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Items: 1 to 50 of 193

1.

The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD.

Uematsu A, Kido K, Takahashi H, Takahashi C, Yanagihara Y, Saeki N, Yoshida S, Maekawa M, Honda M, Kai T, Shimizu K, Higashiyama S, Imai Y, Tokunaga F, Sawasaki T.

J Biol Chem. 2019 Jul 31. pii: jbc.RA119.010119. doi: 10.1074/jbc.RA119.010119. [Epub ahead of print]

2.

Cullin-3/KCTD10 complex is essential for K27-polyubiquitination of EIF3D in human hepatocellular carcinoma HepG2 cells.

Maekawa M, Hiyoshi H, Nakayama J, Kido K, Sawasaki T, Semba K, Kubota E, Joh T, Higashiyama S.

Biochem Biophys Res Commun. 2019 Sep 3;516(4):1116-1122. doi: 10.1016/j.bbrc.2019.07.010. Epub 2019 Jul 5.

3.

Tyrosine Kinase-Dependent Defense Responses Against Herbivory in Arabidopsis.

Miyamoto T, Uemura T, Nemoto K, Daito M, Nozawa A, Sawasaki T, Arimura GI.

Front Plant Sci. 2019 Jun 12;10:776. doi: 10.3389/fpls.2019.00776. eCollection 2019.

4.

PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation.

Miyakawa K, Matsunaga S, Yokoyama M, Nomaguchi M, Kimura Y, Nishi M, Kimura H, Sato H, Hirano H, Tamura T, Akari H, Miura T, Adachi A, Sawasaki T, Yamamoto N, Ryo A.

Nat Commun. 2019 Apr 23;10(1):1844. doi: 10.1038/s41467-019-09867-7.

5.

The mesenchymal transition subtype more responsive to dose dense taxane chemotherapy combined with carboplatin than to conventional taxane and carboplatin chemotherapy in high grade serous ovarian carcinoma: A survey of Japanese Gynecologic Oncology Group study (JGOG3016A1).

Murakami R, Matsumura N, Michimae H, Tanabe H, Yunokawa M, Iwase H, Sasagawa M, Nakamura T, Tokuyama O, Takano M, Sugiyama T, Sawasaki T, Isonishi S, Takehara K, Nakai H, Okamoto A, Mandai M, Konishi I.

Gynecol Oncol. 2019 May;153(2):312-319. doi: 10.1016/j.ygyno.2019.02.010. Epub 2019 Mar 8.

PMID:
30853361
6.

A multi-institutional observational study on the effects of three-dimensional radiotherapy and weekly 40-mg/m2 cisplatin on postoperative uterine cervical cancer patients with high-risk prognostic factors.

Isohashi F, Takano T, Onuki M, Arimoto T, Kawamura N, Hara R, Kawano Y, Ota Y, Inokuchi H, Shinjo H, Saito T, Fujiwara S, Sawasaki T, Ando K, Horie K, Okamoto H, Murakami N, Hasumi Y, Kasamatsu T, Toita T.

Int J Clin Oncol. 2019 May;24(5):575-582. doi: 10.1007/s10147-018-01380-z. Epub 2018 Dec 22.

7.

The Ring-Type E3 Ubiquitin Ligase JUL1 Targets the VQ-Motif Protein JAV1 to Coordinate Jasmonate Signaling.

Ali MRM, Uemura T, Ramadan A, Adachi K, Nemoto K, Nozawa A, Hoshino R, Abe H, Sawasaki T, Arimura GI.

Plant Physiol. 2019 Apr;179(4):1273-1284. doi: 10.1104/pp.18.00715. Epub 2018 Dec 20.

8.

Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system.

Nakanishi A, Kaneko N, Takeda H, Sawasaki T, Morikawa S, Zhou W, Kurata M, Yamamoto T, Akbar SMF, Zako T, Masumoto J.

Inflamm Regen. 2018 Nov 12;38:27. doi: 10.1186/s41232-018-0085-6. eCollection 2018.

9.

The ubiquitin ligase RNF38 promotes RUNX1 ubiquitination and enhances RUNX1-mediated suppression of erythroid transcription program.

Yonezawa T, Takahashi H, Shikata S, Sawasaki T, Kitamura T, Goyama S.

Biochem Biophys Res Commun. 2018 Nov 2;505(3):905-909. doi: 10.1016/j.bbrc.2018.10.006. Epub 2018 Oct 9.

PMID:
30309654
10.

Engineered membrane protein antigens successfully induce antibodies against extracellular regions of claudin-5.

Hashimoto Y, Zhou W, Hamauchi K, Shirakura K, Doi T, Yagi K, Sawasaki T, Okada Y, Kondoh M, Takeda H.

Sci Rep. 2018 May 30;8(1):8383. doi: 10.1038/s41598-018-26560-9.

11.

The malaria parasite RhopH protein complex interacts with erythrocyte calmyrin identified from a comprehensive erythrocyte protein library.

Miura T, Takeo S, Ntege EH, Otsuki H, Sawasaki T, Ishino T, Takashima E, Tsuboi T.

Biochem Biophys Res Commun. 2018 Jun 2;500(2):261-267. doi: 10.1016/j.bbrc.2018.04.056. Epub 2018 Apr 13.

PMID:
29653104
12.

[AGIA tag system: a super-sensitive detection and capture peptide tag suitable for cell biology].

Takeda H, Sawasaki T.

Seikagaku. 2017 Apr;89(2):302-7. Japanese. No abstract available.

PMID:
29625003
13.

Identification of new abscisic acid receptor agonists using a wheat cell-free based drug screening system.

Nemoto K, Kagawa M, Nozawa A, Hasegawa Y, Hayashi M, Imai K, Tomii K, Sawasaki T.

Sci Rep. 2018 Mar 9;8(1):4268. doi: 10.1038/s41598-018-22538-9.

14.

Functional G-Protein-Coupled Receptor (GPCR) Synthesis: The Pharmacological Analysis of Human Histamine H1 Receptor (HRH1) Synthesized by a Wheat Germ Cell-Free Protein Synthesis System Combined with Asolectin Glycerosomes.

Suzuki Y, Ogasawara T, Tanaka Y, Takeda H, Sawasaki T, Mogi M, Liu S, Maeyama K.

Front Pharmacol. 2018 Feb 6;9:38. doi: 10.3389/fphar.2018.00038. eCollection 2018.

15.

DANFIN functions as an inhibitor of transcription factor NF-κB and potentiates the antitumor effect of bortezomib in multiple myeloma.

Uematsu A, Kido K, Manabe E, Takeda H, Takahashi H, Hayashi M, Imai Y, Sawasaki T.

Biochem Biophys Res Commun. 2018 Jan 15;495(3):2289-2295. doi: 10.1016/j.bbrc.2017.12.142. Epub 2017 Dec 25.

16.

Applications of reconstituted inflammasomes in a cell-free system to drug discovery and elucidation of the pathogenesis of autoinflammatory diseases.

Kaneko N, Iwasaki T, Ito Y, Takeda H, Sawasaki T, Morikawa S, Nakano N, Kurata M, Masumoto J.

Inflamm Regen. 2017 May 3;37:9. doi: 10.1186/s41232-017-0040-y. eCollection 2017. Review.

17.

Tyrosine phosphorylation of the GARU E3 ubiquitin ligase promotes gibberellin signalling by preventing GID1 degradation.

Nemoto K, Ramadan A, Arimura GI, Imai K, Tomii K, Shinozaki K, Sawasaki T.

Nat Commun. 2017 Oct 17;8(1):1004. doi: 10.1038/s41467-017-01005-5.

18.

Involvement of PUF60 in Transcriptional and Post-transcriptional Regulation of Hepatitis B Virus Pregenomic RNA Expression.

Sun S, Nakashima K, Ito M, Li Y, Chida T, Takahashi H, Watashi K, Sawasaki T, Wakita T, Suzuki T.

Sci Rep. 2017 Oct 9;7(1):12874. doi: 10.1038/s41598-017-12497-y.

19.

Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model.

Hashimoto Y, Shirakura K, Okada Y, Takeda H, Endo K, Tamura M, Watari A, Sadamura Y, Sawasaki T, Doi T, Yagi K, Kondoh M.

J Pharmacol Exp Ther. 2017 Nov;363(2):275-283. doi: 10.1124/jpet.117.243014. Epub 2017 Aug 17.

PMID:
28819070
20.

Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models.

Liu S, Hasegawa H, Takemasa E, Suzuki Y, Oka K, Kiyoi T, Takeda H, Ogasawara T, Sawasaki T, Yasukawa M, Maeyama K.

J Immunol. 2017 Sep 1;199(5):1584-1595. doi: 10.4049/jimmunol.1700192. Epub 2017 Jul 17.

21.

Autophosphorylation Assays Using Plant Receptor Kinases Synthesized in Cell-Free Systems.

Nemoto K, Nozawa A, Yamanaka S, Nomura S, Kido K, Sawasaki T.

Methods Mol Biol. 2017;1621:113-120. doi: 10.1007/978-1-4939-7063-6_11.

PMID:
28567648
22.

Cell-Free Synthesis of Plant Receptor Kinases.

Nozawa A, Nemoto K, Nomura S, Yamanaka S, Kido K, Sawasaki T.

Methods Mol Biol. 2017;1621:37-46. doi: 10.1007/978-1-4939-7063-6_4.

PMID:
28567641
23.

CP5 system, for simple and highly efficient protein purification with a C-terminal designed mini tag.

Takeda H, Zhou W, Kido K, Suno R, Iwasaki T, Kobayashi T, Sawasaki T.

PLoS One. 2017 May 25;12(5):e0178246. doi: 10.1371/journal.pone.0178246. eCollection 2017.

24.

The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1.

Yonezawa T, Takahashi H, Shikata S, Liu X, Tamura M, Asada S, Fukushima T, Fukuyama T, Tanaka Y, Sawasaki T, Kitamura T, Goyama S.

J Biol Chem. 2017 Jul 28;292(30):12528-12541. doi: 10.1074/jbc.M117.785675. Epub 2017 May 23.

25.

Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction.

Krug SM, Hayaishi T, Iguchi D, Watari A, Takahashi A, Fromm M, Nagahama M, Takeda H, Okada Y, Sawasaki T, Doi T, Yagi K, Kondoh M.

J Control Release. 2017 Aug 28;260:1-11. doi: 10.1016/j.jconrel.2017.05.024. Epub 2017 May 18.

PMID:
28528740
26.

Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks.

Yamamoto T, Taira Nihira N, Yogosawa S, Aoki K, Takeda H, Sawasaki T, Yoshida K.

FEBS Lett. 2017 Mar;591(6):842-853. doi: 10.1002/1873-3468.12596. Epub 2017 Mar 6.

27.

HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.

Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, Inoue JI.

PLoS Pathog. 2017 Jan 19;13(1):e1006162. doi: 10.1371/journal.ppat.1006162. eCollection 2017 Jan.

28.

OsMYC2, an essential factor for JA-inductive sakuranetin production in rice, interacts with MYC2-like proteins that enhance its transactivation ability.

Ogawa S, Miyamoto K, Nemoto K, Sawasaki T, Yamane H, Nojiri H, Okada K.

Sci Rep. 2017 Jan 9;7:40175. doi: 10.1038/srep40175.

29.

Plant Aurora kinases interact with and phosphorylate transcription factors.

Takagi M, Sakamoto T, Suzuki R, Nemoto K, Obayashi T, Hirakawa T, Matsunaga TM, Kurihara D, Nariai Y, Urano T, Sawasaki T, Matsunaga S.

J Plant Res. 2016 Nov;129(6):1165-1178. Epub 2016 Oct 12.

PMID:
27734173
30.

Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop.

Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Maruyama S, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K, Nakayama T, Ohara O, Yasukawa M, Sawasaki T, Kurosaki T, Yamashita M.

Nat Commun. 2016 Sep 1;7:12596. doi: 10.1038/ncomms12596.

31.

Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage.

Sakamaki K, Ishii TM, Sakata T, Takemoto K, Takagi C, Takeuchi A, Morishita R, Takahashi H, Nozawa A, Shinoda H, Chiba K, Sugimoto H, Saito A, Tamate S, Satou Y, Jung SK, Matsuoka S, Koyamada K, Sawasaki T, Nagai T, Ueno N.

Biochim Biophys Acta. 2016 Nov;1863(11):2766-2783. doi: 10.1016/j.bbamcr.2016.08.010. Epub 2016 Aug 23.

32.

Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.

Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, Tokunaga F.

Nat Commun. 2016 Aug 24;7:12547. doi: 10.1038/ncomms12547.

33.

Nod2-Nodosome in a Cell-Free System: Implications in Pathogenesis and Drug Discovery for Blau Syndrome and Early-Onset Sarcoidosis.

Iwasaki T, Kaneko N, Ito Y, Takeda H, Sawasaki T, Heike T, Migita K, Agematsu K, Kawakami A, Morikawa S, Mokuda S, Kurata M, Masumoto J.

ScientificWorldJournal. 2016;2016:2597376. doi: 10.1155/2016/2597376. Epub 2016 Jun 15.

34.

H11/HSPB8 Restricts HIV-2 Vpx to Restore the Anti-Viral Activity of SAMHD1.

Kudoh A, Miyakawa K, Matsunaga S, Matsushima Y, Kosugi I, Kimura H, Hayakawa S, Sawasaki T, Ryo A.

Front Microbiol. 2016 Jun 13;7:883. doi: 10.3389/fmicb.2016.00883. eCollection 2016.

35.

MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis.

Santolini M, Sakakibara I, Gauthier M, Ribas-Aulinas F, Takahashi H, Sawasaki T, Mouly V, Concordet JP, Defossez PA, Hakim V, Maire P.

Nucleic Acids Res. 2016 Oct 14;44(18):8621-8640. Epub 2016 Jun 14.

36.

AGIA Tag System Based on a High Affinity Rabbit Monoclonal Antibody against Human Dopamine Receptor D1 for Protein Analysis.

Yano T, Takeda H, Uematsu A, Yamanaka S, Nomura S, Nemoto K, Iwasaki T, Takahashi H, Sawasaki T.

PLoS One. 2016 Jun 6;11(6):e0156716. doi: 10.1371/journal.pone.0156716. eCollection 2016.

37.

Establishment of a Wheat Cell-Free Synthesized Protein Array Containing 250 Human and Mouse E3 Ubiquitin Ligases to Identify Novel Interaction between E3 Ligases and Substrate Proteins.

Takahashi H, Uematsu A, Yamanaka S, Imamura M, Nakajima T, Doi K, Yasuoka S, Takahashi C, Takeda H, Sawasaki T.

PLoS One. 2016 Jun 1;11(6):e0156718. doi: 10.1371/journal.pone.0156718. eCollection 2016.

38.

Involvement of the 3' Untranslated Region in Encapsidation of the Hepatitis C Virus.

Shi G, Ando T, Suzuki R, Matsuda M, Nakashima K, Ito M, Omatsu T, Oba M, Ochiai H, Kato T, Mizutani T, Sawasaki T, Wakita T, Suzuki T.

PLoS Pathog. 2016 Feb 11;12(2):e1005441. doi: 10.1371/journal.ppat.1005441. eCollection 2016 Feb.

39.

Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells.

Suzuki J, Maruyama S, Tamauchi H, Kuwahara M, Horiuchi M, Mizuki M, Ochi M, Sawasaki T, Zhu J, Yasukawa M, Yamashita M.

Immunology. 2016 Apr;147(4):476-87. doi: 10.1111/imm.12580. Epub 2016 Feb 9.

40.

Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication.

Suzuki Y, Chin WX, Han Q, Ichiyama K, Lee CH, Eyo ZW, Ebina H, Takahashi H, Takahashi C, Tan BH, Hishiki T, Ohba K, Matsuyama T, Koyanagi Y, Tan YJ, Sawasaki T, Chu JJ, Vasudevan SG, Sano K, Yamamoto N.

PLoS Pathog. 2016 Jan 6;12(1):e1005357. doi: 10.1371/journal.ppat.1005357. eCollection 2016 Jan.

41.

A cell-free enzymatic activity assay for the evaluation of HIV-1 drug resistance to protease inhibitors.

Matsunaga S, Masaoka T, Sawasaki T, Morishita R, Iwatani Y, Tatsumi M, Endo Y, Yamamoto N, Sugiura W, Ryo A.

Front Microbiol. 2015 Oct 31;6:1220. doi: 10.3389/fmicb.2015.01220. eCollection 2015.

42.

Wheat germ-based protein libraries for the functional characterisation of the Arabidopsis E2 ubiquitin conjugating enzymes and the RING-type E3 ubiquitin ligase enzymes.

Ramadan A, Nemoto K, Seki M, Shinozaki K, Takeda H, Takahashi H, Sawasaki T.

BMC Plant Biol. 2015 Nov 10;15:275. doi: 10.1186/s12870-015-0660-9.

43.

Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD.

Furukawa H, Oka S, Shimada K, Masuo K, Nakajima F, Funano S, Tanaka Y, Komiya A, Fukui N, Sawasaki T, Tadokoro K, Nose M, Tsuchiya N, Tohma S.

Biomark Insights. 2015 Aug 16;10:63-73. doi: 10.4137/BMI.S28209. eCollection 2015.

44.

Reconstituted AIM2 inflammasome in cell-free system.

Kaneko N, Ito Y, Iwasaki T, Takeda H, Sawasaki T, Migita K, Agematsu K, Kawakami A, Morikawa S, Mokuda S, Kurata M, Masumoto J.

J Immunol Methods. 2015 Nov;426:76-81. doi: 10.1016/j.jim.2015.08.004. Epub 2015 Aug 8.

PMID:
26259507
45.

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly.

Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, Kii I, Nishiyama T, Kakita A, Takeda H, Takeuchi A, Arai Y, Ito A, Komura H, Hirao H, Satomura K, Inoue M, Muramatsu S, Matsui K, Tada M, Sato M, Saijo E, Shigemitsu Y, Sakai S, Umetsu Y, Goda N, Takino N, Takahashi H, Hagiwara M, Sawasaki T, Iwasaki G, Nakamura Y, Nabeshima Y, Teplow DB, Hoshi M.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4465-74. doi: 10.1073/pnas.1421182112. Epub 2015 Jul 29.

46.

Functional Characterization of the Receiver Domain for Phosphorelay Control in Hybrid Sensor Kinases.

Kinoshita-Kikuta E, Kinoshita E, Eguchi Y, Yanagihara S, Edahiro K, Inoue Y, Taniguchi M, Yoshida M, Yamamoto K, Takahashi H, Sawasaki T, Utsumi R, Koike T.

PLoS One. 2015 Jul 7;10(7):e0132598. doi: 10.1371/journal.pone.0132598. eCollection 2015. Erratum in: PLoS One. 2015;10(8):e0136022.

47.

Claudin-1 Binder Enhances Epidermal Permeability in a Human Keratinocyte Model.

Nakajima M, Nagase S, Iida M, Takeda S, Yamashita M, Watari A, Shirasago Y, Fukasawa M, Takeda H, Sawasaki T, Yagi K, Kondoh M.

J Pharmacol Exp Ther. 2015 Sep;354(3):440-7. doi: 10.1124/jpet.115.225391. Epub 2015 Jul 2.

PMID:
26139628
48.

Novel Autoantigens Associated with Lupus Nephritis.

Onishi S, Adnan E, Ishizaki J, Miyazaki T, Tanaka Y, Matsumoto T, Suemori K, Shudou M, Okura T, Takeda H, Sawasaki T, Yasukawa M, Hasegawa H.

PLoS One. 2015 Jun 22;10(6):e0126564. doi: 10.1371/journal.pone.0126564. eCollection 2015.

49.

Production of monoclonal antibodies against GPCR using cell-free synthesized GPCR antigen and biotinylated liposome-based interaction assay.

Takeda H, Ogasawara T, Ozawa T, Muraguchi A, Jih PJ, Morishita R, Uchigashima M, Watanabe M, Fujimoto T, Iwasaki T, Endo Y, Sawasaki T.

Sci Rep. 2015 Jun 10;5:11333. doi: 10.1038/srep11333.

50.

Members of the Plant CRK Superfamily Are Capable of Trans- and Autophosphorylation of Tyrosine Residues.

Nemoto K, Takemori N, Seki M, Shinozaki K, Sawasaki T.

J Biol Chem. 2015 Jul 3;290(27):16665-77. doi: 10.1074/jbc.M114.617274. Epub 2015 May 12.

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