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Items: 39


Neutrophil Diversity in Health and Disease.

Silvestre-Roig C, Fridlender ZG, Glogauer M, Scapini P.

Trends Immunol. 2019 Jul;40(7):565-583. doi: 10.1016/ Epub 2019 May 31. Review.


IL-10-producing B cells are characterized by a specific methylation signature.

Tonon S, Mion F, Dong J, Chang HD, Dalla E, Scapini P, Perruolo G, Zanello A, Dugo M, Cassatella MA, Colombo MP, Radbruch A, Tripodo C, Pucillo CE.

Eur J Immunol. 2019 Aug;49(8):1213-1225. doi: 10.1002/eji.201848025. Epub 2019 May 7.


Frontline Science: Mast cells regulate neutrophil homeostasis by influencing macrophage clearance activity.

Jachetti E, D'Incà F, Danelli L, Magris R, Dal Secco C, Vit F, Cancila V, Tripodo C, Scapini P, Colombo MP, Pucillo C, Frossi B.

J Leukoc Biol. 2019 Apr;105(4):633-644. doi: 10.1002/JLB.4HI1018-390R. Epub 2019 Feb 28.


Deciphering myeloid-derived suppressor cells: isolation and markers in humans, mice and non-human primates.

Cassetta L, Baekkevold ES, Brandau S, Bujko A, Cassatella MA, Dorhoi A, Krieg C, Lin A, Loré K, Marini O, Pollard JW, Roussel M, Scapini P, Umansky V, Adema GJ.

Cancer Immunol Immunother. 2019 Apr;68(4):687-697. doi: 10.1007/s00262-019-02302-2. Epub 2019 Jan 25. Review.


Recent advances on the crosstalk between neutrophils and B or T lymphocytes.

Costa S, Bevilacqua D, Cassatella MA, Scapini P.

Immunology. 2019 Jan;156(1):23-32. doi: 10.1111/imm.13005. Epub 2018 Oct 10. Review.


Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells.

Costa S, Marini O, Bevilacqua D, DeFranco AL, Hou B, Lonardi S, Vermi W, Rodegher P, Panato A, Tagliaro F, Lowell CA, Cassatella MA, Girolomoni G, Scapini P.

J Leukoc Biol. 2017 Sep;102(3):791-803. doi: 10.1189/jlb.3MA0217-054RR. Epub 2017 Jun 22.


Location in the spleen dictates the function of murine neutrophils.

Scapini P, Cassatella MA.

J Exp Med. 2017 May 1;214(5):1207-1209. doi: 10.1084/jem.20170655. Epub 2017 Apr 19.


Mature CD10+ and immature CD10- neutrophils present in G-CSF-treated donors display opposite effects on T cells.

Marini O, Costa S, Bevilacqua D, Calzetti F, Tamassia N, Spina C, De Sabata D, Tinazzi E, Lunardi C, Scupoli MT, Cavallini C, Zoratti E, Tinazzi I, Marchetta A, Vassanelli A, Cantini M, Gandini G, Ruzzenente A, Guglielmi A, Missale F, Vermi W, Tecchio C, Cassatella MA, Scapini P.

Blood. 2017 Mar 9;129(10):1343-1356. doi: 10.1182/blood-2016-04-713206. Epub 2017 Jan 4. Erratum in: Blood. 2017 Jun 15;129(24):3271.


Human neutrophils in the saga of cellular heterogeneity: insights and open questions.

Scapini P, Marini O, Tecchio C, Cassatella MA.

Immunol Rev. 2016 Sep;273(1):48-60. doi: 10.1111/imr.12448. Review.


Identification of granulocytic myeloid-derived suppressor cells (G-MDSCs) in the peripheral blood of Hodgkin and non-Hodgkin lymphoma patients.

Marini O, Spina C, Mimiola E, Cassaro A, Malerba G, Todeschini G, Perbellini O, Scupoli M, Carli G, Facchinelli D, Cassatella M, Scapini P, Tecchio C.

Oncotarget. 2016 May 10;7(19):27676-88. doi: 10.18632/oncotarget.8507.


IFNα enhances the production of IL-6 by human neutrophils activated via TLR8.

Zimmermann M, Arruda-Silva F, Bianchetto-Aguilera F, Finotti G, Calzetti F, Scapini P, Lunardi C, Cassatella MA, Tamassia N.

Sci Rep. 2016 Jan 21;6:19674. doi: 10.1038/srep19674.


Src family kinases and Syk are required for neutrophil extracellular trap formation in response to β-glucan particles.

Nanì S, Fumagalli L, Sinha U, Kamen L, Scapini P, Berton G.

J Innate Immun. 2015;7(1):59-73. doi: 10.1159/000365249. Epub 2014 Sep 24.


Social networking of human neutrophils within the immune system.

Scapini P, Cassatella MA.

Blood. 2014 Jul 31;124(5):710-9. doi: 10.1182/blood-2014-03-453217. Epub 2014 Jun 12. Review.


Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice.

Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL.

J Immunol. 2014 Feb 1;192(3):875-85. doi: 10.4049/jimmunol.1300683. Epub 2013 Dec 30.


Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation.

Lamagna C, Scapini P, van Ziffle JA, DeFranco AL, Lowell CA.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):E3311-20. doi: 10.1073/pnas.1300617110. Epub 2013 Aug 12.


On the cytokines produced by human neutrophils in tumors.

Tecchio C, Scapini P, Pizzolo G, Cassatella MA.

Semin Cancer Biol. 2013 Jun;23(3):159-70. doi: 10.1016/j.semcancer.2013.02.004. Epub 2013 Feb 11. Review.


Deletion of Syk in neutrophils prevents immune complex arthritis.

Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA.

J Immunol. 2011 Oct 15;187(8):4319-30. doi: 10.4049/jimmunol.1100341. Epub 2011 Sep 14.


B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.

Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):E823-32. doi: 10.1073/pnas.1107913108. Epub 2011 Sep 12.


The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.

Tavares RM, Turer EE, Liu CL, Advincula R, Scapini P, Rhee L, Barrera J, Lowell CA, Utz PJ, Malynn BA, Ma A.

Immunity. 2010 Aug 27;33(2):181-91. doi: 10.1016/j.immuni.2010.07.017. Epub 2010 Aug 12.


Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.

Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA.

J Exp Med. 2010 Aug 2;207(8):1757-73. doi: 10.1084/jem.20100086. Epub 2010 Jul 12.


Multiple roles of Lyn kinase in myeloid cell signaling and function.

Scapini P, Pereira S, Zhang H, Lowell CA.

Immunol Rev. 2009 Mar;228(1):23-40. doi: 10.1111/j.1600-065X.2008.00758.x. Review.


Regulation of B-cell-activating factor (BAFF)/B lymphocyte stimulator (BLyS) expression in human neutrophils.

Scapini P, Bazzoni F, Cassatella MA.

Immunol Lett. 2008 Feb 15;116(1):1-6. Epub 2007 Dec 7. Review.


High serum levels of B-lymphocyte stimulator are associated with clinical-pathological features and outcome in classical Hodgkin lymphoma.

Tecchio C, Nadali G, Scapini P, Bonetto C, Visco C, Tamassia N, Vassilakopoulos TP, Pangalis GA, Calzetti F, Nardelli B, Roschke V, Gottardi M, Zampieri F, Gherlinzoni F, Facchetti F, Pizzolo G, Cassatella MA.

Br J Haematol. 2007 Jun;137(6):553-9.


Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis.

Cassatella MA, Pereira-da-Silva G, Tinazzi I, Facchetti F, Scapini P, Calzetti F, Tamassia N, Wei P, Nardelli B, Roschke V, Vecchi A, Mantovani A, Bambara LM, Edwards SW, Carletto A.

J Immunol. 2007 Jun 1;178(11):7325-33. Erratum in: J Immunol. 2007 Jul 15;179(2):1390. da Silva, Gabriela Pereira [corrected to Pereira-da-Silva, Gabriela].


Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophils.

Merck E, Gaillard C, Scuiller M, Scapini P, Cassatella MA, Trinchieri G, Bates EE.

J Immunol. 2006 Mar 1;176(5):3149-56.


Proinflammatory mediators elicit secretion of the intracellular B-lymphocyte stimulator pool (BLyS) that is stored in activated neutrophils: implications for inflammatory diseases.

Scapini P, Carletto A, Nardelli B, Calzetti F, Roschke V, Merigo F, Tamassia N, Pieropan S, Biasi D, Sbarbati A, Sozzani S, Bambara L, Cassatella MA.

Blood. 2005 Jan 15;105(2):830-7. Epub 2004 Sep 9.


CXCL1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A.

Scapini P, Morini M, Tecchio C, Minghelli S, Di Carlo E, Tanghetti E, Albini A, Lowell C, Berton G, Noonan DM, Cassatella MA.

J Immunol. 2004 Apr 15;172(8):5034-40.


IFNalpha-stimulated neutrophils and monocytes release a soluble form of TNF-related apoptosis-inducing ligand (TRAIL/Apo-2 ligand) displaying apoptotic activity on leukemic cells.

Tecchio C, Huber V, Scapini P, Calzetti F, Margotto D, Todeschini G, Pilla L, Martinelli G, Pizzolo G, Rivoltini L, Cassatella MA.

Blood. 2004 May 15;103(10):3837-44. Epub 2004 Jan 15.


Unique regulation of CCL18 production by maturing dendritic cells.

Vulcano M, Struyf S, Scapini P, Cassatella M, Bernasconi S, Bonecchi R, Calleri A, Penna G, Adorini L, Luini W, Mantovani A, Van Damme J, Sozzani S.

J Immunol. 2003 Apr 1;170(7):3843-9.


G-CSF-stimulated neutrophils are a prominent source of functional BLyS.

Scapini P, Nardelli B, Nadali G, Calzetti F, Pizzolo G, Montecucco C, Cassatella MA.

J Exp Med. 2003 Feb 3;197(3):297-302.


Generation of biologically active angiostatin kringle 1-3 by activated human neutrophils.

Scapini P, Nesi L, Morini M, Tanghetti E, Belleri M, Noonan D, Presta M, Albini A, Cassatella MA.

J Immunol. 2002 Jun 1;168(11):5798-804.


Neutrophils produce biologically active macrophage inflammatory protein-3alpha (MIP-3alpha)/CCL20 and MIP-3beta/CCL19.

Scapini P, Laudanna C, Pinardi C, Allavena P, Mantovani A, Sozzani S, Cassatella MA.

Eur J Immunol. 2001 Jul;31(7):1981-8.


The neutrophil as a cellular source of chemokines.

Scapini P, Lapinet-Vera JA, Gasperini S, Calzetti F, Bazzoni F, Cassatella MA.

Immunol Rev. 2000 Oct;177:195-203. Review.


Human immunodeficiency virus transactivator protein (Tat) stimulates chemotaxis, calcium mobilization, and activation of human polymorphonuclear leukocytes: implications for Tat-mediated pathogenesis.

Benelli R, Barbero A, Ferrini S, Scapini P, Cassatella M, Bussolino F, Tacchetti C, Noonan DM, Albini A.

J Infect Dis. 2000 Dec;182(6):1643-51. Epub 2000 Nov 8.


On the detection of neutrophil-derived vascular endothelial growth factor (VEGF).

Scapini P, Calzetti F, Cassatella MA.

J Immunol Methods. 1999 Dec 17;232(1-2):121-9.


Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: evidence for an IL-10-induced pathway that is independent of STAT protein activation.

Cassatella MA, Gasperini S, Bovolenta C, Calzetti F, Vollebregt M, Scapini P, Marchi M, Suzuki R, Suzuki A, Yoshimura A.

Blood. 1999 Oct 15;94(8):2880-9.

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