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Items: 1 to 50 of 327

1.

Programmable microencapsulation for enhanced mesenchymal stem cell persistence and immunomodulation.

Mao AS, Özkale B, Shah NJ, Vining KH, Descombes T, Zhang L, Tringides CM, Wong SW, Shin JW, Scadden DT, Weitz DA, Mooney DJ.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15392-15397. doi: 10.1073/pnas.1819415116. Epub 2019 Jul 16.

PMID:
31311862
2.

Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping.

Severe N, Karabacak NM, Gustafsson K, Baryawno N, Courties G, Kfoury Y, Kokkaliaris KD, Rhee C, Lee D, Scadden EW, Garcia-Robledo JE, Brouse T, Nahrendorf M, Toner M, Scadden DT.

Cell Stem Cell. 2019 Oct 3;25(4):570-583.e7. doi: 10.1016/j.stem.2019.06.003. Epub 2019 Jul 3.

PMID:
31279774
3.

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia.

Baryawno N, Przybylski D, Kowalczyk MS, Kfoury Y, Severe N, Gustafsson K, Kokkaliaris KD, Mercier F, Tabaka M, Hofree M, Dionne D, Papazian A, Lee D, Ashenberg O, Subramanian A, Vaishnav ED, Rozenblatt-Rosen O, Regev A, Scadden DT.

Cell. 2019 Jun 13;177(7):1915-1932.e16. doi: 10.1016/j.cell.2019.04.040. Epub 2019 May 23.

PMID:
31130381
4.

Growing old in the age of heterogeneity: the perils of shifting clonality.

Gustafsson K, Scadden DT.

Curr Opin Hematol. 2019 Jul;26(4):222-227. doi: 10.1097/MOH.0000000000000513.

PMID:
31045646
5.

Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress.

Scaramozza A, Park D, Kollu S, Beerman I, Sun X, Rossi DJ, Lin CP, Scadden DT, Crist C, Brack AS.

Cell Stem Cell. 2019 Jun 6;24(6):944-957.e5. doi: 10.1016/j.stem.2019.03.020. Epub 2019 Apr 18.

6.

The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.

Christian S, Merz C, Evans L, Gradl S, Seidel H, Friberg A, Eheim A, Lejeune P, Brzezinka K, Zimmermann K, Ferrara S, Meyer H, Lesche R, Stoeckigt D, Bauser M, Haegebarth A, Sykes DB, Scadden DT, Losman JA, Janzer A.

Leukemia. 2019 Oct;33(10):2403-2415. doi: 10.1038/s41375-019-0461-5. Epub 2019 Apr 2.

PMID:
30940908
7.

Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.

Ni F, Yu WM, Wang X, Fay ME, Young KM, Qiu Y, Lam WA, Sulchek TA, Cheng T, Scadden DT, Qu CK.

Cell Stem Cell. 2019 Apr 4;24(4):608-620.e6. doi: 10.1016/j.stem.2019.02.009. Epub 2019 Mar 14.

PMID:
30880025
8.

Stem Cell Transplant Approaches for Patients With Blood Cancers.

Scadden DT.

Oncology (Williston Park). 2019 Mar 13;33(3):86-8. No abstract available.

9.

Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke.

Courties G, Frodermann V, Honold L, Zheng Y, Herisson F, Schloss MJ, Sun Y, Presumey J, Severe N, Engblom C, Hulsmans M, Cremer S, Rohde D, Pittet MJ, Scadden DT, Swirski FK, Kim DE, Moskowitz MA, Nahrendorf M.

Circ Res. 2019 Apr 26;124(9):1372-1385. doi: 10.1161/CIRCRESAHA.118.314518.

PMID:
30782088
10.

An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation.

Shah NJ, Mao AS, Shih TY, Kerr MD, Sharda A, Raimondo TM, Weaver JC, Vrbanac VD, Deruaz M, Tager AM, Mooney DJ, Scadden DT.

Nat Biotechnol. 2019 Mar;37(3):293-302. doi: 10.1038/s41587-019-0017-2. Epub 2019 Feb 11.

11.

Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation.

Czechowicz A, Palchaudhuri R, Scheck A, Hu Y, Hoggatt J, Saez B, Pang WW, Mansour MK, Tate TA, Chan YY, Walck E, Wernig G, Shizuru JA, Winau F, Scadden DT, Rossi DJ.

Nat Commun. 2019 Feb 6;10(1):617. doi: 10.1038/s41467-018-08201-x.

12.

Cell Cycle Analysis of Hematopoietic Stem and Progenitor Cells by Multicolor Flow Cytometry.

Galvin A, Weglarz M, Folz-Donahue K, Handley M, Baum M, Mazzola M, Litwa H, Scadden DT, Silberstein L.

Curr Protoc Cytom. 2019 Jan;87(1):e50. doi: 10.1002/cpcy.50. Epub 2018 Oct 18.

PMID:
30335223
13.

A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets.

Almeida FF, Tognarelli S, Marçais A, Kueh AJ, Friede ME, Liao Y, Willis SN, Luong K, Faure F, Mercier FE, Galluso J, Firth M, Narni-Mancinelli E, Rais B, Scadden DT, Spallotta F, Weil S, Giannattasio A, Kalensee F, Zöller T, Huntington ND, Schleicher U, Chiocchetti AG, Ugolini S, Herold MJ, Shi W, Koch J, Steinle A, Vivier E, Walzer T, Belz GT, Ullrich E.

Oncoimmunology. 2018 Aug 15;7(10):e1475875. doi: 10.1080/2162402X.2018.1475875. eCollection 2018.

14.

Modulating Bone Marrow Hematopoietic Lineage Potential to Prevent Bone Metastasis in Breast Cancer.

Ubellacker JM, Baryawno N, Severe N, DeCristo MJ, Sceneay J, Hutchinson JN, Haider MT, Rhee CS, Qin Y, Gregory WM, Garrido-Castro AC, Holen I, Brown JE, Coleman RE, Scadden DT, McAllister SS.

Cancer Res. 2018 Sep 15;78(18):5300-5314. doi: 10.1158/0008-5472.CAN-18-0548. Epub 2018 Jul 31.

15.

dropEst: pipeline for accurate estimation of molecular counts in droplet-based single-cell RNA-seq experiments.

Petukhov V, Guo J, Baryawno N, Severe N, Scadden DT, Samsonova MG, Kharchenko PV.

Genome Biol. 2018 Jun 19;19(1):78. doi: 10.1186/s13059-018-1449-6.

16.

Bone marrow drives central nervous system regeneration after radiation injury.

Dietrich J, Baryawno N, Nayyar N, Valtis YK, Yang B, Ly I, Besnard A, Severe N, Gustafsson KU, Andronesi OC, Batchelor TT, Sahay A, Scadden DT.

J Clin Invest. 2018 Jun 1;128(6):2651. doi: 10.1172/JCI121592. Epub 2018 Jun 1. No abstract available.

17.

The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model.

García-Peydró M, Fuentes P, Mosquera M, García-León MJ, Alcain J, Rodríguez A, García de Miguel P, Menéndez P, Weijer K, Spits H, Scadden DT, Cuesta-Mateos C, Muñoz-Calleja C, Sánchez-Madrid F, Toribio ML.

J Clin Invest. 2018 Jul 2;128(7):2802-2818. doi: 10.1172/JCI92981. Epub 2018 May 21.

18.

Sipa1 deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm.

Xiao P, Dolinska M, Sandhow L, Kondo M, Johansson AS, Bouderlique T, Zhao Y, Li X, Dimitriou M, Rassidakis GZ, Hellström-Lindberg E, Minato N, Walfridsson J, Scadden DT, Sigvardsson M, Qian H.

Blood Adv. 2018 Mar 13;2(5):534-548. doi: 10.1182/bloodadvances.2017013599.

19.

Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell.

Hoggatt J, Singh P, Tate TA, Chou BK, Datari SR, Fukuda S, Liu L, Kharchenko PV, Schajnovitz A, Baryawno N, Mercier FE, Boyer J, Gardner J, Morrow DM, Scadden DT, Pelus LM.

Cell. 2018 Jan 11;172(1-2):191-204.e10. doi: 10.1016/j.cell.2017.11.003. Epub 2017 Dec 7.

20.

Bone marrow drives central nervous system regeneration after radiation injury.

Dietrich J, Baryawno N, Nayyar N, Valtis YK, Yang B, Ly I, Besnard A, Severe N, Gustafsson KU, Andronesi OC, Batchelor TT, Sahay A, Scadden DT.

J Clin Invest. 2018 Jan 2;128(1):281-293. doi: 10.1172/JCI90647. Epub 2017 Dec 4. Erratum in: J Clin Invest. 2018 Jun 1;128(6):2651.

21.

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils.

Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ.

Science. 2017 Dec 1;358(6367). pii: eaal5081. doi: 10.1126/science.aal5081.

22.

Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1.

Schiroli G, Ferrari S, Conway A, Jacob A, Capo V, Albano L, Plati T, Castiello MC, Sanvito F, Gennery AR, Bovolenta C, Palchaudhuri R, Scadden DT, Holmes MC, Villa A, Sitia G, Lombardo A, Genovese P, Naldini L.

Sci Transl Med. 2017 Oct 11;9(411). pii: eaan0820. doi: 10.1126/scitranslmed.aan0820.

PMID:
29021165
23.

The metabolic regulator mTORC1 controls terminal myeloid differentiation.

Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA.

Sci Immunol. 2017 May 26;2(11). pii: eaam6641. doi: 10.1126/sciimmunol.aam6641.

PMID:
28763796
24.

ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells.

Garrison BS, Rybak AP, Beerman I, Heesters B, Mercier FE, Scadden DT, Bryder D, Baron R, Rossi DJ.

Blood. 2017 Aug 3;130(5):619-624. doi: 10.1182/blood-2016-09-738591. Epub 2017 Jun 14.

25.

Hematopoiesis: Reconciling Historic Controversies about the Niche.

Baryawno N, Severe N, Scadden DT.

Cell Stem Cell. 2017 May 4;20(5):590-592. doi: 10.1016/j.stem.2017.03.025.

26.

Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells.

Kalaitzidis D, Lee D, Efeyan A, Kfoury Y, Nayyar N, Sykes DB, Mercier FE, Papazian A, Baryawno N, Victora GD, Neuberg D, Sabatini DM, Scadden DT.

J Clin Invest. 2017 Apr 3;127(4):1405-1413. doi: 10.1172/JCI89452. Epub 2017 Mar 20.

27.

Written in bone: young bone makes young blood.

Gustafsson K, Scadden DT.

EMBO J. 2017 Apr 3;36(7):831-833. doi: 10.15252/embj.201796634. Epub 2017 Mar 13. No abstract available.

28.

Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells.

Yu VWC, Yusuf RZ, Oki T, Wu J, Saez B, Wang X, Cook C, Baryawno N, Ziller MJ, Lee E, Gu H, Meissner A, Lin CP, Kharchenko PV, Scadden DT.

Cell. 2017 Feb 23;168(5):944-945. doi: 10.1016/j.cell.2017.02.010. No abstract available.

29.

Shipping mouse bone marrow: Keep it in the bone.

Papazian AE, Kfoury YS, Scadden DT.

Exp Hematol. 2017 May;49:68-72. doi: 10.1016/j.exphem.2016.12.008. Epub 2016 Dec 30.

PMID:
28043821
30.

Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.

Lewis TA, Sykes DB, Law JM, Muñoz B, Rustiguel JK, Nonato MC, Scadden DT, Schreiber SL.

ACS Med Chem Lett. 2016 Sep 28;7(12):1112-1117. eCollection 2016 Dec 8.

31.

Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease.

Hahm E, Wei C, Fernandez I, Li J, Tardi NJ, Tracy M, Wadhwani S, Cao Y, Peev V, Zloza A, Lusciks J, Hayek SS, O'Connor C, Bitzer M, Gupta V, Sever S, Sykes DB, Scadden DT, Reiser J.

Nat Med. 2017 Jan;23(1):100-106. doi: 10.1038/nm.4242. Epub 2016 Dec 12.

32.

Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells.

Yu VWC, Yusuf RZ, Oki T, Wu J, Saez B, Wang X, Cook C, Baryawno N, Ziller MJ, Lee E, Gu H, Meissner A, Lin CP, Kharchenko PV, Scadden DT.

Cell. 2016 Nov 17;167(5):1310-1322.e17. doi: 10.1016/j.cell.2016.10.045. Erratum in: Cell. 2017 Feb 23;168(5):944-945.

33.

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment.

Dong L, Yu WM, Zheng H, Loh ML, Bunting ST, Pauly M, Huang G, Zhou M, Broxmeyer HE, Scadden DT, Qu CK.

Nature. 2016 Nov 10;539(7628):304-308. doi: 10.1038/nature20131. Epub 2016 Oct 26.

34.

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

Sykes DB, Kfoury YS, Mercier FE, Wawer MJ, Law JM, Haynes MK, Lewis TA, Schajnovitz A, Jain E, Lee D, Meyer H, Pierce KA, Tolliday NJ, Waller A, Ferrara SJ, Eheim AL, Stoeckigt D, Maxcy KL, Cobert JM, Bachand J, Szekely BA, Mukherjee S, Sklar LA, Kotz JD, Clish CB, Sadreyev RI, Clemons PA, Janzer A, Schreiber SL, Scadden DT.

Cell. 2016 Sep 22;167(1):171-186.e15. doi: 10.1016/j.cell.2016.08.057. Epub 2016 Sep 15.

35.

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.

German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, Kaelin WG Jr, Haigis MC.

Mol Cell. 2016 Sep 15;63(6):1006-20. doi: 10.1016/j.molcel.2016.08.014.

36.

Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators.

Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA, Papazian A, Lee D, Chitteti BR, Srour EF, Hoggatt J, Tate T, Lo Celso C, Ono N, Nutt S, Heino J, Sipilä K, Shioda T, Osawa M, Lin CP, Hu GF, Scadden DT.

Cell Stem Cell. 2016 Oct 6;19(4):530-543. doi: 10.1016/j.stem.2016.07.004. Epub 2016 Aug 11.

37.

Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells.

Goncalves KA, Silberstein L, Li S, Severe N, Hu MG, Yang H, Scadden DT, Hu GF.

Cell. 2016 Aug 11;166(4):894-906. doi: 10.1016/j.cell.2016.06.042.

38.

Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow.

Yu VW, Lymperi S, Oki T, Jones A, Swiatek P, Vasic R, Ferraro F, Scadden DT.

Stem Cell Reports. 2016 Aug 9;7(2):220-35. doi: 10.1016/j.stemcr.2016.06.009. Epub 2016 Jul 21.

39.

Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis.

Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Golan K, Khatib E, Kumari A, Kollet O, Shakhar G, Butler JM, Rafii S, Adams RH, Scadden DT, Lin CP, Lapidot T.

Nature. 2016 Oct 13;538(7624):274. doi: 10.1038/nature19088. Epub 2016 Jul 20. No abstract available.

PMID:
27437586
40.

Targeting the Warburg effect for leukemia therapy: Magnitude matters.

Wang YH, Scadden DT.

Mol Cell Oncol. 2015 May 6;2(3):e981988. doi: 10.4161/23723556.2014.981988. eCollection 2015 Jul-Sep.

41.

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin.

Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT.

Nat Biotechnol. 2016 Jul;34(7):738-45. doi: 10.1038/nbt.3584. Epub 2016 Jun 6.

42.

Hematopoietic Stem Cell Niche in Health and Disease.

Hoggatt J, Kfoury Y, Scadden DT.

Annu Rev Pathol. 2016 May 23;11:555-81. doi: 10.1146/annurev-pathol-012615-044414. Review.

PMID:
27193455
43.

Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse.

Mercier FE, Sykes DB, Scadden DT.

Stem Cell Reports. 2016 Jun 14;6(6):985-992. doi: 10.1016/j.stemcr.2016.04.010. Epub 2016 May 12.

44.

Heterogeneity of the bone marrow niche.

Yu VW, Scadden DT.

Curr Opin Hematol. 2016 Jul;23(4):331-8. doi: 10.1097/MOH.0000000000000265. Review.

PMID:
27177311
45.

Blood and Bone.

Scadden DT.

N Engl J Med. 2016 May 12;374(19):1891-3. doi: 10.1056/NEJMcibr1601737. No abstract available.

PMID:
27168440
46.

Hematopoietic Stem Cell and Its Bone Marrow Niche.

Yu VW, Scadden DT.

Curr Top Dev Biol. 2016;118:21-44. doi: 10.1016/bs.ctdb.2016.01.009. Epub 2016 Mar 21. Review.

PMID:
27137653
47.

Distinct bone marrow blood vessels differentially regulate haematopoiesis.

Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Kollet O, Shakhar G, Butler JM, Rafii S, Adams RH, Scadden DT, Lin CP, Lapidot T.

Nature. 2016 Apr 21;532(7599):323-8. doi: 10.1038/nature17624. Epub 2016 Apr 13.

48.

Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy.

Lee D, Wang YH, Kalaitzidis D, Ramachandran J, Eda H, Sykes DB, Raje N, Scadden DT.

J Clin Invest. 2016 Apr 1;126(4):1300-10. doi: 10.1172/JCI84620. Epub 2016 Feb 29.

49.

Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway.

Ramasamy S, Saez B, Mukhopadhyay S, Ding D, Ahmed AM, Chen X, Pucci F, Yamin R, Wang J, Pittet MJ, Kelleher CM, Scadden DT, Sweetser DA.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1871-6. doi: 10.1073/pnas.1511380113. Epub 2016 Feb 1.

50.

Not All Created Equal: Lineage Hard-Wiring in the Production of Blood.

Mercier FE, Scadden DT.

Cell. 2015 Dec 17;163(7):1568-70. doi: 10.1016/j.cell.2015.12.013.

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