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Antiviral Activity of Faecal Water Samples from HIV-1 Infected Subjects Treated With a Specific Probiotic Formulation.

Falasca F, Cavallari EN, Innocenti GP, Scagnolari C, Mezzaroma I, Santinelli L, Ceccarelli G, Vullo V, Turriziani O, d'Ettorre G.

Curr HIV Res. 2019 Sep 3. doi: 10.2174/1570162X17666190903230622. [Epub ahead of print]


Differential interferon gene expression in bronchiolitis caused by respiratory syncytial virus-A genotype ON1.

Pierangeli A, Viscido A, Bitossi C, Frasca F, Gentile M, Oliveto G, Frassanito A, Nenna R, Midulla F, Scagnolari C.

Med Microbiol Immunol. 2019 Sep 4. doi: 10.1007/s00430-019-00633-6. [Epub ahead of print]


Challenges in the management of HIV infection: update on the role of probiotic supplementation as a possible complementary therapeutic strategy for cART treated people living with HIV/AIDS.

Ceccarelli G, Statzu M, Santinelli L, Pinacchio C, Bitossi C, Cavallari EN, Vullo V, Scagnolari C, d'Ettorre G.

Expert Opin Biol Ther. 2019 Sep;19(9):949-965. doi: 10.1080/14712598.2019.1638907. Epub 2019 Jul 10.


Short-Term Probiotic Administration Increases Fecal-Anti Candida Activity in Healthy Subjects.

De Angelis M, Scagnolari C, Oliva A, Cavallari EN, Celani L, Santinelli L, Innocenti GP, Borrazzo C, Ceccarelli G, Vullo V, d'Ettorre G.

Microorganisms. 2019 Jun 3;7(6). pii: E162. doi: 10.3390/microorganisms7060162.


Increased expression of IL-32 correlates with IFN-γ, Th1 and Tc1 in virologically suppressed HIV-1-infected patients.

Santinelli L, Statzu M, Pierangeli A, Frasca F, Bressan A, Pinacchio C, Nonne C, Turriziani O, Antonelli G, d'Ettorre G, Scagnolari C.

Cytokine. 2019 Aug;120:273-281. doi: 10.1016/j.cyto.2019.01.012. Epub 2019 Mar 23.


Increased IL-17 and/or IFN-γ producing T-cell subsets in gut mucosa of long-term-treated HIV-1-infected women.

d'Ettorre G, Borrazzo C, Pinacchio C, Santinelli L, Cavallari EN, Statzu M, Fanello G, Ceccarelli G, Antonelli G, Vullo V, Mastroianni CM, Scagnolari C.

AIDS. 2019 Mar 15;33(4):627-636. doi: 10.1097/QAD.0000000000002122.


Increased SAMHD1 transcript expression correlates with interferon-related genes in HIV-1-infected patients.

Statzu M, Santinelli L, Viscido A, Pinacchio C, Ceccarelli G, Rotondo C, Corano Scheri G, Mezzaroma I, Turriziani O, Antonelli G, d'Ettorre G, Scagnolari C.

Med Microbiol Immunol. 2019 Oct;208(5):679-691. doi: 10.1007/s00430-018-0574-x. Epub 2018 Dec 18.


Early Post-Transplant Torquetenovirus Viremia Predicts Cytomegalovirus Reactivations In Solid Organ Transplant Recipients.

Maggi F, Focosi D, Statzu M, Bianco G, Costa C, Macera L, Spezia PG, Medici C, Albert E, Navarro D, Scagnolari C, Pistello M, Cavallo R, Antonelli G.

Sci Rep. 2018 Oct 19;8(1):15490. doi: 10.1038/s41598-018-33909-7.


Respiratory syncytial virus.

Pierangeli A, Scagnolari C, Antonelli G.

Minerva Pediatr. 2018 Dec;70(6):553-565. doi: 10.23736/S0026-4946.18.05312-4. Epub 2018 Oct 18. Review.


How Respiratory Syncytial Virus Genotypes Influence the Clinical Course in Infants Hospitalized for Bronchiolitis.

Midulla F, Nenna R, Scagnolari C, Petrarca L, Frassanito A, Viscido A, Arima S, Antonelli G, Pierangeli A.

J Infect Dis. 2019 Jan 29;219(4):526-534. doi: 10.1093/infdis/jiy496.


Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation.

Pinacchio C, Scheri GC, Statzu M, Santinelli L, Ceccarelli G, Innocenti GP, Vullo V, Antonelli G, Brenchley JM, d'Ettorre G, Scagnolari C.

J Immunol Res. 2018 Aug 12;2018:1738676. doi: 10.1155/2018/1738676. eCollection 2018.


Impact of IFN lambda 3/4 single nucleotide polymorphisms on the cytomegalovirus reactivation in autologous stem cell transplant patients.

Annibali O, Piccioni L, Tomarchio V, Circhetta E, Sarlo C, Franceschini L, Cantonetti M, Rizzo E, Angeletti S, Tirindelli MC, Scagnolari C, Statzu M, Avvisati G, Riva E.

PLoS One. 2018 Jul 23;13(7):e0200221. doi: 10.1371/journal.pone.0200221. eCollection 2018.


Analysis of the immune response in infants hospitalized with viral bronchiolitis shows different Th1/Th2 profiles associated with respiratory syncytial virus and human rhinovirus.

Fedele G, Schiavoni I, Nenna R, Pierangeli A, Frassanito A, Leone P, Petrarca L, Scagnolari C, Midulla F.

Pediatr Allergy Immunol. 2018 Aug;29(5):555-557. doi: 10.1111/pai.12919. Epub 2018 May 30. No abstract available.


Type I interferon and HIV: Subtle balance between antiviral activity, immunopathogenesis and the microbiome.

Scagnolari C, Antonelli G.

Cytokine Growth Factor Rev. 2018 Apr;40:19-31. doi: 10.1016/j.cytogfr.2018.03.003. Epub 2018 Mar 16. Review.


Interferon lambda receptor 1 (IFNL1R) transcript is highly expressed in rhinovirus bronchiolitis and correlates with disease severity.

Pierangeli A, Statzu M, Nenna R, Santinelli L, Petrarca L, Frassanito A, Gentile M, Antonelli G, Midulla F, Scagnolari C.

J Clin Virol. 2018 May;102:101-109. doi: 10.1016/j.jcv.2018.03.003. Epub 2018 Mar 10.


Direct-acting antiviral therapy enhances total CD4+ and CD8+ T-cells responses, but does not alter T-cells activation among HCV mono-infected, and HCV/HIV-1 co-infected patients.

Najafi Fard S, Schietroma I, Corano Scheri G, Giustini N, Serafino S, Cavallari EN, Pinacchio C, De Girolamo G, Ceccarelli G, Scagnolari C, Vullo V, d'Ettorre G.

Clin Res Hepatol Gastroenterol. 2018 Sep;42(4):319-329. doi: 10.1016/j.clinre.2017.11.006. Epub 2017 Dec 24.


Interferon lambda4 polymorphism is not associated with human papillomavirus infection outcome.

Cannella F, Scagnolari C, Statzu M, Sciandra I, Recine N, d'Ettorre G, Antonelli G, Pierangeli A.

Virus Genes. 2018 Apr;54(2):319-322. doi: 10.1007/s11262-017-1527-y. Epub 2017 Dec 14.


Acute bronchiolitis: Influence of viral co-infection in infants hospitalized over 12 consecutive epidemic seasons.

Petrarca L, Nenna R, Frassanito A, Pierangeli A, Leonardi S, Scagnolari C, Antonelli G, Papoff P, Moretti C, Midulla F.

J Med Virol. 2018 Apr;90(4):631-638. doi: 10.1002/jmv.24994. Epub 2017 Dec 11.


CD38 modulates respiratory syncytial virus-driven proinflammatory processes in human monocyte-derived dendritic cells.

Schiavoni I, Scagnolari C, Horenstein AL, Leone P, Pierangeli A, Malavasi F, Ausiello CM, Fedele G.

Immunology. 2018 May;154(1):122-131. doi: 10.1111/imm.12873. Epub 2017 Dec 18.


Impact of High-Dose Multi-Strain Probiotic Supplementation on Neurocognitive Performance and Central Nervous System Immune Activation of HIV-1 Infected Individuals.

Ceccarelli G, Brenchley JM, Cavallari EN, Scheri GC, Fratino M, Pinacchio C, Schietroma I, Fard SN, Scagnolari C, Mezzaroma I, Vullo V, d'Ettorre G.

Nutrients. 2017 Nov 21;9(11). pii: E1269. doi: 10.3390/nu9111269.


A pilot study on the effects of probiotic supplementation on neuropsychological performance and microRNA-29a-c levels in antiretroviral-treated HIV-1-infected patients.

Ceccarelli G, Fratino M, Selvaggi C, Giustini N, Serafino S, Schietroma I, Corano Scheri G, Pavone P, Passavanti G, Alunni Fegatelli D, Mezzaroma I, Antonelli G, Vullo V, Scagnolari C, d'Ettorre G.

Brain Behav. 2017 Jul 16;7(8):e00756. doi: 10.1002/brb3.756. eCollection 2017 Aug.


Respiratory syncytial virus bronchiolitis, weather conditions and air pollution in an Italian urban area: An observational study.

Nenna R, Evangelisti M, Frassanito A, Scagnolari C, Pierangeli A, Antonelli G, Nicolai A, Arima S, Moretti C, Papoff P, Villa MP, Midulla F.

Environ Res. 2017 Oct;158:188-193. doi: 10.1016/j.envres.2017.06.014. Epub 2017 Jul 3.


Probiotic supplementation promotes a reduction in T-cell activation, an increase in Th17 frequencies, and a recovery of intestinal epithelium integrity and mitochondrial morphology in ART-treated HIV-1-positive patients.

d'Ettorre G, Rossi G, Scagnolari C, Andreotti M, Giustini N, Serafino S, Schietroma I, Scheri GC, Fard SN, Trinchieri V, Mastromarino P, Selvaggi C, Scarpona S, Fanello G, Fiocca F, Ceccarelli G, Antonelli G, Brenchley JM, Vullo V.

Immun Inflamm Dis. 2017 Sep;5(3):244-260. doi: 10.1002/iid3.160. Epub 2017 Apr 20.


Rhinovirus species/genotypes and interferon-λ: subtypes, receptor and polymorphisms - missing pieces of the puzzle of childhood asthma?

Scagnolari C, Midulla F, Nenna R, Papoff P, Antonelli G, Pierangeli A.

Eur Respir J. 2017 Mar 29;49(3). pii: 1700060. doi: 10.1183/13993003.00060-2017. Print 2017 Mar. No abstract available.


Antiviral Activity of the Combination of Interferon and Ribavirin Against Chikungunya Virus: Are the Results Conclusive?

Scagnolari C, Caputo B, Rezza G, Antonelli G.

J Infect Dis. 2017 Feb 1;215(3):492-493. doi: 10.1093/infdis/jiw579. No abstract available.


Consolidation of molecular testing in clinical virology.

Scagnolari C, Turriziani O, Monteleone K, Pierangeli A, Antonelli G.

Expert Rev Anti Infect Ther. 2017 Apr;15(4):387-400. doi: 10.1080/14787210.2017.1271711. Epub 2016 Dec 24. Review.


Risk Factors for Virus-induced Acute Respiratory Tract Infections in Children Younger Than 3 Years and Recurrent Wheezing at 36 Months Follow-Up After Discharge.

Nicolai A, Frassanito A, Nenna R, Cangiano G, Petrarca L, Papoff P, Pierangeli A, Scagnolari C, Moretti C, Midulla F.

Pediatr Infect Dis J. 2017 Feb;36(2):179-183. doi: 10.1097/INF.0000000000001385.


Probiotics Differently Affect Gut-Associated Lymphoid Tissue Indolamine-2,3-Dioxygenase mRNA and Cerebrospinal Fluid Neopterin Levels in Antiretroviral-Treated HIV-1 Infected Patients: A Pilot Study.

Scagnolari C, Corano Scheri G, Selvaggi C, Schietroma I, Najafi Fard S, Mastrangelo A, Giustini N, Serafino S, Pinacchio C, Pavone P, Fanello G, Ceccarelli G, Vullo V, d'Ettorre G.

Int J Mol Sci. 2016 Sep 27;17(10). pii: E1639.


IFN-stimulated gene expression is independent of the IFNL4 genotype in chronic HIV-1 infection.

Monteleone K, Scheri GC, Statzu M, Selvaggi C, Falasca F, Giustini N, Mezzaroma I, Turriziani O, d'Ettorre G, Antonelli G, Scagnolari C.

Arch Virol. 2016 Nov;161(11):3263-8. doi: 10.1007/s00705-016-3016-3. Epub 2016 Aug 24.


Bronchiolitis: Analysis of 10 consecutive epidemic seasons.

Cangiano G, Nenna R, Frassanito A, Evangelisti M, Nicolai A, Scagnolari C, Pierangeli A, Antonelli G, Papoff P, Petrarca L, Capocaccia P, Moretti C, Midulla F.

Pediatr Pulmonol. 2016 Dec;51(12):1330-1335. doi: 10.1002/ppul.23476. Epub 2016 May 26.


Role of Interferons in Chronic Hepatitis C Infection.

Scagnolari C, Monteleone K, Cacciotti G, Antonelli G.

Curr Drug Targets. 2017;18(7):844-850. doi: 10.2174/1389450117666160201112632. Review.


ISG15 expression correlates with HIV-1 viral load and with factors regulating T cell response.

Scagnolari C, Monteleone K, Selvaggi C, Pierangeli A, D'Ettorre G, Mezzaroma I, Turriziani O, Gentile M, Vullo V, Antonelli G.

Immunobiology. 2016 Feb;221(2):282-90. doi: 10.1016/j.imbio.2015.10.007. Epub 2015 Oct 30.


Frequent detection of high human papillomavirus DNA loads in oral potentially malignant disorders.

Pierangeli A, Cannella F, Scagnolari C, Gentile M, Sciandra I, Antonelli G, Ciolfi C, Russo C, Palaia G, Romeo U, Polimeni A.

Clin Microbiol Infect. 2016 Jan;22(1):95.e9-95.e15. doi: 10.1016/j.cmi.2015.09.011. Epub 2015 Sep 25.


Variation in interferon sensitivity and induction between Usutu and West Nile (lineages 1 and 2) viruses.

Cacciotti G, Caputo B, Selvaggi C, la Sala A, Vitiello L, Diallo D, Ceianu C, Antonelli G, Nowotny N, Scagnolari C.

Virology. 2015 Nov;485:189-98. doi: 10.1016/j.virol.2015.07.015. Epub 2015 Aug 14.


Analysis of Th17 and Tc17 Frequencies and Antiviral Defenses in Gut-Associated Lymphoid Tissue of Chronic HIV-1 Positive Patients.

d'Ettorre G, Ceccarelli G, Andreotti M, Selvaggi C, Giustini N, Serafino S, Schietroma I, Nunnari G, Antonelli G, Vullo V, Scagnolari C.

Mediators Inflamm. 2015;2015:395484. doi: 10.1155/2015/395484. Epub 2015 Jun 28.


Viral Load in Infants Hospitalized for Respiratory Syncytial Virus Bronchiolitis Correlates with Recurrent Wheezing at Thirty-Six-Month Follow-Up.

Nenna R, Ferrara M, Nicolai A, Pierangeli A, Scagnolari C, Papoff P, Antonelli G, Moretti C, Midulla F.

Pediatr Infect Dis J. 2015 Oct;34(10):1131-2. doi: 10.1097/INF.0000000000000825.


Dual effect of Thymosin α 1 on human monocyte-derived dendritic cell in vitro stimulated with viral and bacterial toll-like receptor agonists.

Giacomini E, Severa M, Cruciani M, Etna MP, Rizzo F, Pardini M, Scagnolari C, Garaci E, Coccia EM.

Expert Opin Biol Ther. 2015;15 Suppl 1:S59-70. doi: 10.1517/14712598.2015.1019460. Epub 2015 Jun 22.


MicroRNA-29 family expression and its relation to antiviral immune response and viro-immunological markers in HIV-1-infected patients.

Monteleone K, Selvaggi C, Cacciotti G, Falasca F, Mezzaroma I, D'Ettorre G, Turriziani O, Vullo V, Antonelli G, Scagnolari C.

BMC Infect Dis. 2015 Feb 12;15:51. doi: 10.1186/s12879-015-0768-4.


Lack of usutu virus RNA in cerebrospinal fluid of patients with encephalitis of unknown etiology, Tuscany, Italy.

Maggi F, Mazzetti P, Focosi D, Macera L, Scagnolari C, Manzin A, Antonelli G, Nelli LC.

J Med Virol. 2015 Jun;87(6):913-6. doi: 10.1002/jmv.24149. Epub 2015 Feb 24.


Twenty-five years of type I interferon-based treatment: a critical analysis of its therapeutic use.

Antonelli G, Scagnolari C, Moschella F, Proietti E.

Cytokine Growth Factor Rev. 2015 Apr;26(2):121-31. doi: 10.1016/j.cytogfr.2014.12.006. Epub 2014 Dec 30. Review.


TLR9 is expressed in human papillomavirus-positive cervical cells and is overexpressed in persistent infections.

Cannella F, Pierangeli A, Scagnolari C, Cacciotti G, Tranquilli G, Stentella P, Recine N, Antonelli G.

Immunobiology. 2015 Mar;220(3):363-8. doi: 10.1016/j.imbio.2014.10.012. Epub 2014 Oct 23.


Elevated antinuclear antibodies and altered anti-Epstein-Barr virus immune responses.

Cuomo L, Cirone M, Di Gregorio AO, Vitillo M, Cattivelli M, Magliocca V, Maiorano S, Meledandri M, Scagnolari C, La Rocca S, Trivedi P.

Virus Res. 2015 Jan 2;195:95-9. doi: 10.1016/j.virusres.2014.09.014. Epub 2014 Oct 7.


Hepatitis C virus and interferon type III (interferon-λ3/interleukin-28B and interferon-λ4): genetic basis of susceptibility to infection and response to antiviral treatment.

Riva E, Scagnolari C, Turriziani O, Antonelli G.

Clin Microbiol Infect. 2014 Dec;20(12):1237-45. doi: 10.1111/1469-0691.12797. Epub 2014 Dec 12. Review.


Rapid spread of the novel respiratory syncytial virus A ON1 genotype, central Italy, 2011 to 2013.

Pierangeli A, Trotta D, Scagnolari C, Ferreri ML, Nicolai A, Midulla F, Marinelli K, Antonelli G, Bagnarelli P.

Euro Surveill. 2014 Jul 3;19(26). pii: 20843.


Recurrent wheezing 36 months after bronchiolitis is associated with rhinovirus infections and blood eosinophilia.

Midulla F, Nicolai A, Ferrara M, Gentile F, Pierangeli A, Bonci E, Scagnolari C, Moretti C, Antonelli G, Papoff P.

Acta Paediatr. 2014 Oct;103(10):1094-9. doi: 10.1111/apa.12720. Epub 2014 Jul 7.


In vitro assessment of the biologic activity of interferon beta formulations used for the treatment of relapsing multiple sclerosis.

Scagnolari C, Selvaggi C, Di Biase E, Fraulo M, Dangond F, Antonelli G.

J Immunoassay Immunochem. 2014;35(3):288-99. doi: 10.1080/15321819.2013.848815.


Interleukin-32 isoforms: expression, interaction with interferon-regulated genes and clinical significance in chronically HIV-1-infected patients.

Monteleone K, Di Maio P, Cacciotti G, Falasca F, Fraulo M, Falciano M, Mezzaroma I, D'Ettorre G, Turriziani O, Scagnolari C.

Med Microbiol Immunol. 2014 Jun;203(3):207-16. doi: 10.1007/s00430-014-0329-2. Epub 2014 Feb 20.


Interferon lambda 1 expression in cervical cells differs between low-risk and high-risk human papillomavirus-positive women.

Cannella F, Scagnolari C, Selvaggi C, Stentella P, Recine N, Antonelli G, Pierangeli A.

Med Microbiol Immunol. 2014 Jun;203(3):177-84. doi: 10.1007/s00430-014-0330-9. Epub 2014 Feb 8.


Interferon lambda 1-3 expression in infants hospitalized for RSV or HRV associated bronchiolitis.

Selvaggi C, Pierangeli A, Fabiani M, Spano L, Nicolai A, Papoff P, Moretti C, Midulla F, Antonelli G, Scagnolari C.

J Infect. 2014 May;68(5):467-77. doi: 10.1016/j.jinf.2013.12.010. Epub 2014 Jan 2.


Bordetella pertussis in infants hospitalized for acute respiratory symptoms remains a concern.

Nicolai A, Nenna R, Stefanelli P, Carannante A, Schiavariello C, Pierangeli A, Scagnolari C, Moretti C, Papoff P, Bonci E, Ferrara M, Papasso S, Midulla F.

BMC Infect Dis. 2013 Nov 8;13:526. doi: 10.1186/1471-2334-13-526.

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