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Items: 38


Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy.

Singh B, Covelo A, Martell-Martínez H, Nanclares C, Sherman MA, Okematti E, Meints J, Teravskis PJ, Gallardo C, Savonenko AV, Benneyworth MA, Lesné SE, Liao D, Araque A, Lee MK.

Acta Neuropathol. 2019 Oct;138(4):551-574. doi: 10.1007/s00401-019-02032-w. Epub 2019 Jun 6.


PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R).

Horti AG, Naik R, Foss CA, Minn I, Misheneva V, Du Y, Wang Y, Mathews WB, Wu Y, Hall A, LaCourse C, Ahn HH, Nam H, Lesniak WG, Valentine H, Pletnikova O, Troncoso JC, Smith MD, Calabresi PA, Savonenko AV, Dannals RF, Pletnikov MV, Pomper MG.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1686-1691. doi: 10.1073/pnas.1812155116. Epub 2019 Jan 11.


Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation.

Modi HR, Wang Q, Gd S, Sherman D, Greenwald E, Savonenko AV, Geocadin RG, Thakor NV.

PLoS One. 2017 Sep 28;12(9):e0182707. doi: 10.1371/journal.pone.0182707. eCollection 2017.


Association between serotonin denervation and resting-state functional connectivity in mild cognitive impairment.

Barrett FS, Workman CI, Sair HI, Savonenko AV, Kraut MA, Sodums DJ, Joo JJ, Nassery N, Marano CM, Munro CA, Brandt J, Zhou Y, Wong DF, Smith GS.

Hum Brain Mapp. 2017 Jul;38(7):3391-3401. doi: 10.1002/hbm.23595. Epub 2017 Apr 5.


Increased Sparsity of Hippocampal CA1 Neuronal Ensembles in a Mouse Model of Down Syndrome Assayed by Arc Expression.

Smith-Hicks CL, Cai P, Savonenko AV, Reeves RH, Worley PF.

Front Neural Circuits. 2017 Feb 3;11:6. doi: 10.3389/fncir.2017.00006. eCollection 2017.


Sex-related dimorphism in dentate gyrus atrophy and behavioral phenotypes in an inducible tTa:APPsi transgenic model of Alzheimer's disease.

Melnikova T, Park D, Becker L, Lee D, Cho E, Sayyida N, Tian J, Bandeen-Roche K, Borchelt DR, Savonenko AV.

Neurobiol Dis. 2016 Dec;96:171-185. doi: 10.1016/j.nbd.2016.08.009. Epub 2016 Aug 26.


Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation.

Savonenko AV, Melnikova T, Wang Y, Ravert H, Gao Y, Koppel J, Lee D, Pletnikova O, Cho E, Sayyida N, Hiatt A, Troncoso J, Davies P, Dannals RF, Pomper MG, Horti AG.

PLoS One. 2015 Jun 18;10(6):e0129618. doi: 10.1371/journal.pone.0129618. eCollection 2015.


Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice.

LaClair KD, Manaye KF, Lee DL, Allard JS, Savonenko AV, Troncoso JC, Wong PC.

Mol Neurodegener. 2013 Jun 13;8:18. doi: 10.1186/1750-1326-8-18. Erratum in: Mol Neurodegener. 2013;8:26.


Alzheimer's therapeutics: translation of preclinical science to clinical drug development.

Savonenko AV, Melnikova T, Hiatt A, Li T, Worley PF, Troncoso JC, Wong PC, Price DL.

Neuropsychopharmacology. 2012 Jan;37(1):261-77. doi: 10.1038/npp.2011.211. Epub 2011 Sep 21. Review.


Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2).

Horti AG, Gao Y, Ravert HT, Finley P, Valentine H, Wong DF, Endres CJ, Savonenko AV, Dannals RF.

Bioorg Med Chem. 2010 Jul 15;18(14):5202-7. doi: 10.1016/j.bmc.2010.05.058. Epub 2010 May 25.


Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease.

Klevytska AM, Tebbenkamp AT, Savonenko AV, Borchelt DR.

J Neuropathol Exp Neurol. 2010 Apr;69(4):396-404. doi: 10.1097/NEN.0b013e3181d6c436.


Modeling an anti-amyloid combination therapy for Alzheimer's disease.

Chow VW, Savonenko AV, Melnikova T, Kim H, Price DL, Li T, Wong PC.

Sci Transl Med. 2010 Jan 6;2(13):13ra1. doi: 10.1126/scitranslmed.3000337.


Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice.

Savonenko AV, Melnikova T, Laird FM, Stewart KA, Price DL, Wong PC.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5585-90. doi: 10.1073/pnas.0710373105. Epub 2008 Apr 2.


Amyloid precursor protein increases cortical neuron size in transgenic mice.

Oh ES, Savonenko AV, King JF, Fangmark Tucker SM, Rudow GL, Xu G, Borchelt DR, Troncoso JC.

Neurobiol Aging. 2009 Aug;30(8):1238-44. doi: 10.1016/j.neurobiolaging.2007.12.024. Epub 2008 Mar 4.


Morphometry of the human substantia nigra in ageing and Parkinson's disease.

Rudow G, O'Brien R, Savonenko AV, Resnick SM, Zonderman AB, Pletnikova O, Marsh L, Dawson TM, Crain BJ, West MJ, Troncoso JC.

Acta Neuropathol. 2008 Apr;115(4):461-70. doi: 10.1007/s00401-008-0352-8. Epub 2008 Feb 23.


BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

Laird FM, Cai H, Savonenko AV, Farah MH, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee HK, Wong PC.

J Neurosci. 2005 Dec 14;25(50):11693-709.


Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease.

Jankowsky JL, Slunt HH, Gonzales V, Savonenko AV, Wen JC, Jenkins NA, Copeland NG, Younkin LH, Lester HA, Younkin SG, Borchelt DR.

PLoS Med. 2005 Dec;2(12):e355. Epub 2005 Nov 15.


Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease.

Jankowsky JL, Melnikova T, Fadale DJ, Xu GM, Slunt HH, Gonzales V, Younkin LH, Younkin SG, Borchelt DR, Savonenko AV.

J Neurosci. 2005 May 25;25(21):5217-24.


Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice.

Schilling G, Savonenko AV, Klevytska A, Morton JL, Tucker SM, Poirier M, Gale A, Chan N, Gonzales V, Slunt HH, Coonfield ML, Jenkins NA, Copeland NG, Ross CA, Borchelt DR.

Hum Mol Genet. 2004 Aug 1;13(15):1599-610. Epub 2004 Jun 9.


Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice.

Schilling G, Savonenko AV, Coonfield ML, Morton JL, Vorovich E, Gale A, Neslon C, Chan N, Eaton M, Fromholt D, Ross CA, Borchelt DR.

Exp Neurol. 2004 May;187(1):137-49.


The cognitive effects of ovariectomy and estrogen replacement are modulated by aging.

Savonenko AV, Markowska AL.

Neuroscience. 2003;119(3):821-30.


Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APP SWE.

Savonenko AV, Xu GM, Price DL, Borchelt DR, Markowska AL.

Neurobiol Dis. 2003 Apr;12(3):194-211.


Escape from shock versus escape from shock accompanied by a visual stimulus in rats.

Zieliński K, Savonenko AV.

Acta Neurobiol Exp (Wars). 2000;60(4):457-65.


How do rats cope with the two-way escape problem in a homogeneous shuttle box?

Savonenko AV, Brush FR, Zieliński K.

Acta Neurobiol Exp (Wars). 1999;59(2):145-57.


Studies of individual differences as a method for discriminating the stages of acquisition of a conditioned reflex.

Savonenko AV, Danilets AV, Zelin'ski K.

Neurosci Behav Physiol. 1999 May-Jun;29(3):295-303.


[Cytochemical brain characteristics of rejecting alcohol Wistar rats with various learning ability].

Sergutina AV, Savonenko AV, Gershteĭn LM, Nikol'skaia KA.

Biull Eksp Biol Med. 1999 Feb;127(2):180-2. Russian. No abstract available.


Effects of conditioned and predictive stimuli on the fly-away escape response in a two-way shuttle box.

Savonenko AV, Zieliński K.

Acta Neurobiol Exp (Wars). 1998;58(4):321. No abstract available.


[The study of individual differences as a method for dividing into stages the acquisition of a complex reflex].

Savonenko AV, Danilets AV, Zieliński K.

Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 Mar-Apr;48(2):240-50. Russian.


[The dependence of learning an active avoidance reaction on overcoming a problem-solving situation in a shuttle box].

Savonenko AV, Zieliński K.

Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 Mar-Apr;48(2):229-39. Russian.


Morphochemical features of sensorimotor cortex and neostriatum neurons in rats with different levels of alcohol preference.

Gershtein LM, Nikol'skaya KA, Savonenko AV.

Neurosci Behav Physiol. 1997 Jan-Feb;27(1):53-8.


[Weak magnetic fields and cognitive activity].

Nikol'skaia KA, Shtemler AV, Savonenko AV, Osipov AI, Nikol'skiĭ SV.

Biofizika. 1996 Jul-Aug;41(4):887-93. Russian.


[The psychophysiological markers of a predisposition to the development of alcohol dependence in rats].

Savonenko AV, Adrianov OS, Nikol'skaia KA, Osipov AI, Eshchenko OV.

Zh Vyssh Nerv Deiat Im I P Pavlova. 1995 Mar-Apr;45(2):416-9. Russian. No abstract available.


[The morphochemical characteristics of the neurons of the sensorimotor cortex and neostriatum in rats with differing degrees of alcohol preference].

Gershteĭn LM, Nikol'skaia KA, Savonenko AV.

Fiziol Zh Im I M Sechenova. 1995 Mar;81(3):90-6. Russian.


Change in behavior with the development of long-term sensitization of a defensive reflex in the edible snail.

Beregovoi NA, Gainutdinov KL, Safronova OG, Savonenko AV.

Neurosci Behav Physiol. 1991 Jul-Aug;21(4):321-3. No abstract available.


[Behavioral changes during the acquisition of long-term sensitization of the defensive reflex in the edible snail].

Beregovoĭ NA, Gaĭnutdinov KhL, Safronova OG, Savonenko AV.

Zh Vyssh Nerv Deiat Im I P Pavlova. 1990 May-Jun;40(3):594-6. Russian.


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