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Items: 1 to 50 of 81

1.

TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation.

Chiramel AI, Meyerson NR, McNally KL, Broeckel RM, Montoya VR, Méndez-Solís O, Robertson SJ, Sturdevant GL, Lubick KJ, Nair V, Youseff BH, Ireland RM, Bosio CM, Kim K, Luban J, Hirsch VM, Taylor RT, Bouamr F, Sawyer SL, Best SM.

Cell Rep. 2019 Jun 11;27(11):3269-3283.e6. doi: 10.1016/j.celrep.2019.05.040.

2.

Selective use of primate CD4 receptors by HIV-1.

Warren CJ, Meyerson NR, Dirasantha O, Feldman ER, Wilkerson GK, Sawyer SL.

PLoS Biol. 2019 Jun 10;17(6):e3000304. doi: 10.1371/journal.pbio.3000304. eCollection 2019 Jun.

3.

A glycan shield on chimpanzee CD4 protects against infection by primate lentiviruses (HIV/SIV).

Warren CJ, Meyerson NR, Stabell AC, Fattor WT, Wilkerson GK, Sawyer SL.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11460-11469. doi: 10.1073/pnas.1813909116. Epub 2019 May 21.

PMID:
31113887
4.

A metaanalysis of bat phylogenetics and positive selection based on genomes and transcriptomes from 18 species.

Hawkins JA, Kaczmarek ME, Müller MA, Drosten C, Press WH, Sawyer SL.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11351-11360. doi: 10.1073/pnas.1814995116. Epub 2019 May 21.

5.

How host genetics dictates successful viral zoonosis.

Warren CJ, Sawyer SL.

PLoS Biol. 2019 Apr 19;17(4):e3000217. doi: 10.1371/journal.pbio.3000217. eCollection 2019 Apr.

6.

Infantile Myofibromatosis With Intracranial Extradural Involvement and PDGFRB Mutation: A Case Report and Review of the Literature.

Al Qawahmed R, Sawyer SL, Vassilyadi M, Qin W, Boycott KM, Michaud J.

Pediatr Dev Pathol. 2019 May-Jun;22(3):258-264. doi: 10.1177/1093526618787736. Epub 2018 Aug 13. Review.

PMID:
30103666
7.

Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication.

Zhang J, Zhao J, Xu S, Li J, He S, Zeng Y, Xie L, Xie N, Liu T, Lee K, Seo GJ, Chen L, Stabell AC, Xia Z, Sawyer SL, Jung J, Huang C, Feng P.

Cell Host Microbe. 2018 Aug 8;24(2):234-248.e5. doi: 10.1016/j.chom.2018.07.004.

8.

A ZPR1 mutation is associated with a novel syndrome of growth restriction, distinct craniofacial features, alopecia, and hypoplastic kidneys.

Ito YA, Smith AC, Kernohan KD, Pena IA, Ahmed A, McDonell LM, Beaulieu C, Bulman DE, Smidt A, Sawyer SL; Care4Rare Canada Consortium, Dyment DA, Boycott KM, Clericuzio CL.

Clin Genet. 2018 Oct;94(3-4):303-312. doi: 10.1111/cge.13388. Epub 2018 Jun 29.

PMID:
29851065
9.

Control of yeast retrotransposons mediated through nucleoporin evolution.

Rowley PA, Patterson K, Sandmeyer SB, Sawyer SL.

PLoS Genet. 2018 Apr 25;14(4):e1007325. doi: 10.1371/journal.pgen.1007325. eCollection 2018 Apr.

10.

Correction: Species-specific vulnerability of RanBP2 shaped the evolution of SIV as it transmitted in African apes.

Meyerson NR, Warren CJ, Vieira DASA, Diaz-Griffero F, Sawyer SL.

PLoS Pathog. 2018 Apr 3;14(4):e1006983. doi: 10.1371/journal.ppat.1006983. eCollection 2018 Apr.

11.

Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir.

Stabell AC, Meyerson NR, Gullberg RC, Gilchrist AR, Webb KJ, Old WM, Perera R, Sawyer SL.

Elife. 2018 Mar 20;7. pii: e31919. doi: 10.7554/eLife.31919.

12.

Species-specific vulnerability of RanBP2 shaped the evolution of SIV as it transmitted in African apes.

Meyerson NR, Warren CJ, Vieira DASA, Diaz-Griferro F, Sawyer SL.

PLoS Pathog. 2018 Mar 8;14(3):e1006906. doi: 10.1371/journal.ppat.1006906. eCollection 2018 Mar. Erratum in: PLoS Pathog. 2018 Apr 3;14 (4):e1006983.

13.

Using family history forms in pediatric oncology to identify patients for genetic assessment.

Hamilton A, Smith E, Hamon J, Tomiak E, Bassal M, Sawyer SL.

Curr Oncol. 2017 Dec;24(6):e441-e445. doi: 10.3747/co.24.3710. Epub 2017 Dec 20.

14.

Broad spectrum of neuropsychiatric phenotypes associated with white matter disease in PTEN hamartoma tumor syndrome.

Balci TB, Davila J, Lewis D, Boafo A, Sell E, Richer J, Nikkel SM, Armour CM, Tomiak E, Lines MA, Sawyer SL.

Am J Med Genet B Neuropsychiatr Genet. 2018 Jan;177(1):101-109. doi: 10.1002/ajmg.b.32610. Epub 2017 Nov 20.

PMID:
29152901
15.

Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation.

Meyerson NR, Zhou L, Guo YR, Zhao C, Tao YJ, Krug RM, Sawyer SL.

Cell Host Microbe. 2017 Nov 8;22(5):627-638.e7. doi: 10.1016/j.chom.2017.10.003. Epub 2017 Nov 5.

16.

Owl monkey CCR5 reveals synergism between CD4 and CCR5 in HIV-1 entry.

Nahabedian J, Sharma A, Kaczmarek ME, Wilkerson GK, Sawyer SL, Overbaugh J.

Virology. 2017 Dec;512:180-186. doi: 10.1016/j.virol.2017.09.018.

17.

MCM3AP in recessive Charcot-Marie-Tooth neuropathy and mild intellectual disability.

Ylikallio E, Woldegebriel R, Tumiati M, Isohanni P, Ryan MM, Stark Z, Walsh M, Sawyer SL, Bell KM, Oshlack A, Lockhart PJ, Shcherbii M, Estrada-Cuzcano A, Atkinson D, Hartley T, Tetreault M, Cuppen I, van der Pol WL, Candayan A, Battaloglu E, Parman Y, van Gassen KLI, van den Boogaard MH, Boycott KM, Kauppi L, Jordanova A, Lönnqvist T, Tyynismaa H.

Brain. 2017 Aug 1;140(8):2093-2103. doi: 10.1093/brain/awx138.

PMID:
28633435
18.

H3.1 K36M mutation in a congenital-onset soft tissue neoplasm.

Kernohan KD, Grynspan D, Ramphal R, Bareke E, Wang YC, Nizalik E; Care4Rare Canada Consortium, Ragoussis J, Jabado N, Boycott KM, Majewski J, Sawyer SL.

Pediatr Blood Cancer. 2017 Dec;64(12). doi: 10.1002/pbc.26633. Epub 2017 May 16.

PMID:
28509377
19.

Benchmarking outcomes in the Neonatal Intensive Care Unit: Cytogenetic and molecular diagnostic rates in a retrospective cohort.

Malam F, Hartley T, Gillespie MK, Armour CM, Bariciak E, Graham GE, Nikkel SM, Richer J, Sawyer SL, Boycott KM, Dyment DA.

Am J Med Genet A. 2017 Jul;173(7):1839-1847. doi: 10.1002/ajmg.a.38250. Epub 2017 May 9.

PMID:
28488422
20.

Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins.

Stabell AC, Hawkins J, Li M, Gao X, David M, Press WH, Sawyer SL.

PLoS Pathog. 2016 Dec 27;12(12):e1006066. doi: 10.1371/journal.ppat.1006066. eCollection 2016 Dec.

21.

XRN1 Is a Species-Specific Virus Restriction Factor in Yeasts.

Rowley PA, Ho B, Bushong S, Johnson A, Sawyer SL.

PLoS Pathog. 2016 Oct 6;12(10):e1005890. doi: 10.1371/journal.ppat.1005890. eCollection 2016 Oct. Erratum in: PLoS Pathog. 2016 Oct 28;12 (10 ):e1006002.

22.

An Intrinsically Disordered Region of the DNA Repair Protein Nbs1 Is a Species-Specific Barrier to Herpes Simplex Virus 1 in Primates.

Lou DI, Kim ET, Meyerson NR, Pancholi NJ, Mohni KN, Enard D, Petrov DA, Weller SK, Weitzman MD, Sawyer SL.

Cell Host Microbe. 2016 Aug 10;20(2):178-88. doi: 10.1016/j.chom.2016.07.003.

23.

Modulation of LINE-1 Retrotransposition by a Human SAMHD1 Polymorphism.

White TE, Brandariz-Nuñez A, Han K, Sawyer SL, Kim B, Diaz-Griffero F.

Virol Rep. 2016 Dec;6:53-60.

24.

A putative SUMO interacting motif in the B30.2/SPRY domain of rhesus macaque TRIM5α important for NF-κB/AP-1 signaling and HIV-1 restriction.

Nepveu-Traversy MÉ, Demogines A, Fricke T, Plourde MB, Riopel K, Veillette M, Diaz-Griffero F, Sawyer SL, Berthoux L.

Heliyon. 2016 Jan 21;2(1):e00056. doi: 10.1016/j.heliyon.2015.e00056. eCollection 2016 Jan.

25.

At the mercy of viruses.

Wilke CO, Sawyer SL.

Elife. 2016 May 17;5. pii: e16758. doi: 10.7554/eLife.16758.

26.

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.

Lu C, Jain SU, Hoelper D, Bechet D, Molden RC, Ran L, Murphy D, Venneti S, Hameed M, Pawel BR, Wunder JS, Dickson BC, Lundgren SM, Jani KS, De Jay N, Papillon-Cavanagh S, Andrulis IL, Sawyer SL, Grynspan D, Turcotte RE, Nadaf J, Fahiminiyah S, Muir TW, Majewski J, Thompson CB, Chi P, Garcia BA, Allis CD, Jabado N, Lewis PW.

Science. 2016 May 13;352(6287):844-9. doi: 10.1126/science.aac7272.

27.

Late diagnosis of cerebral folate deficiency: Fewer seizures with folinic acid in adult siblings.

Ferreira P, Luco SM, Sawyer SL, Davila J, Boycott KM, Dyment DA.

Neurol Genet. 2015 Dec 22;2(1):e38. doi: 10.1212/NXG.0000000000000038. eCollection 2016 Feb.

28.

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats.

Ng M, Ndungo E, Kaczmarek ME, Herbert AS, Binger T, Kuehne AI, Jangra RK, Hawkins JA, Gifford RJ, Biswas R, Demogines A, James RM, Yu M, Brummelkamp TR, Drosten C, Wang LF, Kuhn JH, Müller MA, Dye JM, Sawyer SL, Chandran K.

Elife. 2015 Dec 23;4. pii: e11785. doi: 10.7554/eLife.11785.

29.

Clinical reappraisal of SHORT syndrome with PIK3R1 mutations: toward recommendation for molecular testing and management.

Avila M, Dyment DA, Sagen JV, St-Onge J, Moog U, Chung BHY, Mo S, Mansour S, Albanese A, Garcia S, Martin DO, Lopez AA, Claudi T, König R, White SM, Sawyer SL, Bernstein JA, Slattery L, Jobling RK, Yoon G, Curry CJ, Merrer ML, Luyer BL, Héron D, Mathieu-Dramard M, Bitoun P, Odent S, Amiel J, Kuentz P, Thevenon J, Laville M, Reznik Y, Fagour C, Nunes ML, Delesalle D, Manouvrier S, Lascols O, Huet F, Binquet C, Faivre L, Rivière JB, Vigouroux C, Njølstad PR, Innes AM, Thauvin-Robinet C.

Clin Genet. 2016 Apr;89(4):501-506. doi: 10.1111/cge.12688. Epub 2015 Nov 27.

30.

Computational and Functional Analysis of the Virus-Receptor Interface Reveals Host Range Trade-Offs in New World Arenaviruses.

Kerr SA, Jackson EL, Lungu OI, Meyer AG, Demogines A, Ellington AD, Georgiou G, Wilke CO, Sawyer SL.

J Virol. 2015 Nov;89(22):11643-53. doi: 10.1128/JVI.01408-15. Epub 2015 Sep 9.

31.

Utility of whole-exome sequencing for those near the end of the diagnostic odyssey: time to address gaps in care.

Sawyer SL, Hartley T, Dyment DA, Beaulieu CL, Schwartzentruber J, Smith A, Bedford HM, Bernard G, Bernier FP, Brais B, Bulman DE, Warman Chardon J, Chitayat D, Deladoëy J, Fernandez BA, Frosk P, Geraghty MT, Gerull B, Gibson W, Gow RM, Graham GE, Green JS, Heon E, Horvath G, Innes AM, Jabado N, Kim RH, Koenekoop RK, Khan A, Lehmann OJ, Mendoza-Londono R, Michaud JL, Nikkel SM, Penney LS, Polychronakos C, Richer J, Rouleau GA, Samuels ME, Siu VM, Suchowersky O, Tarnopolsky MA, Yoon G, Zahir FR; FORGE Canada Consortium; Care4Rare Canada Consortium, Majewski J, Boycott KM.

Clin Genet. 2016 Mar;89(3):275-84. doi: 10.1111/cge.12654. Epub 2015 Sep 22. Review.

32.

Receptor tyrosine kinase mutations in developmental syndromes and cancer: two sides of the same coin.

McDonell LM, Kernohan KD, Boycott KM, Sawyer SL.

Hum Mol Genet. 2015 Oct 15;24(R1):R60-6. doi: 10.1093/hmg/ddv254. Epub 2015 Jul 7. Review.

33.

Homozygous mutations in MFN2 cause multiple symmetric lipomatosis associated with neuropathy.

Sawyer SL, Cheuk-Him Ng A, Innes AM, Wagner JD, Dyment DA, Tetreault M; Care4Rare Canada Consortium, Majewski J, Boycott KM, Screaton RA, Nicholson G.

Hum Mol Genet. 2015 Sep 15;24(18):5109-14. doi: 10.1093/hmg/ddv229. Epub 2015 Jun 17.

PMID:
26085578
34.

Identification of Owl Monkey CD4 Receptors Broadly Compatible with Early-Stage HIV-1 Isolates.

Meyerson NR, Sharma A, Wilkerson GK, Overbaugh J, Sawyer SL.

J Virol. 2015 Aug;89(16):8611-22. doi: 10.1128/JVI.00890-15. Epub 2015 Jun 10.

35.

Brain malformations in a patient with deletion 2p16.1: A refinement of the phenotype to BCL11A.

Balci TB, Sawyer SL, Davila J, Humphreys P, Dyment DA.

Eur J Med Genet. 2015 Jun-Jul;58(6-7):351-4. doi: 10.1016/j.ejmg.2015.04.006. Epub 2015 May 13.

PMID:
25979662
36.

Atypical fibrodysplasia ossificans progressiva diagnosed by whole-exome sequencing.

Liu H, Sawyer SL, Gos M, Grynspan D, Issa K, Ramphal R, Rotaru C; FORGE Canada Consortium, Majewski J, Boycott KM, Graham G, Bromwich M.

Am J Med Genet A. 2015 Jun;167(6):1337-41. doi: 10.1002/ajmg.a.36969. Epub 2015 Apr 21.

PMID:
25899773
37.

The effect of species representation on the detection of positive selection in primate gene data sets.

McBee RM, Rozmiarek SA, Meyerson NR, Rowley PA, Sawyer SL.

Mol Biol Evol. 2015 Apr;32(4):1091-6. doi: 10.1093/molbev/msu399. Epub 2015 Jan 2.

38.

Biallelic mutations in BRCA1 cause a new Fanconi anemia subtype.

Sawyer SL, Tian L, Kähkönen M, Schwartzentruber J, Kircher M; University of Washington Centre for Mendelian Genomics; FORGE Canada Consortium, Majewski J, Dyment DA, Innes AM, Boycott KM, Moreau LA, Moilanen JS, Greenberg RA.

Cancer Discov. 2015 Feb;5(2):135-42. doi: 10.1158/2159-8290.CD-14-1156. Epub 2014 Dec 3.

39.

Whole-exome sequencing broadens the phenotypic spectrum of rare pediatric epilepsy: a retrospective study.

Dyment DA, Tétreault M, Beaulieu CL, Hartley T, Ferreira P, Chardon JW, Marcadier J, Sawyer SL, Mosca SJ, Innes AM, Parboosingh JS, Bulman DE, Schwartzentruber J, Majewski J, Tarnopolsky M, Boycott KM; FORGE Canada Consortium; Care4Rare Canada.

Clin Genet. 2015 Jul;88(1):34-40. doi: 10.1111/cge.12464. Epub 2014 Aug 28.

PMID:
25046240
40.

Rapid evolution of BRCA1 and BRCA2 in humans and other primates.

Lou DI, McBee RM, Le UQ, Stone AC, Wilkerson GK, Demogines AM, Sawyer SL.

BMC Evol Biol. 2014 Jul 11;14:155. doi: 10.1186/1471-2148-14-155.

41.

Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins.

Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, Tepp WH, Zhang SC, Johnson EA, Sawyer SL, Dong M.

PLoS Pathog. 2014 Jul 10;10(7):e1004177. doi: 10.1371/journal.ppat.1004177. eCollection 2014 Jul.

42.

Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.

White TE, Brandariz-Nuñez A, Valle-Casuso JC, Knowlton C, Kim B, Sawyer SL, Diaz-Griffero F.

Virology. 2014 Jul;460-461:34-44. doi: 10.1016/j.virol.2014.04.023. Epub 2014 May 29.

43.

Reply to Schmitt et al.: Data-filtering schemes for avoiding double-counting in circle sequencing.

Hussmann JA, Lou DI, Sawyer SL, Press WH.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):E1561. No abstract available.

44.

Positive selection of primate genes that promote HIV-1 replication.

Meyerson NR, Rowley PA, Swan CH, Le DT, Wilkerson GK, Sawyer SL.

Virology. 2014 Apr;454-455:291-8. doi: 10.1016/j.virol.2014.02.029. Epub 2014 Mar 21.

45.

An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.

Brownstein CA, Beggs AH, Homer N, Merriman B, Yu TW, Flannery KC, DeChene ET, Towne MC, Savage SK, Price EN, Holm IA, Luquette LJ, Lyon E, Majzoub J, Neupert P, McCallie D Jr, Szolovits P, Willard HF, Mendelsohn NJ, Temme R, Finkel RS, Yum SW, Medne L, Sunyaev SR, Adzhubey I, Cassa CA, de Bakker PI, Duzkale H, Dworzyński P, Fairbrother W, Francioli L, Funke BH, Giovanni MA, Handsaker RE, Lage K, Lebo MS, Lek M, Leshchiner I, MacArthur DG, McLaughlin HM, Murray MF, Pers TH, Polak PP, Raychaudhuri S, Rehm HL, Soemedi R, Stitziel NO, Vestecka S, Supper J, Gugenmus C, Klocke B, Hahn A, Schubach M, Menzel M, Biskup S, Freisinger P, Deng M, Braun M, Perner S, Smith RJ, Andorf JL, Huang J, Ryckman K, Sheffield VC, Stone EM, Bair T, Black-Ziegelbein EA, Braun TA, Darbro B, DeLuca AP, Kolbe DL, Scheetz TE, Shearer AE, Sompallae R, Wang K, Bassuk AG, Edens E, Mathews K, Moore SA, Shchelochkov OA, Trapane P, Bossler A, Campbell CA, Heusel JW, Kwitek A, Maga T, Panzer K, Wassink T, Van Daele D, Azaiez H, Booth K, Meyer N, Segal MM, Williams MS, Tromp G, White P, Corsmeier D, Fitzgerald-Butt S, Herman G, Lamb-Thrush D, McBride KL, Newsom D, Pierson CR, Rakowsky AT, Maver A, Lovrečić L, Palandačić A, Peterlin B, Torkamani A, Wedell A, Huss M, Alexeyenko A, Lindvall JM, Magnusson M, Nilsson D, Stranneheim H, Taylan F, Gilissen C, Hoischen A, van Bon B, Yntema H, Nelen M, Zhang W, Sager J, Zhang L, Blair K, Kural D, Cariaso M, Lennon GG, Javed A, Agrawal S, Ng PC, Sandhu KS, Krishna S, Veeramachaneni V, Isakov O, Halperin E, Friedman E, Shomron N, Glusman G, Roach JC, Caballero J, Cox HC, Mauldin D, Ament SA, Rowen L, Richards DR, San Lucas FA, Gonzalez-Garay ML, Caskey CT, Bai Y, Huang Y, Fang F, Zhang Y, Wang Z, Barrera J, Garcia-Lobo JM, González-Lamuño D, Llorca J, Rodriguez MC, Varela I, Reese MG, De La Vega FM, Kiruluta E, Cargill M, Hart RK, Sorenson JM, Lyon GJ, Stevenson DA, Bray BE, Moore BM, Eilbeck K, Yandell M, Zhao H, Hou L, Chen X, Yan X, Chen M, Li C, Yang C, Gunel M, Li P, Kong Y, Alexander AC, Albertyn ZI, Boycott KM, Bulman DE, Gordon PM, Innes AM, Knoppers BM, Majewski J, Marshall CR, Parboosingh JS, Sawyer SL, Samuels ME, Schwartzentruber J, Kohane IS, Margulies DM.

Genome Biol. 2014 Mar 25;15(3):R53. doi: 10.1186/gb-2014-15-3-r53.

46.

Analyzing machupo virus-receptor binding by molecular dynamics simulations.

Meyer AG, Sawyer SL, Ellington AD, Wilke CO.

PeerJ. 2014 Feb 27;2:e266. doi: 10.7717/peerj.266. eCollection 2014.

47.

Identification of genes for childhood heritable diseases.

Boycott KM, Dyment DA, Sawyer SL, Vanstone MR, Beaulieu CL.

Annu Rev Med. 2014;65:19-31. doi: 10.1146/annurev-med-101712-122108. Review.

PMID:
24422568
48.

High-throughput DNA sequencing errors are reduced by orders of magnitude using circle sequencing.

Lou DI, Hussmann JA, McBee RM, Acevedo A, Andino R, Press WH, Sawyer SL.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19872-7. doi: 10.1073/pnas.1319590110. Epub 2013 Nov 15.

49.

An evolutionary screen highlights canonical and noncanonical candidate antiviral genes within the primate TRIM gene family.

Malfavon-Borja R, Sawyer SL, Wu LI, Emerman M, Malik HS.

Genome Biol Evol. 2013;5(11):2141-54. doi: 10.1093/gbe/evt163.

50.

Exome sequencing as a diagnostic tool for pediatric-onset ataxia.

Sawyer SL, Schwartzentruber J, Beaulieu CL, Dyment D, Smith A, Warman Chardon J, Yoon G, Rouleau GA, Suchowersky O, Siu V, Murphy L, Hegele RA, Marshall CR; FORGE Canada Consortium, Bulman DE, Majewski J, Tarnopolsky M, Boycott KM.

Hum Mutat. 2014 Jan;35(1):45-9.

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