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Items: 1 to 50 of 85

1.

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.

Persson EK, Verstraete K, Heyndrickx I, Gevaert E, Aegerter H, Percier JM, Deswarte K, Verschueren KHG, Dansercoer A, Gras D, Chanez P, Bachert C, Gonçalves A, Van Gorp H, De Haard H, Blanchetot C, Saunders M, Hammad H, Savvides SN, Lambrecht BN.

Science. 2019 May 24;364(6442). pii: eaaw4295. doi: 10.1126/science.aaw4295.

PMID:
31123109
2.

Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis.

Slowicka K, Serramito-Gómez I, Boada-Romero E, Martens A, Sze M, Petta I, Vikkula HK, De Rycke R, Parthoens E, Lippens S, Savvides SN, Wullaert A, Vereecke L, Pimentel-Muiños FX, van Loo G.

Nat Commun. 2019 Apr 23;10(1):1834. doi: 10.1038/s41467-019-09667-z.

3.

Disruption of endocytosis through chemical inhibition of clathrin heavy chain function.

Dejonghe W, Sharma I, Denoo B, De Munck S, Lu Q, Mishev K, Bulut H, Mylle E, De Rycke R, Vasileva M, Savatin DV, Nerinckx W, Staes A, Drozdzecki A, Audenaert D, Yperman K, Madder A, Friml J, Van Damme D, Gevaert K, Haucke V, Savvides SN, Winne J, Russinova E.

Nat Chem Biol. 2019 Jun;15(6):641-649. doi: 10.1038/s41589-019-0262-1. Epub 2019 Apr 22.

PMID:
31011214
4.

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation.

Dondelinger Y, Delanghe T, Priem D, Wynosky-Dolfi MA, Sorobetea D, Rojas-Rivera D, Giansanti P, Roelandt R, Gropengiesser J, Ruckdeschel K, Savvides SN, Heck AJR, Vandenabeele P, Brodsky IE, Bertrand MJM.

Nat Commun. 2019 Apr 15;10(1):1729. doi: 10.1038/s41467-019-09690-0.

5.

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.

Verschueren KHG, Blanchet C, Felix J, Dansercoer A, De Vos D, Bloch Y, Van Beeumen J, Svergun D, Gutsche I, Savvides SN, Verstraete K.

Nature. 2019 Apr;568(7753):571-575. doi: 10.1038/s41586-019-1095-5. Epub 2019 Apr 3.

PMID:
30944476
6.

Revisiting the combinatorial potential of cytokine subunits in the IL-12 family.

Detry S, Składanowska K, Vuylsteke M, Savvides SN, Bloch Y.

Biochem Pharmacol. 2019 Jul;165:240-248. doi: 10.1016/j.bcp.2019.03.026. Epub 2019 Mar 15.

PMID:
30885765
7.

IL-33trap is a novel IL-33-neutralizing biologic that inhibits allergic airway inflammation.

Holgado A, Braun H, Van Nuffel E, Detry S, Schuijs MJ, Deswarte K, Vergote K, Haegman M, Baudelet G, Haustraete J, Hammad H, Lambrecht BN, Savvides SN, Afonina IS, Beyaert R.

J Allergy Clin Immunol. 2019 Jul;144(1):204-215. doi: 10.1016/j.jaci.2019.02.028. Epub 2019 Mar 13.

PMID:
30876911
8.

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.

Govindarajan S, Gaublomme D, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys Y, Tavernier S, Iwawaki T, Bloch Y, Savvides SN, Lambrecht BN, Janssens S, Elewaut D, Drennan MB.

Nat Commun. 2018 Dec 17;9(1):5340. doi: 10.1038/s41467-018-07758-x.

9.

A CARD9 Founder Mutation Disrupts NF-κB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation.

De Bruyne M, Hoste L, Bogaert DJ, Van den Bossche L, Tavernier SJ, Parthoens E, Migaud M, Konopnicki D, Yombi JC, Lambrecht BN, van Daele S, Alves de Medeiros AK, Brochez L, Beyaert R, De Baere E, Puel A, Casanova JL, Goffard JC, Savvides SN, Haerynck F, Staal J, Dullaers M.

Front Immunol. 2018 Oct 31;9:2366. doi: 10.3389/fimmu.2018.02366. eCollection 2018.

10.

Structure and oligomerization of the periplasmic domain of GspL from the type II secretion system of Pseudomonas aeruginosa.

Fulara A, Vandenberghe I, Read RJ, Devreese B, Savvides SN.

Sci Rep. 2018 Nov 13;8(1):16760. doi: 10.1038/s41598-018-34956-w.

11.

Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells.

Liénart S, Merceron R, Vanderaa C, Lambert F, Colau D, Stockis J, van der Woning B, De Haard H, Saunders M, Coulie PG, Savvides SN, Lucas S.

Science. 2018 Nov 23;362(6417):952-956. doi: 10.1126/science.aau2909. Epub 2018 Oct 25.

PMID:
30361387
12.

Pathophysiology and inhibition of IL-23 signaling in psoriatic arthritis: A molecular insight.

Nguyen CT, Bloch Y, Składanowska K, Savvides SN, Adamopoulos IE.

Clin Immunol. 2018 Sep 6. pii: S1521-6616(18)30476-5. doi: 10.1016/j.clim.2018.09.002. [Epub ahead of print]

PMID:
30196070
13.

Nonselective Chemical Inhibition of Sec7 Domain-Containing ARF GTPase Exchange Factors.

Mishev K, Lu Q, Denoo B, Peurois F, Dejonghe W, Hullaert J, De Rycke R, Boeren S, Bretou M, De Munck S, Sharma I, Goodman K, Kalinowska K, Storme V, Nguyen LSL, Drozdzecki A, Martins S, Nerinckx W, Audenaert D, Vert G, Madder A, Otegui MS, Isono E, Savvides SN, Annaert W, De Vries S, Cherfils J, Winne J, Russinova E.

Plant Cell. 2018 Oct;30(10):2573-2593. doi: 10.1105/tpc.18.00145. Epub 2018 Jul 17.

PMID:
30018157
14.

Sensory-Neuropathy-Causing Mutations in ATL3 Cause Aberrant ER Membrane Tethering.

Krols M, Detry S, Asselbergh B, Almeida-Souza L, Kremer A, Lippens S, De Rycke R, De Winter V, Müller FJ, Kurth I, McMahon HT, Savvides SN, Timmerman V, Janssens S.

Cell Rep. 2018 May 15;23(7):2026-2038. doi: 10.1016/j.celrep.2018.04.071.

15.

Author Correction: Virtual screening for inhibitors of the human TSLP:TSLPR interaction.

Van Rompaey D, Verstraete K, Peelman F, Savvides SN, Augustyns K, Van Der Veken P, De Winter H.

Sci Rep. 2018 Apr 24;8(1):6673. doi: 10.1038/s41598-018-24798-x.

16.

Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.

Song L, Merceron R, Gracia B, Quintana AL, Risseeuw MDP, Hulpia F, Cos P, Aínsa JA, Munier-Lehmann H, Savvides SN, Van Calenbergh S.

J Med Chem. 2018 Apr 12;61(7):2753-2775. doi: 10.1021/acs.jmedchem.7b01570. Epub 2018 Mar 15.

PMID:
29510037
17.

Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rβ1.

Bloch Y, Bouchareychas L, Merceron R, Składanowska K, Van den Bossche L, Detry S, Govindarajan S, Elewaut D, Haerynck F, Dullaers M, Adamopoulos IE, Savvides SN.

Immunity. 2018 Jan 16;48(1):45-58.e6. doi: 10.1016/j.immuni.2017.12.008. Epub 2017 Dec 26.

18.

Virtual screening for inhibitors of the human TSLP:TSLPR interaction.

Van Rompaey D, Verstraete K, Peelman F, Savvides SN, Augustyns K, Van Der Veken P, De Winter H.

Sci Rep. 2017 Dec 8;7(1):17211. doi: 10.1038/s41598-017-17620-7. Erratum in: Sci Rep. 2018 Apr 24;8(1):6673.

19.

Structural dissection of Shewanella oneidensis old yellow enzyme 4 bound to a Meisenheimer complex and (nitro)phenolic ligands.

Elegheert J, Brigé A, Van Beeumen J, Savvides SN.

FEBS Lett. 2017 Oct;591(20):3391-3401. doi: 10.1002/1873-3468.12833. Epub 2017 Sep 15.

20.

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B, Chávez-Gutiérrez L.

Cell. 2017 Jul 27;170(3):443-456.e14. doi: 10.1016/j.cell.2017.07.004.

21.

Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress.

Devos S, Van Putte W, Vitse J, Van Driessche G, Stremersch S, Van Den Broek W, Raemdonck K, Braeckmans K, Stahlberg H, Kudryashev M, Savvides SN, Devreese B.

Environ Microbiol. 2017 Oct;19(10):3930-3937. doi: 10.1111/1462-2920.13793. Epub 2017 Jun 22.

PMID:
28488744
22.

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma.

Verstraete K, Peelman F, Braun H, Lopez J, Van Rompaey D, Dansercoer A, Vandenberghe I, Pauwels K, Tavernier J, Lambrecht BN, Hammad H, De Winter H, Beyaert R, Lippens G, Savvides SN.

Nat Commun. 2017 Apr 3;8:14937. doi: 10.1038/ncomms14937.

23.

Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10.

Hammad H, Vanderkerken M, Pouliot P, Deswarte K, Toussaint W, Vergote K, Vandersarren L, Janssens S, Ramou I, Savvides SN, Haigh JJ, Hendriks R, Kopf M, Craessaerts K, de Strooper B, Kearney JF, Conrad DH, Lambrecht BN.

Nat Immunol. 2017 Mar;18(3):313-320. doi: 10.1038/ni.3657. Epub 2017 Jan 9.

PMID:
28068307
24.

Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures.

Felix J, Savvides SN.

Nat Rev Immunol. 2017 Feb;17(2):112-129. doi: 10.1038/nri.2016.134. Epub 2016 Dec 28. Review.

PMID:
28028310
25.

Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.

Felix J, Kandiah E, De Munck S, Bloch Y, van Zundert GC, Pauwels K, Dansercoer A, Novanska K, Read RJ, Bonvin AM, Vergauwen B, Verstraete K, Gutsche I, Savvides SN.

Nat Commun. 2016 Nov 7;7:13228. doi: 10.1038/ncomms13228.

26.

Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1.

Felix J, De Munck S, Verstraete K, Meuris L, Callewaert N, Elegheert J, Savvides SN.

Structure. 2015 Sep 1;23(9):1621-1631. doi: 10.1016/j.str.2015.06.019. Epub 2015 Jul 30.

27.

Structural basis of IL-23 antagonism by an Alphabody protein scaffold.

Desmet J, Verstraete K, Bloch Y, Lorent E, Wen Y, Devreese B, Vandenbroucke K, Loverix S, Hettmann T, Deroo S, Somers K, Henderikx P, Lasters I, Savvides SN.

Nat Commun. 2014 Oct 30;5:5237. doi: 10.1038/ncomms6237.

28.

20 years of leptin: insights into signaling assemblies of the leptin receptor.

Peelman F, Zabeau L, Moharana K, Savvides SN, Tavernier J.

J Endocrinol. 2014 Oct;223(1):T9-23. doi: 10.1530/JOE-14-0264. Epub 2014 Jul 25. Review.

PMID:
25063754
29.

The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.

Wen Y, Behiels E, Felix J, Elegheert J, Vergauwen B, Devreese B, Savvides SN.

Nucleic Acids Res. 2014 Sep;42(15):10134-47. doi: 10.1093/nar/gku665. Epub 2014 Jul 23.

30.

Structural and mechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins.

Moharana K, Zabeau L, Peelman F, Ringler P, Stahlberg H, Tavernier J, Savvides SN.

Structure. 2014 Jun 10;22(6):866-77. doi: 10.1016/j.str.2014.04.012. Epub 2014 May 29.

31.

Structural basis of the proinflammatory signaling complex mediated by TSLP.

Verstraete K, van Schie L, Vyncke L, Bloch Y, Tavernier J, Pauwels E, Peelman F, Savvides SN.

Nat Struct Mol Biol. 2014 Apr;21(4):375-82. doi: 10.1038/nsmb.2794. Epub 2014 Mar 16.

PMID:
24632570
32.

Characterization of a type D1A EUL-related lectin from rice expressed in Pichia pastoris.

Al Atalah B, Vanderschaeghe D, Bloch Y, Proost P, Plas K, Callewaert N, Savvides SN, Van Damme EJ.

Biol Chem. 2014 Apr;395(4):413-24. doi: 10.1515/hsz-2013-0267.

PMID:
24231122
33.

Molecular and structural basis of glutathione import in Gram-positive bacteria via GshT and the cystine ABC importer TcyBC of Streptococcus mutans.

Vergauwen B, Verstraete K, Senadheera DB, Dansercoer A, Cvitkovitch DG, Guédon E, Savvides SN.

Mol Microbiol. 2013 Jul;89(2):288-303. doi: 10.1111/mmi.12274. Epub 2013 Jun 10.

34.

Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor.

Felix J, Elegheert J, Gutsche I, Shkumatov AV, Wen Y, Bracke N, Pannecoucke E, Vandenberghe I, Devreese B, Svergun DI, Pauwels E, Vergauwen B, Savvides SN.

Structure. 2013 Apr 2;21(4):528-39. doi: 10.1016/j.str.2013.01.018. Epub 2013 Mar 7.

35.

Structural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preference.

Buysschaert G, Verstraete K, Savvides SN, Vergauwen B.

FEBS J. 2013 Mar;280(5):1358-70. doi: 10.1111/febs.12128. Epub 2013 Feb 11.

36.

New insights into the assembly of bacterial secretins: structural studies of the periplasmic domain of XcpQ from Pseudomonas aeruginosa.

Van der Meeren R, Wen Y, Van Gelder P, Tommassen J, Devreese B, Savvides SN.

J Biol Chem. 2013 Jan 11;288(2):1214-25. doi: 10.1074/jbc.M112.432096. Epub 2012 Nov 27.

37.

Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases.

Verstraete K, Savvides SN.

Nat Rev Cancer. 2012 Nov;12(11):753-66. doi: 10.1038/nrc3371. Epub 2012 Oct 18. Review.

PMID:
23076159
38.

Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1.

Elegheert J, Bracke N, Pouliot P, Gutsche I, Shkumatov AV, Tarbouriech N, Verstraete K, Bekaert A, Burmeister WP, Svergun DI, Lambrecht BN, Vergauwen B, Savvides SN.

Nat Struct Mol Biol. 2012 Sep;19(9):938-47. doi: 10.1038/nsmb.2367. Epub 2012 Aug 19.

PMID:
22902366
39.

Crystallization of an atypical short-chain dehydrogenase from Vibrio vulnificus lacking the conserved catalytic tetrad.

Buysschaert G, Verstraete K, Savvides SN, Vergauwen B.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):771-4. doi: 10.1107/S1744309112018672. Epub 2012 Jun 27.

40.

Glutathione biosynthesis in bacteria by bifunctional GshF is driven by a modular structure featuring a novel hybrid ATP-grasp fold.

Stout J, De Vos D, Vergauwen B, Savvides SN.

J Mol Biol. 2012 Mar 2;416(4):486-94. doi: 10.1016/j.jmb.2011.12.046. Epub 2011 Dec 28.

PMID:
22226834
41.

Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles.

Elegheert J, Desfosses A, Shkumatov AV, Wu X, Bracke N, Verstraete K, Van Craenenbroeck K, Brooks BR, Svergun DI, Vergauwen B, Gutsche I, Savvides SN.

Structure. 2011 Dec 7;19(12):1762-72. doi: 10.1016/j.str.2011.10.012.

42.

Delineation of the Pasteurellaceae-specific GbpA-family of glutathione-binding proteins.

Vergauwen B, Van der Meeren R, Dansercoer A, Savvides SN.

BMC Biochem. 2011 Nov 16;12:59. doi: 10.1186/1471-2091-12-59.

43.

Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes.

Verstraete K, Remmerie B, Elegheert J, Lintermans B, Haegeman G, Vanhoenacker P, Van Craenenbroeck K, Savvides SN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Mar 1;67(Pt 3):325-31. doi: 10.1107/S1744309111003319. Epub 2011 Feb 23.

44.

Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex.

Verstraete K, Vandriessche G, Januar M, Elegheert J, Shkumatov AV, Desfosses A, Van Craenenbroeck K, Svergun DI, Gutsche I, Vergauwen B, Savvides SN.

Blood. 2011 Jul 7;118(1):60-8. doi: 10.1182/blood-2011-01-329532. Epub 2011 Mar 9.

45.

Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA.

Vergauwen B, Elegheert J, Dansercoer A, Devreese B, Savvides SN.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13270-5. doi: 10.1073/pnas.1005198107. Epub 2010 Jul 13.

46.

Hydrophobic surface patches on LolA of Pseudomonas aeruginosa are essential for lipoprotein binding.

Remans K, Pauwels K, van Ulsen P, Buts L, Cornelis P, Tommassen J, Savvides SN, Decanniere K, Van Gelder P.

J Mol Biol. 2010 Sep 3;401(5):921-30. doi: 10.1016/j.jmb.2010.06.067. Epub 2010 Jul 8.

PMID:
20620146
47.

Construction of cellobiose phosphorylase variants with broadened acceptor specificity towards anomerically substituted glucosides.

De Groeve MR, Remmery L, Van Hoorebeke A, Stout J, Desmet T, Savvides SN, Soetaert W.

Biotechnol Bioeng. 2010 Oct 15;107(3):413-20. doi: 10.1002/bit.22818.

PMID:
20517986
48.

Crystallization and X-ray diffraction studies of inverting trehalose phosphorylase from Thermoanaerobacter sp.

Van Hoorebeke A, Stout J, Van der Meeren R, Kyndt J, Van Beeumen J, Savvides SN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Apr 1;66(Pt 4):442-7. doi: 10.1107/S1744309110005749. Epub 2010 Mar 31.

49.

Crystallization and X-ray diffraction studies of cellobiose phosphorylase from Cellulomonas uda.

Van Hoorebeke A, Stout J, Kyndt J, De Groeve M, Dix I, Desmet T, Soetaert W, Van Beeumen J, Savvides SN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Mar 1;66(Pt 3):346-51. doi: 10.1107/S1744309110002642. Epub 2010 Feb 27.

50.

Development and application of a screening assay for glycoside phosphorylases.

De Groeve MR, Tran GH, Van Hoorebeke A, Stout J, Desmet T, Savvides SN, Soetaert W.

Anal Biochem. 2010 Jun 1;401(1):162-7. doi: 10.1016/j.ab.2010.02.028. Epub 2010 Feb 24.

PMID:
20188057

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