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Items: 46

1.

Mammalian Mitochondrial Complex I Structure and Disease-Causing Mutations.

Fiedorczuk K, Sazanov LA.

Trends Cell Biol. 2018 Oct;28(10):835-867. doi: 10.1016/j.tcb.2018.06.006. Epub 2018 Jul 26. Review.

PMID:
30055843
2.

Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain.

Letts JA, Sazanov LA.

Nat Struct Mol Biol. 2017 Oct 5;24(10):800-808. doi: 10.1038/nsmb.3460. Review.

PMID:
28981073
3.

Atomic structure of the entire mammalian mitochondrial complex I.

Fiedorczuk K, Letts JA, Degliesposti G, Kaszuba K, Skehel M, Sazanov LA.

Nature. 2016 Oct 20;538(7625):406-410. doi: 10.1038/nature19794. Epub 2016 Sep 5.

4.

Purification of Ovine Respiratory Complex I Results in a Highly Active and Stable Preparation.

Letts JA, Degliesposti G, Fiedorczuk K, Skehel M, Sazanov LA.

J Biol Chem. 2016 Nov 18;291(47):24657-24675. Epub 2016 Sep 26.

5.

The architecture of respiratory supercomplexes.

Letts JA, Fiedorczuk K, Sazanov LA.

Nature. 2016 Sep 29;537(7622):644-648. doi: 10.1038/nature19774. Epub 2016 Sep 21.

PMID:
27654913
6.

Reversible FMN dissociation from Escherichia coli respiratory complex I.

Holt PJ, Efremov RG, Nakamaru-Ogiso E, Sazanov LA.

Biochim Biophys Acta. 2016 Nov;1857(11):1777-1785. doi: 10.1016/j.bbabio.2016.08.008. Epub 2016 Aug 27.

7.

Structure of bacterial respiratory complex I.

Berrisford JM, Baradaran R, Sazanov LA.

Biochim Biophys Acta. 2016 Jul;1857(7):892-901. doi: 10.1016/j.bbabio.2016.01.012. Epub 2016 Jan 22.

8.

Gaining mass: the structure of respiratory complex I-from bacterial towards mitochondrial versions.

Letts JA, Sazanov LA.

Curr Opin Struct Biol. 2015 Aug;33:135-45. doi: 10.1016/j.sbi.2015.08.008. Epub 2015 Sep 19. Review.

PMID:
26387075
9.

A giant molecular proton pump: structure and mechanism of respiratory complex I.

Sazanov LA.

Nat Rev Mol Cell Biol. 2015 Jun;16(6):375-88. doi: 10.1038/nrm3997. Epub 2015 May 20. Review.

PMID:
25991374
10.

The mechanism of coupling between electron transfer and proton translocation in respiratory complex I.

Sazanov LA.

J Bioenerg Biomembr. 2014 Aug;46(4):247-53. doi: 10.1007/s10863-014-9554-z. Epub 2014 Jun 19. Review.

PMID:
24943718
11.

Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation.

Heikal A, Nakatani Y, Dunn E, Weimar MR, Day CL, Baker EN, Lott JS, Sazanov LA, Cook GM.

Mol Microbiol. 2014 Mar;91(5):950-64. doi: 10.1111/mmi.12507. Epub 2014 Jan 21.

12.

A long road towards the structure of respiratory complex I, a giant molecular proton pump.

Sazanov LA, Baradaran R, Efremov RG, Berrisford JM, Minhas G.

Biochem Soc Trans. 2013 Oct;41(5):1265-71. doi: 10.1042/BST20130193.

PMID:
24059518
13.

Crystal structure of the entire respiratory complex I.

Baradaran R, Berrisford JM, Minhas GS, Sazanov LA.

Nature. 2013 Feb 28;494(7438):443-8. doi: 10.1038/nature11871. Epub 2013 Feb 17.

14.

Structure of Escherichia coli OmpF porin from lipidic mesophase.

Efremov RG, Sazanov LA.

J Struct Biol. 2012 Jun;178(3):311-8. doi: 10.1016/j.jsb.2012.03.005. Epub 2012 Mar 29.

PMID:
22484237
15.

The coupling mechanism of respiratory complex I - a structural and evolutionary perspective.

Efremov RG, Sazanov LA.

Biochim Biophys Acta. 2012 Oct;1817(10):1785-95. doi: 10.1016/j.bbabio.2012.02.015. Epub 2012 Feb 22. Review.

16.

Respiratory complex I: 'steam engine' of the cell?

Efremov RG, Sazanov LA.

Curr Opin Struct Biol. 2011 Aug;21(4):532-40. doi: 10.1016/j.sbi.2011.07.002. Epub 2011 Aug 8. Review.

PMID:
21831629
17.

Structure of the membrane domain of respiratory complex I.

Efremov RG, Sazanov LA.

Nature. 2011 Aug 7;476(7361):414-20. doi: 10.1038/nature10330.

PMID:
21822288
18.

Evolution of respiratory complex I: "supernumerary" subunits are present in the alpha-proteobacterial enzyme.

Yip CY, Harbour ME, Jayawardena K, Fearnley IM, Sazanov LA.

J Biol Chem. 2011 Feb 18;286(7):5023-33. doi: 10.1074/jbc.M110.194993. Epub 2010 Nov 29.

19.

The architecture of respiratory complex I.

Efremov RG, Baradaran R, Sazanov LA.

Nature. 2010 May 27;465(7297):441-5. doi: 10.1038/nature09066.

PMID:
20505720
20.

Structural basis for the mechanism of respiratory complex I.

Berrisford JM, Sazanov LA.

J Biol Chem. 2009 Oct 23;284(43):29773-83. doi: 10.1074/jbc.M109.032144. Epub 2009 Jul 27.

21.

Chemical and NADH-induced, ROS-dependent, cross-linking between subunits of complex I from Escherichia coli and Thermus thermophilus.

Berrisford JM, Thompson CJ, Sazanov LA.

Biochemistry. 2008 Sep 30;47(39):10262-70. doi: 10.1021/bi801160u. Epub 2008 Sep 5.

PMID:
18771280
22.

Three-dimensional structure of respiratory complex I from Escherichia coli in ice in the presence of nucleotides.

Morgan DJ, Sazanov LA.

Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):711-8. doi: 10.1016/j.bbabio.2008.03.023. Epub 2008 Apr 3.

23.

Single particle analysis confirms distal location of subunits NuoL and NuoM in Escherichia coli complex I.

Baranova EA, Morgan DJ, Sazanov LA.

J Struct Biol. 2007 Aug;159(2):238-42. Epub 2007 Jan 30.

PMID:
17360196
24.

Respiratory complex I: mechanistic and structural insights provided by the crystal structure of the hydrophilic domain.

Sazanov LA.

Biochemistry. 2007 Mar 6;46(9):2275-88. Epub 2007 Feb 3. Review.

PMID:
17274631
25.

Projection structure of the membrane domain of Escherichia coli respiratory complex I at 8 A resolution.

Baranova EA, Holt PJ, Sazanov LA.

J Mol Biol. 2007 Feb 9;366(1):140-54. Epub 2006 Nov 11.

PMID:
17157874
26.

Identification of a novel subunit of respiratory complex I from Thermus thermophilus.

Hinchliffe P, Carroll J, Sazanov LA.

Biochemistry. 2006 Apr 11;45(14):4413-20.

PMID:
16584177
27.

Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus.

Sazanov LA, Hinchliffe P.

Science. 2006 Mar 10;311(5766):1430-6. Epub 2006 Feb 9.

28.

Organization of iron-sulfur clusters in respiratory complex I.

Hinchliffe P, Sazanov LA.

Science. 2005 Jul 29;309(5735):771-4.

29.

Substrate-induced conformational change in bacterial complex I.

Mamedova AA, Holt PJ, Carroll J, Sazanov LA.

J Biol Chem. 2004 May 28;279(22):23830-6. Epub 2004 Mar 22.

30.
31.

A role for native lipids in the stabilization and two-dimensional crystallization of the Escherichia coli NADH-ubiquinone oxidoreductase (complex I).

Sazanov LA, Carroll J, Holt P, Toime L, Fearnley IM.

J Biol Chem. 2003 May 23;278(21):19483-91. Epub 2003 Mar 10.

33.

Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme.

Sazanov LA, Peak-Chew SY, Fearnley IM, Walker JE.

Biochemistry. 2000 Jun 20;39(24):7229-35.

PMID:
10852722
34.
35.
36.
37.

Detection and characterization of a complex I-like NADH-specific dehydrogenase from pea thylakoids.

Sazanov LA, Burrows P, Nixon PJ.

Biochem Soc Trans. 1996 Aug;24(3):739-43. Review. No abstract available.

PMID:
8878837
40.

Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism.

Efanov AM, Koshkin AA, Sazanov LA, Borodulina OI, Varfolomeev SD, Zaitsev SV.

FEBS Lett. 1994 Nov 28;355(2):114-6.

42.

Proton-translocating transhydrogenase in bacteria.

Jackson JB, Cotton NP, Williams R, Bizouarn T, Hutton MN, Sazanov LA, Thomas CM.

Biochem Soc Trans. 1993 Nov;21(4):1010-3. Review. No abstract available.

PMID:
8131888
43.

Activation and inhibition of mitochondrial transhydrogenase by metal ions.

Sazanov LA, Jackson JB.

Biochim Biophys Acta. 1993 Sep 13;1144(2):225-8.

PMID:
8369341
44.

Possible functions of the NADP-linked isocitrate dehydrogenase and H(+)-transhydrogenase in heart mitochondria.

Sazanov LA, Jackson JB.

Biochem Soc Trans. 1993 Aug;21 ( Pt 3)(3):260S. No abstract available.

PMID:
8224412
45.
46.

Respiratory burst inhibition in human neutrophils by ultra-low doses of [D-Ala2]methionine enkephalinamide.

Zaitsev SV, Sazanov LA, Koshkin AA, Sud'ina GF, Varfolomeev SD.

FEBS Lett. 1991 Oct 7;291(1):84-6.

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