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Items: 1 to 50 of 69

1.

Structure-Activity Relationship Studies of 3- or 4-Pyridine Derivatives of DS-6930.

Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Matsui Y, Wakimoto S, Ogata T, Araki K, Sawamura R, Watanabe N, Mori M, Tanaka J.

ACS Med Chem Lett. 2019 Feb 26;10(3):358-362. doi: 10.1021/acsmedchemlett.8b00645. eCollection 2019 Mar 14.

2.

Functional characterization of UBXN-6, a C-terminal cofactor of CDC-48, in C. elegans.

Mojumder S, Sawamura R, Murayama Y, Ogura T, Yamanaka K.

Biochem Biophys Res Commun. 2019 Feb 5;509(2):462-468. doi: 10.1016/j.bbrc.2018.12.155. Epub 2018 Dec 27.

PMID:
30595383
3.

Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification.

Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Shimada K, Onishi Y, Matsui Y, Wakimoto S, Kuroha M, Ogata T, Araki K, Ohsumi J, Sawamura R, Watanabe N, Yamamoto H, Fujimoto K, Tani Y, Mori M, Tanaka J.

Bioorg Med Chem. 2018 Oct 1;26(18):5079-5098. doi: 10.1016/j.bmc.2018.09.006. Epub 2018 Sep 8.

PMID:
30241907
4.

Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization.

Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Shimada K, Onishi Y, Matsui Y, Wakimoto S, Kuroha M, Ogata T, Araki K, Ohsumi J, Sawamura R, Watanabe N, Yamamoto H, Fujimoto K, Tani Y, Mori M, Tanaka J.

Bioorg Med Chem. 2018 Oct 1;26(18):5099-5117. doi: 10.1016/j.bmc.2018.09.005. Epub 2018 Sep 8.

PMID:
30220602
5.

Autoimmune hepatitis in 828 Brazilian children and adolescents: clinical and laboratory findings, histological profile, treatments, and outcomes.

Porta G, Carvalho E, Santos JL, Gama J, Borges CV, Seixas RBPM, Ferreira AR, Miura IK, Silveira TR, Silva LR, Fagundes EDT, Bellomo-Brandao MA, Sawamura R, Vieira SM, Melere MU, Marques CDF, Pugliese RP, Danesi VL, Porta A, Marsillac ME, Valladares MA, Menezes DG, Kieling C, Paula MN, Vasconcelos JR, Ferreira CT, Perin N, Resende LR, Maia J, Tommaso AMA, Hessel G.

J Pediatr (Rio J). 2019 Jul - Aug;95(4):419-427. doi: 10.1016/j.jped.2018.04.007. Epub 2018 May 30.

6.

Daidzein reductase of Eggerthella sp. YY7918, its octameric subunit structure containing FMN/FAD/4Fe-4S, and its enantioselective production of R-dihydroisoflavones.

Kawada Y, Goshima T, Sawamura R, Yokoyama SI, Yanase E, Niwa T, Ebihara A, Inagaki M, Yamaguchi K, Kuwata K, Kato Y, Sakurada O, Suzuki T.

J Biosci Bioeng. 2018 Sep;126(3):301-309. doi: 10.1016/j.jbiosc.2018.03.018. Epub 2018 Apr 23.

PMID:
29699942
7.

Evaluation of nonalcoholic fatty liver disease using magnetic resonance in obese children and adolescents.

Benetolo PO, Fernandes MIM, Ciampo IRLD, Elias-Junior J, Sawamura R.

J Pediatr (Rio J). 2019 Jan - Feb;95(1):34-40. doi: 10.1016/j.jped.2017.12.010. Epub 2018 Feb 10.

8.

DNA methylation analyses of the candidate genes identified by a methylome-wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder.

Sugawara H, Murata Y, Ikegame T, Sawamura R, Shimanaga S, Takeoka Y, Saito T, Ikeda M, Yoshikawa A, Nishimura F, Kawamura Y, Kakiuchi C, Sasaki T, Iwata N, Hashimoto M, Kasai K, Kato T, Bundo M, Iwamoto K.

Psychiatry Clin Neurosci. 2018 Apr;72(4):245-254. doi: 10.1111/pcn.12645. Epub 2018 Mar 11.

9.

ACRODERMATITIS ENTEROPATHICA: CLINICAL MANIFESTATIONS AND PEDIATRIC DIAGNOSIS.

Ciampo IRLD, Sawamura R, Ciampo LAD, Fernandes MIM.

Rev Paul Pediatr. 2018 Apr-Jun;36(2):238-241. doi: 10.1590/1984-0462/;2018;36;2;00010. Epub 2018 Jan 15. Portuguese, English.

10.

Generation of biallelic F0 mutants in medaka using the CRISPR/Cas9 system.

Sawamura R, Osafune N, Murakami T, Furukawa F, Kitano T.

Genes Cells. 2017 Aug;22(8):756-763. doi: 10.1111/gtc.12511. Epub 2017 Jul 14.

11.

Assessing the proposed association between DED and gluten-free diet introduction in celiac children.

de Queiroz AM, Arid J, de Carvalho FK, da Silva RAB, Küchler EC, Sawamura R, da Silva LAB, Nelson-Filho P.

Spec Care Dentist. 2017 Jul;37(4):194-198. doi: 10.1111/scd.12227.

PMID:
28677884
12.

Endoscopic Treatment of Gastric Outlet Obstruction Secondary to Accidental Acid Ingestion in a Child.

Andrade M, Sawamura R, Cupo P, Del Ciampo IR, Fernandes MI.

J Pediatr Gastroenterol Nutr. 2016 Jan;62(1):90-2. doi: 10.1097/MPG.0000000000000936.

PMID:
26252917
13.

Nutritional status of adolescents with cystic fibrosis treated at a reference center in the southeast region of Brazil.

Del Ciampo IR, Del Ciampo LA, Sawamura R, de Oliveira LR, Fernandes MI.

Ital J Pediatr. 2015 Jul 30;41:51. doi: 10.1186/s13052-015-0159-x.

14.

Pharmacokinetics of loxoprofen and its active metabolite after dermal application of loxoprofen gel to rats.

Sawamura R, Kazui M, Kurihara A, Izumi T.

Pharmazie. 2015 Feb;70(2):74-80.

PMID:
25997245
15.

[Early manifestations of cystic fibrosis in a premature patient with complex meconium ileus at birth].

del Ciampo IR, Oliveira TQ, del Ciampo LA, Sawamura R, Torres LA, Augustin AE, Fernandes MI.

Rev Paul Pediatr. 2015 Apr-Jun;33(2):241-5. doi: 10.1016/j.rpped.2014.12.004. Epub 2015 Mar 28. Portuguese.

16.

Oral aspects in celiac disease children: clinical and dental enamel chemical evaluation.

de Carvalho FK, de Queiroz AM, Bezerra da Silva RA, Sawamura R, Bachmann L, Bezerra da Silva LA, Nelson-Filho P.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Jun;119(6):636-43. doi: 10.1016/j.oooo.2015.02.483. Epub 2015 Mar 2.

17.

Bioactivation of loxoprofen to a pharmacologically active metabolite and its disposition kinetics in human skin.

Sawamura R, Sakurai H, Wada N, Nishiya Y, Honda T, Kazui M, Kurihara A, Shinagawa A, Izumi T.

Biopharm Drug Dispos. 2015 Sep;36(6):352-363. doi: 10.1002/bdd.1945. Epub 2015 Apr 21.

PMID:
25765700
18.

The role of G-protein-coupled receptor 120 in fatty acids sensing in chicken oral tissues.

Sawamura R, Kawabata Y, Kawabata F, Nishimura S, Tabata S.

Biochem Biophys Res Commun. 2015 Mar 6;458(2):387-91. doi: 10.1016/j.bbrc.2015.01.125. Epub 2015 Feb 3.

PMID:
25656577
19.

Absorption, distribution, metabolism and excretion of loxoprofen after dermal application of loxoprofen gel to rats.

Sawamura R, Kazui M, Kurihara A, Izumi T.

Xenobiotica. 2014 Nov;44(11):1026-38. doi: 10.3109/00498254.2014.926571. Epub 2014 Jun 11.

PMID:
24916900
20.

Cystic fibrosis: from protein-energy malnutrition to obesity with dyslipidemia.

Del Ciampo IR, Sawamura R, Fernandes MI.

Iran J Pediatr. 2013 Oct;23(5):605-6. No abstract available.

21.

A conserved α helix of Bcs1, a mitochondrial AAA chaperone, is required for the Respiratory Complex III maturation.

Sawamura R, Ogura T, Esaki M.

Biochem Biophys Res Commun. 2014 Jan 17;443(3):997-1002. doi: 10.1016/j.bbrc.2013.12.084. Epub 2013 Dec 19.

PMID:
24361883
22.

Antiviral activity of diarylheptanoid stereoisomers against respiratory syncytial virus in vitro and in vivo.

Konno K, Miura M, Toriyama M, Motohashi S, Sawamura R, Watanabe W, Yoshida H, Kato M, Yamamoto R, Yasukawa K, Kurokawa M.

J Nat Med. 2013 Oct;67(4):773-81. doi: 10.1007/s11418-013-0743-6. Epub 2013 Jan 24.

PMID:
23344928
23.

Autoimmune hepatitis associated with leprosy in a child.

Sawamura R, Frade MA, Ramalho LN, Roxo Junior P, Benevides L, Fernandes MI.

J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):e15-6. doi: 10.1097/MPG.0b013e31824cf539. No abstract available.

PMID:
22331015
24.

Antiviral activities of diarylheptanoids isolated from Alpinia officinarum against respiratory syncytial virus, poliovirus, measles virus, and herpes simplex virus type 1 in vitro.

Konno K, Sawamura R, Sun Y, Yasukawa K, Shimizu T, Watanabe W, Kato M, Yamamoto R, Kurokawa M.

Nat Prod Commun. 2011 Dec;6(12):1881-4.

PMID:
22312729
25.

Association of Wilson disease with neurofibromatosis.

Sawamura R, Ottoboni-Brunaldi M, Ramalho LN, Zucoloto S, Balancin ML, Fernandes MI.

Rev Esp Enferm Dig. 2011 Oct;103(10):551-3. English, Spanish. No abstract available.

26.

Efficacy of Brazilian Propolis against Herpes Simplex Virus Type 1 Infection in Mice and Their Modes of Antiherpetic Efficacies.

Shimizu T, Takeshita Y, Takamori Y, Kai H, Sawamura R, Yoshida H, Watanabe W, Tsutsumi A, Park YK, Yasukawa K, Matsuno K, Shiraki K, Kurokawa M.

Evid Based Complement Alternat Med. 2011;2011:976196. doi: 10.1155/2011/976196. Epub 2011 Jun 14.

27.

Longitudinal evaluation of hepatic osteodystrophy in children and adolescents with chronic cholestatic liver disease.

Taveira AT, Pereira FA, Fernandes MI, Sawamura R, Nogueira-Barbosa MH, Paula FJ.

Braz J Med Biol Res. 2010 Nov;43(11):1127-34. Epub 2010 Oct 29.

28.

In vitro and in vivo anti-influenza virus activity of diarylheptanoids isolated from Alpinia officinarum.

Sawamura R, Shimizu T, Sun Y, Yasukawa K, Miura M, Toriyama M, Motohashi S, Watanabe W, Konno K, Kurokawa M.

Antivir Chem Chemother. 2010 Oct 28;21(1):33-41. doi: 10.3851/IMP1676.

PMID:
21045258
29.

Hepatoportal sclerosis and extrahepatic portal venous obstruction associated with anti-phospholipid antibody syndrome in child.

Sawamura R, Louzada-Junior P, Ferriani VP, Ramalho LN, Fernandes MI.

J Trop Pediatr. 2011 Jun;57(3):222-4. doi: 10.1093/tropej/fmq069. Epub 2010 Jul 31.

PMID:
20675717
30.

Predictability of idiosyncratic drug toxicity risk for carboxylic acid-containing drugs based on the chemical stability of acyl glucuronide.

Sawamura R, Okudaira N, Watanabe K, Murai T, Kobayashi Y, Tachibana M, Ohnuki T, Masuda K, Honma H, Kurihara A, Okazaki O.

Drug Metab Dispos. 2010 Oct;38(10):1857-64. doi: 10.1124/dmd.110.034173. Epub 2010 Jul 6. Erratum in: Drug Metab Dispos. 2010 Dec;38(12):2347.

PMID:
20606003
31.

Functional disorder of primary immunity responding to respiratory syncytial virus infection in offspring mice exposed to a flame retardant, decabrominated diphenyl ether, perinatally.

Watanabe W, Shimizu T, Sawamura R, Hino A, Konno K, Kurokawa M.

J Med Virol. 2010 May;82(6):1075-82. doi: 10.1002/jmv.21770.

PMID:
20419825
32.

Antiviral activities of diarylheptanoids against influenza virus in vitro.

Sawamura R, Sun Y, Yasukawa K, Shimizu T, Watanabe W, Kurokawa M.

J Nat Med. 2010 Jan;64(1):117-20. doi: 10.1007/s11418-009-0372-2. Epub 2009 Nov 7.

PMID:
20091245
33.

Effects of tetrabromobisphenol A, a brominated flame retardant, on the immune response to respiratory syncytial virus infection in mice.

Watanabe W, Shimizu T, Sawamura R, Hino A, Konno K, Hirose A, Kurokawa M.

Int Immunopharmacol. 2010 Apr;10(4):393-7. doi: 10.1016/j.intimp.2009.12.014. Epub 2010 Jan 13.

PMID:
20074668
34.

Modulation of cytokine production by 7-hydroxycoumarin in vitro and its efficacy against influenza infection in mice.

Kurokawa M, Watanabe W, Shimizu T, Sawamura R, Shiraki K.

Antiviral Res. 2010 Feb;85(2):373-80. doi: 10.1016/j.antiviral.2009.11.001. Epub 2009 Nov 11.

PMID:
19913056
35.

Novel CC chemokine receptor 4 antagonist RS-1154 inhibits ovalbumin-induced ear swelling in mice.

Nakagami Y, Kawashima K, Yonekubo K, Etori M, Jojima T, Miyazaki S, Sawamura R, Hirahara K, Nara F, Yamashita M.

Eur J Pharmacol. 2009 Dec 10;624(1-3):38-44. doi: 10.1016/j.ejphar.2009.09.058. Epub 2009 Oct 8.

PMID:
19818758
36.

Evaluation of swallowing in children with vomiting after feeding.

Duca AP, Dantas RO, Rodrigues AA, Sawamura R.

Dysphagia. 2008 Jun;23(2):177-82. Epub 2007 Nov 1.

PMID:
17973160
37.

Impairment of bone mass development in children with chronic cholestatic liver disease.

de Albuquerque Taveira AT, Fernandes MI, Galvão LC, Sawamura R, de Mello Vieira E, de Paula FJ.

Clin Endocrinol (Oxf). 2007 Apr;66(4):518-23.

PMID:
17371469
38.

Occurrence and production of chloramines in the chlorination of creatinine in aqueous solution.

Tachikawa M, Aburada T, Tezuka M, Sawamura R.

Water Res. 2005 Jan-Feb;39(2-3):371-9. Epub 2004 Nov 30.

PMID:
15644245
39.

Effects of isocyanuric acid on the monochlorodimedone chlorinating rates with free chlorine and ammonia chloramine in water.

Tachikawa M, Sayama C, Saita K, Tezuka M, Sawamura R.

Water Res. 2002 May;36(10):2547-54.

PMID:
12153021
40.

Human leukocyte antigen class II alleles in white Brazilian patients with celiac disease.

Silva EM, Fernandes MI, Galvão LC, Sawamura R, Donadi EA.

J Pediatr Gastroenterol Nutr. 2000 Oct;31(4):391-4.

PMID:
11045836
41.

Inhibitory effect of azole antifungal agents on the glucuronidation of lorazepam using rabbit liver microsomes in vitro.

Sawamura R, Sato H, Kawakami J, Iga T.

Biol Pharm Bull. 2000 May;23(5):669-71.

PMID:
10823688
42.

Hepatic capillariasis in children: report of 3 cases in Brazil.

Sawamura R, Fernandes MI, Peres LC, Galvão LC, Goldani HA, Jorge SM, de Melo Rocha G, de Souza NM.

Am J Trop Med Hyg. 1999 Oct;61(4):642-7.

PMID:
10548302
43.

[Increased intestinal permeability to 51 Cr-EDTA among children with persistent diarrhea].

Sawamura R, Fernandes MI, Troncon LE, Iazigi N.

Arq Gastroenterol. 1997 Jan-Mar;34(1):55-61. Portuguese.

PMID:
9458961
44.

Report of two cases of children with Budd-Chiari syndrome successfully treated with streptokinase.

Sawamura R, Fernandes MI, Galvão LC, Goldani HA.

Arq Gastroenterol. 1996 Jul-Sep;33(3):179-81. Review.

PMID:
9201332
45.

[Neonatal cholestasis and cytomegalovirus infection: clinical and histopathologic forms].

Passos OA, Fernandes MI, Galvão LC, Zucolotto S, Sawamura R, Goldani HA.

J Pediatr (Rio J). 1996 May-Jun;72(3):159-63. Portuguese.

46.

[Organization of disaster-related psychiatric care and psychiatric medicine in Japan--relief activities, mental health care, training in disaster medicine, and relationship between the committee of 7 psychiatric representatives and legislation].

Sakai T, Yoneda H, Okamura T, Kuroda K, Yokota S, Sawamura R.

Seishin Shinkeigaku Zasshi. 1996;98(10):771-4; discussion 777-81. Japanese. No abstract available.

PMID:
9053924
47.

[Hepatic glycogenosis in childhood: clinical and laboratory findings in 20 patients].

Ferreira AM, Fernandes MI, Galvão LC, Sawamura R, Goldani HA, de Oliveira JA.

Arq Gastroenterol. 1995 Jul-Sep;32(3):146-51. Portuguese.

PMID:
8728790
48.

[Excretion of 99m Tc-DISIDA through the bile ducts in the etiological diagnosis of neonatal cholestasis].

Ferretti-Cisneros MC, Fernandes MI, Galvão LC, Maciel LM, Sawamura R.

Arq Gastroenterol. 1995 Apr-Jun;32(2):85-90. Portuguese.

PMID:
8540806
49.

In vitro effect of chromium and other trace metals on mouse hepatotoxicity induced by carbon tetrachloride exposure.

Tezuka M, Sadanobu S, Gomi K, Tachikawa M, Sawamura R.

Biol Pharm Bull. 1995 Feb;18(2):256-61.

PMID:
7742794
50.

[Lactose content and beta-galactosidase activity in yogurt, cheeses and curdled milk made in Brazil].

Galvão LC, Fernandes MI, Sawamura R.

Arq Gastroenterol. 1995 Jan-Mar;32(1):8-14. Portuguese.

PMID:
7575185

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