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Oestradiol and leptin have separate but additive anorexigenic effects and differentially target fat mass in rats.

Côté I, Green SM, Yarrow JF, Conover CF, Toklu HZ, Morgan D, Carter CS, Tümer N, Scarpace PJ.

J Neuroendocrinol. 2018 Nov;30(11):e12646. doi: 10.1111/jne.12646.


Limiting feeding to the active phase reduces blood pressure without the necessity of caloric reduction or fat mass loss.

Cote I, Toklu HZ, Green SM, Morgan D, Carter CS, Tümer N, Scarpace PJ.

Am J Physiol Regul Integr Comp Physiol. 2018 Oct 1;315(4):R751-R758. doi: 10.1152/ajpregu.00076.2018. Epub 2018 Jul 19.


ACE2 activator diminazene aceturate reduces adiposity but preserves lean mass in young and old rats.

Bruce EB, Sakarya Y, Kirichenko N, Toklu HZ, Sumners C, Morgan D, Tümer N, Scarpace PJ, Carter CS.

Exp Gerontol. 2018 Oct 1;111:133-140. doi: 10.1016/j.exger.2018.07.008. Epub 2018 Jul 11.


Activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction.

Côté I, Green SM, Morgan D, Carter CS, Tümer N, Scarpace PJ.

Can J Physiol Pharmacol. 2018 Mar;96(3):308-312. doi: 10.1139/cjpp-2017-0440. Epub 2017 Nov 13.


iBAT sympathetic innervation is not required for body weight loss induced by central leptin delivery.

Côté I, Sakarya Y, Green SM, Morgan D, Carter CS, Tümer N, Scarpace PJ.

Am J Physiol Endocrinol Metab. 2018 Mar 1;314(3):E224-E231. doi: 10.1152/ajpendo.00219.2017. Epub 2017 Oct 31.


Differential physiological responses to central leptin overexpression in male and female rats.

Côté I, Green SM, Toklu HZ, Morgan D, Carter CS, Tümer N, Scarpace PJ.

J Neuroendocrinol. 2017 Dec;29(12). doi: 10.1111/jne.12552.


Maternal Western diet age-specifically alters female offspring voluntary physical activity and dopamine- and leptin-related gene expression.

Ruegsegger GN, Grigsby KB, Kelty TJ, Zidon TM, Childs TE, Vieira-Potter VJ, Klinkebiel DL, Matheny M, Scarpace PJ, Booth FW.

FASEB J. 2017 Dec;31(12):5371-5383. doi: 10.1096/fj.201700389R. Epub 2017 Aug 9.


Effect of High-Salt Diet on Age-Related High Blood Pressure and Hypothalamic Redox Signaling.

Basgut B, Whidden MA, Kirichenko N, Woods M, Erdos B, Scarpace PJ, Tümer N.

Pharmacology. 2017;100(3-4):105-114. doi: 10.1159/000472259. Epub 2017 May 19.


Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum.

Toklu HZ, Yang Z, Oktay S, Sakarya Y, Kirichenko N, Matheny MK, Muller-Delp J, Strang K, Scarpace PJ, Wang KKW, Tümer N.

Behav Brain Res. 2018 Mar 15;340:14-22. doi: 10.1016/j.bbr.2017.04.025. Epub 2017 Apr 15.


Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction.

Côté I, Sakarya Y, Kirichenko N, Morgan D, Carter CS, Tümer N, Scarpace PJ.

Can J Physiol Pharmacol. 2017 Feb;95(2):206-214. doi: 10.1139/cjpp-2016-0290. Epub 2016 Oct 19.


Intracerebroventricular tempol administration in older rats reduces oxidative stress in the hypothalamus but does not change STAT3 signalling or SIRT1/AMPK pathway.

Toklu HZ, Scarpace PJ, Sakarya Y, Kirichenko N, Matheny M, Bruce EB, Carter CS, Morgan D, Tümer N.

Appl Physiol Nutr Metab. 2017 Jan;42(1):59-67. doi: 10.1139/apnm-2016-0067. Epub 2016 Oct 6.


Age Impaired endothelium-dependent vasodilation is improved by resveratrol in rat mesenteric arteries.

Gocmez SS, Scarpace PJ, Whidden MA, Erdos B, Kirichenko N, Sakarya Y, Utkan T, Tumer N.

J Exerc Nutrition Biochem. 2016 Mar 31;20(1):41-8. doi: 10.20463/jenb.2016.


Anorexic response to rapamycin does not appear to involve a central mechanism.

Toklu HZ, Bruce EB, Sakarya Y, Carter CS, Morgan D, Matheny MK, Kirichenko N, Scarpace PJ, Tümer N.

Clin Exp Pharmacol Physiol. 2016 Sep;43(9):802-7. doi: 10.1111/1440-1681.12601.


High dietary fructose does not exacerbate the detrimental consequences of high fat diet on basilar artery function.

Toklu HZ, Muller-Delp J, Sakaraya Y, Oktay S, Kirichenko N, Matheny M, Carter CS, Morgan D, Strehler KY, Tumer N, Scarpace PJ.

J Physiol Pharmacol. 2016 Apr;67(2):205-16.


Protective effects of resveratrol on aging-induced cognitive impairment in rats.

Gocmez SS, Gacar N, Utkan T, Gacar G, Scarpace PJ, Tumer N.

Neurobiol Learn Mem. 2016 May;131:131-6. doi: 10.1016/j.nlm.2016.03.022. Epub 2016 Mar 31.


Onset of leptin resistance shows temporal differences related to dose or pulsed treatment.

Strehler KY, Matheny M, Kirichenko N, Sakarya Y, Bruce E, Toklu HZ, Carter CS, Morgan D, Tümer N, Scarpace PJ.

Eur J Pharmacol. 2016 May 15;779:177-85. doi: 10.1016/j.ejphar.2016.03.026. Epub 2016 Mar 22.


Fructose consumption does not worsen bone deficits resulting from high-fat feeding in young male rats.

Yarrow JF, Toklu HZ, Balaez A, Phillips EG, Otzel DM, Chen C, Wronski TJ, Aguirre JI, Sakarya Y, Tümer N, Scarpace PJ.

Bone. 2016 Apr;85:99-106. doi: 10.1016/j.bone.2016.02.004. Epub 2016 Feb 12.


Successful aging: Advancing the science of physical independence in older adults.

Anton SD, Woods AJ, Ashizawa T, Barb D, Buford TW, Carter CS, Clark DJ, Cohen RA, Corbett DB, Cruz-Almeida Y, Dotson V, Ebner N, Efron PA, Fillingim RB, Foster TC, Gundermann DM, Joseph AM, Karabetian C, Leeuwenburgh C, Manini TM, Marsiske M, Mankowski RT, Mutchie HL, Perri MG, Ranka S, Rashidi P, Sandesara B, Scarpace PJ, Sibille KT, Solberg LM, Someya S, Uphold C, Wohlgemuth S, Wu SS, Pahor M.

Ageing Res Rev. 2015 Nov;24(Pt B):304-27. doi: 10.1016/j.arr.2015.09.005. Epub 2015 Oct 14. Review.


The functional and structural changes in the basilar artery due to overpressure blast injury.

Toklu HZ, Muller-Delp J, Yang Z, Oktay Ş, Sakarya Y, Strang K, Ghosh P, Delp MD, Scarpace PJ, Wang KK, Tümer N.

J Cereb Blood Flow Metab. 2015 Dec;35(12):1950-6. doi: 10.1038/jcbfm.2015.151. Epub 2015 Jun 24.


Rapamycin Versus Intermittent Feeding: Dissociable Effects on Physiological and Behavioral Outcomes When Initiated Early and Late in Life.

Carter CS, Khamiss D, Matheny M, Toklu HZ, Kirichenko N, Strehler KY, Tümer N, Scarpace PJ, Morgan D.

J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):866-75. doi: 10.1093/gerona/glu238. Epub 2015 Jan 23.


Rapamycin Normalizes Serum Leptin by Alleviating Obesity and Reducing Leptin Synthesis in Aged Rats.

Scarpace PJ, Matheny M, Strehler KY, Toklu HZ, Kirichenko N, Carter CS, Morgan D, Tümer N.

J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):891-9. doi: 10.1093/gerona/glu230. Epub 2015 Jan 23.


Targeted leptin receptor blockade: role of ventral tegmental area and nucleus of the solitary tract leptin receptors in body weight homeostasis.

Matheny M, Strehler KY, King M, Tümer N, Scarpace PJ.

J Endocrinol. 2014 Jul;222(1):27-41. doi: 10.1530/JOE-13-0455.


The effects of aging on the functional and structural properties of the rat basilar artery.

Tümer N, Toklu HZ, Muller-Delp JM, Oktay S, Ghosh P, Strang K, Delp MD, Scarpace PJ.

Physiol Rep. 2014 Jun 6;2(6). pii: e12031. doi: 10.14814/phy2.12031. Print 2014 Jun 1.


Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia.

Cuenca AG, Cuenca AL, Winfield RD, Joiner DN, Gentile L, Delano MJ, Kelly-Scumpia KM, Scumpia PO, Matheny MK, Scarpace PJ, Vila L, Efron PA, LaFace DM, Moldawer LL.

J Immunol. 2014 Jun 15;192(12):6111-9. doi: 10.4049/jimmunol.1302895. Epub 2014 May 14.


The effects of enalapril and losartan on mechanical ventilation-induced sympathoadrenal activation and oxidative stress in rats.

Toklu HZ, Kwon OS, Sakarya Y, Powers SK, Llinas K, Kirichenko N, Sollanek KJ, Wiggs MP, Smuder AJ, Talbert EE, Scarpace PJ, Tümer N.

J Surg Res. 2014 May 15;188(2):510-6. doi: 10.1016/j.jss.2014.01.054. Epub 2014 Feb 6.


Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla.

Tümer N, Svetlov S, Whidden M, Kirichenko N, Prima V, Erdos B, Sherman A, Kobeissy F, Yezierski R, Scarpace PJ, Vierck C, Wang KK.

Neurosci Lett. 2013 Jun 7;544:62-7. doi: 10.1016/j.neulet.2013.03.042. Epub 2013 Apr 6.


Dietary components in the development of leptin resistance.

Vasselli JR, Scarpace PJ, Harris RB, Banks WA.

Adv Nutr. 2013 Mar 1;4(2):164-75. doi: 10.3945/an.112.003152. Review.


Leptin overexpression in VTA trans-activates the hypothalamus whereas prolonged leptin action in either region cross-desensitizes.

Scarpace PJ, Matheny M, Kirichenko N, Gao YX, Tümer N, Zhang Y.

Neuropharmacology. 2013 Feb;65:90-100. doi: 10.1016/j.neuropharm.2012.09.005. Epub 2012 Sep 13.


Simultaneous introduction of a novel high fat diet and wheel running induces anorexia.

Scarpace ET, Matheny M, Strehler KY, Shapiro A, Cheng KY, Tümer N, Scarpace PJ.

Physiol Behav. 2012 Feb 28;105(4):909-14. doi: 10.1016/j.physbeh.2011.11.011. Epub 2011 Nov 13.


Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia.

Carter CS, Marzetti E, Leeuwenburgh C, Manini T, Foster TC, Groban L, Scarpace PJ, Morgan D.

J Gerontol A Biol Sci Med Sci. 2012 Jan;67(1):17-27. doi: 10.1093/gerona/glr042. Epub 2011 Jun 2. Review.


POMC overexpression in the ventral tegmental area ameliorates dietary obesity.

Andino LM, Ryder DJ, Shapiro A, Matheny MK, Zhang Y, Judge MK, Cheng KY, Tümer N, Scarpace PJ.

J Endocrinol. 2011 Aug;210(2):199-207. doi: 10.1530/JOE-10-0418. Epub 2011 May 12.


Effect of age on high-fat diet-induced hypertension.

Erdos B, Kirichenko N, Whidden M, Basgut B, Woods M, Cudykier I, Tawil R, Scarpace PJ, Tumer N.

Am J Physiol Heart Circ Physiol. 2011 Jul;301(1):H164-72. doi: 10.1152/ajpheart.01289.2010. Epub 2011 May 6.


Prevention and reversal of diet-induced leptin resistance with a sugar-free diet despite high fat content.

Shapiro A, Tümer N, Gao Y, Cheng KY, Scarpace PJ.

Br J Nutr. 2011 Aug;106(3):390-7. doi: 10.1017/S000711451100033X. Epub 2011 Mar 22.


Simultaneous POMC gene transfer to hypothalamus and brainstem increases physical activity, lipolysis and reduces adult-onset obesity.

Zhang Y, Rodrigues E, Li G, Gao Y, King M, Carter CS, Tumer N, Cheng KY, Scarpace PJ.

Eur J Neurosci. 2011 Apr;33(8):1541-50. doi: 10.1111/j.1460-9568.2011.07633.x. Epub 2011 Mar 2.


Region-specific diet-induced and leptin-induced cellular leptin resistance includes the ventral tegmental area in rats.

Matheny M, Shapiro A, Tümer N, Scarpace PJ.

Neuropharmacology. 2011 Feb-Mar;60(2-3):480-7. doi: 10.1016/j.neuropharm.2010.11.002. Epub 2010 Nov 5.


The act of voluntary wheel running reverses dietary hyperphagia and increases leptin signaling in ventral tegmental area of aged obese rats.

Shapiro A, Cheng KY, Gao Y, Seo DO, Anton S, Carter CS, Zhang Y, Tumer N, Scarpace PJ.

Gerontology. 2011;57(4):335-42. doi: 10.1159/000321343. Epub 2010 Sep 24.


Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity.

Zhang Y, Rodrigues E, Gao YX, King M, Cheng KY, Erdös B, Tümer N, Carter C, Scarpace PJ.

Neuroscience. 2010 Sep 15;169(4):1662-71. doi: 10.1016/j.neuroscience.2010.06.001. Epub 2010 Jun 9.


Wheel running eliminates high-fat preference and enhances leptin signaling in the ventral tegmental area.

Scarpace PJ, Matheny M, Zhang Y.

Physiol Behav. 2010 May 11;100(2):173-9. doi: 10.1016/j.physbeh.2010.02.017. Epub 2010 Mar 1.


Intermittent MTII application evokes repeated anorexia and robust fat and weight loss.

Zhang Y, Collazo R, Gao Y, Li G, Scarpace PJ.

Peptides. 2010 Apr;31(4):639-43. doi: 10.1016/j.peptides.2009.12.019. Epub 2009 Dec 23.


Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasis.

Matheny M, Zhang Y, Shapiro A, Tümer N, Scarpace PJ.

Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1254-61. doi: 10.1152/ajpregu.90449.2008. Epub 2009 Sep 2.


Effect of high-fat diet feeding on hypothalamic redox signaling and central blood pressure regulation.

Erdos B, Broxson CS, Cudykier I, Basgut B, Whidden M, Landa T, Scarpace PJ, Tümer N.

Hypertens Res. 2009 Nov;32(11):983-8. doi: 10.1038/hr.2009.129. Epub 2009 Aug 28.


Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding.

Judge MK, Zhang Y, Scarpace PJ.

J Endocrinol. 2009 Nov;203(2):281-90. doi: 10.1677/JOE-09-0210. Epub 2009 Aug 13.


The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo.

Zhang J, Scarpace PJ.

Br J Pharmacol. 2009 Sep;158(2):475-82. doi: 10.1111/j.1476-5381.2009.00246.x. Epub 2009 May 6.


Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity.

Manfredsson FP, Tumer N, Erdos B, Landa T, Broxson CS, Sullivan LF, Rising AC, Foust KD, Zhang Y, Muzyczka N, Gorbatyuk OS, Scarpace PJ, Mandel RJ.

Mol Ther. 2009 Jun;17(6):980-91. doi: 10.1038/mt.2009.45. Epub 2009 Mar 10.


Leptin resistance: a prediposing factor for diet-induced obesity.

Scarpace PJ, Zhang Y.

Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R493-500. doi: 10.1152/ajpregu.90669.2008. Epub 2008 Dec 17. Review.


Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding.

Shapiro A, Mu W, Roncal C, Cheng KY, Johnson RJ, Scarpace PJ.

Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1370-5. doi: 10.1152/ajpregu.00195.2008. Epub 2008 Aug 13.


Prolonged hyperphagia with high-fat feeding contributes to exacerbated weight gain in rats with adult-onset obesity.

Judge MK, Zhang J, Tümer N, Carter C, Daniels MJ, Scarpace PJ.

Am J Physiol Regul Integr Comp Physiol. 2008 Sep;295(3):R773-80. doi: 10.1152/ajpregu.00727.2007. Epub 2008 Jul 2.


Synergy between leptin therapy and a seemingly negligible amount of voluntary wheel running prevents progression of dietary obesity in leptin-resistant rats.

Shapiro A, Matheny M, Zhang Y, Tümer N, Cheng KY, Rogrigues E, Zolotukhin S, Scarpace PJ.

Diabetes. 2008 Mar;57(3):614-22. Epub 2007 Dec 17.


Leptin antagonist reverses hypertension caused by leptin overexpression, but fails to normalize obesity-related hypertension.

Tümer N, Erdös B, Matheny M, Cudykier I, Scarpace PJ.

J Hypertens. 2007 Dec;25(12):2471-8.


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