Sort by
Items per page

Send to

Choose Destination

Search results

Items: 34


Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia.

Romanelli F, Corbo A, Salehi M, Yadav MC, Salman S, Petrosian D, Rashidbaigi OJ, Chait J, Kuruvilla J, Plummer M, Radichev I, Margulies KB, Gerdes AM, Pinkerton AB, Millán JL, Savinov AY, Savinova OV.

PLoS One. 2017 Oct 12;12(10):e0186426. doi: 10.1371/journal.pone.0186426. eCollection 2017.


Self-Transducible Bimodal PDX1-FOXP3 Protein Lifts Insulin Secretion and Curbs Autoimmunity, Boosting Tregs in Type 1 Diabetic Mice.

Amatya C, Radichev IA, Ellefson J, Williams M, Savinov AY.

Mol Ther. 2018 Jan 3;26(1):184-198. doi: 10.1016/j.ymthe.2017.08.014. Epub 2017 Sep 7.


Loss of Peripheral Protection in Pancreatic Islets by Proteolysis-Driven Impairment of VTCN1 (B7-H4) Presentation Is Associated with the Development of Autoimmune Diabetes.

Radichev IA, Maneva-Radicheva LV, Amatya C, Salehi M, Parker C, Ellefson J, Burn P, Savinov AY.

J Immunol. 2016 Feb 15;196(4):1495-506. doi: 10.4049/jimmunol.1403251. Epub 2016 Jan 15.


Transgenic Overexpression of Tissue-Nonspecific Alkaline Phosphatase (TNAP) in Vascular Endothelium Results in Generalized Arterial Calcification.

Savinov AY, Salehi M, Yadav MC, Radichev I, Millán JL, Savinova OV.

J Am Heart Assoc. 2015 Dec 16;4(12). pii: e002499. doi: 10.1161/JAHA.115.002499.


Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1.

Maneva-Radicheva L, Amatya C, Parker C, Ellefson J, Radichev I, Raghavan A, Charles ML, Williams MS, Robbins MS, Savinov AY.

PLoS One. 2014 Sep 26;9(9):e107213. doi: 10.1371/journal.pone.0107213. eCollection 2014.


Preclinical characterization of recombinant human tissue kallikrein-1 as a novel treatment for type 2 diabetes mellitus.

Kolodka T, Charles ML, Raghavan A, Radichev IA, Amatya C, Ellefson J, Savinov AY, Nag A, Williams MS, Robbins MS.

PLoS One. 2014 Aug 6;9(8):e103981. doi: 10.1371/journal.pone.0103981. eCollection 2014.


Nardilysin-dependent proteolysis of cell-associated VTCN1 (B7-H4) marks type 1 diabetes development.

Radichev IA, Maneva-Radicheva LV, Amatya C, Parker C, Ellefson J, Wasserfall C, Atkinson M, Burn P, Savinov AY.

Diabetes. 2014 Oct;63(10):3470-82. doi: 10.2337/db14-0213. Epub 2014 May 21.


Interference with islet-specific homing of autoreactive T cells: an emerging therapeutic strategy for type 1 diabetes.

Savinov AY, Burn P.

Drug Discov Today. 2010 Jul;15(13-14):531-9. doi: 10.1016/j.drudis.2010.05.013. Review.


Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis.

Shiryaev SA, Remacle AG, Savinov AY, Chernov AV, Cieplak P, Radichev IA, Williams R, Shiryaeva TN, Gawlik K, Postnova TI, Ratnikov BI, Eroshkin AM, Motamedchaboki K, Smith JW, Strongin AY.

J Biol Chem. 2009 Oct 30;284(44):30615-26. doi: 10.1074/jbc.M109.041244. Epub 2009 Sep 2.


Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells.

Rozanov DV, Savinov AY, Golubkov VS, Rozanova OL, Postnova TI, Sergienko EA, Vasile S, Aleshin AE, Rega MF, Pellecchia M, Strongin AY.

Mol Cancer Ther. 2009 Jun;8(6):1515-25. doi: 10.1158/1535-7163.MCT-09-0202. Epub 2009 Jun 9.


Human beta-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies.

Lee SH, Hao E, Savinov AY, Geron I, Strongin AY, Itkin-Ansari P.

Transplantation. 2009 Apr 15;87(7):983-91. doi: 10.1097/TP.0b013e31819c86ea.


Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis.

Shiryaev SA, Savinov AY, Cieplak P, Ratnikov BI, Motamedchaboki K, Smith JW, Strongin AY.

PLoS One. 2009;4(3):e4952. doi: 10.1371/journal.pone.0004952. Epub 2009 Mar 20.


Matrix metalloproteinases, T cell homing and beta-cell mass in type 1 diabetes.

Savinov AY, Strongin AY.

Vitam Horm. 2009;80:541-62. doi: 10.1016/S0083-6729(08)00618-3. Review.


Molecular signature of MT1-MMP: transactivation of the downstream universal gene network in cancer.

Rozanov DV, Savinov AY, Williams R, Liu K, Golubkov VS, Krajewski S, Strongin AY.

Cancer Res. 2008 Jun 1;68(11):4086-96. doi: 10.1158/0008-5472.CAN-07-6458.


Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.

Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R, Fugere M, Day R, Sabet M, Pellecchia M, Liddington RC, Smith JW, Mustelin T, Guiney DG, Lebl M, Strongin AY.

J Biol Chem. 2007 Jul 20;282(29):20847-53. Epub 2007 May 30.


Defining the roles of T cell membrane proteinase and CD44 in type 1 diabetes.

Savinov AY, Strongin AY.

IUBMB Life. 2007 Jan;59(1):6-13. Review.


Membrane type-1 matrix metalloproteinase confers aneuploidy and tumorigenicity on mammary epithelial cells.

Golubkov VS, Chekanov AV, Savinov AY, Rozanov DV, Golubkova NV, Strongin AY.

Cancer Res. 2006 Nov 1;66(21):10460-5.


O-glycosylation regulates autolysis of cellular membrane type-1 matrix metalloproteinase (MT1-MMP).

Remacle AG, Chekanov AV, Golubkov VS, Savinov AY, Rozanov DV, Strongin AY.

J Biol Chem. 2006 Jun 23;281(25):16897-905. Epub 2006 Apr 20.


Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients.

Savinov AY, Remacle AG, Golubkov VS, Krajewska M, Kennedy S, Duffy MJ, Rozanov DV, Krajewski S, Strongin AY.

Cancer Res. 2006 Mar 1;66(5):2716-24.


Both PA63 and PA83 are endocytosed within an anthrax protective antigen mixed heptamer: a putative mechanism to overcome a furin deficiency.

Chekanov AV, Remacle AG, Golubkov VS, Akatov VS, Sikora S, Savinov AY, Fugere M, Day R, Rozanov DV, Strongin AY.

Arch Biochem Biophys. 2006 Feb 1;446(1):52-9. Epub 2005 Dec 7.


Efficient synthetic inhibitors of anthrax lethal factor.

Forino M, Johnson S, Wong TY, Rozanov DV, Savinov AY, Li W, Fattorusso R, Becattini B, Orry AJ, Jung D, Abagyan RA, Smith JW, Alibek K, Liddington RC, Strongin AY, Pellecchia M.

Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9499-504. Epub 2005 Jun 27.


Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas.

Savinov AY, Rozanov DV, Golubkov VS, Wong FS, Strongin AY.

J Biol Chem. 2005 Jul 29;280(30):27755-8. Epub 2005 Jun 8.


Membrane type-1 matrix metalloproteinase (MT1-MMP) exhibits an important intracellular cleavage function and causes chromosome instability.

Golubkov VS, Boyd S, Savinov AY, Chekanov AV, Osterman AL, Remacle A, Rozanov DV, Doxsey SJ, Strongin AY.

J Biol Chem. 2005 Jul 1;280(26):25079-86. Epub 2005 May 4.


Matrix metalloproteinase-26 is associated with estrogen-dependent malignancies and targets alpha1-antitrypsin serpin.

Li W, Savinov AY, Rozanov DV, Golubkov VS, Hedayat H, Postnova TI, Golubkova NV, Linli Y, Krajewski S, Strongin AY.

Cancer Res. 2004 Dec 1;64(23):8657-65.


Cellular membrane type-1 matrix metalloproteinase (MT1-MMP) cleaves C3b, an essential component of the complement system.

Rozanov DV, Savinov AY, Golubkov VS, Postnova TI, Remacle A, Tomlinson S, Strongin AY.

J Biol Chem. 2004 Nov 5;279(45):46551-7. Epub 2004 Sep 14.


Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells.

Savinov AY, Wong FS, Stonebraker AC, Chervonsky AV.

J Exp Med. 2003 Mar 3;197(5):643-56.


Contribution of Fas to diabetes development.

Savinov AY, Tcherepanov A, Green EA, Flavell RA, Chervonsky AV.

Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):628-32. Epub 2003 Jan 13.


IFN-gamma affects homing of diabetogenic T cells.

Savinov AY, Wong FS, Chervonsky AV.

J Immunol. 2001 Dec 1;167(11):6637-43.


Hidden variables: unstable Abeta chain genes encoding antigen recognition structures in tumor survivors.

Liu Y, McMinimy DL, Savinov AY, Johnson KA, Kremlev SG, Chapoval AI, Egorov IK.

Mol Immunol. 2000 Dec;37(18):1091-110.


The A beta 6w302 gene and molecular mechanisms of resistance to the spread of radiation-induced lymphoma in a mouse mutant, survivor-27.

Liu Y, Savinov AY, McMinimy DL, Kremlev SG, Chapoval AI, Egorov IK.

Radiats Biol Radioecol. 2000 Sep-Oct;40(5):500-5.


Supplemental Content

Loading ...
Support Center