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Items: 46


Prognostic Relevance of Steroid Sulfation in Adrenocortical Carcinoma Revealed by Molecular Phenotyping Using High-Resolution Mass Spectrometry Imaging.

Sun N, Kunzke T, Sbiera S, Kircher S, Feuchtinger A, Aichler M, Herterich S, Ronchi CL, Weigand I, Schlegel N, Waldmann J, Fragoso MCV, Whitsett TG, Gill AJ, Fassnacht M, Walch A, Kroiss M.

Clin Chem. 2019 Sep 6. pii: clinchem.2019.306043. doi: 10.1373/clinchem.2019.306043. [Epub ahead of print]


Value of Molecular Classification for Prognostic Assessment of Adrenocortical Carcinoma.

Assié G, Jouinot A, Fassnacht M, Libé R, Garinet S, Jacob L, Hamzaoui N, Neou M, Sakat J, de La Villéon B, Perlemoine K, Ragazzon B, Sibony M, Tissier F, Gaujoux S, Dousset B, Sbiera S, Ronchi CL, Kroiss M, Korpershoek E, De Krijger R, Waldmann J, Quinkler M, Haissaguerre M, Tabarin A, Chabre O, Luconi M, Mannelli M, Groussin L, Bertagna X, Baudin E, Amar L, Coste J, Beuschlein F, Bertherat J.

JAMA Oncol. 2019 Jul 11. doi: 10.1001/jamaoncol.2019.1558. [Epub ahead of print]


Driver mutations in USP8 wild type Cushing's disease.

Sbiera S, Perez-Rivas LG, Taranets L, Weigand I, Flitsch J, Graf E, Monoranu CM, Saeger W, Hagel C, Honegger J, Assie G, Hermus AR, Stalla GK, Herterich S, Ronchi CL, Deutschbein T, Reincke M, Strom TM, Popov N, Theodoropoulou M, Fassnacht M.

Neuro Oncol. 2019 Jun 19. pii: noz109. doi: 10.1093/neuonc/noz109. [Epub ahead of print]


Impact of USP8 Gene Mutations on Protein Deregulation in Cushing Disease.

Weigand I, Knobloch L, Flitsch J, Saeger W, Monoranu CM, Höfner K, Herterich S, Rotermund R, Ronchi CL, Buchfelder M, Glatzel M, Hagel C, Fassnacht M, Deutschbein T, Sbiera S.

J Clin Endocrinol Metab. 2019 Jul 1;104(7):2535-2546. doi: 10.1210/jc.2018-02564.


Alterations in Protein Kinase A Substrate Specificity as a Potential Cause of Cushing Syndrome.

Bathon K, Weigand I, Vanselow JT, Ronchi CL, Sbiera S, Schlosser A, Fassnacht M, Calebiro D.

Endocrinology. 2019 Feb 1;160(2):447-459. doi: 10.1210/en.2018-00775.


Hsp90 inhibition in adrenocortical carcinoma: Limited drug synergism with mitotane.

Sbiera S, Kendl S, Weigand I, Sbiera I, Fassnacht M, Kroiss M.

Mol Cell Endocrinol. 2019 Jan 15;480:36-41. doi: 10.1016/j.mce.2018.10.009. Epub 2018 Oct 10.


Targeted Molecular Analysis in Adrenocortical Carcinomas: A Strategy Toward Improved Personalized Prognostication.

Lippert J, Appenzeller S, Liang R, Sbiera S, Kircher S, Altieri B, Nanda I, Weigand I, Gehrig A, Steinhauer S, Riemens RJM, Rosenwald A, Müller CR, Kroiss M, Rost S, Fassnacht M, Ronchi CL.

J Clin Endocrinol Metab. 2018 Dec 1;103(12):4511-4523. doi: 10.1210/jc.2018-01348.


High-Resolution Tissue Mass Spectrometry Imaging Reveals a Refined Functional Anatomy of the Human Adult Adrenal Gland.

Sun N, Wu Y, Nanba K, Sbiera S, Kircher S, Kunzke T, Aichler M, Berezowska S, Reibetanz J, Rainey WE, Fassnacht M, Walch A, Kroiss M.

Endocrinology. 2018 Mar 1;159(3):1511-1524. doi: 10.1210/en.2018-00064.


ERCC1 as predictive biomarker to platinum-based chemotherapy in adrenocortical carcinomas.

Laufs V, Altieri B, Sbiera S, Kircher S, Steinhauer S, Beuschlein F, Quinkler M, Willenberg HS, Rosenwald A, Fassnacht M, Ronchi CL.

Eur J Endocrinol. 2018 Feb;178(2):181-188. doi: 10.1530/EJE-17-0788. Epub 2017 Nov 29.


Gemcitabine-Based Chemotherapy in Adrenocortical Carcinoma: A Multicenter Study of Efficacy and Predictive Factors.

Henning JEK, Deutschbein T, Altieri B, Steinhauer S, Kircher S, Sbiera S, Wild V, Schlötelburg W, Kroiss M, Perotti P, Rosenwald A, Berruti A, Fassnacht M, Ronchi CL.

J Clin Endocrinol Metab. 2017 Nov 1;102(11):4323-4332. doi: 10.1210/jc.2017-01624.


Assessment of VAV2 Expression Refines Prognostic Prediction in Adrenocortical Carcinoma.

Sbiera S, Sbiera I, Ruggiero C, Doghman-Bouguerra M, Korpershoek E, de Krijger RR, Ettaieb H, Haak H, Volante M, Papotti M, Reimondo G, Terzolo M, Luconi M, Nesi G, Mannelli M, Libé R, Ragazzon B, Assié G, Bertherat J, Altieri B, Fadda G, Rogowski-Lehmann N, Reincke M, Beuschlein F, Fassnacht M, Lalli E.

J Clin Endocrinol Metab. 2017 Sep 1;102(9):3491-3498. doi: 10.1210/jc.2017-00984.


Topoisomerase 2α and thymidylate synthase expression in adrenocortical cancer.

Roca E, Berruti A, Sbiera S, Rapa I, Oneda E, Sperone P, Ronchi CL, Ferrari L, Grisanti S, Germano A, Zaggia B, Scagliotti GV, Fassnacht M, Volante M, Terzolo M, Papotti M.

Endocr Relat Cancer. 2017 Jul;24(7):319-327. doi: 10.1530/ERC-17-0095. Epub 2017 Apr 21.


Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion.

Ruggiero C, Doghman-Bouguerra M, Sbiera S, Sbiera I, Parsons M, Ragazzon B, Morin A, Robidel E, Favier J, Bertherat J, Fassnacht M, Lalli E.

Sci Signal. 2017 Mar 7;10(469). pii: eaal2464. doi: 10.1126/scisignal.aal2464.


Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas.

Weigand I, Ronchi CL, Rizk-Rabin M, Dalmazi GD, Wild V, Bathon K, Rubin B, Calebiro D, Beuschlein F, Bertherat J, Fassnacht M, Sbiera S.

Sci Rep. 2017 Mar 8;7(1):49. doi: 10.1038/s41598-017-00125-8.


Livin/BIRC7 expression as malignancy marker in adrenocortical tumors.

Altieri B, Sbiera S, Della Casa S, Weigand I, Wild V, Steinhauer S, Fadda G, Kocot A, Bekteshi M, Mambretti EM, Rosenwald A, Pontecorvi A, Fassnacht M, Ronchi CL.

Oncotarget. 2017 Feb 7;8(6):9323-9338. doi: 10.18632/oncotarget.14067.


Lack of Ubiquitin Specific Protease 8 (USP8) Mutations in Canine Corticotroph Pituitary Adenomas.

Sbiera S, Tryfonidou MA, Weigand I, Grinwis GC, Broeckx B, Herterich S, Allolio B, Deutschbein T, Fassnacht M, Meij BP.

PLoS One. 2016 Dec 22;11(12):e0169009. doi: 10.1371/journal.pone.0169009. eCollection 2016.


DNA Methylation Is an Independent Prognostic Marker of Survival in Adrenocortical Cancer.

Jouinot A, Assie G, Libe R, Fassnacht M, Papathomas T, Barreau O, de la Villeon B, Faillot S, Hamzaoui N, Neou M, Perlemoine K, Rene-Corail F, Rodriguez S, Sibony M, Tissier F, Dousset B, Sbiera S, Ronchi C, Kroiss M, Korpershoek E, de Krijger R, Waldmann J, K D, Bartsch, Quinkler M, Haissaguerre M, Tabarin A, Chabre O, Sturm N, Luconi M, Mantero F, Mannelli M, Cohen R, Kerlan V, Touraine P, Barrande G, Groussin L, Bertagna X, Baudin E, Amar L, Beuschlein F, Clauser E, Coste J, Bertherat J.

J Clin Endocrinol Metab. 2017 Mar 1;102(3):923-932. doi: 10.1210/jc.2016-3205.


Drug Synergism of Proteasome Inhibitors and Mitotane by Complementary Activation of ER Stress in Adrenocortical Carcinoma Cells.

Kroiss M, Sbiera S, Kendl S, Kurlbaum M, Fassnacht M.

Horm Cancer. 2016 Dec;7(5-6):345-355. Epub 2016 Sep 8.


FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling ER and mitochondria.

Doghman-Bouguerra M, Granatiero V, Sbiera S, Sbiera I, Lacas-Gervais S, Brau F, Fassnacht M, Rizzuto R, Lalli E.

EMBO Rep. 2016 Sep;17(9):1264-80. doi: 10.15252/embr.201541504. Epub 2016 Jul 11.


Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas Without PRKACA p.Leu206Arg Mutation.

Ronchi CL, Di Dalmazi G, Faillot S, Sbiera S, Assié G, Weigand I, Calebiro D, Schwarzmayr T, Appenzeller S, Rubin B, Waldmann J, Scaroni C, Bartsch DK, Mantero F, Mannelli M, Kastelan D, Chiodini I, Bertherat J, Reincke M, Strom TM, Fassnacht M, Beuschlein F; European Network for the Study of Adrenocortical Tumors (ENSAT).

J Clin Endocrinol Metab. 2016 Sep;101(9):3526-38. doi: 10.1210/jc.2016-1586. Epub 2016 Jul 7.


The adrenal specific toxicant mitotane directly interacts with lipid membranes and alters membrane properties depending on lipid composition.

Scheidt HA, Haralampiev I, Theisgen S, Schirbel A, Sbiera S, Huster D, Kroiss M, Müller P.

Mol Cell Endocrinol. 2016 Jun 15;428:68-81. doi: 10.1016/j.mce.2016.03.022. Epub 2016 Mar 18.


Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas.

Ronchi CL, Peverelli E, Herterich S, Weigand I, Mantovani G, Schwarzmayr T, Sbiera S, Allolio B, Honegger J, Appenzeller S, Lania AG, Reincke M, Calebiro D, Spada A, Buchfelder M, Flitsch J, Strom TM, Fassnacht M.

Eur J Endocrinol. 2016 Mar;174(3):363-72. doi: 10.1530/EJE-15-1064. Epub 2015 Dec 23.


Association of mitotane with chylomicrons and serum lipoproteins: practical implications for treatment of adrenocortical carcinoma.

Kroiss M, Plonné D, Kendl S, Schirmer D, Ronchi CL, Schirbel A, Zink M, Lapa C, Klinker H, Fassnacht M, Heinz W, Sbiera S.

Eur J Endocrinol. 2016 Mar;174(3):343-53. doi: 10.1530/EJE-15-0946. Epub 2015 Dec 15.


Role of Endocrine Gland-Derived Vascular Endothelial Growth Factor (EG-VEGF) and Its Receptors in Adrenocortical Tumors.

Heck D, Wortmann S, Kraus L, Ronchi CL, Sinnott RO, Fassnacht M, Sbiera S.

Horm Cancer. 2015 Dec;6(5-6):225-36.


The New Molecular Landscape of Cushing's Disease.

Sbiera S, Deutschbein T, Weigand I, Reincke M, Fassnacht M, Allolio B.

Trends Endocrinol Metab. 2015 Oct;26(10):573-583. doi: 10.1016/j.tem.2015.08.003. Review.


Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells.

Sbiera S, Leich E, Liebisch G, Sbiera I, Schirbel A, Wiemer L, Matysik S, Eckhardt C, Gardill F, Gehl A, Kendl S, Weigand I, Bala M, Ronchi CL, Deutschbein T, Schmitz G, Rosenwald A, Allolio B, Fassnacht M, Kroiss M.

Endocrinology. 2015 Nov;156(11):3895-908. doi: 10.1210/en.2015-1367. Epub 2015 Aug 25.


Notch1 pathway in adrenocortical carcinomas: correlations with clinical outcome.

Ronchi CL, Sbiera S, Altieri B, Steinhauer S, Wild V, Bekteshi M, Kroiss M, Fassnacht M, Allolio B.

Endocr Relat Cancer. 2015 Aug;22(4):531-43. doi: 10.1530/ERC-15-0163. Epub 2015 May 15.


Mutations in the deubiquitinase gene USP8 cause Cushing's disease.

Reincke M, Sbiera S, Hayakawa A, Theodoropoulou M, Osswald A, Beuschlein F, Meitinger T, Mizuno-Yamasaki E, Kawaguchi K, Saeki Y, Tanaka K, Wieland T, Graf E, Saeger W, Ronchi CL, Allolio B, Buchfelder M, Strom TM, Fassnacht M, Komada M.

Nat Genet. 2015 Jan;47(1):31-8. doi: 10.1038/ng.3166. Epub 2014 Dec 8.


Expression of LIN28 and its regulatory microRNAs in adult adrenocortical cancer.

Faria AM, Sbiera S, Ribeiro TC, Soares IC, Mariani BM, Freire DS, de Sousa GR, Lerario AM, Ronchi CL, Deutschbein T, Wakamatsu A, Alves VA, Zerbini MC, Mendonca BB, Fragoso MC, Latronico AC, Fassnacht M, Almeida MQ.

Clin Endocrinol (Oxf). 2015 Apr;82(4):481-8. doi: 10.1111/cen.12607. Epub 2014 Nov 3.


CYP2W1 is highly expressed in adrenal glands and is positively associated with the response to mitotane in adrenocortical carcinoma.

Ronchi CL, Sbiera S, Volante M, Steinhauer S, Scott-Wild V, Altieri B, Kroiss M, Bala M, Papotti M, Deutschbein T, Terzolo M, Fassnacht M, Allolio B.

PLoS One. 2014 Aug 21;9(8):e105855. doi: 10.1371/journal.pone.0105855. eCollection 2014.


Integrated genomic characterization of adrenocortical carcinoma.

Assié G, Letouzé E, Fassnacht M, Jouinot A, Luscap W, Barreau O, Omeiri H, Rodriguez S, Perlemoine K, René-Corail F, Elarouci N, Sbiera S, Kroiss M, Allolio B, Waldmann J, Quinkler M, Mannelli M, Mantero F, Papathomas T, De Krijger R, Tabarin A, Kerlan V, Baudin E, Tissier F, Dousset B, Groussin L, Amar L, Clauser E, Bertagna X, Ragazzon B, Beuschlein F, Libé R, de Reyniès A, Bertherat J.

Nat Genet. 2014 Jun;46(6):607-12. doi: 10.1038/ng.2953. Epub 2014 Apr 20.


EJE prize 2014: current and evolving treatment options in adrenocortical carcinoma: where do we stand and where do we want to go?

Ronchi CL, Kroiss M, Sbiera S, Deutschbein T, Fassnacht M.

Eur J Endocrinol. 2014 Jul;171(1):R1-R11. doi: 10.1530/EJE-14-0273. Epub 2014 Apr 8. Review.


Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome.

Beuschlein F, Fassnacht M, Assié G, Calebiro D, Stratakis CA, Osswald A, Ronchi CL, Wieland T, Sbiera S, Faucz FR, Schaak K, Schmittfull A, Schwarzmayr T, Barreau O, Vezzosi D, Rizk-Rabin M, Zabel U, Szarek E, Salpea P, Forlino A, Vetro A, Zuffardi O, Kisker C, Diener S, Meitinger T, Lohse MJ, Reincke M, Bertherat J, Strom TM, Allolio B.

N Engl J Med. 2014 Mar 13;370(11):1019-28. doi: 10.1056/NEJMoa1310359. Epub 2014 Feb 26.


Single nucleotide polymorphism array profiling of adrenocortical tumors--evidence for an adenoma carcinoma sequence?

Ronchi CL, Sbiera S, Leich E, Henzel K, Rosenwald A, Allolio B, Fassnacht M.

PLoS One. 2013 Sep 16;8(9):e73959. doi: 10.1371/journal.pone.0073959. eCollection 2013.


Survivin in adrenocortical tumors - pathophysiological implications and therapeutic potential.

Sbiera S, Kroiss M, Thamm T, Beyer M, Majidi F, Kuehner D, Wobser M, Becker JC, Adam P, Ronchi C, Allolio B, Fassnacht M.

Horm Metab Res. 2013 Feb;45(2):137-46. doi: 10.1055/s-0032-1327750. Epub 2012 Nov 9.


Low SGK1 expression in human adrenocortical tumors is associated with ACTH-independent glucocorticoid secretion and poor prognosis.

Ronchi CL, Sbiera S, Leich E, Tissier F, Steinhauer S, Deutschbein T, Fassnacht M, Allolio B.

J Clin Endocrinol Metab. 2012 Dec;97(12):E2251-60. doi: 10.1210/jc.2012-2669. Epub 2012 Oct 9.


Ribonucleotide reductase large subunit (RRM1) gene expression may predict efficacy of adjuvant mitotane in adrenocortical cancer.

Volante M, Terzolo M, Fassnacht M, Rapa I, Germano A, Sbiera S, Daffara F, Sperone P, Scagliotti G, Allolio B, Papotti M, Berruti A.

Clin Cancer Res. 2012 Jun 15;18(12):3452-61. doi: 10.1158/1078-0432.CCR-11-2692. Epub 2012 Apr 30.


Single nucleotide polymorphism microarray analysis in cortisol-secreting adrenocortical adenomas identifies new candidate genes and pathways.

Ronchi CL, Leich E, Sbiera S, Weismann D, Rosenwald A, Allolio B, Fassnacht M.

Neoplasia. 2012 Mar;14(3):206-18.


Influence of short-term glucocorticoid therapy on regulatory T cells in vivo.

Sbiera S, Dexneit T, Reichardt SD, Michel KD, van den Brandt J, Schmull S, Kraus L, Beyer M, Mlynski R, Wortmann S, Allolio B, Reichardt HM, Fassnacht M.

PLoS One. 2011;6(9):e24345. doi: 10.1371/journal.pone.0024345. Epub 2011 Sep 2.


Sunitinib Inhibits Cell Proliferation and Alters Steroidogenesis by Down-Regulation of HSD3B2 in Adrenocortical Carcinoma Cells.

Kroiss M, Reuss M, Kühner D, Johanssen S, Beyer M, Zink M, Hartmann MF, Dhir V, Wudy SA, Arlt W, Sbiera S, Allolio B, Fassnacht M.

Front Endocrinol (Lausanne). 2011 Sep 9;2:27. doi: 10.3389/fendo.2011.00027. eCollection 2011.


β-catenin activation is associated with specific clinical and pathologic characteristics and a poor outcome in adrenocortical carcinoma.

Gaujoux S, Grabar S, Fassnacht M, Ragazzon B, Launay P, Libé R, Chokri I, Audebourg A, Royer B, Sbiera S, Vacher-Lavenu MC, Dousset B, Bertagna X, Allolio B, Bertherat J, Tissier F.

Clin Cancer Res. 2011 Jan 15;17(2):328-36. doi: 10.1158/1078-0432.CCR-10-2006. Epub 2010 Nov 18.


Epidermal growth factor receptor in adrenocortical tumors: analysis of gene sequence, protein expression and correlation with clinical outcome.

Adam P, Hahner S, Hartmann M, Heinrich B, Quinkler M, Willenberg HS, Saeger W, Sbiera S, Schmull S, Voelker HU, Ströbel P, Allolio B, Fassnacht M.

Mod Pathol. 2010 Dec;23(12):1596-604. doi: 10.1038/modpathol.2010.153. Epub 2010 Aug 6.


High diagnostic and prognostic value of steroidogenic factor-1 expression in adrenal tumors.

Sbiera S, Schmull S, Assie G, Voelker HU, Kraus L, Beyer M, Ragazzon B, Beuschlein F, Willenberg HS, Hahner S, Saeger W, Bertherat J, Allolio B, Fassnacht M.

J Clin Endocrinol Metab. 2010 Oct;95(10):E161-71. doi: 10.1210/jc.2010-0653. Epub 2010 Jul 21.


Expression of excision repair cross complementing group 1 and prognosis in adrenocortical carcinoma patients treated with platinum-based chemotherapy.

Ronchi CL, Sbiera S, Kraus L, Wortmann S, Johanssen S, Adam P, Willenberg HS, Hahner S, Allolio B, Fassnacht M.

Endocr Relat Cancer. 2009 Sep;16(3):907-18. doi: 10.1677/ERC-08-0224. Epub 2009 Feb 24.


Dendritic cell based immunotherapy--a promising therapeutic approach for endocrine malignancies.

Sbiera S, Wortmann S, Fassnacht M.

Horm Metab Res. 2008 Feb;40(2):89-98. doi: 10.1055/s-2007-1022549. Review.


Association of human polyomavirus JC with peripheral blood of immunoimpaired and healthy individuals.

Dörries K, Sbiera S, Drews K, Arendt G, Eggers C, Dörries R.

J Neurovirol. 2003;9 Suppl 1:81-7.


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