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Hyperfiltration-mediated Injury in the Remaining Kidney of a Transplant Donor.

Srivastava T, Hariharan S, Alon US, McCarthy ET, Sharma R, El-Meanawy A, Savin VJ, Sharma M.

Transplantation. 2018 Oct;102(10):1624-1635. doi: 10.1097/TP.0000000000002304. Review.


Multiple Targets for Novel Therapy of FSGS Associated with Circulating Permeability Factor.

Savin VJ, Sharma M, Zhou J, Genochi D, Sharma R, Srivastava T, Ilahe A, Budhiraja P, Gupta A, McCarthy ET.

Biomed Res Int. 2017;2017:6232616. doi: 10.1155/2017/6232616. Epub 2017 Aug 10. Review.


Mechanotransduction signaling in podocytes from fluid flow shear stress.

Srivastava T, Dai H, Heruth DP, Alon US, Garola RE, Zhou J, Duncan RS, El-Meanawy A, McCarthy ET, Sharma R, Johnson ML, Savin VJ, Sharma M.

Am J Physiol Renal Physiol. 2018 Jan 1;314(1):F22-F34. doi: 10.1152/ajprenal.00325.2017. Epub 2017 Sep 6.


Normalization of Testosterone Levels After Testosterone Replacement Therapy Is Not Associated With Reduced Myocardial Infarction in Smokers.

Oni OA, Sharma R, Chen G, Sharma M, Gupta K, Dawn B, Sharma R, Parashara D, Savin VJ, Cherian G, Ambrose JA, Barua RS.

Mayo Clin Proc Innov Qual Outcomes. 2017 May 18;1(1):57-66. doi: 10.1016/j.mayocpiqo.2017.05.003. eCollection 2017 Jul.


Role of biomechanical forces in hyperfiltration-mediated glomerular injury in congenital anomalies of the kidney and urinary tract.

Srivastava T, Thiagarajan G, Alon US, Sharma R, El-Meanawy A, McCarthy ET, Savin VJ, Sharma M.

Nephrol Dial Transplant. 2017 May 1;32(5):759-765. doi: 10.1093/ndt/gfw430. Review.


Hyperfiltration-associated biomechanical forces in glomerular injury and response: Potential role for eicosanoids.

Sharma M, Sharma R, McCarthy ET, Savin VJ, Srivastava T.

Prostaglandins Other Lipid Mediat. 2017 Sep;132:59-68. doi: 10.1016/j.prostaglandins.2017.01.003. Epub 2017 Jan 17. Review.


Association Between Testosterone Replacement Therapy and the Incidence of DVT and Pulmonary Embolism: A Retrospective Cohort Study of the Veterans Administration Database.

Sharma R, Oni OA, Chen G, Sharma M, Dawn B, Sharma R, Parashara D, Savin VJ, Barua RS, Gupta K.

Chest. 2016 Sep;150(3):563-71. doi: 10.1016/j.chest.2016.05.007. Epub 2016 May 12.


Serum glomerular albumin permeability activity: association with rapid progression to end-stage renal disease in focal segmental glomerulosclerosis.

Pudur S, Srivastava T, Sharma M, Sharma R, Tarima S, Dai H, McCarthy ET, Savin VJ.

Springerplus. 2016 Apr 11;5:432. doi: 10.1186/s40064-016-2077-9. eCollection 2016.


Fluorescence dilution technique for measurement of albumin reflection coefficient in isolated glomeruli.

Fan F, Chen CC, Zhang J, Schreck CM, Roman EA, Williams JM, Hirata T, Sharma M, Beard DA, Savin VJ, Roman RJ.

Am J Physiol Renal Physiol. 2015 Dec 15;309(12):F1049-59. doi: 10.1152/ajprenal.00311.2015. Epub 2015 Oct 7.


Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men.

Sharma R, Oni OA, Gupta K, Chen G, Sharma M, Dawn B, Sharma R, Parashara D, Savin VJ, Ambrose JA, Barua RS.

Eur Heart J. 2015 Oct 21;36(40):2706-15. doi: 10.1093/eurheartj/ehv346. Epub 2015 Aug 6.


Efficacy of galactose and adalimumab in patients with resistant focal segmental glomerulosclerosis: report of the font clinical trial group.

Trachtman H, Vento S, Herreshoff E, Radeva M, Gassman J, Stein DT, Savin VJ, Sharma M, Reiser J, Wei C, Somers M, Srivastava T, Gipson DS.

BMC Nephrol. 2015 Jul 22;16:111. doi: 10.1186/s12882-015-0094-5.


Renal and Hematological Effects of CLCF-1, a B-Cell-Stimulating Cytokine of the IL-6 Family.

Savin VJ, Sharma M, Zhou J, Gennochi D, Fields T, Sharma R, McCarthy ET, Srivastava T, Domen J, Tormo A, Gauchat JF.

J Immunol Res. 2015;2015:714964. doi: 10.1155/2015/714964. Epub 2015 Jun 4.


Janus kinase 2/signal transducer and activator of transcription 3 inhibitors attenuate the effect of cardiotrophin-like cytokine factor 1 and human focal segmental glomerulosclerosis serum on glomerular filtration barrier.

Sharma M, Zhou J, Gauchat JF, Sharma R, McCarthy ET, Srivastava T, Savin VJ.

Transl Res. 2015 Oct;166(4):384-98. doi: 10.1016/j.trsl.2015.03.002. Epub 2015 Mar 16.


Ethanol at low concentrations protects glomerular podocytes through alcohol dehydrogenase and 20-HETE.

McCarthy ET, Zhou J, Eckert R, Genochio D, Sharma R, Oni O, De A, Srivastava T, Sharma R, Savin VJ, Sharma M.

Prostaglandins Other Lipid Mediat. 2015 Jan-Mar;116-117:88-98. doi: 10.1016/j.prostaglandins.2014.10.006. Epub 2014 Nov 4.


Cyclooxygenase-2, prostaglandin E2, and prostanoid receptor EP2 in fluid flow shear stress-mediated injury in the solitary kidney.

Srivastava T, Alon US, Cudmore PA, Tarakji B, Kats A, Garola RE, Duncan RS, McCarthy ET, Sharma R, Johnson ML, Bonewald LF, El-Meanawy A, Savin VJ, Sharma M.

Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1323-33. doi: 10.1152/ajprenal.00335.2014. Epub 2014 Sep 18.


Galactose treatment in focal segmental glomerulosclerosis.

Trachtman H, Savin VJ.

Pediatr Nephrol. 2014 May;29(5):931. doi: 10.1007/s00467-013-2700-8. Epub 2013 Dec 22. No abstract available.


Permeability factors in nephrotic syndrome and focal segmental glomerulosclerosis.

Savin VJ, McCarthy ET, Sharma M.

Kidney Res Clin Pract. 2012 Dec;31(4):205-13. doi: 10.1016/j.krcp.2012.10.002. Epub 2012 Oct 16. Review.


Endothelin receptor A-specific stimulation of glomerular inflammation and injury in a streptozotocin-induced rat model of diabetes.

Saleh MA, Boesen EI, Pollock JS, Savin VJ, Pollock DM.

Diabetologia. 2011 Apr;54(4):979-88. doi: 10.1007/s00125-010-2021-4. Epub 2010 Dec 30.


Circulating permeability factors in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis.

McCarthy ET, Sharma M, Savin VJ.

Clin J Am Soc Nephrol. 2010 Nov;5(11):2115-21. doi: 10.2215/CJN.03800609. Epub 2010 Oct 21. Review.


Endothelin-1 increases glomerular permeability and inflammation independent of blood pressure in the rat.

Saleh MA, Boesen EI, Pollock JS, Savin VJ, Pollock DM.

Hypertension. 2010 Nov;56(5):942-9. doi: 10.1161/HYPERTENSIONAHA.110.156570. Epub 2010 Sep 7. Erratum in: Hypertension. 2011 Oct;58(4):e31.


The urine proteome for radiation biodosimetry: effect of total body vs. local kidney irradiation.

Sharma M, Halligan BD, Wakim BT, Savin VJ, Cohen EP, Moulder JE.

Health Phys. 2010 Feb;98(2):186-95. doi: 10.1097/HP.0b013e3181b17cbd.


Plasma "factors" in recurrent nephrotic syndrome after kidney transplantation: causes or consequences of glomerular injury?

Savin VJ, Sharma M.

Am J Kidney Dis. 2009 Sep;54(3):406-9. doi: 10.1053/j.ajkd.2009.06.010. No abstract available.


8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier.

Sharma M, McCarthy ET, Reddy DS, Patel PK, Savin VJ, Medhora M, Falck JR.

Prostaglandins Other Lipid Mediat. 2009 Jun;89(1-2):43-51.


Antibodies to protein tyrosine phosphatase receptor type O (PTPro) increase glomerular albumin permeability (P(alb)).

Charba DS, Wiggins RC, Goyal M, Wharram BL, Wiggins JE, McCarthy ET, Sharma R, Sharma M, Savin VJ.

Am J Physiol Renal Physiol. 2009 Jul;297(1):F138-44. doi: 10.1152/ajprenal.00122.2008. Epub 2009 Apr 29.


ADMA injures the glomerular filtration barrier: role of nitric oxide and superoxide.

Sharma M, Zhou Z, Miura H, Papapetropoulos A, McCarthy ET, Sharma R, Savin VJ, Lianos EA.

Am J Physiol Renal Physiol. 2009 Jun;296(6):F1386-95. doi: 10.1152/ajprenal.90369.2008. Epub 2009 Mar 18.


The Urine Proteome as a Biomarker of Radiation Injury: Submitted to Proteomics- Clinical Applications Special Issue: "Renal and Urinary Proteomics (Thongboonkerd)"

Sharma M, Halligan BD, Wakim BT, Savin VJ, Cohen EP, Moulder JE.

Proteomics Clin Appl. 2008 Jun 18;2(7-8):1065-1086.


Galactose binds to focal segmental glomerulosclerosis permeability factor and inhibits its activity.

Savin VJ, McCarthy ET, Sharma R, Charba D, Sharma M.

Transl Res. 2008 Jun;151(6):288-92. doi: 10.1016/j.trsl.2008.04.001. Epub 2008 May 2.


Serum permeability activity in steroid-resistant minimal change nephrotic syndrome is abolished by treatment of Hodgkin disease.

Aggarwal N, Batwara R, McCarthy ET, Sharma R, Sharma M, Savin VJ.

Am J Kidney Dis. 2007 Nov;50(5):826-9.


Chymase increases glomerular albumin permeability via protease-activated receptor-2.

Sharma R, Prasad V, McCarthy ET, Savin VJ, Dileepan KN, Stechschulte DJ, Lianos E, Wiegmann T, Sharma M.

Mol Cell Biochem. 2007 Mar;297(1-2):161-9. Epub 2006 Nov 11.


Recurrence of proteinuria following renal transplantation in congenital nephrotic syndrome of the Finnish type.

Srivastava T, Garola RE, Kestila M, Tryggvason K, Ruotsalainen V, Sharma M, Savin VJ, Jalanko H, Warady BA.

Pediatr Nephrol. 2006 May;21(5):711-8. Epub 2006 Mar 4.


Arachidonic acid metabolites mediate the radiation-induced increase in glomerular albumin permeability.

Sharma M, McCarthy ET, Sharma R, Fish BL, Savin VJ, Cohen EP, Moulder JE.

Exp Biol Med (Maywood). 2006 Jan;231(1):99-106.


Nitric oxide preserves the glomerular protein permeability barrier by antagonizing superoxide.

Sharma M, McCarthy ET, Savin VJ, Lianos EA.

Kidney Int. 2005 Dec;68(6):2735-44.


Preemptive plasmapheresis and recurrence of FSGS in high-risk renal transplant recipients.

Gohh RY, Yango AF, Morrissey PE, Monaco AP, Gautam A, Sharma M, McCarthy ET, Savin VJ.

Am J Transplant. 2005 Dec;5(12):2907-12.


Chronically increased intrarenal angiotensin II causes nephropathy in an animal model of type 2 diabetes.

Sharma R, Sharma M, Reddy S, Savin VJ, Nagaria AM, Wiegmann TB.

Front Biosci. 2006 Jan 1;11:968-76. Review.


Transforming growth factor-beta, 20-HETE interaction, and glomerular injury in Dahl salt-sensitive rats.

Dahly-Vernon AJ, Sharma M, McCarthy ET, Savin VJ, Ledbetter SR, Roman RJ.

Hypertension. 2005 Apr;45(4):643-8. Epub 2005 Feb 21.


Glomerular permeability activity: prevalence and prognostic value in pediatric patients with idiopathic nephrotic syndrome.

Trachtman H, Greenbaum LA, McCarthy ET, Sharma M, Gauthier BG, Frank R, Warady B, Savin VJ.

Am J Kidney Dis. 2004 Oct;44(4):604-10.


The focal segmental glomerulosclerosis permeability factor: biochemical characteristics and biological effects.

Sharma M, Sharma R, McCarthy ET, Savin VJ.

Exp Biol Med (Maywood). 2004 Jan;229(1):85-98.


Permeability factors in focal segmental glomerulosclerosis.

Savin VJ, McCarthy ET, Sharma M.

Semin Nephrol. 2003 Mar;23(2):147-60. Review.


Proteinuria after injection of human focal segmental glomerulosclerosis factor.

Sharma M, Sharma R, Reddy SR, McCarthy ET, Savin VJ.

Transplantation. 2002 Feb 15;73(3):366-72.


Induction of metallothionein-I protects glomeruli from superoxide-mediated increase in albumin permeability.

Sharma R, Sharma M, Datta PK, Savin VJ.

Exp Biol Med (Maywood). 2002 Jan;227(1):26-31.


Both subtype 1 and 2 receptors of angiotensin II participate in regulation of intracellular calcium in glomerular epithelial cells.

Sharma R, Sharma M, Vamos S, Savin VJ, Wiegmann TB.

J Lab Clin Med. 2001 Jul;138(1):40-9.


Early detection of radiation-induced glomerular injury by albumin permeability assay.

Sharma M, Sharma R, Ge XL, Fish BL, McCarthy ET, Savin VJ, Cohen EP, Moulder JE.

Radiat Res. 2001 Mar;155(3):474-80.


Components of normal serum block the focal segmental glomerulosclerosis factor activity in vitro.

Sharma R, Sharma M, McCarthy ET, Ge XL, Savin VJ.

Kidney Int. 2000 Nov;58(5):1973-9.


"The FSGS factor:" enrichment and in vivo effect of activity from focal segmental glomerulosclerosis plasma.

Sharma M, Sharma R, McCarthy ET, Savin VJ.

J Am Soc Nephrol. 1999 Mar;10(3):552-61.


Recurrent and de novo renal diseases after renal transplantation: a report from the renal allograft disease registry.

Hariharan S, Peddi VR, Savin VJ, Johnson CP, First MR, Roza AM, Adams MB.

Am J Kidney Dis. 1998 Jun;31(6):928-31.


Documentation of angiotensin II receptors in glomerular epithelial cells.

Sharma M, Sharma R, Greene AS, McCarthy ET, Savin VJ.

Am J Physiol. 1998 Mar;274(3 Pt 2):F623-7.


TNF-alpha increases albumin permeability of isolated rat glomeruli through the generation of superoxide.

McCarthy ET, Sharma R, Sharma M, Li JZ, Ge XL, Dileepan KN, Savin VJ.

J Am Soc Nephrol. 1998 Mar;9(3):433-8.

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