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A preclinical study combining the DNA repair inhibitor Dbait with radiotherapy for the treatment of melanoma.

Biau J, Devun F, Jdey W, Kotula E, Quanz M, Chautard E, Sayarath M, Sun JS, Verrelle P, Dutreix M.

Neoplasia. 2014 Oct 23;16(10):835-44. doi: 10.1016/j.neo.2014.08.008. eCollection 2014 Oct.


Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice.

Favaudon V, Caplier L, Monceau V, Pouzoulet F, Sayarath M, Fouillade C, Poupon MF, Brito I, Hupé P, Bourhis J, Hall J, Fontaine JJ, Vozenin MC.

Sci Transl Med. 2014 Jul 16;6(245):245ra93. doi: 10.1126/scitranslmed.3008973.


Heat shock protein 90α (Hsp90α) is phosphorylated in response to DNA damage and accumulates in repair foci.

Quanz M, Herbette A, Sayarath M, de Koning L, Dubois T, Sun JS, Dutreix M.

J Biol Chem. 2012 Mar 16;287(12):8803-15. doi: 10.1074/jbc.M111.320887. Epub 2012 Jan 23.

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