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Items: 1 to 50 of 53

1.

Boosting BCG with proteins or rAd5 does not enhance protection against tuberculosis in rhesus macaques.

Darrah PA, DiFazio RM, Maiello P, Gideon HP, Myers AJ, Rodgers MA, Hackney JA, Lindenstrom T, Evans T, Scanga CA, Prikhodko V, Andersen P, Lin PL, Laddy D, Roederer M, Seder RA, Flynn JL.

NPJ Vaccines. 2019 May 28;4:21. doi: 10.1038/s41541-019-0113-9. eCollection 2019.

2.

Activity of Moxifloxacin against Mycobacterium tuberculosis in Acid Phase and Nonreplicative-Persister Phenotype Phase in a Hollow-Fiber Infection Model.

Louie A, Duncanson B, Myrick J, Maynard M, Nole J, Brown D, Schmidt S, Neely M, Scanga CA, Peloquin C, Drusano GL.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e01470-18. doi: 10.1128/AAC.01470-18. Print 2018 Dec.

3.

Preexisting Simian Immunodeficiency Virus Infection Increases Susceptibility to Tuberculosis in Mauritian Cynomolgus Macaques.

Rodgers MA, Ameel C, Ellis-Connell AL, Balgeman AJ, Maiello P, Barry GL, Friedrich TC, Klein E, O'Connor SL, Scanga CA.

Infect Immun. 2018 Nov 20;86(12). pii: e00565-18. doi: 10.1128/IAI.00565-18. Print 2018 Dec.

4.

Identification of Mycobacterium tuberculosis using volatile biomarkers in culture and exhaled breath.

Mellors TR, Nasir M, Franchina FA, Smolinska A, Blanchet L, Flynn JL, Tomko J, O'Malley M, Scanga CA, Lin PL, Wagner J, Hill JE.

J Breath Res. 2018 Oct 30;13(1):016004. doi: 10.1088/1752-7163/aacd18.

PMID:
29910196
5.

Linezolid Kills Acid-Phase and Nonreplicative-Persister-Phase Mycobacterium tuberculosis in a Hollow-Fiber Infection Model.

Drusano GL, Myrick J, Maynard M, Nole J, Duncanson B, Brown D, Schmidt S, Neely M, Scanga CA, Peloquin C, Louie A.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00221-18. doi: 10.1128/AAC.00221-18. Print 2018 Aug.

6.

Rhesus Macaques Are More Susceptible to Progressive Tuberculosis than Cynomolgus Macaques: a Quantitative Comparison.

Maiello P, DiFazio RM, Cadena AM, Rodgers MA, Lin PL, Scanga CA, Flynn JL.

Infect Immun. 2018 Jan 22;86(2). pii: e00505-17. doi: 10.1128/IAI.00505-17. Print 2018 Feb.

7.

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates.

White AG, Maiello P, Coleman MT, Tomko JA, Frye LJ, Scanga CA, Lin PL, Flynn JL.

J Vis Exp. 2017 Sep 5;(127). doi: 10.3791/56375.

8.

Positron Emission Tomography Imaging of Macaques with Tuberculosis Identifies Temporal Changes in Granuloma Glucose Metabolism and Integrin α4β1-Expressing Immune Cells.

Mattila JT, Beaino W, Maiello P, Coleman MT, White AG, Scanga CA, Flynn JL, Anderson CJ.

J Immunol. 2017 Jul 15;199(2):806-815. doi: 10.4049/jimmunol.1700231. Epub 2017 Jun 7.

9.

Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes.

Rockwood N, Costa DL, Amaral EP, Du Bruyn E, Kubler A, Gil-Santana L, Fukutani KF, Scanga CA, Flynn JL, Jackson SH, Wilkinson KA, Bishai WR, Sher A, Wilkinson RJ, Andrade BB.

Front Immunol. 2017 May 12;8:542. doi: 10.3389/fimmu.2017.00542. eCollection 2017.

10.

Characterization of T Cells Specific for CFP-10 and ESAT-6 in Mycobacterium tuberculosis-Infected Mauritian Cynomolgus Macaques.

Ellis A, Balgeman A, Rodgers M, Updike C, Tomko J, Maiello P, Scanga CA, O'Connor SL.

Infect Immun. 2017 Mar 23;85(4). pii: e01009-16. doi: 10.1128/IAI.01009-16. Print 2017 Apr.

11.

Widespread Virus Replication in Alveoli Drives Acute Respiratory Distress Syndrome in Aerosolized H5N1 Influenza Infection of Macaques.

Wonderlich ER, Swan ZD, Bissel SJ, Hartman AL, Carney JP, O'Malley KJ, Obadan AO, Santos J, Walker R, Sturgeon TJ, Frye LJ Jr, Maiello P, Scanga CA, Bowling JD, Bouwer AL, Duangkhae PA, Wiley CA, Flynn JL, Wang J, Cole KS, Perez DR, Reed DS, Barratt-Boyes SM.

J Immunol. 2017 Feb 15;198(4):1616-1626. doi: 10.4049/jimmunol.1601770. Epub 2017 Jan 6.

12.

A new method to evaluate macaque health using exhaled breath: A case study of M. tuberculosis in a BSL-3 setting.

Mellors TR, Blanchet L, Flynn JL, Tomko J, O'Malley M, Scanga CA, Lin PL, Hill JE.

J Appl Physiol (1985). 2017 Mar 1;122(3):695-701. doi: 10.1152/japplphysiol.00888.2016. Epub 2017 Jan 5.

13.

Lack of IL-1 Receptor-Associated Kinase-4 Leads to Defective Th1 Cell Responses and Renders Mice Susceptible to Mycobacterial Infection.

Marinho FV, Fahel JS, Scanga CA, Gomes MT, Guimarães G, Carvalho GR, Morales SV, Báfica A, Oliveira SC.

J Immunol. 2016 Sep 1;197(5):1852-63. doi: 10.4049/jimmunol.1502157. Epub 2016 Jul 20.

14.

A tuberculosis ontology for host systems biology.

Levine DM, Dutta NK, Eckels J, Scanga C, Stein C, Mehra S, Kaushal D, Karakousis PC, Salamon H.

Tuberculosis (Edinb). 2015 Sep;95(5):570-4. doi: 10.1016/j.tube.2015.05.012. Epub 2015 Jun 30.

15.

PET/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis.

Coleman MT, Chen RY, Lee M, Lin PL, Dodd LE, Maiello P, Via LE, Kim Y, Marriner G, Dartois V, Scanga C, Janssen C, Wang J, Klein E, Cho SN, Barry CE 3rd, Flynn JL.

Sci Transl Med. 2014 Dec 3;6(265):265ra167. doi: 10.1126/scitranslmed.3009500.

16.

Modeling tuberculosis in nonhuman primates.

Scanga CA, Flynn JL.

Cold Spring Harb Perspect Med. 2014 Sep 11;4(12):a018564. doi: 10.1101/cshperspect.a018564. Review.

17.

Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose Mycobacterium tuberculosis challenge.

Darrah PA, Bolton DL, Lackner AA, Kaushal D, Aye PP, Mehra S, Blanchard JL, Didier PJ, Roy CJ, Rao SS, Hokey DA, Scanga CA, Sizemore DR, Sadoff JC, Roederer M, Seder RA.

J Immunol. 2014 Aug 15;193(4):1799-811. doi: 10.4049/jimmunol.1400676. Epub 2014 Jul 14.

18.

In vivo imaging in an ABSL-3 regional biocontainment laboratory.

Scanga CA, Lopresti BJ, Tomko J, Frye LJ, Coleman TM, Fillmore D, Carney JP, Lin PL, Flynn JL, Gardner CL, Sun C, Klimstra WB, Ryman KD, Reed DS, Fisher DJ, Cole KS.

Pathog Dis. 2014 Jul;71(2):207-12. doi: 10.1111/2049-632X.12186. Epub 2014 Jun 18. Review.

PMID:
24838691
19.

Radiologic Responses in Cynomolgus Macaques for Assessing Tuberculosis Chemotherapy Regimens.

Lin PL, Coleman T, Carney JP, Lopresti BJ, Tomko J, Fillmore D, Dartois V, Scanga C, Frye LJ, Janssen C, Klein E, Barry CE 3rd, Flynn JL.

Antimicrob Agents Chemother. 2013 Sep;57(9):4237-4244. doi: 10.1128/AAC.00277-13. Epub 2013 Jun 24.

20.

Prime-boost vaccination with rBCG/rAd35 enhances CD8⁺ cytolytic T-cell responses in lesions from Mycobacterium tuberculosis-infected primates.

Rahman S, Magalhaes I, Rahman J, Ahmed RK, Sizemore DR, Scanga CA, Weichold F, Verreck F, Kondova I, Sadoff J, Thorstensson R, Spångberg M, Svensson M, Andersson J, Maeurer M, Brighenti S.

Mol Med. 2012 May 9;18:647-58. doi: 10.2119/molmed.2011.00222.

21.

Mycobacterial infections and the inflammatory seesaw.

Scanga CA, Flynn JL.

Cell Host Microbe. 2010 Mar 18;7(3):177-9. doi: 10.1016/j.chom.2010.03.003.

22.

Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis.

Sun R, Skeiky YA, Izzo A, Dheenadhayalan V, Imam Z, Penn E, Stagliano K, Haddock S, Mueller S, Fulkerson J, Scanga C, Grover A, Derrick SC, Morris S, Hone DM, Horwitz MA, Kaufmann SH, Sadoff JC.

Vaccine. 2009 Jul 16;27(33):4412-23. doi: 10.1016/j.vaccine.2009.05.048. Epub 2009 Jun 2.

PMID:
19500523
23.

rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector.

Magalhaes I, Sizemore DR, Ahmed RK, Mueller S, Wehlin L, Scanga C, Weichold F, Schirru G, Pau MG, Goudsmit J, Kühlmann-Berenzon S, Spångberg M, Andersson J, Gaines H, Thorstensson R, Skeiky YA, Sadoff J, Maeurer M.

PLoS One. 2008;3(11):e3790. doi: 10.1371/journal.pone.0003790. Epub 2008 Nov 21.

24.

TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus pneumoniae.

Lee KS, Scanga CA, Bachelder EM, Chen Q, Snapper CM.

Cell Immunol. 2007 Feb;245(2):103-10. Epub 2007 May 22.

25.
26.

TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis.

Bafica A, Scanga CA, Feng CG, Leifer C, Cheever A, Sher A.

J Exp Med. 2005 Dec 19;202(12):1715-24.

27.

Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production.

Bafica A, Scanga CA, Serhan C, Machado F, White S, Sher A, Aliberti J.

J Clin Invest. 2005 Jun;115(6):1601-6.

28.

Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 production.

Feng CG, Jankovic D, Kullberg M, Cheever A, Scanga CA, Hieny S, Caspar P, Yap GS, Sher A.

J Immunol. 2005 Apr 1;174(7):4185-92.

29.

Suppression of allergic airway disease using mycobacterial lipoglycans.

Sayers I, Severn W, Scanga CB, Hudson J, Le Gros G, Harper JL.

J Allergy Clin Immunol. 2004 Aug;114(2):302-9.

PMID:
15316507
31.

Influence of coinfecting pathogens on HIV expression: evidence for a role of Toll-like receptors.

Báfica A, Scanga CA, Schito M, Chaussabel D, Sher A.

J Immunol. 2004 Jun 15;172(12):7229-34. Review.

33.
34.

The induction of Toll-like receptor tolerance enhances rather than suppresses HIV-1 gene expression in transgenic mice.

Báfica A, Scanga CA, Equils O, Sher A.

J Leukoc Biol. 2004 Mar;75(3):460-6. Epub 2003 Dec 4.

PMID:
14657211
36.
37.

Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii.

Sher A, Collazzo C, Scanga C, Jankovic D, Yap G, Aliberti J.

Immunol Res. 2003;27(2-3):521-8. Review.

PMID:
12857995
38.

Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells.

Scanga CA, Aliberti J, Jankovic D, Tilloy F, Bennouna S, Denkers EY, Medzhitov R, Sher A.

J Immunol. 2002 Jun 15;168(12):5997-6001.

39.
40.

Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology.

Mohan VP, Scanga CA, Yu K, Scott HM, Tanaka KE, Tsang E, Tsai MM, Flynn JL, Chan J.

Infect Immun. 2001 Mar;69(3):1847-55.

41.

Dendritic cell elimination as an assay of cytotoxic T lymphocyte activity in vivo.

Ritchie DS, Hermans IF, Lumsden JM, Scanga CB, Roberts JM, Yang J, Kemp RA, Ronchese F.

J Immunol Methods. 2000 Dec 1;246(1-2):109-17.

PMID:
11121552
42.

Changes in anesthetic sensitivity and glutamate receptors in the aging canine brain.

Magnusson KR, Scanga C, Wagner AE, Dunlop C.

J Gerontol A Biol Sci Med Sci. 2000 Sep;55(9):B448-54.

PMID:
10995042
43.
44.

Development of an asthma vaccine: research into BCG.

Scanga CB, Le Gros G.

Drugs. 2000 Jun;59(6):1217-21. Review.

PMID:
10882158
45.
46.

Reactivation of latent tuberculosis: variations on the Cornell murine model.

Scanga CA, Mohan VP, Joseph H, Yu K, Chan J, Flynn JL.

Infect Immun. 1999 Sep;67(9):4531-8.

47.

Effects of weight loss and exercise training on natural killer cell activity in obese women.

Scanga CB, Verde TJ, Paolone AM, Andersen RE, Wadden TA.

Med Sci Sports Exerc. 1998 Dec;30(12):1666-71.

PMID:
9861597
48.

Effects of aminoguanidine on latent murine tuberculosis.

Flynn JL, Scanga CA, Tanaka KE, Chan J.

J Immunol. 1998 Feb 15;160(4):1796-803.

49.
50.

Attachment glycoproteins and receptor specificity of rat coronaviruses.

Gagneten S, Scanga CA, Dveksler GS, Beauchemin N, Percy D, Holmes KV.

Lab Anim Sci. 1996 Apr;46(2):159-66.

PMID:
8723231

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