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Items: 1 to 50 of 96

1.

Effective lead optimization targeting the displacement of bridging receptor-ligand water molecules.

Chen D, Li Y, Zhao M, Tan W, Li X, Savidge T, Guo W, Fan X.

Phys Chem Chem Phys. 2018 Sep 17. doi: 10.1039/c8cp04118k. [Epub ahead of print]

PMID:
30221291
2.

Microbiota dysbiosis and its pathophysiological significance in bowel obstruction.

Hegde S, Lin YM, Golovko G, Khanipov K, Cong Y, Savidge T, Fofanov Y, Shi XZ.

Sci Rep. 2018 Sep 3;8(1):13044. doi: 10.1038/s41598-018-31033-0.

3.

Aging impairs protective host defenses against Clostridioides (Clostridium) difficile infection in mice by suppressing neutrophil and IL-22 mediated immunity.

Peniche AG, Spinler JK, Boonma P, Savidge TC, Dann SM.

Anaerobe. 2018 Aug 9;54:83-91. doi: 10.1016/j.anaerobe.2018.07.011. [Epub ahead of print]

PMID:
30099125
4.

Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life.

Zhong XS, Winston JH, Luo X, Kline KT, Nayeem SZ, Cong Y, Savidge TC, Dashwood RH, Powell DW, Li Q.

Cell Mol Gastroenterol Hepatol. 2018 Mar 9;6(1):65-78. doi: 10.1016/j.jcmgh.2018.02.014. eCollection 2018.

5.

Reply.

Bajaj JS, Savidge T, Kassam ZA, Hylemon PB, Gillevet PM.

Hepatology. 2018 Sep;68(3):1206. doi: 10.1002/hep.30092. No abstract available.

PMID:
29774575
6.

Antibiotic-Associated Disruption of Microbiota Composition and Function in Cirrhosis Is Restored by Fecal Transplant.

Bajaj JS, Kakiyama G, Savidge T, Takei H, Kassam ZA, Fagan A, Gavis EA, Pandak WM, Nittono H, Hylemon PB, Boonma P, Haag A, Heuman DM, Fuchs M, John B, Sikaroodi M, Gillevet PM.

Hepatology. 2018 Apr 17. doi: 10.1002/hep.30037. [Epub ahead of print]

PMID:
29665102
7.

Next-Generation Probiotics Targeting Clostridium difficile through Precursor-Directed Antimicrobial Biosynthesis.

Spinler JK, Auchtung J, Brown A, Boonma P, Oezguen N, Ross CL, Luna RA, Runge J, Versalovic J, Peniche A, Dann SM, Britton RA, Haag A, Savidge TC.

Infect Immun. 2017 Sep 20;85(10). pii: e00303-17. doi: 10.1128/IAI.00303-17. Print 2017 Oct.

8.

Cytokines Are Markers of the Clostridium difficile-Induced Inflammatory Response and Predict Disease Severity.

Yu H, Chen K, Sun Y, Carter M, Garey KW, Savidge TC, Devaraj S, Tessier ME, von Rosenvinge EC, Kelly CP, Pasetti MF, Feng H.

Clin Vaccine Immunol. 2017 Aug 4;24(8). pii: e00037-17. doi: 10.1128/CVI.00037-17. Print 2017 Aug.

9.

Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome.

Labus JS, Hollister EB, Jacobs J, Kirbach K, Oezguen N, Gupta A, Acosta J, Luna RA, Aagaard K, Versalovic J, Savidge T, Hsiao E, Tillisch K, Mayer EA.

Microbiome. 2017 May 1;5(1):49. doi: 10.1186/s40168-017-0260-z.

10.

Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder.

Luna RA, Oezguen N, Balderas M, Venkatachalam A, Runge JK, Versalovic J, Veenstra-VanderWeele J, Anderson GM, Savidge T, Williams KC.

Cell Mol Gastroenterol Hepatol. 2016 Dec 11;3(2):218-230. doi: 10.1016/j.jcmgh.2016.11.008. eCollection 2017 Mar.

11.

The Association between GABA-Modulators and Clostridium difficile Infection - A Matched Retrospective Case-Control Study.

Ström J, Tham J, Månsson F, Ahl J, Savidge TC, Dann SM, Resman F.

PLoS One. 2017 Jan 6;12(1):e0169386. doi: 10.1371/journal.pone.0169386. eCollection 2017.

12.

GABA-producing Bifidobacterium dentium modulates visceral sensitivity in the intestine.

Pokusaeva K, Johnson C, Luk B, Uribe G, Fu Y, Oezguen N, Matsunami RK, Lugo M, Major A, Mori-Akiyama Y, Hollister EB, Dann SM, Shi XZ, Engler DA, Savidge T, Versalovic J.

Neurogastroenterol Motil. 2017 Jan;29(1). doi: 10.1111/nmo.12904. Epub 2016 Jul 25.

13.

The Brain-Gut-Microbiome Axis: What Role Does It Play in Autism Spectrum Disorder?

Luna RA, Savidge TC, Williams KC.

Curr Dev Disord Rep. 2016 Mar;3(1):75-81. Epub 2016 Feb 26.

14.

Probiotics as adjunctive therapy for preventing Clostridium difficile infection - What are we waiting for?

Spinler JK, Ross CL, Savidge TC.

Anaerobe. 2016 Oct;41:51-57. doi: 10.1016/j.anaerobe.2016.05.007. Epub 2016 May 13. Review.

15.

Administration of probiotic kefir to mice with Clostridium difficile infection exacerbates disease.

Spinler JK, Brown A, Ross CL, Boonma P, Conner ME, Savidge TC.

Anaerobe. 2016 Aug;40:54-7. doi: 10.1016/j.anaerobe.2016.05.008. Epub 2016 May 11.

16.

Structural and functional changes within the gut microbiota and susceptibility to Clostridium difficile infection.

Ross CL, Spinler JK, Savidge TC.

Anaerobe. 2016 Oct;41:37-43. doi: 10.1016/j.anaerobe.2016.05.006. Epub 2016 May 12. Review.

17.

Regulation of protein-ligand binding affinity by hydrogen bond pairing.

Chen D, Oezguen N, Urvil P, Ferguson C, Dann SM, Savidge TC.

Sci Adv. 2016 Mar 25;2(3):e1501240. doi: 10.1126/sciadv.1501240. eCollection 2016 Mar.

18.

Epigenetic Regulation of Enteric Neurotransmission by Gut Bacteria.

Savidge TC.

Front Cell Neurosci. 2016 Jan 8;9:503. doi: 10.3389/fncel.2015.00503. eCollection 2015. Review.

19.

Glial Orchestrated Neurodegeneration: An Important Crossroad for Neural Stem Cell Therapy to the Intestine.

Savidge TC.

Cell Mol Gastroenterol Hepatol. 2015 Nov 26;2(1):9-10. doi: 10.1016/j.jcmgh.2015.11.007. eCollection 2016 Jan. No abstract available.

20.

BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase".

Chen D, Savidge T.

Science. 2015 Aug 28;349(6251):936. doi: 10.1126/science.aab0095. Epub 2015 Aug 27.

21.

Identification of toxemia in patients with Clostridium difficile infection.

Yu H, Chen K, Wu J, Yang Z, Shi L, Barlow LL, Aronoff DM, Garey KW, Savidge TC, von Rosenvinge EC, Kelly CP, Feng H.

PLoS One. 2015 Apr 17;10(4):e0124235. doi: 10.1371/journal.pone.0124235. eCollection 2015.

22.

Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis.

MacEachern SJ, Patel BA, Keenan CM, Dicay M, Chapman K, McCafferty DM, Savidge TC, Beck PL, MacNaughton WK, Sharkey KA.

Gastroenterology. 2015 Aug;149(2):445-55.e3. doi: 10.1053/j.gastro.2015.04.007. Epub 2015 Apr 9.

23.

Allele variants of enterotoxigenic Escherichia coli heat-labile toxin are globally transmitted and associated with colonization factors.

Joffré E, von Mentzer A, Abd El Ghany M, Oezguen N, Savidge T, Dougan G, Svennerholm AM, Sjöling Å.

J Bacteriol. 2015 Jan;197(2):392-403. doi: 10.1128/JB.02050-14. Epub 2014 Nov 17.

24.

Critical roles of Clostridium difficile toxin B enzymatic activities in pathogenesis.

Li S, Shi L, Yang Z, Zhang Y, Perez-Cordon G, Huang T, Ramsey J, Oezguen N, Savidge TC, Feng H.

Infect Immun. 2015 Feb;83(2):502-13. doi: 10.1128/IAI.02316-14. Epub 2014 Nov 17.

25.

Importance of NO and its related compounds in enteric nervous system regulation of gut homeostasis and disease susceptibility.

Savidge TC.

Curr Opin Pharmacol. 2014 Dec;19:54-60. doi: 10.1016/j.coph.2014.07.009. Epub 2014 Aug 7. Review.

26.

HIV replication in conjunction with granzyme B production by CCR5+ memory CD4 T cells: Implications for bystander cell and tissue pathologies.

Couturier J, Hutchison AT, Medina MA, Gingaras C, Urvil P, Yu X, Nguyen C, Mahale P, Lin L, Kozinetz CA, Schmitz JE, Kimata JT, Savidge TC, Lewis DE.

Virology. 2014 Aug;462-463:175-88. doi: 10.1016/j.virol.2014.06.008. Epub 2014 Jul 4.

27.

Reprint of: Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract.

Sharkey KA, Savidge TC.

Auton Neurosci. 2014 May;182:70-82. doi: 10.1016/j.autneu.2014.03.004. Epub 2014 Mar 15.

PMID:
24674836
28.

Gut microbiota influences low fermentable substrate diet efficacy in children with irritable bowel syndrome.

Chumpitazi BP, Hollister EB, Oezguen N, Tsai CM, McMeans AR, Luna RA, Savidge TC, Versalovic J, Shulman RJ.

Gut Microbes. 2014 Mar-Apr;5(2):165-75. doi: 10.4161/gmic.27923. Epub 2014 Jan 27.

29.

Brain-gut microbiome interactions and functional bowel disorders.

Mayer EA, Savidge T, Shulman RJ.

Gastroenterology. 2014 May;146(6):1500-12. doi: 10.1053/j.gastro.2014.02.037. Epub 2014 Feb 28. Review.

30.

Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract.

Sharkey KA, Savidge TC.

Auton Neurosci. 2014 Apr;181:94-106. doi: 10.1016/j.autneu.2013.12.006. Epub 2013 Dec 22. Review.

31.

Recent insights into Clostridium difficile pathogenesis.

Peniche AG, Savidge TC, Dann SM.

Curr Opin Infect Dis. 2013 Oct;26(5):447-53. doi: 10.1097/01.qco.0000433318.82618.c6. Review.

PMID:
23982235
32.

Community-Acquired Clostridium Difficile Infection: Awareness and Clinical Implications.

Juneau C, Mendias EN, Wagal N, Loeffelholz M, Savidge T, Croisant S, Dann S.

J Nurse Pract. 2013 Jan;9(1):1-6.

33.

A segment of 97 amino acids within the translocation domain of Clostridium difficile toxin B is essential for toxicity.

Zhang Y, Shi L, Li S, Yang Z, Standley C, Yang Z, ZhuGe R, Savidge T, Wang X, Feng H.

PLoS One. 2013;8(3):e58634. doi: 10.1371/journal.pone.0058634. Epub 2013 Mar 6.

34.

Performance of the LHCb RICH detector at the LHC.

LHCb RICH Collaboration, Adinolfi M, Aglieri Rinella G, Albrecht E, Bellunato T, Benson S, Blake T, Blanks C, Brisbane S, Brook NH, Calvi M, Cameron B, Cardinale R, Carson L, Contu A, Coombes M, D'Ambrosio C, Easo S, Egede U, Eisenhardt S, Fanchini E, Fitzpatrick C, Fontanelli F, Forty R, Frei C, Gandini P, Gao R, Garra Tico J, Giachero A, Gibson V, Gotti C, Gregson S, Gys T, Haines SC, Hampson T, Harnew N, Hill D, Hunt P, John M, Jones CR, Johnson D, Kanaya N, Katvars S, Kerzel U, Kim YM, Koblitz S, Kucharczyk M, Lambert D, Main A, Maino M, Malde S, Mangiafave N, Matteuzzi C, Mini' G, Mollen A, Morant J, Mountain R, Morris JV, Muheim F, Muresan R, Nardulli J, Owen P, Papanestis A, Patel M, Patrick GN, Perego DL, Pessina G, Petrolini A, Piedigrossi D, Plackett R, Playfer S, Powell A, Rademacker JH, Ricciardi S, Rogers GJ, Sail P, Sannino M, Savidge T, Sepp I, Sigurdsson S, Soler FJ, Solomin A, Soomro F, Sparkes A, Spradlin P, Storaci B, Thomas C, Topp-Joergensen S, Torr N, Ullaland O, Vervink K, Voong D, Websdale D, Wilkinson G, Wotton SA, Wyllie K, Xing F, Young R.

Eur Phys J C Part Fields. 2013;73(5):2431. Epub 2013 May 15.

36.

A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection.

Wang H, Sun X, Zhang Y, Li S, Chen K, Shi L, Nie W, Kumar R, Tzipori S, Wang J, Savidge T, Feng H.

Infect Immun. 2012 Aug;80(8):2678-88. doi: 10.1128/IAI.00215-12. Epub 2012 May 21.

37.

Granzyme B- and Fas ligand-mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4+ T cells.

Medina MA, Couturier J, Feske ML, Mahne AE, Turner M, Yu X, Kozinetz CA, Orozco AF, Hutchison AT, Savidge TC, Rodgers JR, Lewis DE.

J Leukoc Biol. 2012 May;91(5):759-71. doi: 10.1189/jlb.0511264. Epub 2012 Mar 13.

38.

Clostridial toxins: sensing a target in a hostile gut environment.

Oezguen N, Power TD, Urvil P, Feng H, Pothoulakis C, Stamler JS, Braun W, Savidge TC.

Gut Microbes. 2012 Jan-Feb;3(1):35-41. doi: 10.4161/gmic.19250. Epub 2012 Jan 1. Review.

39.

Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins.

Savidge TC, Urvil P, Oezguen N, Ali K, Choudhury A, Acharya V, Pinchuk I, Torres AG, English RD, Wiktorowicz JE, Loeffelholz M, Kumar R, Shi L, Nie W, Braun W, Herman B, Hausladen A, Feng H, Stamler JS, Pothoulakis C.

Nat Med. 2011 Aug 21;17(9):1136-41. doi: 10.1038/nm.2405.

40.

Glia and NO nicotine: a perfect harmony for secretory control.

Savidge TC.

J Physiol. 2011 Aug 1;589(Pt 15):3685-6. doi: 10.1113/jphysiol.2011.213207. No abstract available.

41.

Quantification of cysteinyl S-nitrosylation by fluorescence in unbiased proteomic studies.

Wiktorowicz JE, Stafford S, Rea H, Urvil P, Soman K, Kurosky A, Perez-Polo JR, Savidge TC.

Biochemistry. 2011 Jun 28;50(25):5601-14. doi: 10.1021/bi200008b. Epub 2011 Jun 7.

42.

S-nitrosothiol signals in the enteric nervous system: lessons learnt from big brother.

Savidge TC.

Front Neurosci. 2011 Mar 9;5:31. doi: 10.3389/fnins.2011.00031. eCollection 2011.

43.

Enteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF.

Van Landeghem L, Chevalier J, Mahé MM, Wedel T, Urvil P, Derkinderen P, Savidge T, Neunlist M.

Am J Physiol Gastrointest Liver Physiol. 2011 Jun;300(6):G976-87. doi: 10.1152/ajpgi.00427.2010. Epub 2011 Feb 24.

44.

Enteric glia protect against Shigella flexneri invasion in intestinal epithelial cells: a role for S-nitrosoglutathione.

Flamant M, Aubert P, Rolli-Derkinderen M, Bourreille A, Neunlist MR, Mahé MM, Meurette G, Marteyn B, Savidge T, Galmiche JP, Sansonetti PJ, Neunlist M.

Gut. 2011 Apr;60(4):473-84. doi: 10.1136/gut.2010.229237. Epub 2010 Dec 7.

PMID:
21139062
45.

Corticotropin-releasing factor regulates TLR4 expression in the colon and protects mice from colitis.

Chaniotou Z, Giannogonas P, Theoharis S, Teli T, Gay J, Savidge T, Koutmani Y, Brugni J, Kokkotou E, Pothoulakis C, Karalis KP.

Gastroenterology. 2010 Dec;139(6):2083-92. doi: 10.1053/j.gastro.2010.08.024. Epub 2010 Aug 20.

PMID:
20732324
46.

The enterotoxicity of Clostridium difficile toxins.

Sun X, Savidge T, Feng H.

Toxins (Basel). 2010 Jul;2(7):1848-80. doi: 10.3390/toxins2071848. Epub 2010 Jul 14. Review.

47.

Melanin-concentrating hormone (MCH) modulates C difficile toxin A-mediated enteritis in mice.

Kokkotou E, Espinoza DO, Torres D, Karagiannides I, Kosteletos S, Savidge T, O'Brien M, Pothoulakis C.

Gut. 2009 Jan;58(1):34-40. doi: 10.1136/gut.2008.155341. Epub 2008 Sep 29.

48.

MIND the gap: an astroglial perspective on barrier regulation.

Savidge TC.

Neuron Glia Biol. 2007 Aug;3(3):191-7. doi: 10.1017/S1740925X08000124.

PMID:
18634610
49.

Neuro-glial crosstalk in inflammatory bowel disease.

Neunlist M, Van Landeghem L, Bourreille A, Savidge T.

J Intern Med. 2008 Jun;263(6):577-83. doi: 10.1111/j.1365-2796.2008.01963.x. Review.

50.

Clock gene expression in the murine gastrointestinal tract: endogenous rhythmicity and effects of a feeding regimen.

Hoogerwerf WA, Hellmich HL, Cornélissen G, Halberg F, Shahinian VB, Bostwick J, Savidge TC, Cassone VM.

Gastroenterology. 2007 Oct;133(4):1250-60. Epub 2007 Jul 12.

PMID:
17919497

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