Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 195

1.

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.

Boyer DR, Li B, Sun C, Fan W, Zhou K, Hughes MP, Sawaya MR, Jiang L, Eisenberg DS.

Proc Natl Acad Sci U S A. 2020 Feb 3. pii: 201917914. doi: 10.1073/pnas.1917914117. [Epub ahead of print]

PMID:
32015135
2.

Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid.

Basavalingappa V, Bera S, Xue B, Azuri I, Tang Y, Tao K, Shimon LJW, Sawaya MR, Kolusheva S, Eisenberg DS, Kronik L, Cao Y, Wei G, Gazit E.

Nat Commun. 2019 Nov 20;10(1):5256. doi: 10.1038/s41467-019-13250-x.

3.

Non-proteinaceous hydrolase comprised of a phenylalanine metallo-supramolecular amyloid-like structure.

Makam P, Yamijala SSRKC, Tao K, Shimon LJW, Eisenberg DS, Sawaya MR, Wong BM, Gazit E.

Nat Catal. 2019 Nov;2(11):977-985. doi: 10.1038/s41929-019-0348-x. Epub 2019 Sep 23.

PMID:
31742246
4.

Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs.

Boyer DR, Li B, Sun C, Fan W, Sawaya MR, Jiang L, Eisenberg DS.

Nat Struct Mol Biol. 2019 Nov;26(11):1044-1052. doi: 10.1038/s41594-019-0322-y. Epub 2019 Nov 6.

PMID:
31695184
5.

Structure-based inhibitors of amyloid beta core suggest a common interface with tau.

Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS.

Elife. 2019 Oct 15;8. pii: e46924. doi: 10.7554/eLife.46924.

6.

Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples.

Seidler PM, Boyer DR, Murray KA, Yang TP, Bentzel M, Sawaya MR, Rosenberg G, Cascio D, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Eisenberg DS.

J Biol Chem. 2019 Nov 1;294(44):16451-16464. doi: 10.1074/jbc.RA119.009688. Epub 2019 Sep 19.

PMID:
31537646
7.

Author Correction: Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.

Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS.

Nat Struct Mol Biol. 2019 Oct;26(10):988. doi: 10.1038/s41594-019-0316-9.

PMID:
31530939
8.

Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.

Warmack RA, Boyer DR, Zee CT, Richards LS, Sawaya MR, Cascio D, Gonen T, Eisenberg DS, Clarke SG.

Nat Commun. 2019 Jul 26;10(1):3357. doi: 10.1038/s41467-019-11183-z.

9.

Cryo-EM structures of four polymorphic TDP-43 amyloid cores.

Cao Q, Boyer DR, Sawaya MR, Ge P, Eisenberg DS.

Nat Struct Mol Biol. 2019 Jul;26(7):619-627. doi: 10.1038/s41594-019-0248-4. Epub 2019 Jun 24.

PMID:
31235914
10.

Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria.

Kattke MD, Gosschalk JE, Martinez OE, Kumar G, Gale RT, Cascio D, Sawaya MR, Philips M, Brown ED, Clubb RT.

PLoS Pathog. 2019 Apr 19;15(4):e1007723. doi: 10.1371/journal.ppat.1007723. eCollection 2019 Apr.

11.

Erratum for Siegel et al., "Structure and Mechanism of LcpA, a Phosphotransferase That Mediates Glycosylation of a Gram-Positive Bacterial Cell Wall-Anchored Protein".

Siegel SD, Amer BR, Wu C, Sawaya MR, Gosschalk JE, Clubb RT, Ton-That H.

mBio. 2019 Apr 16;10(2). pii: e00617-19. doi: 10.1128/mBio.00617-19. No abstract available.

12.

Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ.

Zee CT, Glynn C, Gallagher-Jones M, Miao J, Santiago CG, Cascio D, Gonen T, Sawaya MR, Rodriguez JA.

IUCrJ. 2019 Jan 24;6(Pt 2):197-205. doi: 10.1107/S2052252518017621. eCollection 2019 Mar 1.

13.

Structure and Mechanism of LcpA, a Phosphotransferase That Mediates Glycosylation of a Gram-Positive Bacterial Cell Wall-Anchored Protein.

Siegel SD, Amer BR, Wu C, Sawaya MR, Gosschalk JE, Clubb RT, Ton-That H.

mBio. 2019 Feb 19;10(1). pii: e01580-18. doi: 10.1128/mBio.01580-18. Erratum in: MBio. 2019 Apr 16;10(2):.

14.

Transition of Metastable Cross-α Crystals into Cross-β Fibrils by β-Turn Flipping.

Mondal S, Jacoby G, Sawaya MR, Arnon ZA, Adler-Abramovich L, Rehak P, Vuković L, Shimon LJW, Král P, Beck R, Gazit E.

J Am Chem Soc. 2019 Jan 9;141(1):363-369. doi: 10.1021/jacs.8b10289. Epub 2018 Dec 26.

PMID:
30532955
15.

Author Correction: Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.

Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L.

Nat Chem. 2018 Dec;10(12):1267. doi: 10.1038/s41557-018-0182-9.

PMID:
30420778
16.

Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems.

Tuukkanen AT, Freire D, Chan S, Arbing MA, Reed RW, Evans TJ, Zenkeviciutė G, Kim J, Kahng S, Sawaya MR, Chaton CT, Wilmanns M, Eisenberg D, Parret AHA, Korotkov KV.

J Mol Biol. 2019 Jan 18;431(2):289-307. doi: 10.1016/j.jmb.2018.11.003. Epub 2018 Nov 10.

17.

Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis.

Brumshtein B, Esswein SR, Sawaya MR, Rosenberg G, Ly AT, Landau M, Eisenberg DS.

J Biol Chem. 2018 Dec 21;293(51):19659-19671. doi: 10.1074/jbc.RA118.004142. Epub 2018 Oct 24.

18.

Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.

Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L.

Nat Chem. 2018 Dec;10(12):1213-1221. doi: 10.1038/s41557-018-0147-z. Epub 2018 Oct 8. Erratum in: Nat Chem. 2018 Nov 12;:.

19.

Au courant computation of the PDB to audit diffraction anisotropy of soluble and membrane proteins.

Robert X, Kassis-Sahyoun J, Ceres N, Martin J, Sawaya MR, Read RJ, Gouet P, Falson P, Chaptal V.

Data Brief. 2018 May 19;19:753-757. doi: 10.1016/j.dib.2018.05.072. eCollection 2018 Aug.

20.

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel.

Li B, Ge P, Murray KA, Sheth P, Zhang M, Nair G, Sawaya MR, Shin WS, Boyer DR, Ye S, Eisenberg DS, Zhou ZH, Jiang L.

Nat Commun. 2018 Sep 6;9(1):3609. doi: 10.1038/s41467-018-05971-2.

21.

Atomic insights into the genesis of cellular filaments by globular proteins.

McPartland L, Heller DM, Eisenberg DS, Hochschild A, Sawaya MR.

Nat Struct Mol Biol. 2018 Aug;25(8):705-714. doi: 10.1038/s41594-018-0096-7. Epub 2018 Aug 3.

22.

Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.

Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS.

Nat Struct Mol Biol. 2018 Jun;25(6):463-471. doi: 10.1038/s41594-018-0064-2. Epub 2018 May 21. Erratum in: Nat Struct Mol Biol. 2019 Oct;26(10):988.

23.

Crystal structures of amyloidogenic segments of human transthyretin.

Saelices L, Sievers SA, Sawaya MR, Eisenberg DS.

Protein Sci. 2018 Jul;27(7):1295-1303. doi: 10.1002/pro.3420. Epub 2018 Jun 13.

24.

Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2.

Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS.

Nat Struct Mol Biol. 2018 Apr;25(4):311-319. doi: 10.1038/s41594-018-0045-5. Epub 2018 Mar 12.

25.

Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations.

Sangwan S, Sawaya MR, Murray KA, Hughes MP, Eisenberg DS.

Protein Sci. 2018 Jul;27(7):1231-1242. doi: 10.1002/pro.3391. Epub 2018 Mar 10.

26.

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks.

Hughes MP, Sawaya MR, Boyer DR, Goldschmidt L, Rodriguez JA, Cascio D, Chong L, Gonen T, Eisenberg DS.

Science. 2018 Feb 9;359(6376):698-701. doi: 10.1126/science.aan6398.

27.

Structure-based inhibitors of tau aggregation.

Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS.

Nat Chem. 2018 Feb;10(2):170-176. doi: 10.1038/nchem.2889. Epub 2017 Nov 20.

28.

Distal amyloid β-protein fragments template amyloid assembly.

Do TD, Sangwan S, de Almeida NEC, Ilitchev AI, Giammona M, Sawaya MR, Buratto SK, Eisenberg DS, Bowers MT.

Protein Sci. 2018 Jul;27(7):1181-1190. doi: 10.1002/pro.3375. Epub 2018 Feb 16.

29.

Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp.

Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA.

Nat Struct Mol Biol. 2018 Feb;25(2):131-134. doi: 10.1038/s41594-017-0018-0. Epub 2018 Jan 15.

30.

Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.

Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS.

J Biol Chem. 2018 Feb 23;293(8):2888-2902. doi: 10.1074/jbc.M117.806109. Epub 2017 Dec 27.

31.

Catastrophic disassembly of actin filaments via Mical-mediated oxidation.

Grintsevich EE, Ge P, Sawaya MR, Yesilyurt HG, Terman JR, Zhou ZH, Reisler E.

Nat Commun. 2017 Dec 19;8(1):2183. doi: 10.1038/s41467-017-02357-8.

32.

Ultrafast Time-Resolved Studies on Fluorescein for Recognition Strands Architecture in Amyloid Fibrils.

Hanczyc P, Mikhailovsky A, Boyer DR, Sawaya MR, Heeger A, Eisenberg D.

J Phys Chem B. 2018 Jan 11;122(1):8-18. doi: 10.1021/acs.jpcb.7b07923. Epub 2018 Jan 3.

PMID:
29237120
33.

X-ray diffraction reveals the intrinsic difference in the physical properties of membrane and soluble proteins.

Robert X, Kassis-Sahyoun J, Ceres N, Martin J, Sawaya MR, Read RJ, Gouet P, Falson P, Chaptal V.

Sci Rep. 2017 Dec 5;7(1):17013. doi: 10.1038/s41598-017-17216-1.

34.

Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS).

Sangwan S, Zhao A, Adams KL, Jayson CK, Sawaya MR, Guenther EL, Pan AC, Ngo J, Moore DM, Soriaga AB, Do TD, Goldschmidt L, Nelson R, Bowers MT, Koehler CM, Shaw DE, Novitch BG, Eisenberg DS.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8770-8775. doi: 10.1073/pnas.1705091114. Epub 2017 Jul 31.

35.

Neurodegeneration: Taming tangled tau.

Eisenberg DS, Sawaya MR.

Nature. 2017 Jul 13;547(7662):170-171. doi: 10.1038/nature23094. Epub 2017 Jul 5. No abstract available.

36.

Flow-aligned, single-shot fiber diffraction using a femtosecond X-ray free-electron laser.

Popp D, Loh ND, Zorgati H, Ghoshdastider U, Liow LT, Ivanova MI, Larsson M, DePonte DP, Bean R, Beyerlein KR, Gati C, Oberthuer D, Arnlund D, Brändén G, Berntsen P, Cascio D, Chavas LMG, Chen JPJ, Ding K, Fleckenstein H, Gumprecht L, Harimoorthy R, Mossou E, Sawaya MR, Brewster AS, Hattne J, Sauter NK, Seibert M, Seuring C, Stellato F, Tilp T, Eisenberg DS, Messerschmidt M, Williams GJ, Koglin JE, Makowski L, Millane RP, Forsyth T, Boutet S, White TA, Barty A, Chapman H, Chen SL, Liang M, Neutze R, Robinson RC.

Cytoskeleton (Hoboken). 2017 Dec;74(12):472-481. doi: 10.1002/cm.21378. Epub 2017 Jun 19.

37.

The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril.

Tayeb-Fligelman E, Tabachnikov O, Moshe A, Goldshmidt-Tran O, Sawaya MR, Coquelle N, Colletier JP, Landau M.

Science. 2017 Feb 24;355(6327):831-833. doi: 10.1126/science.aaf4901.

38.

Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.

de la Cruz MJ, Hattne J, Shi D, Seidler P, Rodriguez J, Reyes FE, Sawaya MR, Cascio D, Weiss SC, Kim SK, Hinck CS, Hinck AP, Calero G, Eisenberg D, Gonen T.

Nat Methods. 2017 Feb 13;14(4):399-402. doi: 10.1038/nmeth.4178.

39.

Structural Studies of Amyloid Proteins at the Molecular Level.

Eisenberg DS, Sawaya MR.

Annu Rev Biochem. 2017 Jun 20;86:69-95. doi: 10.1146/annurev-biochem-061516-045104. Epub 2017 Jan 3. Review.

PMID:
28125289
40.

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity.

Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Philipp S, Griner S, Jiang L, Glabe CG, Westermark GT, Gonen T, Eisenberg DS.

Elife. 2017 Jan 3;6. pii: e19273. doi: 10.7554/eLife.19273.

41.

Crystal Structure of the Streptomyces coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal.

Kattke MD, Chan AH, Duong A, Sexton DL, Sawaya MR, Cascio D, Elliot MA, Clubb RT.

PLoS One. 2016 Dec 9;11(12):e0167763. doi: 10.1371/journal.pone.0167763. eCollection 2016.

42.

De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure.

Colletier JP, Sawaya MR, Gingery M, Rodriguez JA, Cascio D, Brewster AS, Michels-Clark T, Hice RH, Coquelle N, Boutet S, Williams GJ, Messerschmidt M, DePonte DP, Sierra RG, Laksmono H, Koglin JE, Hunter MS, Park HW, Uervirojnangkoorn M, Bideshi DK, Brunger AT, Federici BA, Sauter NK, Eisenberg DS.

Nature. 2016 Nov 3;539(7627):43-47. doi: 10.1038/nature19825. Epub 2016 Sep 28.

43.

Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity.

Flores BN, Dulchavsky ME, Krans A, Sawaya MR, Paulson HL, Todd PK, Barmada SJ, Ivanova MI.

PLoS One. 2016 Oct 24;11(10):e0165084. doi: 10.1371/journal.pone.0165084. eCollection 2016.

44.

Characterization of WY 14,643 and its Complex with Aldose Reductase.

Sawaya MR, Verma M, Balendiran V, Rath NP, Cascio D, Balendiran GK.

Sci Rep. 2016 Oct 10;6:34394. doi: 10.1038/srep34394.

45.

Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED.

Sawaya MR, Rodriguez J, Cascio D, Collazo MJ, Shi D, Reyes FE, Hattne J, Gonen T, Eisenberg DS.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11232-11236. Epub 2016 Sep 19.

46.

The function of the PduJ microcompartment shell protein is determined by the genomic position of its encoding gene.

Chowdhury C, Chun S, Sawaya MR, Yeates TO, Bobik TA.

Mol Microbiol. 2016 Sep;101(5):770-83. doi: 10.1111/mmi.13423. Epub 2016 Jun 7.

47.

Implications for Alzheimer's disease of an atomic resolution structure of amyloid-β(1-42) fibrils.

Eisenberg DS, Sawaya MR.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9398-400. doi: 10.1073/pnas.1610806113. Epub 2016 Aug 9. No abstract available.

48.

A PII-Like Protein Regulated by Bicarbonate: Structural and Biochemical Studies of the Carboxysome-Associated CPII Protein.

Wheatley NM, Eden KD, Ngo J, Rosinski JS, Sawaya MR, Cascio D, Collazo M, Hoveida H, Hubbell WL, Yeates TO.

J Mol Biol. 2016 Oct 9;428(20):4013-4030. doi: 10.1016/j.jmb.2016.07.015. Epub 2016 Jul 25.

49.

The formation, function and regulation of amyloids: insights from structural biology.

Landreh M, Sawaya MR, Hipp MS, Eisenberg DS, Wüthrich K, Hartl FU.

J Intern Med. 2016 Aug;280(2):164-76. doi: 10.1111/joim.12500. Epub 2016 May 30. Review.

50.

Progress in low-resolution ab initio phasing with CrowdPhase.

Jorda J, Sawaya MR, Yeates TO.

Acta Crystallogr D Struct Biol. 2016 Mar;72(Pt 3):446-53. doi: 10.1107/S2059798316003405. Epub 2016 Mar 1.

Supplemental Content

Loading ...
Support Center