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Items: 16

1.

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis.

Wiel C, Le Gal K, Ibrahim MX, Jahangir CA, Kashif M, Yao H, Ziegler DV, Xu X, Ghosh T, Mondal T, Kanduri C, Lindahl P, Sayin VI, Bergo MO.

Cell. 2019 Jul 11;178(2):330-345.e22. doi: 10.1016/j.cell.2019.06.005. Epub 2019 Jun 27.

PMID:
31257027
2.

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.

Lignitto L, LeBoeuf SE, Homer H, Jiang S, Askenazi M, Karakousi TR, Pass HI, Bhutkar AJ, Tsirigos A, Ueberheide B, Sayin VI, Papagiannakopoulos T, Pagano M.

Cell. 2019 Jul 11;178(2):316-329.e18. doi: 10.1016/j.cell.2019.06.003. Epub 2019 Jun 27.

PMID:
31257023
3.

TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.

McLoughlin MR, Orlicky DJ, Prigge JR, Krishna P, Talago EA, Cavigli IR, Eriksson S, Miller CG, Kundert JA, Sayin VI, Sabol RA, Heinemann J, Brandenberger LO, Iverson SV, Bothner B, Papagiannakopoulos T, Shearn CT, Arnér ESJ, Schmidt EE.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11408-11417. doi: 10.1073/pnas.1903244116. Epub 2019 May 16.

PMID:
31097586
4.

Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice.

Petersen DR, Saba LM, Sayin VI, Papagiannakopoulos T, Schmidt EE, Merrill GF, Orlicky DJ, Shearn CT.

PLoS One. 2018 May 25;13(5):e0198139. doi: 10.1371/journal.pone.0198139. eCollection 2018.

5.

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.

Romero R, Sayin VI, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Sánchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, Thomas CJ, Goparaju C, Davies A, Dolgalev I, Heguy A, Allaj V, Poirier JT, Moreira AL, Rudin CM, Pass HI, Vander Heiden MG, Jacks T, Papagiannakopoulos T.

Nat Med. 2017 Nov;23(11):1362-1368. doi: 10.1038/nm.4407. Epub 2017 Oct 2.

6.

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.

Sayin VI, LeBoeuf SE, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou AM, Ubriaco J, Muir A, Karagiannis D, Morris PJ, Thomas CJ, Possemato R, Vander Heiden MG, Papagiannakopoulos T.

Elife. 2017 Oct 2;6. pii: e28083. doi: 10.7554/eLife.28083.

7.

Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events.

Ashouri A, Sayin VI, Van den Eynden J, Singh SX, Papagiannakopoulos T, Larsson E.

Nat Commun. 2016 Oct 25;7:13197. doi: 10.1038/ncomms13197.

8.

Targeting Zfp148 activates p53 and reduces tumor initiation in the gut.

Nilton A, Sayin VI, Zou ZV, Sayin SI, Bondjers C, Gul N, Agren P, Fogelstrand P, Nilsson O, Bergo MO, Lindahl P.

Oncotarget. 2016 Aug 30;7(35):56183-56192. doi: 10.18632/oncotarget.10899.

9.

Application of CRISPR-mediated genome engineering in cancer research.

Sayin VI, Papagiannakopoulos T.

Cancer Lett. 2017 Feb 28;387:10-17. doi: 10.1016/j.canlet.2016.03.029. Epub 2016 Mar 18. Review.

PMID:
27000990
10.

Antioxidants can increase melanoma metastasis in mice.

Le Gal K, Ibrahim MX, Wiel C, Sayin VI, Akula MK, Karlsson C, Dalin MG, Akyürek LM, Lindahl P, Nilsson J, Bergo MO.

Sci Transl Med. 2015 Oct 7;7(308):308re8. doi: 10.1126/scitranslmed.aad3740.

PMID:
26446958
11.

Oncogene-induced senescence underlies the mutual exclusive nature of oncogenic KRAS and BRAF.

Cisowski J, Sayin VI, Liu M, Karlsson C, Bergo MO.

Oncogene. 2016 Mar 10;35(10):1328-33. doi: 10.1038/onc.2015.186. Epub 2015 Jun 1.

PMID:
26028035
12.

Loss of one copy of Zfp148 reduces lesional macrophage proliferation and atherosclerosis in mice by activating p53.

Sayin VI, Khan OM, Pehlivanoglu LE, Staffas A, Ibrahim MX, Asplund A, Agren P, Nilton A, Bergström G, Bergo MO, Borén J, Lindahl P.

Circ Res. 2014 Oct 10;115(9):781-9. doi: 10.1161/CIRCRESAHA.115.304992. Epub 2014 Sep 11.

PMID:
25212213
13.

Antioxidants accelerate lung cancer progression in mice.

Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P, Bergo MO.

Sci Transl Med. 2014 Jan 29;6(221):221ra15. doi: 10.1126/scitranslmed.3007653.

14.

Zinc finger protein 148 is dispensable for primitive and definitive hematopoiesis in mice.

Nilton A, Sayin VI, Staffas A, Larsson E, Rolf J, Petit MM, Palmqvist L, Swolin B, Cardell S, Lindahl P.

PLoS One. 2013 Jul 31;8(7):e70022. doi: 10.1371/journal.pone.0070022. Print 2013.

15.

Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria.

Ibrahim MX, Sayin VI, Akula MK, Liu M, Fong LG, Young SG, Bergo MO.

Science. 2013 Jun 14;340(6138):1330-3. doi: 10.1126/science.1238880. Epub 2013 May 16.

16.

Zfp148 deficiency causes lung maturation defects and lethality in newborn mice that are rescued by deletion of p53 or antioxidant treatment.

Sayin VI, Nilton A, Ibrahim MX, Ågren P, Larsson E, Petit MM, Hultén LM, Ståhlman M, Johansson BR, Bergo MO, Lindahl P.

PLoS One. 2013;8(2):e55720. doi: 10.1371/journal.pone.0055720. Epub 2013 Feb 6.

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