune I, Flote VG, Lundgren S, Bertheussen GF, Frydenberg H, Wist E, Schlichting E, Schäfer H, Fjøsne HE, Vettukattil R, Lømo J, Bathen TF, Giskeødegård GF.

Br J Cancer. 2018 Oct;119(9):1144-1154. doi: 10.1038/s41416-018-0211-x. Epub 2018 Nov 7.


The role of disclosure attitudes in the relationship between posttraumatic stress disorder symptom severity and perceived social support among emergency service workers.

Köhler M, Schäfer H, Goebel S, Pedersen A.

Psychiatry Res. 2018 Dec;270:602-610. doi: 10.1016/j.psychres.2018.10.049. Epub 2018 Oct 22.


Recombinant AfusinC, an anionic fungal CSαβ defensin from Aspergillus fumigatus, exhibits antimicrobial activity against gram-positive bacteria.

Contreras G, Braun MS, Schäfer H, Wink M.

PLoS One. 2018 Oct 11;13(10):e0205509. doi: 10.1371/journal.pone.0205509. eCollection 2018.


The antioxidant transcription factor Nrf2 modulates the stress response and phenotype of malignant as well as premalignant pancreatic ductal epithelial cells by inducing expression of the ATF3 splicing variant ΔZip2.

Kha ML, Hesse L, Deisinger F, Sipos B, Röcken C, Arlt A, Sebens S, Helm O, Schäfer H.

Oncogene. 2019 Feb;38(9):1461-1476. doi: 10.1038/s41388-018-0518-3. Epub 2018 Oct 9.


Hyper-N-glycosylated SAMD14 and neurabin-I as driver autoantigens of primary central nervous system lymphoma.

Thurner L, Preuss KD, Bewarder M, Kemele M, Fadle N, Regitz E, Altmeyer S, Schormann C, Poeschel V, Ziepert M, Walter S, Roth P, Weller M, Szczepanowski M, Klapper W, Monoranu C, Rosenwald A, Möller P, Hartmann S, Hansmann ML, Mackensen A, Schäfer H, Schorb E, Illerhaus G, Buslei R, Bohle RM, Stilgenbauer S, Kim YJ, Pfreundschuh M.

Blood. 2018 Dec 27;132(26):2744-2753. doi: 10.1182/blood-2018-03-836932. Epub 2018 Sep 24.


Severe Acute Liver Injury Following Therapeutic Doses of Acetaminophen in a Patient With Spinal Muscular Atrophy.

Brehm TT, Wehmeyer MH, Fuhrmann V, Schäfer H, Kluwe J.

Am J Ther. 2019 Jul/Aug;26(4):e528-e529. doi: 10.1097/MJT.0000000000000829. No abstract available.


Quantitative Lipoprotein Subclass and Low Molecular Weight Metabolite Analysis in Human Serum and Plasma by 1H NMR Spectroscopy in a Multilaboratory Trial.

Jiménez B, Holmes E, Heude C, Tolson RF, Harvey N, Lodge SL, Chetwynd AJ, Cannet C, Fang F, Pearce JTM, Lewis MR, Viant MR, Lindon JC, Spraul M, Schäfer H, Nicholson JK.

Anal Chem. 2018 Oct 16;90(20):11962-11971. doi: 10.1021/acs.analchem.8b02412. Epub 2018 Sep 27.


Free-Sustaining Three-Dimensional S235 Steel-Based Porous Electrocatalyst for Highly Efficient and Durable Oxygen Evolution.

Han W, Kuepper K, Hou P, Akram W, Eickmeier H, Hardege J, Steinhart M, Schäfer H.

ChemSusChem. 2018 Oct 24;11(20):3661-3671. doi: 10.1002/cssc.201801351. Epub 2018 Sep 12.


Alveolar capillary dysplasia with left heart obstruction - rare but lethal.

Stark VC, Schneider EP, Biermann D, Hauck PA, Kozlik-Feldmann R, Schäfer H, Gottschalk U.

J Neonatal Perinatal Med. 2018;11(3):289-293. doi: 10.3233/NPM-17119.


Schistosomiasis detected during appendectomy.

Kraef C, Arand J, Veletzky L, Schäfer H, Jordan S, Schmiedel S, Ramharter M.

Lancet. 2018 Jun 23;391(10139):2546. doi: 10.1016/S0140-6736(18)31329-1. No abstract available.


TRAIL/NF-κB/CX3CL1 Mediated Onco-Immuno Crosstalk Leading to TRAIL Resistance of Pancreatic Cancer Cell Lines.

Geismann C, Erhart W, Grohmann F, Schreiber S, Schneider G, Schäfer H, Arlt A.

Int J Mol Sci. 2018 Jun 4;19(6). pii: E1661. doi: 10.3390/ijms19061661.


A Regio- and Diastereoselective Anodic Aryl-Aryl Coupling in the Biomimetic Total Synthesis of (-)-Thebaine.

Lipp A, Ferenc D, Gütz C, Geffe M, Vierengel N, Schollmeyer D, Schäfer HJ, Waldvogel SR, Opatz T.

Angew Chem Int Ed Engl. 2018 Aug 20;57(34):11055-11059. doi: 10.1002/anie.201803887. Epub 2018 Jun 14.


Electrochemical initiation of electron-catalyzed phenanthridine synthesis by trifluoromethylation of isonitriles.

Lübbesmeyer M, Leifert D, Schäfer H, Studer A.

Chem Commun (Camb). 2018 Feb 27;54(18):2240-2243. doi: 10.1039/c7cc09302k.


Ordered Topographically Patterned Silicon by Insect-Inspired Capillary Submicron Stamping.

Han W, Hou P, Sadaf S, Schäfer H, Walder L, Steinhart M.

ACS Appl Mater Interfaces. 2018 Feb 28;10(8):7451-7458. doi: 10.1021/acsami.7b18163. Epub 2018 Feb 14.


The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma.

Lenk L, Pein M, Will O, Gomez B, Viol F, Hauser C, Egberts JH, Gundlach JP, Helm O, Tiwari S, Weiskirchen R, Rose-John S, Röcken C, Mikulits W, Wenzel P, Schneider G, Saur D, Schäfer H, Sebens S.

Oncoimmunology. 2017 Oct 26;7(1):e1368603. doi: 10.1080/2162402X.2017.1368603. eCollection 2017.


Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral halitosis.

Pol A, Renkema GH, Tangerman A, Winkel EG, Engelke UF, de Brouwer APM, Lloyd KC, Araiza RS, van den Heuvel L, Omran H, Olbrich H, Oude Elberink M, Gilissen C, Rodenburg RJ, Sass JO, Schwab KO, Schäfer H, Venselaar H, Sequeira JS, Op den Camp HJM, Wevers RA.

Nat Genet. 2018 Jan;50(1):120-129. doi: 10.1038/s41588-017-0006-7. Epub 2017 Dec 18.


Diabetes as risk factor for pancreatic cancer: Hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cells.

Rahn S, Zimmermann V, Viol F, Knaack H, Stemmer K, Peters L, Lenk L, Ungefroren H, Saur D, Schäfer H, Helm O, Sebens S.

Cancer Lett. 2018 Feb 28;415:129-150. doi: 10.1016/j.canlet.2017.12.004. Epub 2017 Dec 6.


Costs and benefits of diagnostic testing: four ways to improve patient care by purposive use of in vitro diagnostics.

Binder C, Schmid M, Dieterle T, Schäfer HH.

Swiss Med Wkly. 2017 Nov 20;147:w14546. doi: 10.4414/smw.2017.14546. eCollection 2017.


Deconvoluting interrelationships between concentrations and chemical shifts in urine provides a powerful analysis tool.

Takis PG, Schäfer H, Spraul M, Luchinat C.

Nat Commun. 2017 Nov 21;8(1):1662. doi: 10.1038/s41467-017-01587-0.


Electro-oxidation of a cobalt based steel in LiOH: a non-noble metal based electro-catalyst suitable for durable water-splitting in an acidic milieu.

Schäfer H, Küpper K, Müller-Buschbaum K, Daum D, Steinhart M, Wollschläger J, Krupp U, Schmidt M, Han W, Stangl J.

Nanoscale. 2017 Nov 23;9(45):17829-17838. doi: 10.1039/c7nr06527b.


Bacterial SBP56 identified as a Cu-dependent methanethiol oxidase widely distributed in the biosphere.

Eyice Ö, Myronova N, Pol A, Carrión O, Todd JD, Smith TJ, Gurman SJ, Cuthbertson A, Mazard S, Mennink-Kersten MA, Bugg TD, Andersson KK, Johnston AW, Op den Camp HJ, Schäfer H.

ISME J. 2018 Jan;12(1):145-160. doi: 10.1038/ismej.2017.148. Epub 2017 Oct 24.


Unsymmetrical Biaryl Compounds: Metal- and Reagent-Free Electrochemical Couplings Are on the Advance.

Schäfer HJ.

Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15502-15503. doi: 10.1002/anie.201707804. Epub 2017 Oct 19.


Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells.

Diehl K, Dinges LA, Helm O, Ammar N, Plundrich D, Arlt A, Röcken C, Sebens S, Schäfer H.

Oncogene. 2018 Jan 4;37(1):39-51. doi: 10.1038/onc.2017.299. Epub 2017 Aug 28.


Biologically active recombinant human erythropoietin expressed in hairy root cultures and regenerated plantlets of Nicotiana tabacum L.

Gurusamy PD, Schäfer H, Ramamoorthy S, Wink M.

PLoS One. 2017 Aug 11;12(8):e0182367. doi: 10.1371/journal.pone.0182367. eCollection 2017.


Toward Reliable Lipoprotein Particle Predictions from NMR Spectra of Human Blood: An Interlaboratory Ring Test.

Monsonis Centelles S, Hoefsloot HCJ, Khakimov B, Ebrahimi P, Lind MV, Kristensen M, de Roo N, Jacobs DM, van Duynhoven J, Cannet C, Fang F, Humpfer E, Schäfer H, Spraul M, Engelsen SB, Smilde AK.

Anal Chem. 2017 Aug 1;89(15):8004-8012. doi: 10.1021/acs.analchem.7b01329. Epub 2017 Jul 20.


Improvement in Renal Cystic Disease of Tuberous Sclerosis Complex After Treatment with Mammalian Target of Rapamycin Inhibitor.

Siroky BJ, Towbin AJ, Trout AT, Schäfer H, Thamann AR, Agricola KD, Tudor C, Capal J, Dixon BP, Krueger DA, Franz DN.

J Pediatr. 2017 Aug;187:318-322.e2. doi: 10.1016/j.jpeds.2017.05.015. Epub 2017 Jun 7.


Deactivation vs. asynchronous pacing - prospective evaluation of a protocol for rhythm management in patients with magnetic resonance conditional pacemakers undergoing adenosine stress cardiovascular magnetic resonance imaging.

Klein-Wiele O, Garmer M, Barbone G, Urbien R, Busch M, Kara K, Schäfer H, Schulte-Hermes M, Hailer B, Grönemeyer D.

BMC Cardiovasc Disord. 2017 Jun 2;17(1):142. doi: 10.1186/s12872-017-0579-1.


Safety and efficacy of clip-based vs. suture mediated vascular closure for femoral access hemostasis: A prospective randomized single center study comparing the StarClose and the ProGlide device.

Klein-Wiele O, Baliota M, Kara K, Käunicke M, Schäfer H, Garbrecht M, Abdulghafor M, Garmer M, Hailer B.

Catheter Cardiovasc Interv. 2018 Feb 15;91(3):402-407. doi: 10.1002/ccd.27116. Epub 2017 May 13.


Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization.

Beckert B, Abdelshahid M, Schäfer H, Steinchen W, Arenz S, Berninghausen O, Beckmann R, Bange G, Turgay K, Wilson DN.

EMBO J. 2017 Jul 14;36(14):2061-2072. doi: 10.15252/embj.201696189. Epub 2017 May 3.


Case report of an intracaval leiomyomatosis 10 months after complete hysterectomy.

Schäfer HM, Isaak A, Gürke L.

Int J Surg Case Rep. 2017;35:1-3. doi: 10.1016/j.ijscr.2017.03.031. Epub 2017 Mar 31.

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