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Items: 34


Impaired adult neurogenesis is an early event in Alzheimer's disease neurodegeneration, mediated by intracellular Aβ oligomers.

Scopa C, Marrocco F, Latina V, Ruggeri F, Corvaglia V, La Regina F, Ammassari-Teule M, Middei S, Amadoro G, Meli G, Scardigli R, Cattaneo A.

Cell Death Differ. 2019 Oct 7. doi: 10.1038/s41418-019-0409-3. [Epub ahead of print]


ProNGF Is a Cell-Type-Specific Mitogen for Adult Hippocampal and for Induced Neural Stem Cells.

Corvaglia V, Cilli D, Scopa C, Brandi R, Arisi I, Malerba F, La Regina F, Scardigli R, Cattaneo A.

Stem Cells. 2019 Sep;37(9):1223-1237. doi: 10.1002/stem.3037. Epub 2019 Jun 22.


Running-Activated Neural Stem Cells Enhance Subventricular Neurogenesis and Improve Olfactory Behavior in p21 Knockout Mice.

Nicolis di Robilant V, Scardigli R, Strimpakos G, Tirone F, Middei S, Scopa C, De Bardi M, Battistini L, Saraulli D, Farioli Vecchioli S.

Mol Neurobiol. 2019 Nov;56(11):7534-7556. doi: 10.1007/s12035-019-1590-6. Epub 2019 May 6.


p16Ink4a Prevents the Activation of Aged Quiescent Dentate Gyrus Stem Cells by Physical Exercise.

Micheli L, D'Andrea G, Ceccarelli M, Ferri A, Scardigli R, Tirone F.

Front Cell Neurosci. 2019 Feb 7;13:10. doi: 10.3389/fncel.2019.00010. eCollection 2019.


Corrigendum: Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes.

Russo A, Scardigli R, La Regina F, Murray ME, Romano N, Dickson DW, Wolozin B, Cattaneo A, Ceci M.

Hum Mol Genet. 2019 Apr 1;28(7):1226. doi: 10.1093/hmg/ddy407. No abstract available.


Exploiting natural polysaccharides to enhance in vitro bio-constructs of primary neurons and progenitor cells.

Medelin M, Porrelli D, Aurand ER, Scaini D, Travan A, Borgogna MA, Cok M, Donati I, Marsich E, Scopa C, Scardigli R, Paoletti S, Ballerini L.

Acta Biomater. 2018 Jun;73:285-301. doi: 10.1016/j.actbio.2018.03.041. Epub 2018 Apr 3.


Physical exercise rescues defective neural stem cells and neurogenesis in the adult subventricular zone of Btg1 knockout mice.

Mastrorilli V, Scopa C, Saraulli D, Costanzi M, Scardigli R, Rouault JP, Farioli-Vecchioli S, Tirone F.

Brain Struct Funct. 2017 Aug;222(6):2855-2876. doi: 10.1007/s00429-017-1376-4. Epub 2017 Feb 28.


Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes.

Russo A, Scardigli R, La Regina F, Murray ME, Romano N, Dickson DW, Wolozin B, Cattaneo A, Ceci M.

Hum Mol Genet. 2017 Apr 15;26(8):1407-1418. doi: 10.1093/hmg/ddx035. Erratum in: Hum Mol Genet. 2019 Apr 1;28(7):1226.


Neutralization of nerve growth factor impairs proliferation and differentiation of adult neural progenitors in the subventricular zone.

Scardigli R, Capelli P, Vignone D, Brandi R, Ceci M, La Regina F, Piras E, Cintoli S, Berardi N, Capsoni S, Cattaneo A.

Stem Cells. 2014 Sep;32(9):2516-28. doi: 10.1002/stem.1744.


Tis21 is required for adult neurogenesis in the subventricular zone and for olfactory behavior regulating cyclins, BMP4, Hes1/5 and Ids.

Farioli-Vecchioli S, Ceccarelli M, Saraulli D, Micheli L, Cannas S, D'Alessandro F, Scardigli R, Leonardi L, Cinà I, Costanzi M, Mattera A, Cestari V, Tirone F.

Front Cell Neurosci. 2014 Apr 7;8:98. doi: 10.3389/fncel.2014.00098. eCollection 2014.


ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice.

Tiveron C, Fasulo L, Capsoni S, Malerba F, Marinelli S, Paoletti F, Piccinin S, Scardigli R, Amato G, Brandi R, Capelli P, D'Aguanno S, Florenzano F, La Regina F, Lecci A, Manca A, Meli G, Pistillo L, Berretta N, Nisticò R, Pavone F, Cattaneo A.

Cell Death Differ. 2013 Aug;20(8):1017-30. doi: 10.1038/cdd.2013.22. Epub 2013 Mar 29.


Btg1 is Required to Maintain the Pool of Stem and Progenitor Cells of the Dentate Gyrus and Subventricular Zone.

Farioli-Vecchioli S, Micheli L, Saraulli D, Ceccarelli M, Cannas S, Scardigli R, Leonardi L, Cinà I, Costanzi M, Ciotti MT, Moreira P, Rouault JP, Cestari V, Tirone F.

Front Neurosci. 2012 Aug 30;6:124. doi: 10.3389/fnins.2012.00124. eCollection 2012.


Bystander effect on brain tissue of mesoangioblasts producing neurotrophins.

Su T, Scardigli R, Fasulo L, Paradiso B, Barbieri M, Binaschi A, Bovolenta R, Zucchini S, Cossu G, Cattaneo A, Simonato M.

Cell Transplant. 2012;21(8):1613-27. doi: 10.3727/096368912X640475. Epub 2012 Apr 17.


Direct intracellular selection and biochemical characterization of a recombinant anti-proNGF single chain antibody fragment.

Paoletti F, Malerba F, Konarev PV, Visintin M, Scardigli R, Fasulo L, Lamba D, Svergun DI, Cattaneo A.

Arch Biochem Biophys. 2012 Jun 1;522(1):26-36. doi: 10.1016/ Epub 2012 Apr 10.


Novel fluorescent cycloheximide derivatives for the imaging of protein synthesis.

Paoletti F, Ainger K, Donati I, Scardigli R, Vetere A, Cattaneo A, Campa C.

Biochem Biophys Res Commun. 2010 May 28;396(2):258-64. doi: 10.1016/j.bbrc.2010.04.075. Epub 2010 Apr 23.


RISC activity in hippocampus is essential for contextual memory.

Batassa EM, Costanzi M, Saraulli D, Scardigli R, Barbato C, Cogoni C, Cestari V.

Neurosci Lett. 2010 Mar 8;471(3):185-8. doi: 10.1016/j.neulet.2010.01.038. Epub 2010 Jan 28.


Binding of sFRP-3 to EGF in the extra-cellular space affects proliferation, differentiation and morphogenetic events regulated by the two molecules.

Scardigli R, Gargioli C, Tosoni D, Borello U, Sampaolesi M, Sciorati C, Cannata S, Clementi E, Brunelli S, Cossu G.

PLoS One. 2008 Jun 18;3(6):e2471. doi: 10.1371/journal.pone.0002471.


Validating in utero electroporation for the rapid analysis of gene regulatory elements in the murine telencephalon.

Langevin LM, Mattar P, Scardigli R, Roussigné M, Logan C, Blader P, Schuurmans C.

Dev Dyn. 2007 May;236(5):1273-86.


E1-Ngn2/Cre is a new line for regional activation of Cre recombinase in the developing CNS.

Berger J, Eckert S, Scardigli R, Guillemot F, Gruss P, Stoykova A.

Genesis. 2004 Dec;40(4):195-9.


Conserved and acquired features of neurogenin1 regulation.

Blader P, Lam CS, Rastegar S, Scardigli R, Nicod JC, Simplicio N, Plessy C, Fischer N, Schuurmans C, Guillemot F, Strähle U.

Development. 2004 Nov;131(22):5627-37. Epub 2004 Oct 20.


TGFbeta/BMP activate the smooth muscle/bone differentiation programs in mesoangioblasts.

Tagliafico E, Brunelli S, Bergamaschi A, De Angelis L, Scardigli R, Galli D, Battini R, Bianco P, Ferrari S, Cossu G, Ferrari S.

J Cell Sci. 2004 Sep 1;117(Pt 19):4377-88.


Direct and concentration-dependent regulation of the proneural gene Neurogenin2 by Pax6.

Scardigli R, Bäumer N, Gruss P, Guillemot F, Le Roux I.

Development. 2003 Jul;130(14):3269-81.


Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity.

Parras CM, Schuurmans C, Scardigli R, Kim J, Anderson DJ, Guillemot F.

Genes Dev. 2002 Feb 1;16(3):324-38.


Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord.

Scardigli R, Schuurmans C, Gradwohl G, Guillemot F.

Neuron. 2001 Aug 2;31(2):203-17.


Pax6 is required for the multipotent state of retinal progenitor cells.

Marquardt T, Ashery-Padan R, Andrejewski N, Scardigli R, Guillemot F, Gruss P.

Cell. 2001 Apr 6;105(1):43-55.


Development of a murine orthotopic model of leukemia: evaluation of TP53 gene therapy efficacy.

Bossi G, Scardigli R, Musiani P, Martinelli R, Gentileschi MP, Soddu S, Sacchi A.

Cancer Gene Ther. 2000 Jan;7(1):135-43.


Wt-p53 action in human leukaemia cell lines corresponding to different stages of differentiation.

Rizzo MG, Zepparoni A, Cristofanelli B, Scardigli R, Crescenzi M, Blandino G, Giuliacci S, Ferrari S, Soddu S, Sacchi A.

Br J Cancer. 1998 May;77(9):1429-38.


Expression of exogenous wt-p53 does not affect normal hematopoiesis: implications for bone marrow purging.

Scardigli R, Bossi G, Blandino G, Crescenzi M, Soddu S, Sacchi A.

Gene Ther. 1997 Dec;4(12):1371-8.


Oncogenes belonging to the CSF-1 transduction pathway direct p53 tumor suppressor effects to monocytic differentiation in 32D cells.

Martinelli R, Blandino G, Scardigli R, Crescenzi M, Lombardi D, Sacchi A, Soddu S.

Oncogene. 1997 Jul 31;15(5):607-11.


The beta 4 integrin subunit is expressed in mouse fibroblasts and modulated by transforming growth factor-beta 1.

Scardigli R, Soddu S, Falcioni R, Crescenzi M, Cimino L, Sacchi A.

Exp Cell Res. 1996 Sep 15;227(2):223-9.


Interference with p53 protein inhibits hematopoietic and muscle differentiation.

Soddu S, Blandino G, Scardigli R, Coen S, Marchetti A, Rizzo MG, Bossi G, Cimino L, Crescenzi M, Sacchi A.

J Cell Biol. 1996 Jul;134(1):193-204.


Wild-type p53 induces diverse effects in 32D cells expressing different oncogenes.

Soddu S, Blandino G, Scardigli R, Martinelli R, Rizzo MG, Crescenzi M, Sacchi A.

Mol Cell Biol. 1996 Feb;16(2):487-95.


Wild-type p53 modulates apoptosis of normal, IL-3 deprived, hematopoietic cells.

Blandino G, Scardigli R, Rizzo MG, Crescenzi M, Soddu S, Sacchi A.

Oncogene. 1995 Feb 16;10(4):731-7.


Wild-type p53 gene expression induces granulocytic differentiation of HL-60 cells.

Soddu S, Blandino G, Citro G, Scardigli R, Piaggio G, Ferber A, Calabretta B, Sacchi A.

Blood. 1994 Apr 15;83(8):2230-7.


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