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Items: 1 to 50 of 86

1.

The importance of endothelial dysfunction in resistance artery remodelling and cardiovascular risk.

Masi S, Georgiopoulos G, Chiriacò M, Grassi G, Seravalle G, Savoia C, Volpe M, Taddei S, Rizzoni D, Virdis A.

Cardiovasc Res. 2019 Apr 8. pii: cvz096. doi: 10.1093/cvr/cvz096. [Epub ahead of print]

PMID:
31220219
2.

Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function.

Pujol JB, Heikkila E, Savoia C, Hajibeigi A, De Marchi U, Battiprolu PK, Öz OK, Dioum EHM.

Int J Mol Sci. 2018 Aug 27;19(9). pii: E2542. doi: 10.3390/ijms19092542.

3.

Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21.

Restelli LM, Oettinghaus B, Halliday M, Agca C, Licci M, Sironi L, Savoia C, Hench J, Tolnay M, Neutzner A, Schmidt A, Eckert A, Mallucci G, Scorrano L, Frank S.

Cell Rep. 2018 Aug 7;24(6):1407-1414. doi: 10.1016/j.celrep.2018.07.023.

4.

Age- and Sex-Specific Reference Values for Media/Lumen Ratio in Small Arteries and Relationship With Risk Factors.

Bruno RM, Grassi G, Seravalle G, Savoia C, Rizzoni D, Virdis A; Study Group on Micro- and Macrocirculation of the Italian Society of Hypertension (SIIA).

Hypertension. 2018 Jun;71(6):1193-1200. doi: 10.1161/HYPERTENSIONAHA.117.10634. Epub 2018 Apr 23.

PMID:
29686004
5.

Coordination of GPR40 and Ketogenesis Signaling by Medium Chain Fatty Acids Regulates Beta Cell Function.

Pujol JB, Christinat N, Ratinaud Y, Savoia C, Mitchell SE, Dioum EHM.

Nutrients. 2018 Apr 12;10(4). pii: E473. doi: 10.3390/nu10040473.

6.

VEGFR (Vascular Endothelial Growth Factor Receptor) Inhibition Induces Cardiovascular Damage via Redox-Sensitive Processes.

Neves KB, Rios FJ, van der Mey L, Alves-Lopes R, Cameron AC, Volpe M, Montezano AC, Savoia C, Touyz RM.

Hypertension. 2018 Apr;71(4):638-647. doi: 10.1161/HYPERTENSIONAHA.117.10490. Epub 2018 Feb 26.

PMID:
29483228
7.

Personalized medicine-a modern approach for the diagnosis and management of hypertension.

Savoia C, Volpe M, Grassi G, Borghi C, Agabiti Rosei E, Touyz RM.

Clin Sci (Lond). 2017 Nov 6;131(22):2671-2685. doi: 10.1042/CS20160407. Print 2017 Nov 15. Review.

8.

Hypertension, Diabetes Mellitus, and Excess Cardiovascular Risk: Importance of Baseline Systolic Blood Pressure.

Savoia C, Touyz RM.

Hypertension. 2017 Nov;70(5):882-883. doi: 10.1161/HYPERTENSIONAHA.117.09764. Epub 2017 Aug 28. No abstract available.

PMID:
28847887
9.

Microvascular Alterations in Hypertension and Vascular Aging.

Savoia C, Battistoni A, Calvez V, Cesario V, Montefusco G, Filippini A.

Curr Hypertens Rev. 2017;13(1):16-23. doi: 10.2174/1573402113666170505115010.

PMID:
28474545
10.

Immune Cells in Cardiovascular Disease: Has the Time Arrived for New Targets in Human Hypertension?

Savoia C.

Am J Hypertens. 2017 Jan;30(1):21-23. Epub 2016 Sep 22. Review. No abstract available.

PMID:
27661098
11.

c-Src Inhibition Improves Cardiovascular Function but not Remodeling or Fibrosis in Angiotensin II-Induced Hypertension.

Callera GE, Antunes TT, He Y, Montezano AC, Yogi A, Savoia C, Touyz RM.

Hypertension. 2016 Nov;68(5):1179-1190. Epub 2016 Sep 12.

PMID:
27620391
12.

DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress.

Oettinghaus B, D'Alonzo D, Barbieri E, Restelli LM, Savoia C, Licci M, Tolnay M, Frank S, Scorrano L.

Biochim Biophys Acta. 2016 Aug;1857(8):1267-1276. doi: 10.1016/j.bbabio.2016.03.016. Epub 2016 Mar 17.

13.

Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells.

Kalwat MA, Huang Z, Wichaidit C, McGlynn K, Earnest S, Savoia C, Dioum EM, Schneider JW, Hutchison MR, Cobb MH.

ACS Chem Biol. 2016 Apr 15;11(4):1128-36. doi: 10.1021/acschembio.5b00993. Epub 2016 Feb 10.

14.

Understanding and treating hypertension in diabetic populations.

Volpe M, Battistoni A, Savoia C, Tocci G.

Cardiovasc Diagn Ther. 2015 Oct;5(5):353-63. doi: 10.3978/j.issn.2223-3652.2015.06.02. Review.

15.

Dual renin-angiotensin system blockade and vascular remodeling: is this a real advantage for vascular protection?

Savoia C, Grassi G.

J Hypertens. 2015 Dec;33(12):2392-4. doi: 10.1097/HJH.0000000000000771. No abstract available.

PMID:
26536089
16.

Relationship between NOX4 level and angiotensin II signaling in Gitelman's syndrome. Implications with hypertension.

Calò LA, Savoia C, Davis PA, Pagnin E, Ravarotto V, Maiolino G.

Int J Clin Exp Med. 2015 May 15;8(5):7487-96. eCollection 2015.

17.

Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection.

Janda E, Lascala A, Carresi C, Parafati M, Aprigliano S, Russo V, Savoia C, Ziviani E, Musolino V, Morani F, Isidoro C, Mollace V.

Autophagy. 2015;11(7):1063-80. doi: 10.1080/15548627.2015.1058683. Erratum in: Autophagy. 2017 Mar 4;13(3):638.

18.

Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons.

Oettinghaus B, Schulz JM, Restelli LM, Licci M, Savoia C, Schmidt A, Schmitt K, Grimm A, Morè L, Hench J, Tolnay M, Eckert A, D'Adamo P, Franken P, Ishihara N, Mihara K, Bischofberger J, Scorrano L, Frank S.

Cell Death Differ. 2016 Jan;23(1):18-28. doi: 10.1038/cdd.2015.39. Epub 2015 Apr 24.

19.

Blood pressure control versus atrial fibrillation management in stroke prevention.

Savoia C, Sada L, Volpe M.

Curr Hypertens Rep. 2015 Jun;17(6):553. doi: 10.1007/s11906-015-0553-1. Review.

PMID:
25893476
20.

Extracellular regulated kinase phosphorylates mitofusin 1 to control mitochondrial morphology and apoptosis.

Pyakurel A, Savoia C, Hess D, Scorrano L.

Mol Cell. 2015 Apr 16;58(2):244-54. doi: 10.1016/j.molcel.2015.02.021. Epub 2015 Mar 19.

21.

Reply to Letter by McIntyre et al.

Touyz RM, Montezano AC, Rios FJ, Savoia C.

Can J Cardiol. 2014 Dec;30(12):1733.e3. doi: 10.1016/j.cjca.2014.10.004. Epub 2014 Oct 7. No abstract available.

PMID:
25475481
22.

Evaluation of microvascular structure in humans: a 'state-of-the-art' document of the Working Group on Macrovascular and Microvascular Alterations of the Italian Society of Arterial Hypertension.

Virdis A, Savoia C, Grassi G, Lembo G, Vecchione C, Seravalle G, Taddei S, Volpe M, Rosei EA, Rizzoni D.

J Hypertens. 2014 Nov;32(11):2120-9; discussion 2129. doi: 10.1097/HJH.0000000000000322. Review.

PMID:
25275242
23.

Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.

Savoia CP, Liu QH, Zheng YM, Yadav V, Zhang Z, Wu LG, Wang YX.

Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10):L781-90. doi: 10.1152/ajplung.00149.2014. Epub 2014 Sep 19.

24.

Effects of a long-term treatment with aliskiren or ramipril on structural alterations of subcutaneous small-resistance arteries of diabetic hypertensive patients.

De Ciuceis C, Savoia C, Arrabito E, Porteri E, Mazza M, Rossini C, Duse S, Semeraro F, Agabiti Rosei C, Alonzo A, Sada L, La Boria E, Sarkar A, Petroboni B, Mercantini P, Volpe M, Rizzoni D, Agabiti Rosei E.

Hypertension. 2014 Oct;64(4):717-24. doi: 10.1161/HYPERTENSIONAHA.114.03380. Epub 2014 Jun 30.

PMID:
24980672
25.

Impact of the direct angiotensin II type 2 receptor stimulation on renal function toward a sex-specific therapeutic approach for hypertension.

Savoia C, Volpe M.

Hypertension. 2014 Aug;64(2):227-8. doi: 10.1161/HYPERTENSIONAHA.114.03199. No abstract available.

PMID:
24842919
26.

Hypertension due to antiangiogenic cancer therapy with vascular endothelial growth factor inhibitors: understanding and managing a new syndrome.

Small HY, Montezano AC, Rios FJ, Savoia C, Touyz RM.

Can J Cardiol. 2014 May;30(5):534-43. doi: 10.1016/j.cjca.2014.02.011. Epub 2014 Feb 25. Review.

PMID:
24786444
27.

Immunomodulating treatment with low dose interleukin-4, interleukin-10 and interleukin-11 in psoriasis vulgaris.

Roberti ML, Ricottini L, Capponi A, Sclauzero E, Vicenti P, Fiorentini E, Savoia C, Scornavacca G, Brazioli D, Gaio L, Giannetti R, Ignazzi C, Meloni G, Chinni LM.

J Biol Regul Homeost Agents. 2014 Jan-Mar;28(1):133-9.

PMID:
24750799
28.

Endoplasmic reticulum refilling and mitochondrial calcium extrusion promoted in neurons by NCX1 and NCX3 in ischemic preconditioning are determinant for neuroprotection.

Sisalli MJ, Secondo A, Esposito A, Valsecchi V, Savoia C, Di Renzo GF, Annunziato L, Scorziello A.

Cell Death Differ. 2014 Jul;21(7):1142-9. doi: 10.1038/cdd.2014.32. Epub 2014 Mar 14.

29.

NCX3 regulates mitochondrial Ca(2+) handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death.

Scorziello A, Savoia C, Sisalli MJ, Adornetto A, Secondo A, Boscia F, Esposito A, Polishchuk EV, Polishchuk RS, Molinaro P, Carlucci A, Lignitto L, Di Renzo G, Feliciello A, Annunziato L.

J Cell Sci. 2013 Dec 15;126(Pt 24):5566-77. doi: 10.1242/jcs.129668. Epub 2013 Oct 7.

30.

The direct renin inhibitor aliskiren improves vascular remodelling in transgenic rats harbouring human renin and angiotensinogen genes.

Savoia C, Arrabito E, Parente R, Sada L, Madaro L, Nicoletti C, Zezza L, Alonzo A, Rubattu S, Michelini S, Muller DN, Volpe M.

Clin Sci (Lond). 2013 Aug;125(4):183-9. doi: 10.1042/CS20120395.

PMID:
23438195
31.

New insights in mitochondrial calcium handling by sodium/calcium exchanger.

Scorziello A, Savoia C, Secondo A, Boscia F, Sisalli MJ, Esposito A, Carlucci A, Molinaro P, Lignitto L, Di Renzo G, Feliciello A, Annunziato L.

Adv Exp Med Biol. 2013;961:203-9. doi: 10.1007/978-1-4614-4756-6_17. Review.

PMID:
23224881
32.

Exercise activity and endothelial function: the uprising role of endothelial progenitor cells in vascular protection.

Savoia C, Grassi G.

J Hypertens. 2012 Nov;30(11):2083-4. doi: 10.1097/HJH.0b013e32835a0d31. No abstract available.

PMID:
23052045
33.

Occupancy of brain dopamine D3 receptors and drug craving: a translational approach.

Mugnaini M, Iavarone L, Cavallini P, Griffante C, Oliosi B, Savoia C, Beaver J, Rabiner EA, Micheli F, Heidbreder C, Andorn A, Merlo Pich E, Bani M.

Neuropsychopharmacology. 2013 Jan;38(2):302-12. doi: 10.1038/npp.2012.171. Epub 2012 Sep 12.

34.

New treatment options in the management of hypertension: appraising the potential role of azilsartan medoxomil.

Volpe M, Savoia C.

Integr Blood Press Control. 2012;5:19-25. doi: 10.2147/IBPC.S13784. Epub 2012 Mar 12.

35.

The key role of microvascular structure assessment in treated hypertensive patients.

Savoia C, Grassi G.

J Hypertens. 2012 Apr;30(4):688-90. doi: 10.1097/HJH.0b013e328351c174. No abstract available.

PMID:
22418906
36.

Vascular inflammation and endothelial dysfunction in experimental hypertension.

Savoia C, Sada L, Zezza L, Pucci L, Lauri FM, Befani A, Alonzo A, Volpe M.

Int J Hypertens. 2011;2011:281240. doi: 10.4061/2011/281240. Epub 2011 Sep 11.

37.

Angiotensin receptor modulation and cardiovascular remodeling.

Savoia C, Volpe M.

J Renin Angiotensin Aldosterone Syst. 2011 Sep;12(3):381-4. doi: 10.1177/1470320311417750. Review. No abstract available.

PMID:
21880671
38.

Azabicyclo[3.1.0]hexane-1-carbohydrazides as potent and selective GHSR1a ligands presenting a specific in vivo behavior.

Sabbatini FM, Melotto S, Bernasconi G, Bromidge SM, D'Adamo L, Rinaldi M, Savoia C, Mundi C, Di Francesco C, Zonzini L, Costantini VJ, Perini B, Valerio E, Pozzan A, Perdonà E, Visentini F, Corsi M, Di Fabio R.

ChemMedChem. 2011 Nov 4;6(11):1981-5. doi: 10.1002/cmdc.201100285. Epub 2011 Aug 10. No abstract available.

PMID:
21834097
39.

High blood pressure, ventricular tachycardia and transient left ventricular dysfunction: do not forget pheocromocytoma.

Gregori M, Paneni F, D'Agostino M, Tocci G, Ferrucci A, Savoia C.

High Blood Press Cardiovasc Prev. 2011 Jun 1;18(2):57-9. doi: 10.2165/11593430-000000000-00000.

PMID:
21806080
40.

Rosuvastatin-induced neuroprotection in cortical neurons exposed to OGD/reoxygenation is due to nitric oxide inhibition and ERK1/2 pathway activation.

Savoia C, Sisalli MJ, Di Renzo G, Annunziato L, Scorziello A.

Int J Physiol Pathophysiol Pharmacol. 2011;3(1):57-64. Epub 2011 Jan 6.

41.

Angiotensin II and the vascular phenotype in hypertension.

Savoia C, Burger D, Nishigaki N, Montezano A, Touyz RM.

Expert Rev Mol Med. 2011 Mar 30;13:e11. doi: 10.1017/S1462399411001815. Review.

PMID:
21450123
42.

Control of PKA stability and signalling by the RING ligase praja2.

Lignitto L, Carlucci A, Sepe M, Stefan E, Cuomo O, Nisticò R, Scorziello A, Savoia C, Garbi C, Annunziato L, Feliciello A.

Nat Cell Biol. 2011 Apr;13(4):412-22. doi: 10.1038/ncb2209. Epub 2011 Mar 20.

PMID:
21423175
43.

Angiotensin type 2 receptor in hypertensive cardiovascular disease.

Savoia C, D'Agostino M, Lauri F, Volpe M.

Curr Opin Nephrol Hypertens. 2011 Mar;20(2):125-32. doi: 10.1097/MNH.0b013e3283437fcd. Review.

PMID:
21245762
44.

Discovery process and characterization of novel carbohydrazide derivatives as potent and selective GHSR1a antagonists.

Sabbatini FM, Di Fabio R, Corsi M, Cavanni P, Bromidge SM, St-Denis Y, D'Adamo L, Contini S, Rinaldi M, Guery S, Savoia C, Mundi C, Perini B, Carpenter AJ, Dal Forno G, Faggioni F, Tessari M, Pavone F, Di Francesco C, Buson A, Mattioli M, Perdona' E, Melotto S.

ChemMedChem. 2010 Sep 3;5(9):1450-5. doi: 10.1002/cmdc.201000185. No abstract available.

PMID:
20593439
45.

Countervailing vascular effects of rosiglitazone in high cardiovascular risk mice: role of oxidative stress and PRMT-1.

Savoia C, Ebrahimian T, Lemarié CA, Paradis P, Iglarz M, Amiri F, Javeshgani D, Schiffrin EL.

Clin Sci (Lond). 2010 Feb 9;118(9):583-92. doi: 10.1042/CS20090289.

PMID:
19951259
46.

Natriuretic peptides and cardiovascular damage in the metabolic syndrome: molecular mechanisms and clinical implications.

Savoia C, Volpe M, Alonzo A, Rossi C, Rubattu S.

Clin Sci (Lond). 2009 Nov 9;118(4):231-40. doi: 10.1042/CS20090204. Review.

PMID:
19886866
47.

Reactive oxygen species-mediated effects on vascular remodeling induced by human atrial natriuretic peptide T2238C molecular variant in endothelial cells in vitro.

Scarpino S, Marchitti S, Stanzione R, Evangelista A, Di Castro S, Savoia C, Quarta G, Sciarretta S, Ruco L, Volpe M, Rubattu S.

J Hypertens. 2009 Sep;27(9):1804-13.

PMID:
19702001
48.

Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification.

Holmes IP, Micheli F, Gaines S, Lorthioir O, Watson SP, Fabio RD, Gentile G, Heidbreder C, Savoia C, Worby A.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4799-801. doi: 10.1016/j.bmcl.2009.06.043. Epub 2009 Jun 14.

PMID:
19560918
49.

Dopamine D(3) receptor antagonists: The quest for a potentially selective PET ligand. Part two: Lead optimization.

Micheli F, Holmes I, Arista L, Bonanomi G, Braggio S, Cardullo F, Di Fabio R, Donati D, Gentile G, Hamprecht D, Terreni S, Heidbreder C, Savoia C, Griffante C, Worby A.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4011-3. doi: 10.1016/j.bmcl.2009.06.028. Epub 2009 Jun 13.

PMID:
19553113
50.

Highlights from International Congress : The XI Forum on the Renin-Angiotensin System, Capri, Italy, 11-12 April, 2008.

Azizi M, Borghi C, Coca A, Cosentino F, Crea F, Del Prato S, Lembo G, Mancia G, Modena MG, Rubattu S, Pontremoli R, Ruilope LM, Savoia C, Sciarretta S, Scuteri A, Steckelings UM, Strazzullo P, Trimarco B, Virdis A, Waeber B, Volpe M.

High Blood Press Cardiovasc Prev. 2008 Apr;15(2):91-104. doi: 10.2165/00151642-200815020-00008. No abstract available.

PMID:
23334877

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