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Items: 1 to 50 of 74

1.

Lectin activity of Pseudomonas aeruginosa vaccine candidates PSE17-1, PSE41-5 and PSE54.

Day CJ, Hartley-Tassell LE, Seib KL, Tiralongo J, Bovin N, Savino S, Masignani V, Jennings MP.

Biochem Biophys Res Commun. 2019 May 21;513(1):287-290. doi: 10.1016/j.bbrc.2019.03.092. Epub 2019 Apr 3.

PMID:
30954224
2.

Characterization of a thermostable flavin-containing monooxygenase from Nitrincola lacisaponensis (NiFMO).

Lončar N, Fiorentini F, Bailleul G, Savino S, Romero E, Mattevi A, Fraaije MW.

Appl Microbiol Biotechnol. 2019 Feb;103(4):1755-1764. doi: 10.1007/s00253-018-09579-w. Epub 2019 Jan 4.

PMID:
30607493
3.

Lectin Activity of the TcdA and TcdB Toxins of Clostridium difficile.

Hartley-Tassell LE, Awad MM, Seib KL, Scarselli M, Savino S, Tiralongo J, Lyras D, Day CJ, Jennings MP.

Infect Immun. 2019 Feb 21;87(3). pii: e00676-18. doi: 10.1128/IAI.00676-18. Print 2019 Mar.

4.

The Extreme Structural Plasticity in the CYP153 Subfamily of P450s Directs Development of Designer Hydroxylases.

Fiorentini F, Hatzl AM, Schmidt S, Savino S, Glieder A, Mattevi A.

Biochemistry. 2018 Dec 4;57(48):6701-6714. doi: 10.1021/acs.biochem.8b01052. Epub 2018 Nov 16.

PMID:
30398864
5.

Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis.

Savino S, Toscano A, Purgatorio R, Profilo E, Laghezza A, Tortorella P, Angelelli M, Cellamare S, Scala R, Tricarico D, Marobbio CMT, Perna F, Vitale P, Agamennone M, Dimiccoli V, Tolomeo A, Scilimati A.

Eur J Med Chem. 2018 Oct 5;158:184-200. doi: 10.1016/j.ejmech.2018.08.044. Epub 2018 Aug 18.

PMID:
30216851
6.

A Piezoresistive Sensor to Measure Muscle Contraction and Mechanomyography.

Esposito D, Andreozzi E, Fratini A, Gargiulo GD, Savino S, Niola V, Bifulco P.

Sensors (Basel). 2018 Aug 4;18(8). pii: E2553. doi: 10.3390/s18082553.

7.

Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions.

Savino S, Marzano C, Gandin V, Hoeschele JD, Natile G, Margiotta N.

Int J Mol Sci. 2018 Jul 14;19(7). pii: E2050. doi: 10.3390/ijms19072050.

8.

A mechanical hand for prosthetic applications: multibody model and contact simulation.

Cosenza C, Niola V, Savino S.

Proc Inst Mech Eng H. 2018 Aug;232(8):819-825. doi: 10.1177/0954411918787548. Epub 2018 Jul 12.

PMID:
29999481
9.

Dual-acting antitumor Pt(iv) prodrugs of kiteplatin with dichloroacetate axial ligands.

Savino S, Gandin V, Hoeschele JD, Marzano C, Natile G, Margiotta N.

Dalton Trans. 2018 May 29;47(21):7144-7158. doi: 10.1039/c8dt00686e.

PMID:
29766157
10.

The new European invader Aedes (Finlaya) koreicus: a potential vector of chikungunya virus.

Ciocchetta S, Prow NA, Darbro JM, Frentiu FD, Savino S, Montarsi F, Capelli G, Aaskov JG, Devine GJ.

Pathog Glob Health. 2018 May;112(3):107-114. doi: 10.1080/20477724.2018.1464780. Epub 2018 May 8. Review.

11.

Lectin activity of the pneumococcal pilin proteins.

Day CJ, Paton AW, Harvey RM, Hartley-Tassell LE, Seib KL, Tiralongo J, Bovin N, Savino S, Masignani V, Paton JC, Jennings MP.

Sci Rep. 2017 Dec 19;7(1):17784. doi: 10.1038/s41598-017-17850-9.

12.

Polycyclic Ketone Monooxygenase from the Thermophilic Fungus Thermothelomyces thermophila: A Structurally Distinct Biocatalyst for Bulky Substrates.

Fürst MJ, Savino S, Dudek HM, Gómez Castellanos JR, Gutiérrez de Souza C, Rovida S, Fraaije MW, Mattevi A.

J Am Chem Soc. 2017 Jan 18;139(2):627-630. doi: 10.1021/jacs.6b12246. Epub 2017 Jan 3.

PMID:
28010060
13.

Right ventricular involvement in feline hypertrophic cardiomyopathy.

Schober KE, Savino SI, Yildiz V.

J Vet Cardiol. 2016 Dec;18(4):297-309. doi: 10.1016/j.jvc.2016.08.001. Epub 2016 Sep 22.

PMID:
27667689
14.

Synthesis, Characterization, and Cytotoxicity of the First Oxaliplatin Pt(IV) Derivative Having a TSPO Ligand in the Axial Position.

Savino S, Denora N, Iacobazzi RM, Porcelli L, Azzariti A, Natile G, Margiotta N.

Int J Mol Sci. 2016 Jun 25;17(7). pii: E1010. doi: 10.3390/ijms17071010.

15.

Exploring host-pathogen interactions through genome wide protein microarray analysis.

Scietti L, Sampieri K, Pinzuti I, Bartolini E, Benucci B, Liguori A, Haag AF, Lo Surdo P, Pansegrau W, Nardi-Dei V, Santini L, Arora S, Leber X, Rindi S, Savino S, Costantino P, Maione D, Merola M, Speziale P, Bottomley MJ, Bagnoli F, Masignani V, Pizza M, Scharenberg M, Schlaeppi JM, Nissum M, Liberatori S.

Sci Rep. 2016 Jun 15;6:27996. doi: 10.1038/srep27996.

16.

Encapsulation of lipophilic kiteplatin Pt(iv) prodrugs in PLGA-PEG micelles.

Margiotta N, Savino S, Denora N, Marzano C, Laquintana V, Cutrignelli A, Hoeschele JD, Gandin V, Natile G.

Dalton Trans. 2016 Aug 16;45(33):13070-81. doi: 10.1039/c6dt00763e.

PMID:
27094010
17.

Structural and biochemical insights into 7β-hydroxysteroid dehydrogenase stereoselectivity.

Savino S, Ferrandi EE, Forneris F, Rovida S, Riva S, Monti D, Mattevi A.

Proteins. 2016 Jun;84(6):859-65. doi: 10.1002/prot.25036. Epub 2016 Apr 6.

PMID:
27006087
18.

Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined.

Biagini M, Spinsanti M, De Angelis G, Tomei S, Ferlenghi I, Scarselli M, Rigat F, Messuti N, Biolchi A, Muzzi A, Anderloni G, Brunelli B, Cartocci E, Buricchi F, Tani C, Stella M, Moschioni M, Del Tordello E, Colaprico A, Savino S, Giuliani MM, Delany I, Pizza M, Costantino P, Norais N, Rappuoli R, Masignani V.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2714-9. doi: 10.1073/pnas.1521142113. Epub 2016 Feb 17.

19.

Detecting β-Casein Variation in Bovine Milk.

Caroli AM, Savino S, Bulgari O, Monti E.

Molecules. 2016 Jan 25;21(2):141. doi: 10.3390/molecules21020141.

20.

Cytotoxicity-boosting of kiteplatin by Pt(IV) prodrugs with axial benzoate ligands.

Margiotta N, Savino S, Marzano C, Pacifico C, Hoeschele JD, Gandin V, Natile G.

J Inorg Biochem. 2016 Jul;160:85-93. doi: 10.1016/j.jinorgbio.2015.11.028. Epub 2015 Dec 18.

PMID:
26775068
21.

Emergency anaesthesia in adult patients with Sanfilippo syndrome.

Aguado S, Sanchez D, Fustran N, Savino S.

Rev Esp Anestesiol Reanim. 2016 Apr;63(4):244-5. doi: 10.1016/j.redar.2015.09.004. Epub 2015 Nov 25. English, Spanish. No abstract available.

PMID:
26626437
22.

The three-dimensional structure of "Lonely Guy" from Claviceps purpurea provides insights into the phosphoribohydrolase function of Rossmann fold-containing lysine decarboxylase-like proteins.

Dzurová L, Forneris F, Savino S, Galuszka P, Vrabka J, Frébort I.

Proteins. 2015 Aug;83(8):1539-46. doi: 10.1002/prot.24835. Epub 2015 Jul 1.

PMID:
26010010
23.

Rivaroxaban use in patients with antiphospholipid syndrome and previous venous thromboembolism.

Sciascia S, Breen K, Hunt BJ.

Blood Coagul Fibrinolysis. 2015 Jun;26(4):476-7. doi: 10.1097/MBC.0000000000000247. No abstract available. Erratum in: Blood Coagul Fibrinolysis. 2015 Jul;26(5):597. Savino, Sciascia [corrected to Sciascia, Savino].

PMID:
25923780
24.

Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant.

Bottazzi B, Santini L, Savino S, Giuliani MM, Dueñas Díez AI, Mancuso G, Beninati C, Sironi M, Valentino S, Deban L, Garlanda C, Teti G, Pizza M, Rappuoli R, Mantovani A.

PLoS One. 2015 Mar 18;10(3):e0120807. doi: 10.1371/journal.pone.0120807. eCollection 2015.

25.

Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus.

Bagnoli F, Fontana MR, Soldaini E, Mishra RP, Fiaschi L, Cartocci E, Nardi-Dei V, Ruggiero P, Nosari S, De Falco MG, Lofano G, Marchi S, Galletti B, Mariotti P, Bacconi M, Torre A, Maccari S, Scarselli M, Rinaudo CD, Inoshima N, Savino S, Mori E, Rossi-Paccani S, Baudner B, Pallaoro M, Swennen E, Petracca R, Brettoni C, Liberatori S, Norais N, Monaci E, Bubeck Wardenburg J, Schneewind O, O'Hagan DT, Valiante NM, Bensi G, Bertholet S, De Gregorio E, Rappuoli R, Grandi G.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3680-5. doi: 10.1073/pnas.1424924112. Epub 2015 Mar 9.

26.

Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody.

Malito E, Biancucci M, Faleri A, Ferlenghi I, Scarselli M, Maruggi G, Lo Surdo P, Veggi D, Liguori A, Santini L, Bertoldi I, Petracca R, Marchi S, Romagnoli G, Cartocci E, Vercellino I, Savino S, Spraggon G, Norais N, Pizza M, Rappuoli R, Masignani V, Bottomley MJ.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17128-33. doi: 10.1073/pnas.1419686111. Epub 2014 Nov 17.

27.

Role of ARF6, Rab11 and external Hsp90 in the trafficking and recycling of recombinant-soluble Neisseria meningitidis adhesin A (rNadA) in human epithelial cells.

Bozza G, Capitani M, Montanari P, Benucci B, Biancucci M, Nardi-Dei V, Caproni E, Barrile R, Picciani B, Savino S, Aricò B, Rappuoli R, Pizza M, Luini A, Sallese M, Merola M.

PLoS One. 2014 Oct 27;9(10):e110047. doi: 10.1371/journal.pone.0110047. eCollection 2014.

28.

Monofunctional platinum(II) complexes with potent tumor cell growth inhibitory activity: the effect of a hydrogen-bond donor/acceptor N-heterocyclic ligand.

Margiotta N, Savino S, Gandin V, Marzano C, Natile G.

ChemMedChem. 2014 Jun;9(6):1161-8. doi: 10.1002/cmdc.201402028. Epub 2014 May 2.

PMID:
24799414
29.

Structure and protective efficacy of the Staphylococcus aureus autocleaving protease EpiP.

Kuhn ML, Prachi P, Minasov G, Shuvalova L, Ruan J, Dubrovska I, Winsor J, Giraldi M, Biagini M, Liberatori S, Savino S, Bagnoli F, Anderson WF, Grandi G.

FASEB J. 2014 Apr;28(4):1780-93. doi: 10.1096/fj.13-241737. Epub 2014 Jan 13.

30.

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties.

Faleri A, Santini L, Brier S, Pansegrau W, Lo Surdo P, Scarselli M, Buricchi F, Volpini G, Genovese A, van der Veen S, Lea S, Tang CM, Savino S, Pizza M, Finco O, Norais N, Masignani V.

FASEB J. 2014 Apr;28(4):1644-53. doi: 10.1096/fj.13-239012. Epub 2013 Dec 26.

PMID:
24371123
31.

Protective efficacy induced by recombinant Clostridium difficile toxin fragments.

Leuzzi R, Spencer J, Buckley A, Brettoni C, Martinelli M, Tulli L, Marchi S, Luzzi E, Irvine J, Candlish D, Veggi D, Pansegrau W, Fiaschi L, Savino S, Swennen E, Cakici O, Oviedo-Orta E, Giraldi M, Baudner B, D'Urzo N, Maione D, Soriani M, Rappuoli R, Pizza M, Douce GR, Scarselli M.

Infect Immun. 2013 Aug;81(8):2851-60. doi: 10.1128/IAI.01341-12. Epub 2013 May 28.

32.

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen.

Malito E, Faleri A, Lo Surdo P, Veggi D, Maruggi G, Grassi E, Cartocci E, Bertoldi I, Genovese A, Santini L, Romagnoli G, Borgogni E, Brier S, Lo Passo C, Domina M, Castellino F, Felici F, van der Veen S, Johnson S, Lea SM, Tang CM, Pizza M, Savino S, Norais N, Rappuoli R, Bottomley MJ, Masignani V.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3304-9. doi: 10.1073/pnas.1222845110. Epub 2013 Feb 8.

33.

The factor H binding protein of Neisseria meningitidis interacts with xenosiderophores in vitro.

Veggi D, Gentile MA, Cantini F, Lo Surdo P, Nardi-Dei V, Seib KL, Pizza M, Rappuoli R, Banci L, Savino S, Scarselli M.

Biochemistry. 2012 Nov 20;51(46):9384-93. doi: 10.1021/bi301161w. Epub 2012 Nov 12.

PMID:
23121397
34.

Structural and functional characterization of the Staphylococcus aureus virulence factor and vaccine candidate FhuD2.

Mariotti P, Malito E, Biancucci M, Lo Surdo P, Mishra RP, Nardi-Dei V, Savino S, Nissum M, Spraggon G, Grandi G, Bagnoli F, Bottomley MJ.

Biochem J. 2013 Feb 1;449(3):683-93. doi: 10.1042/BJ20121426.

PMID:
23113737
35.

Development of an influenza virus protein array using Sortagging technology.

Sinisi A, Popp MW, Antos JM, Pansegrau W, Savino S, Nissum M, Rappuoli R, Ploegh HL, Buti L.

Bioconjug Chem. 2012 Jun 20;23(6):1119-26. doi: 10.1021/bc200577u. Epub 2012 May 25.

36.

Could multiple myeloma VEGF modify the systemic microcirculation?

Cicco S, Ditonno P, Reale A, Savino S, Castrovilli A, Catacchio I, Ria R, Vacca A.

Adv Exp Med Biol. 2012;737:155-60. doi: 10.1007/978-1-4614-1566-4_23. No abstract available.

PMID:
22259096
37.

RrgB321, a fusion protein of the three variants of the pneumococcal pilus backbone RrgB, is protective in vivo and elicits opsonic antibodies.

Harfouche C, Filippini S, Gianfaldoni C, Ruggiero P, Moschioni M, Maccari S, Pancotto L, Arcidiacono L, Galletti B, Censini S, Mori E, Giuliani M, Facciotti C, Cartocci E, Savino S, Doro F, Pallaoro M, Nocadello S, Mancuso G, Haston M, Goldblatt D, Barocchi MA, Pizza M, Rappuoli R, Masignani V.

Infect Immun. 2012 Jan;80(1):451-60. doi: 10.1128/IAI.05780-11. Epub 2011 Nov 14.

38.

Antigen identification starting from the genome: a "Reverse Vaccinology" approach applied to MenB.

Palumbo E, Fiaschi L, Brunelli B, Marchi S, Savino S, Pizza M.

Methods Mol Biol. 2012;799:361-403. doi: 10.1007/978-1-61779-346-2_21.

PMID:
21993656
39.

Rational design of a meningococcal antigen inducing broad protective immunity.

Scarselli M, Aricò B, Brunelli B, Savino S, Di Marcello F, Palumbo E, Veggi D, Ciucchi L, Cartocci E, Bottomley MJ, Malito E, Lo Surdo P, Comanducci M, Giuliani MM, Cantini F, Dragonetti S, Colaprico A, Doro F, Giannetti P, Pallaoro M, Brogioni B, Tontini M, Hilleringmann M, Nardi-Dei V, Banci L, Pizza M, Rappuoli R.

Sci Transl Med. 2011 Jul 13;3(91):91ra62. doi: 10.1126/scitranslmed.3002234.

40.

Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce bactericidal antibodies.

Seib KL, Brunelli B, Brogioni B, Palumbo E, Bambini S, Muzzi A, DiMarcello F, Marchi S, van der Ende A, Aricó B, Savino S, Scarselli M, Comanducci M, Rappuoli R, Giuliani MM, Pizza M.

Infect Immun. 2011 Feb;79(2):970-81. doi: 10.1128/IAI.00891-10. Epub 2010 Dec 13.

41.

Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli.

Moriel DG, Bertoldi I, Spagnuolo A, Marchi S, Rosini R, Nesta B, Pastorello I, Corea VA, Torricelli G, Cartocci E, Savino S, Scarselli M, Dobrindt U, Hacker J, Tettelin H, Tallon LJ, Sullivan S, Wieler LH, Ewers C, Pickard D, Dougan G, Fontana MR, Rappuoli R, Pizza M, Serino L.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9072-7. doi: 10.1073/pnas.0915077107. Epub 2010 May 3.

42.

Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans.

Serruto D, Spadafina T, Ciucchi L, Lewis LA, Ram S, Tontini M, Santini L, Biolchi A, Seib KL, Giuliani MM, Donnelly JJ, Berti F, Savino S, Scarselli M, Costantino P, Kroll JS, O'Dwyer C, Qiu J, Plaut AG, Moxon R, Rappuoli R, Pizza M, Aricò B.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3770-5. doi: 10.1073/pnas.0915162107. Epub 2010 Feb 3.

43.

HadA is an atypical new multifunctional trimeric coiled-coil adhesin of Haemophilus influenzae biogroup aegyptius, which promotes entry into host cells.

Serruto D, Spadafina T, Scarselli M, Bambini S, Comanducci M, Höhle S, Kilian M, Veiga E, Cossart P, Oggioni MR, Savino S, Ferlenghi I, Taddei AR, Rappuoli R, Pizza M, Masignani V, Aricò B.

Cell Microbiol. 2009 Jul;11(7):1044-63. doi: 10.1111/j.1462-5822.2009.01306.x. Epub 2009 Mar 12.

PMID:
19290916
44.

Solution structure of the factor H-binding protein, a survival factor and protective antigen of Neisseria meningitidis.

Cantini F, Veggi D, Dragonetti S, Savino S, Scarselli M, Romagnoli G, Pizza M, Banci L, Rappuoli R.

J Biol Chem. 2009 Apr 3;284(14):9022-6. doi: 10.1074/jbc.C800214200. Epub 2009 Feb 4.

45.

SR-A, MARCO and TLRs differentially recognise selected surface proteins from Neisseria meningitidis: an example of fine specificity in microbial ligand recognition by innate immune receptors.

Plüddemann A, Mukhopadhyay S, Sankala M, Savino S, Pizza M, Rappuoli R, Tryggvason K, Gordon S.

J Innate Immun. 2009;1(2):153-63. doi: 10.1159/000155227. Epub 2008 Sep 11.

46.

Epitope mapping of a bactericidal monoclonal antibody against the factor H binding protein of Neisseria meningitidis.

Scarselli M, Cantini F, Santini L, Veggi D, Dragonetti S, Donati C, Savino S, Giuliani MM, Comanducci M, Di Marcello F, Romagnoli G, Pizza M, Banci L, Rappuoli R.

J Mol Biol. 2009 Feb 13;386(1):97-108. doi: 10.1016/j.jmb.2008.12.005. Epub 2008 Dec 11.

PMID:
19100746
47.

Involvement of vessels and PDGFB in muscle splitting during chick limb development.

Tozer S, Bonnin MA, Relaix F, Di Savino S, García-Villalba P, Coumailleau P, Duprez D.

Development. 2007 Jul;134(14):2579-91. Epub 2007 Jun 6.

48.

Identification of Neisseria meningitidis nonlipopolysaccharide ligands for class A macrophage scavenger receptor by using a novel assay.

Peiser L, Makepeace K, Plüddemann A, Savino S, Wright JC, Pizza M, Rappuoli R, Moxon ER, Gordon S.

Infect Immun. 2006 Sep;74(9):5191-9.

49.

A universal vaccine for serogroup B meningococcus.

Giuliani MM, Adu-Bobie J, Comanducci M, Aricò B, Savino S, Santini L, Brunelli B, Bambini S, Biolchi A, Capecchi B, Cartocci E, Ciucchi L, Di Marcello F, Ferlicca F, Galli B, Luzzi E, Masignani V, Serruto D, Veggi D, Contorni M, Morandi M, Bartalesi A, Cinotti V, Mannucci D, Titta F, Ovidi E, Welsch JA, Granoff D, Rappuoli R, Pizza M.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10834-9. Epub 2006 Jul 6.

50.

Solution structure of the immunodominant domain of protective antigen GNA1870 of Neisseria meningitidis.

Cantini F, Savino S, Scarselli M, Masignani V, Pizza M, Romagnoli G, Swennen E, Veggi D, Banci L, Rappuoli R.

J Biol Chem. 2006 Mar 17;281(11):7220-7. Epub 2005 Dec 31.

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