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Current US Food and Drug Administration-Approved Pharmacologic Therapies for the Treatment of Irritable Bowel Syndrome with Diarrhea.

Brenner DM, Sayuk GS.

Adv Ther. 2020 Jan;37(1):83-96. doi: 10.1007/s12325-019-01116-z. Epub 2019 Nov 9. Review.


Editorial: obesity and chronic diarrhoea-A Hill of evidence for causation?

Sayuk GS, Elwing JE.

Aliment Pharmacol Ther. 2019 Nov;50(10):1137-1138. doi: 10.1111/apt.15530. No abstract available.


Higher Esophageal Symptom Burden in Obese Subjects Results From Increased Esophageal Acid Exposure and Not From Dysmotility.

Rogers BD, Patel A, Wang D, Sayuk GS, Gyawali CP.

Clin Gastroenterol Hepatol. 2019 Aug 20. pii: S1542-3565(19)30894-8. doi: 10.1016/j.cgh.2019.08.019. [Epub ahead of print]


Undifferentiated Abdominal Pain in Children Presenting to the Pediatric Emergency Department.

Harris BR, Chinta SS, Colvin R, Schnadower D, Tarr PI, Sayuk GS.

Clin Pediatr (Phila). 2019 Oct;58(11-12):1212-1223. doi: 10.1177/0009922819867459. Epub 2019 Aug 6.


Efficacy and Safety of Eluxadoline in Patients With Irritable Bowel Syndrome With Diarrhea Who Report Inadequate Symptom Control With Loperamide: RELIEF Phase 4 Study.

Brenner DM, Sayuk GS, Gutman CR, Jo E, Elmes SJR, Liu LWC, Cash BD.

Am J Gastroenterol. 2019 Sep;114(9):1502-1511. doi: 10.14309/ajg.0000000000000327.


Editorial: Tong-Xie-Yao-Fang (TXYF) for irritable bowel syndrome with diarrhoea (IBS-D)-ancient medicine meets modern study.

Vitta S, Sayuk GS.

Aliment Pharmacol Ther. 2018 Aug;48(4):485-486. doi: 10.1111/apt.14902. No abstract available.


Health-related quality of life and long-term outcomes after endoscopic therapy for walled-off pancreatic necrosis.

Smith ZL, Gregory MH, Elsner J, Alajlan BA, Kodali D, Hollander T, Sayuk GS, Lang GD, Das KK, Mullady DK, Early DS, Kushnir VM.

Dig Endosc. 2019 Jan;31(1):77-85. doi: 10.1111/den.13264. Epub 2018 Sep 30.


Chronic Cough Is Associated With Long Breaks in Esophageal Peristaltic Integrity on High-resolution Manometry.

Bennett MC, Patel A, Sainani N, Wang D, Sayuk GS, Gyawali CP.

J Neurogastroenterol Motil. 2018 Jul 30;24(3):387-394. doi: 10.5056/jnm17126.


Opioid medication use in patients with gastrointestinal diagnoses vs unexplained gastrointestinal symptoms in the US Veterans Health Administration.

Sayuk GS, Kanuri N, Gyawali CP, Gott BM, Nix BD, Rosenheck RA.

Aliment Pharmacol Ther. 2018 Mar;47(6):784-791. doi: 10.1111/apt.14503. Epub 2018 Jan 12.


Genetic risk factors for perception of symptoms in GERD: an observational cohort study.

Patel A, Hasak S, Nix BD, Sayuk GS, Newberry RD, Gyawali CP.

Aliment Pharmacol Ther. 2018 Jan;47(2):289-297. doi: 10.1111/apt.14414. Epub 2017 Nov 17.


Upper esophageal sphincter (UES) metrics on high-resolution manometry (HRM) differentiate achalasia subtypes.

Blais P, Patel A, Sayuk GS, Gyawali CP.

Neurogastroenterol Motil. 2017 Dec;29(12). doi: 10.1111/nmo.13136. Epub 2017 Jul 14.


Erdheim-Chester Disease presenting with histiocytic colitis and cytokine storm.

Christophi GP, Sharma Y, Farhan Q, Jain U, Walker T, Sayuk GS, Rubin DC.

J Gastrointestin Liver Dis. 2017 Jun;26(2):183-187. doi: 10.15403/jgld.2014.1121.262.erd.


Editorial: Functional Dyspepsia Treatment: Trials and Tribulations of Targeted Strategies.

Sayuk GS.

Am J Gastroenterol. 2017 Jun;112(6):910-912. doi: 10.1038/ajg.2017.121.


Do Consultants Follow Up on Tests They Recommend? Insights from an Academic Inpatient Gastrointestinal Consult Service.

Cassell BE, Walker T, Alghamdi S, Bill J, Blais P, Boutté H, Brown JW, Sayuk GS, Gyawali CP.

Dig Dis Sci. 2017 Jun;62(6):1448-1454. doi: 10.1007/s10620-017-4563-5. Epub 2017 Apr 8.


Comparison of Symptoms, Healthcare Utilization, and Treatment in Diagnosed and Undiagnosed Individuals With Diarrhea-Predominant Irritable Bowel Syndrome.

Sayuk GS, Wolf R, Chang L.

Am J Gastroenterol. 2017 Jun;112(6):892-899. doi: 10.1038/ajg.2016.574. Epub 2017 Jan 17.


Distal mean nocturnal baseline impedance on pH-impedance monitoring predicts reflux burden and symptomatic outcome in gastro-oesophageal reflux disease.

Patel A, Wang D, Sainani N, Sayuk GS, Gyawali CP.

Aliment Pharmacol Ther. 2016 Oct;44(8):890-8. doi: 10.1111/apt.13777. Epub 2016 Aug 24.


Effects of disturbed sleep on gastrointestinal and somatic pain symptoms in irritable bowel syndrome.

Patel A, Hasak S, Cassell B, Ciorba MA, Vivio EE, Kumar M, Gyawali CP, Sayuk GS.

Aliment Pharmacol Ther. 2016 Aug;44(3):246-58. doi: 10.1111/apt.13677. Epub 2016 May 30.


The impact of abuse and mood on bowel symptoms and health-related quality of life in irritable bowel syndrome (IBS).

Kanuri N, Cassell B, Bruce SE, White KS, Gott BM, Gyawali CP, Sayuk GS.

Neurogastroenterol Motil. 2016 Oct;28(10):1508-17. doi: 10.1111/nmo.12848. Epub 2016 May 5.


Prevalence, characteristics, and treatment outcomes of reflux hypersensitivity detected on pH-impedance monitoring.

Patel A, Sayuk GS, Gyawali CP.

Neurogastroenterol Motil. 2016 Sep;28(9):1382-90. doi: 10.1111/nmo.12838. Epub 2016 Apr 8.


The Reply.

Sayuk GS, Gyawali CP.

Am J Med. 2016 Feb;129(2):e41. doi: 10.1016/j.amjmed.2015.09.017. No abstract available.


GERD phenotypes from pH-impedance monitoring predict symptomatic outcomes on prospective evaluation.

Patel A, Sayuk GS, Kushnir VM, Chan WW, Gyawali CP.

Neurogastroenterol Motil. 2016 Apr;28(4):513-21. doi: 10.1111/nmo.12745. Epub 2015 Dec 20.


No association between the common calcium-sensing receptor polymorphism rs1801725 and irritable bowel syndrome.

Romero P, Schmitteckert S, Wouters MM, Houghton LA, Czogalla B, Sayuk GS, Boeckxstaens GE, Guenther P, Holland-Cunz S, Niesler B.

BMC Med Genet. 2015 Dec 11;16:110. doi: 10.1186/s12881-015-0256-0.


Correction: IDO1 and IDO2 Non-Synonymous Gene Variants: Correlation with Crohn's Disease Risk and Clinical Phenotype.

Lee A, Kanuri N, Zhang Y, Sayuk GS, Li E, Ciorba MA.

PLoS One. 2015 Jul 14;10(7):e0133098. doi: 10.1371/journal.pone.0133098. eCollection 2015. No abstract available.


Corrigendum: Impact of Retroflexion Vs. Second Forward View Examination of the Right Colon on Adenoma Detection: A Comparison Study.

Kushnir VM, Oh YS, Hollander T, Chen CH, Sayuk GS, Davidson N, Mullady D, Murad FM, Sharabash NM, Ruettgers E, Dassopoulos T, Easler JJ, Gyawali CP, Edmundowicz SA, Early DS.

Am J Gastroenterol. 2015 Jun;110(6):942. doi: 10.1038/ajg.2015.144. No abstract available.


Diagnosis of Esophageal Motility Disorders: Esophageal Pressure Topography vs. Conventional Line Tracing.

Carlson DA, Ravi K, Kahrilas PJ, Gyawali CP, Bredenoord AJ, Castell DO, Spechler SJ, Halland M, Kanuri N, Katzka DA, Leggett CL, Roman S, Saenz JB, Sayuk GS, Wong AC, Yadlapati R, Ciolino JD, Fox MR, Pandolfino JE.

Am J Gastroenterol. 2015 Jul;110(7):967-77; quiz 978. doi: 10.1038/ajg.2015.159. Epub 2015 Jun 2.


Achalasia symptom response after Heller myotomy segregated by high-resolution manometry subtypes.

Patel A, Patel A, Mirza FA, Soudagar S, Sayuk GS, Gyawali CP.

J Gastroenterol. 2016 Feb;51(2):112-8. doi: 10.1007/s00535-015-1088-6. Epub 2015 May 23.


Beliefs about GI medications and adherence to pharmacotherapy in functional GI disorder outpatients.

Cassell B, Gyawali CP, Kushnir VM, Gott BM, Nix BD, Sayuk GS.

Am J Gastroenterol. 2015 Oct;110(10):1382-7. doi: 10.1038/ajg.2015.132. Epub 2015 Apr 28.


Patient preferences of a resect and discard paradigm.

Vu HT, Sayuk GS, Gupta N, Hollander T, Kim A, Early DS.

Gastrointest Endosc. 2015 Aug;82(2):381-384.e1. doi: 10.1016/j.gie.2015.01.042. Epub 2015 Apr 22.


A meta-analysis of immunogenetic Case-Control Association Studies in irritable bowel syndrome.

Czogalla B, Schmitteckert S, Houghton LA, Sayuk GS, Camilleri M, Olivo-Diaz A, Spiller R, Wouters MM, Boeckxstaens G, Bermejo JL, Niesler B.

Neurogastroenterol Motil. 2015 May;27(5):717-27. doi: 10.1111/nmo.12548. Epub 2015 Mar 30.


Impact of retroflexion vs. second forward view examination of the right colon on adenoma detection: a comparison study.

Kushnir VM, Oh YS, Hollander T, Chen CH, Sayuk GS, Davidson N, Mullady D, Murad FM, Sharabash NM, Ruettgers E, Dassopoulos T, Easler JJ, Gyawali CP, Edmundowicz SA, Early DS.

Am J Gastroenterol. 2015 Mar;110(3):415-22. doi: 10.1038/ajg.2015.21. Epub 2015 Mar 3. Erratum in: Am J Gastroenterol. 2015 Jun;110(6):942.


Irritable bowel syndrome: modern concepts and management options.

Sayuk GS, Gyawali CP.

Am J Med. 2015 Aug;128(8):817-27. doi: 10.1016/j.amjmed.2015.01.036. Epub 2015 Feb 28. Review.


IDO1 and IDO2 non-synonymous gene variants: correlation with crohn's disease risk and clinical phenotype.

Lee A, Kanuri N, Zhang Y, Sayuk GS, Li E, Ciorba MA.

PLoS One. 2014 Dec 26;9(12):e115848. doi: 10.1371/journal.pone.0115848. eCollection 2014. Erratum in: PLoS One. 2015;10(7):e0133098.


Resect and discard approach to colon polyps: real-world applicability among academic and community gastroenterologists.

Vu HT, Sayuk GS, Hollander TG, Clebanoff J, Edmundowicz SA, Gyawali CP, Thyssen EP, Weinstock LB, Early DS.

Dig Dis Sci. 2015 Feb;60(2):502-8. doi: 10.1007/s10620-014-3376-z. Epub 2014 Oct 7.


Parameters on esophageal pH-impedance monitoring that predict outcomes of patients with gastroesophageal reflux disease.

Patel A, Sayuk GS, Gyawali CP.

Clin Gastroenterol Hepatol. 2015 May;13(5):884-91. doi: 10.1016/j.cgh.2014.08.029. Epub 2014 Aug 23.


The impact of psychiatric and extraintestinal comorbidity on quality of life and bowel symptom burden in functional GI disorders.

Vu J, Kushnir V, Cassell B, Gyawali CP, Sayuk GS.

Neurogastroenterol Motil. 2014 Sep;26(9):1323-32. doi: 10.1111/nmo.12396. Epub 2014 Jul 29.


Acid-based parameters on pH-impedance testing predict symptom improvement with medical management better than impedance parameters.

Patel A, Sayuk GS, Gyawali CP.

Am J Gastroenterol. 2014 Jun;109(6):836-44. doi: 10.1038/ajg.2014.63. Epub 2014 Apr 15.


Liver volume in the cirrhotic patient: does size matter?

Hagan MT, Sayuk GS, Lisker-Melman M, Korenblat KM, Kerr TA, Chapman WC, Crippin JS.

Dig Dis Sci. 2014 Apr;59(4):886-91. doi: 10.1007/s10620-014-3038-1. Epub 2014 Feb 7.


Tricyclic antidepressants for management of residual symptoms in inflammatory bowel disease.

Iskandar HN, Cassell B, Kanuri N, Gyawali CP, Gutierrez A, Dassopoulos T, Ciorba MA, Sayuk GS.

J Clin Gastroenterol. 2014 May-Jun;48(5):423-9. doi: 10.1097/MCG.0000000000000049.


Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes.

Grasberger H, Chang L, Shih W, Presson AP, Sayuk GS, Newberry RD, Karagiannides I, Pothoulakis C, Mayer E, Merchant JL.

Am J Gastroenterol. 2013 Nov;108(11):1766-74. doi: 10.1038/ajg.2013.304. Epub 2013 Sep 24.


The impact of opiate pain medications and psychoactive drugs on the quality of colon preparation in outpatient colonoscopy.

Kushnir VM, Bhat P, Chokshi RV, Lee A, Borg BB, Gyawali CP, Sayuk GS.

Dig Liver Dis. 2014 Jan;46(1):56-61. doi: 10.1016/j.dld.2013.07.020. Epub 2013 Sep 6.


Genetic variation in the beta-2 adrenergic receptor (ADRB2) predicts functional gastrointestinal diagnoses and poorer health-related quality of life.

Kushnir VM, Cassell B, Gyawali CP, Newberry RD, Kibe P, Nix BD, Sabzpoushan A, Kanuri ND, Sayuk GS.

Aliment Pharmacol Ther. 2013 Aug;38(3):313-23. doi: 10.1111/apt.12378. Epub 2013 Jun 20.


Witnessed versus unwitnessed random urine tests in the treatment of opioid dependence.

Mallya A, Purnell AL, Svrakic DM, Lovell AM, Freedland KE, Gott BM, Sayuk GS, Cicero TJ, Brawer PA, Trafton JA, Scherrer JF, Lustman PJ.

Am J Addict. 2013 Mar-Apr;22(2):175-7. doi: 10.1111/j.1521-0391.2013.00326.x.


Linaclotide: promising IBS-C efficacy in an era of provisional study endpoints.

Sayuk GS.

Am J Gastroenterol. 2012 Nov;107(11):1726-9. doi: 10.1038/ajg.2012.325.


Sensory neuromodulators in functional nausea and vomiting: predictors of response.

Patel A, Sayuk GS, Kushnir VM, Gyawali CP.

Postgrad Med J. 2013 Mar;89(1049):131-6. doi: 10.1136/postgradmedj-2012-131284. Epub 2012 Oct 30.


Multiple rapid swallow responses segregate achalasia subtypes on high-resolution manometry.

Kushnir V, Sayuk GS, Gyawali CP.

Neurogastroenterol Motil. 2012 Dec;24(12):1069-e561. doi: 10.1111/j.1365-2982.2012.01971.x. Epub 2012 Jul 13.


Polysymptomatic, polysyndromic presentation of patients with urological chronic pelvic pain syndrome.

Lai HH, North CS, Andriole GL, Sayuk GS, Hong BA.

J Urol. 2012 Jun;187(6):2106-12. doi: 10.1016/j.juro.2012.01.081. Epub 2012 Apr 12.


Assessment of concordance of symptom reflux association tests in ambulatory pH monitoring.

Kushnir VM, Sathyamurthy A, Drapekin J, Gaddam S, Sayuk GS, Gyawali CP.

Aliment Pharmacol Ther. 2012 May;35(9):1080-7. doi: 10.1111/j.1365-2036.2012.05066.x. Epub 2012 Mar 20.


AGA Gastroenterology Training Exam (GTE): a progress report.

Sayuk GS, Hirano I, Fitzgerald JT, Stansfield RB, Armbruster BA, Jones TN, Akinyi J, Willis CE; AGA Institute's GTE Subcommittee.

Gastroenterology. 2012 Feb;142(2):201-4.e1-2. doi: 10.1053/j.gastro.2011.12.022. Epub 2011 Dec 16. No abstract available.


Gastroesophageal reflux symptoms in 9/11 survivors and workers: insights gained from tragic losses.

Sayuk GS, Drossman DA.

Am J Gastroenterol. 2011 Nov;106(11):1942-5. doi: 10.1038/ajg.2011.357.


Learners favour high resolution oesophageal manometry with better diagnostic accuracy over conventional line tracings.

Soudagar AS, Sayuk GS, Gyawali CP.

Gut. 2012 Jun;61(6):798-803. doi: 10.1136/gutjnl-2011-301145. Epub 2011 Oct 13.

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