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Items: 1 to 50 of 134

1.

A DNAzyme based knockdown model for Fragile-X syndrome in zebrafish reveals a critical window for therapeutic intervention.

Medishetti R, Rani R, Kavati S, Mahilkar A, Akella V, Saxena U, Kulkarni P, Sevilimedu A.

J Pharmacol Toxicol Methods. 2019 Nov 14:106656. doi: 10.1016/j.vascn.2019.106656. [Epub ahead of print]

PMID:
31734279
2.

A comprehensive study on genome-wide coexpression network of KHDRBS1/Sam68 reveals its cancer and patient-specific association.

Sumithra B, Saxena U, Das AB.

Sci Rep. 2019 Jul 31;9(1):11083. doi: 10.1038/s41598-019-47558-x.

3.

Statins exacerbate glucose intolerance and hyperglycemia in a high sucrose fed rodent model.

Seshadri S, Rapaka N, Prajapati B, Mandaliya D, Patel S, Muggalla CS, Kapadia B, Babu PP, Misra P, Saxena U.

Sci Rep. 2019 Jun 19;9(1):8825. doi: 10.1038/s41598-019-45369-8.

4.

Grade-specific diagnostic and prognostic biomarkers in breast cancer.

Jayanthi VSPKSA, Das AB, Saxena U.

Genomics. 2019 Mar 7. pii: S0888-7543(18)30459-2. doi: 10.1016/j.ygeno.2019.03.001. [Epub ahead of print]

PMID:
30851359
5.

Intracranial pressure influences the level of sympathetic tone.

Guild SJ, Saxena UA, McBryde FD, Malpas SC, Ramchandra R.

Am J Physiol Regul Integr Comp Physiol. 2018 Nov 1;315(5):R1049-R1053. doi: 10.1152/ajpregu.00183.2018. Epub 2018 Sep 12.

6.

Specific Inhibition of Hepatic Lactate Dehydrogenase Reduces Oxalate Production in Mouse Models of Primary Hyperoxaluria.

Lai C, Pursell N, Gierut J, Saxena U, Zhou W, Dills M, Diwanji R, Dutta C, Koser M, Nazef N, Storr R, Kim B, Martin-Higueras C, Salido E, Wang W, Abrams M, Dudek H, Brown BD.

Mol Ther. 2018 Aug 1;26(8):1983-1995. doi: 10.1016/j.ymthe.2018.05.016. Epub 2018 Jun 15.

7.

Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases.

Pursell N, Gierut J, Zhou W, Dills M, Diwanji R, Gjorgjieva M, Saxena U, Yang JS, Shah A, Venkat N, Storr R, Kim B, Wang W, Abrams M, Raffin M, Mithieux G, Rajas F, Dudek H, Brown BD, Lai C.

Mol Ther. 2018 Jul 5;26(7):1771-1782. doi: 10.1016/j.ymthe.2018.04.023. Epub 2018 Apr 27.

8.

Magnetic nanoparticle formulation for targeted delivery of chemotherapeutic irinotecan to lungs.

Kulkarni P, Rajadurai M, Sevilimedu A, Basaveni S, Yellanki S, Medishetti R, Saxena U.

Drug Deliv Transl Res. 2018 Oct;8(5):1450-1459. doi: 10.1007/s13346-018-0527-3.

PMID:
29717474
9.

Role of AMH as Diagnostic Tool for Polycystic Ovarian Syndrome.

Saxena U, Ramani M, Singh P.

J Obstet Gynaecol India. 2018 Apr;68(2):117-122. doi: 10.1007/s13224-017-1066-4. Epub 2017 Nov 15.

10.

Prospective study of neoadjuvant chemoradiotherapy using intensity-modulated radiotherapy and 5 fluorouracil for locally advanced rectal cancer - toxicities and response assessment.

Simson DK, Mitra S, Ahlawat P, Saxena U, Sharma MK, Rawat S, Singh H, Bansal B, Sripathi LK, Tanwar A.

Cancer Manag Res. 2018 Mar 19;10:519-526. doi: 10.2147/CMAR.S142076. eCollection 2018.

11.

Correlation of pharmacokinetics and brain penetration data of adult zebrafish with higher mammals including humans.

Kulkarni P, Medishetti R, Nune N, Yellanki S, Sripuram V, Rao P, Sriram D, Saxena U, Oruganti S, Yogeeswari P.

J Pharmacol Toxicol Methods. 2017 Nov - Dec;88(Pt 2):147-152. doi: 10.1016/j.vascn.2017.09.258. Epub 2017 Sep 30.

PMID:
28974368
13.

Resurrection of whole liver radiotherapy-A case report.

Choudhary S, Mitra S, Sharma MK, Khullar P, Saxena U.

J Egypt Natl Canc Inst. 2017 Jun;29(2):105-108. doi: 10.1016/j.jnci.2017.01.001. Epub 2017 Mar 1.

14.

Novel Zebrafish EAE model: A quick in vivo screen for multiple sclerosis.

Kulkarni P, Yellanki S, Medishetti R, Sriram D, Saxena U, Yogeeswari P.

Mult Scler Relat Disord. 2017 Jan;11:32-39. doi: 10.1016/j.msard.2016.11.010. Epub 2016 Nov 28.

PMID:
28104252
15.

Recent advances in biosensor development for the detection of cancer biomarkers.

Jayanthi VSPKSA, Das AB, Saxena U.

Biosens Bioelectron. 2017 May 15;91:15-23. doi: 10.1016/j.bios.2016.12.014. Epub 2016 Dec 8. Review.

PMID:
27984706
16.

Dosimetric influence of photon beam energy and number of arcs on volumetric modulated arc therapy in carcinoma cervix: A planning study.

Yadav G, Bhushan M, Dewan A, Saxena U, Kumar L, Chauhan D, Raman K, Mitra S, Suhail M.

Rep Pract Oncol Radiother. 2017 Jan-Feb;22(1):1-9. Epub 2016 Oct 17.

17.

Dosimetric impact of setup errors in head and neck cancer patients treated by image-guided radiotherapy.

Kaur I, Rawat S, Ahlawat P, Kakria A, Gupta G, Saxena U, Mishra MB.

J Med Phys. 2016 Apr-Jun;41(2):144-8. doi: 10.4103/0971-6203.181640.

18.

Alternative splicing within the Wnt signaling pathway: role in cancer development.

Sumithra B, Saxena U, Das AB.

Cell Oncol (Dordr). 2016 Feb;39(1):1-13. doi: 10.1007/s13402-015-0266-0. Epub 2016 Jan 13. Review.

PMID:
26762488
19.

Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1.

Dutta C, Avitahl-Curtis N, Pursell N, Larsson Cohen M, Holmes B, Diwanji R, Zhou W, Apponi L, Koser M, Ying B, Chen D, Shui X, Saxena U, Cyr WA, Shah A, Nazef N, Wang W, Abrams M, Dudek H, Salido E, Brown BD, Lai C.

Mol Ther. 2016 Apr;24(4):770-8. doi: 10.1038/mt.2016.4. Epub 2016 Jan 13.

20.

Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism.

Kain V, Kapadia B, Misra P, Saxena U.

Sci Rep. 2015 Sep 8;5:13823. doi: 10.1038/srep13823.

21.

Nanomaterials towards fabrication of cholesterol biosensors: Key roles and design approaches.

Saxena U, Das AB.

Biosens Bioelectron. 2016 Jan 15;75:196-205. doi: 10.1016/j.bios.2015.08.042. Epub 2015 Aug 21. Review.

PMID:
26319162
22.

Crossed and uncrossed acoustic reflex growth functions in normal-hearing adults, typically developing children, and children with suspected auditory processing disorder.

Saxena U, Allan C, Allen P.

Int J Audiol. 2015;54(9):620-6. doi: 10.3109/14992027.2015.1043147. Epub 2015 Jun 24.

PMID:
26107426
23.

Inconsistency and features of single nucleotide variants detected in whole exome sequencing versus transcriptome sequencing: A case study in lung cancer.

O'Brien TD, Jia P, Xia J, Saxena U, Jin H, Vuong H, Kim P, Wang Q, Aryee MJ, Mino-Kenudson M, Engelman JA, Le LP, Iafrate AJ, Heist RS, Pao W, Zhao Z.

Methods. 2015 Jul 15;83:118-27. doi: 10.1016/j.ymeth.2015.04.016. Epub 2015 Apr 23.

24.

Is volumetric modulated arc therapy (RapidArc) better than intensity modulated radiotherapy for gynecological malignancies? A dosimetric comparison.

Sharma MK, Mitra S, Saxena U, Bhushan M, Shrivastava H, Simson DK, Dewan A, Chauhan D.

J Cancer Res Ther. 2014 Oct-Dec;10(4):883-8. doi: 10.4103/0973-1482.138208.

25.

Primary Gastric Burkitt's Lymphoma.

Mitra S, Mehta A, Gupta SK, Sharma A, Louis AR, Sharma MK, Saxena U, Simson DK, Dewan A.

Rare Tumors. 2014 Nov 10;6(4):5300. doi: 10.4081/rt.2014.5300. eCollection 2014 Oct 27.

26.

Structural, transport and optical properties of (La0.6Pr0.4)0.65Ca0.35MnO3 nanocrystals: a wide band-gap magnetic semiconductor.

Kumar S, Dwivedi GD, Kumar S, Mathur RB, Saxena U, Ghosh AK, Joshi AG, Yang HD, Chatterjee S.

Dalton Trans. 2015 Feb 21;44(7):3109-17. doi: 10.1039/c4dt03452j.

PMID:
25567084
27.

Investigational drugs for the management of Huntington's disease: are we there yet?

Kulkarni P, Saxena U.

Expert Opin Investig Drugs. 2014 Dec;23(12):1595-603. doi: 10.1517/13543784.2014.934807. Epub 2014 Aug 1. Review.

PMID:
25084527
28.

Head and neck cancers, the neglected malignancies: present and future treatment strategies.

Kulkarni P, Saxena U.

Expert Opin Ther Targets. 2014 Apr;18(4):351-4. doi: 10.1517/14728222.2014.888059. Epub 2014 Feb 10.

PMID:
24512298
29.

Pathprinting: An integrative approach to understand the functional basis of disease.

Altschuler GM, Hofmann O, Kalatskaya I, Payne R, Ho Sui SJ, Saxena U, Krivtsov AV, Armstrong SA, Cai T, Stein L, Hide WA.

Genome Med. 2013 Jul 26;5(7):68. doi: 10.1186/gm472. eCollection 2013.

30.
31.

Bioenergetics failure in neurodegenerative diseases: back to the future.

Saxena U.

Expert Opin Ther Targets. 2012 Apr;16(4):351-4. doi: 10.1517/14728222.2012.664135. Epub 2012 Feb 18.

PMID:
22339293
32.

Bioenergetics breakdown in Alzheimer's disease: targets for new therapies.

Saxena U.

Int J Physiol Pathophysiol Pharmacol. 2011;3(2):133-9. Epub 2010 Jun 12.

33.

Covalent immobilization of cholesterol oxidase on self-assembled gold nanoparticles for highly sensitive amperometric detection of cholesterol in real samples.

Saxena U, Chakraborty M, Goswami P.

Biosens Bioelectron. 2011 Feb 15;26(6):3037-43. doi: 10.1016/j.bios.2010.12.009. Epub 2010 Dec 14.

PMID:
21195602
34.

Alzheimer's disease amyloid hypothesis at crossroads: where do we go from here?

Saxena U.

Expert Opin Ther Targets. 2010 Dec;14(12):1273-7. doi: 10.1517/14728222.2010.528285.

PMID:
21058918
35.

Prolyl isomerase Pin1 regulates transcription factor LSF (TFCP2) by facilitating dephosphorylation at two serine-proline motifs.

Saxena UH, Owens L, Graham JR, Cooper GM, Hansen U.

J Biol Chem. 2010 Oct 8;285(41):31139-47. doi: 10.1074/jbc.M109.078808. Epub 2010 Aug 3.

36.

Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma.

Yoo BK, Emdad L, Gredler R, Fuller C, Dumur CI, Jones KH, Jackson-Cook C, Su ZZ, Chen D, Saxena UH, Hansen U, Fisher PB, Sarkar D.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8357-62. doi: 10.1073/pnas.1000374107. Epub 2010 Apr 19.

37.

Silk mat as bio-matrix for the immobilization of cholesterol oxidase.

Saxena U, Goswami P.

Appl Biochem Biotechnol. 2010 Oct;162(4):1122-31. doi: 10.1007/s12010-010-8923-2. Epub 2010 Feb 24.

PMID:
20182817
38.

Identification of genes conferring resistance to 5-fluorouracil.

Yoo BK, Gredler R, Vozhilla N, Su ZZ, Chen D, Forcier T, Shah K, Saxena U, Hansen U, Fisher PB, Sarkar D.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12938-43. doi: 10.1073/pnas.0901451106. Epub 2009 Jul 21.

39.

Transcription factors LSF and E2Fs: tandem cyclists driving G0 to S?

Hansen U, Owens L, Saxena UH.

Cell Cycle. 2009 Jul 15;8(14):2146-51. Epub 2009 Jul 21.

40.

Phosphorylation by cyclin C/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of LSF during G1 progression.

Saxena UH, Powell CM, Fecko JK, Cacioppo R, Chou HS, Cooper GM, Hansen U.

Mol Cell Biol. 2009 May;29(9):2335-45. doi: 10.1128/MCB.00687-08. Epub 2009 Feb 23.

41.

Lipid metabolism and Alzheimer's disease: pathways and possibilities.

Saxena U.

Expert Opin Ther Targets. 2009 Mar;13(3):331-8. doi: 10.1517/14728220902738720 . Review.

PMID:
19236155
42.

Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain.

Chambers D, Wilson LJ, Alfonsi F, Hunter E, Saxena U, Blanc E, Lumsden A.

Neural Dev. 2009 Feb 10;4:6. doi: 10.1186/1749-8104-4-6.

43.

Bioactivities of polyphenolics from the roots of Bauhinia racemosa.

Jain R, Saxena U, Rathore K, Jain SC.

Arch Pharm Res. 2008 Dec;31(12):1525-9. doi: 10.1007/s12272-001-2145-7. Epub 2008 Dec 20.

PMID:
19099218
44.

Lipoic acid synthase (LASY): a novel role in inflammation, mitochondrial function, and insulin resistance.

Padmalayam I, Hasham S, Saxena U, Pillarisetti S.

Diabetes. 2009 Mar;58(3):600-8. doi: 10.2337/db08-0473. Epub 2008 Dec 15.

45.

Status of Stat3 in an ovalbumin-induced mouse model of asthma: analysis of the role of Socs3 and IL-6.

Paul B, Mishra V, Chaudhury B, Awasthi A, Das AB, Saxena U, Saxena A, Chauhan LK, Kumar P, Raisuddin S.

Int Arch Allergy Immunol. 2009;148(2):99-108. doi: 10.1159/000155740. Epub 2008 Sep 18.

PMID:
18799889
46.
47.
48.

Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.

Meng CQ, Somers PK, Hoong LK, Zheng XS, Ye Z, Worsencroft KJ, Simpson JE, Hotema MR, Weingarten MD, MacDOnald ML, Hill RR, Marino EM, Suen KL, Luchoomun J, Kunsch C, Landers LK, Stefanopoulos D, Howard RB, Sundell CL, Saxena U, Wasserman MA, Sikorski JA.

J Med Chem. 2004 Dec 2;47(25):6420-32.

PMID:
15566311
49.

Role of oxidative stress and inflammation in the origin of Type 2 diabetes--a paradigm shift.

Pillarisetti S, Saxena U.

Expert Opin Ther Targets. 2004 Oct;8(5):401-8. Review.

PMID:
15469391
50.

Atherosclerosis -- new targets and therapeutics.

Pillarisetti S, Alexander CW, Saxena U.

Curr Med Chem Cardiovasc Hematol Agents. 2004 Oct;2(4):327-34. Review.

PMID:
15320783

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