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Physiology, Development, and Disease Modeling in the Drosophila Excretory System.

Cohen E, Sawyer JK, Peterson NG, Dow JAT, Fox DT.

Genetics. 2020 Feb;214(2):235-264. doi: 10.1534/genetics.119.302289.


Targeted Deletion of Hepatocyte Abca1 Increases Plasma HDL (High-Density Lipoprotein) Reverse Cholesterol Transport via the LDL (Low-Density Lipoprotein) Receptor.

Bashore AC, Liu M, Key CC, Boudyguina E, Wang X, Carroll CM, Sawyer JK, Mullick AE, Lee RG, Macauley SL, Parks JS.

Arterioscler Thromb Vasc Biol. 2019 Sep;39(9):1747-1761. doi: 10.1161/ATVBAHA.119.312382. Epub 2019 Jun 6.


Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut.

Cohen E, Allen SR, Sawyer JK, Fox DT.

Elife. 2018 Aug 17;7. pii: e38327. doi: 10.7554/eLife.38327.


Feeding of tobacco blend or nicotine induced weight loss associated with decreased adipocyte size and increased physical activity in male mice.

Liu M, Chuang Key CC, Weckerle A, Boudyguina E, Sawyer JK, Gebre AK, Spoo W, Makwana O, Parks JS.

Food Chem Toxicol. 2018 Mar;113:287-295. doi: 10.1016/j.fct.2018.01.058. Epub 2018 Feb 5.


Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity.

Cuffe H, Liu M, Key CC, Boudyguina E, Sawyer JK, Weckerle A, Bashore A, Fried SK, Chung S, Parks JS.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):733-743. doi: 10.1161/ATVBAHA.117.309880. Epub 2018 Jan 18.


Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone.

Sawyer JK, Cohen E, Fox DT.

Development. 2017 Nov 15;144(22):4091-4102. doi: 10.1242/dev.153114. Epub 2017 Sep 25.


In vivo activation of leukocyte GPR120/FFAR4 by PUFAs has minimal impact on atherosclerosis in LDL receptor knockout mice.

Shewale SV, Brown AL, Bi X, Boudyguina E, Sawyer JK, Alexander-Miller MA, Parks JS.

J Lipid Res. 2017 Jan;58(1):236-246. doi: 10.1194/jlr.M072769. Epub 2016 Nov 3.


Targeted Knockdown of Hepatic SOAT2 With Antisense Oligonucleotides Stabilizes Atherosclerotic Plaque in ApoB100-only LDLr-/- Mice.

Melchior JT, Olson JD, Kelley KL, Wilson MD, Sawyer JK, Link KM, Rudel LL.

Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1920-7. doi: 10.1161/ATVBAHA.115.305747. Epub 2015 Jul 30.


Cholesterol esters (CE) derived from hepatic sterol O-acyltransferase 2 (SOAT2) are associated with more atherosclerosis than CE from intestinal SOAT2.

Zhang J, Sawyer JK, Marshall SM, Kelley KL, Davis MA, Wilson MD, Brown JM, Rudel LL.

Circ Res. 2014 Oct 24;115(10):826-33. doi: 10.1161/CIRCRESAHA.115.304378. Epub 2014 Sep 19.


Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration.

Cai D, Chen SC, Prasad M, He L, Wang X, Choesmel-Cadamuro V, Sawyer JK, Danuser G, Montell DJ.

Cell. 2014 May 22;157(5):1146-59. doi: 10.1016/j.cell.2014.03.045.


LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis.

Melchior JT, Sawyer JK, Kelley KL, Shah R, Wilson MD, Hantgan RR, Rudel LL.

J Lipid Res. 2013 Sep;54(9):2495-503. doi: 10.1194/jlr.M039644. Epub 2013 Jun 26.


Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice.

Bura KS, Lord C, Marshall S, McDaniel A, Thomas G, Warrier M, Zhang J, Davis MA, Sawyer JK, Shah R, Wilson MD, Dikkers A, Tietge UJ, Collet X, Rudel LL, Temel RE, Brown JM.

J Lipid Res. 2013 Jun;54(6):1567-77. doi: 10.1194/jlr.M034454. Epub 2013 Apr 5.


Phytosterol feeding causes toxicity in ABCG5/G8 knockout mice.

McDaniel AL, Alger HM, Sawyer JK, Kelley KL, Kock ND, Brown JM, Temel RE, Rudel LL.

Am J Pathol. 2013 Apr;182(4):1131-8. doi: 10.1016/j.ajpath.2012.12.014. Epub 2013 Feb 1.


Scavenger receptor class B type I is a plasma membrane cholesterol sensor.

Saddar S, Carriere V, Lee WR, Tanigaki K, Yuhanna IS, Parathath S, Morel E, Warrier M, Sawyer JK, Gerard RD, Temel RE, Brown JM, Connelly M, Mineo C, Shaul PW.

Circ Res. 2013 Jan 4;112(1):140-51. doi: 10.1161/CIRCRESAHA.112.280081. Epub 2012 Sep 28.


ACAT2 and ABCG5/G8 are both required for efficient cholesterol absorption in mice: evidence from thoracic lymph duct cannulation.

Nguyen TM, Sawyer JK, Kelley KL, Davis MA, Kent CR, Rudel LL.

J Lipid Res. 2012 Aug;53(8):1598-609. doi: 10.1194/jlr.M026823. Epub 2012 Jun 5.


Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood.

Zhang J, Kelley KL, Marshall SM, Davis MA, Wilson MD, Sawyer JK, Farese RV Jr, Brown JM, Rudel LL.

J Lipid Res. 2012 Jun;53(6):1144-52. doi: 10.1194/jlr.M024356. Epub 2012 Mar 29.


Cholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulation.

Nguyen TM, Sawyer JK, Kelley KL, Davis MA, Rudel LL.

J Lipid Res. 2012 Jan;53(1):95-104. doi: 10.1194/jlr.M018820. Epub 2011 Nov 1.


Adipose tissue ATP binding cassette transporter A1 contributes to high-density lipoprotein biogenesis in vivo.

Chung S, Sawyer JK, Gebre AK, Maeda N, Parks JS.

Circulation. 2011 Oct 11;124(15):1663-72. doi: 10.1161/CIRCULATIONAHA.111.025445. Epub 2011 Sep 19.


A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension.

Sawyer JK, Choi W, Jung KC, He L, Harris NJ, Peifer M.

Mol Biol Cell. 2011 Jul 15;22(14):2491-508. doi: 10.1091/mbc.E11-05-0411. Epub 2011 May 25.


Biliary sterol secretion is not required for macrophage reverse cholesterol transport.

Temel RE, Sawyer JK, Yu L, Lord C, Degirolamo C, McDaniel A, Marshall S, Wang N, Shah R, Rudel LL, Brown JM.

Cell Metab. 2010 Jul 7;12(1):96-102. doi: 10.1016/j.cmet.2010.05.011.


Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization.

Alger HM, Brown JM, Sawyer JK, Kelley KL, Shah R, Wilson MD, Willingham MC, Rudel LL.

J Biol Chem. 2010 May 7;285(19):14267-74. doi: 10.1074/jbc.M110.118422. Epub 2010 Mar 15.


Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism.

Chung S, Timmins JM, Duong M, Degirolamo C, Rong S, Sawyer JK, Singaraja RR, Hayden MR, Maeda N, Rudel LL, Shelness GS, Parks JS.

J Biol Chem. 2010 Apr 16;285(16):12197-209. doi: 10.1074/jbc.M109.096933. Epub 2010 Feb 23.


Morphogenesis: multitalented GTPases seeking new jobs.

Sawyer JK, Harris NJ, Peifer M.

Curr Biol. 2009 Nov 17;19(21):R985-7. doi: 10.1016/j.cub.2009.09.060. No abstract available.


Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm.

Roeth JF, Sawyer JK, Wilner DA, Peifer M.

PLoS One. 2009 Oct 28;4(10):e7634. doi: 10.1371/journal.pone.0007634.


Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis.

Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Nguyen TM, Zhu X, Duong MN, Brown AL, Lord C, Shah R, Davis MA, Kelley K, Wilson MD, Madenspacher J, Fessler MB, Parks JS, Rudel LL.

Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):24-30. doi: 10.1161/ATVBAHA.109.198036. Epub 2009 Oct 15.


How the cytoskeleton helps build the embryonic body plan: models of morphogenesis from Drosophila.

Harris TJ, Sawyer JK, Peifer M.

Curr Top Dev Biol. 2009;89:55-85. doi: 10.1016/S0070-2153(09)89003-0. Review.


The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction.

Sawyer JK, Harris NJ, Slep KC, Gaul U, Peifer M.

J Cell Biol. 2009 Jul 13;186(1):57-73. doi: 10.1083/jcb.200904001.


Influence of the epicanthal fold on the perceived direction of gaze.

West RW, Salmon TO, Sawyer JK.

Optom Vis Sci. 2008 Nov;85(11):1064-73. doi: 10.1097/OPX.0b013e31818b963b.


Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis.

Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Nguyen T, Zhu X, Duong MN, Wibley AL, Shah R, Davis MA, Kelley K, Wilson MD, Kent C, Parks JS, Rudel LL.

Circulation. 2008 Sep 30;118(14):1467-75. doi: 10.1161/CIRCULATIONAHA.108.793182. Epub 2008 Sep 15.


Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss.

Brown JM, Bell TA 3rd, Alger HM, Sawyer JK, Smith TL, Kelley K, Shah R, Wilson MD, Davis MA, Lee RG, Graham MJ, Crooke RM, Rudel LL.

J Biol Chem. 2008 Apr 18;283(16):10522-34. doi: 10.1074/jbc.M707659200. Epub 2008 Feb 14.


Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice.

Bell TA 3rd, Kelley K, Wilson MD, Sawyer JK, Rudel LL.

Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1396-402. Epub 2007 Apr 12.


Monounsaturated fatty acyl-coenzyme A is predictive of atherosclerosis in human apoB-100 transgenic, LDLr-/- mice.

Bell TA 3rd, Wilson MD, Kelley K, Sawyer JK, Rudel LL.

J Lipid Res. 2007 May;48(5):1122-31. Epub 2007 Feb 4.


Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2.

Temel RE, Lee RG, Kelley KL, Davis MA, Shah R, Sawyer JK, Wilson MD, Rudel LL.

J Lipid Res. 2005 Nov;46(11):2423-31. Epub 2005 Sep 8.


ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice.

Lee RG, Shah R, Sawyer JK, Hamilton RL, Parks JS, Rudel LL.

J Lipid Res. 2005 Jun;46(6):1205-12. Epub 2005 Apr 1.


Effects of peroxisome proliferator-activated receptor alpha/delta agonists on HDL-cholesterol in vervet monkeys.

Wallace JM, Schwarz M, Coward P, Houze J, Sawyer JK, Kelley KL, Chai A, Rudel LL.

J Lipid Res. 2005 May;46(5):1009-16. Epub 2005 Feb 16.


Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential.

Lee RG, Kelley KL, Sawyer JK, Farese RV Jr, Parks JS, Rudel LL.

Circ Res. 2004 Nov 12;95(10):998-1004. Epub 2004 Oct 14.


Influence of dietary fatty acid composition on the relationship between CETP activity and plasma lipoproteins in monkeys.

Fusegawa Y, Kelley KL, Sawyer JK, Shah RN, Rudel LL.

J Lipid Res. 2001 Nov;42(11):1849-57.


Dietary n-3 polyunsaturated fat increases the fractional catabolic rate of medium-sized HDL particles in African green monkeys.

Huggins KW, Colvin PL, Burleson ER, Kelley K, Sawyer JK, Barrett PH, Rudel LL, Parks JS.

J Lipid Res. 2001 Sep;42(9):1457-66.


Determination of the tissue sites responsible for the catabolism of large high density lipoprotein in the African green monkey.

Huggins KW, Burleson ER, Sawyer JK, Kelly K, Rudel LL, Parks JS.

J Lipid Res. 2000 Mar;41(3):384-94.


Validity of animal models for the cholesterol-raising effects of coffee diterpenes in human subjects.

de Roos B, Sawyer JK, Katan MB, Rudel LL.

Proc Nutr Soc. 1999 Aug;58(3):551-7. Review.


Dietary monounsaturated fatty acids promote aortic atherosclerosis in LDL receptor-null, human ApoB100-overexpressing transgenic mice.

Rudel LL, Kelley K, Sawyer JK, Shah R, Wilson MD.

Arterioscler Thromb Vasc Biol. 1998 Nov;18(11):1818-27.


Dietary polyunsaturated fat decreases coronary artery atherosclerosis in a pediatric-aged population of African green monkeys.

Wolfe MS, Sawyer JK, Morgan TM, Bullock BC, Rudel LL.

Arterioscler Thromb. 1994 Apr;14(4):587-97.


Noninvasive assessment of atherosclerosis in nonhuman primates.

Bond MG, Wilmoth SK, Gardin JF, Barnes RW, Sawyer JK.

Adv Exp Med Biol. 1985;183:189-95.


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