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Items: 46


Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of α6 GABAA receptors.

Vasović D, Divović B, Treven M, Knutson DE, Steudle F, Scholze P, Obradović A, Fabjan J, Brković B, Sieghart W, Ernst M, Cook JM, Savić MM.

Eur J Pain. 2019 May;23(5):973-984. doi: 10.1002/ejp.1365. Epub 2019 Feb 4.


Attaining in vivo selectivity of positive modulation of α3βγ2 GABAA receptors in rats: A hard task!

Batinić B, Stanković T, Stephen MR, Kodali R, Tiruveedhula VV, Li G, Scholze P, Marković BD, Obradović AL, Ernst M, Cook JM, Savić MM.

Eur Neuropsychopharmacol. 2018 Aug;28(8):903-914. doi: 10.1016/j.euroneuro.2018.05.014. Epub 2018 Jun 19.


Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability.

Knutson DE, Kodali R, Divović B, Treven M, Stephen MR, Zahn NM, Dobričić V, Huber AT, Meirelles MA, Verma RS, Wimmer L, Witzigmann C, Arnold LA, Chiou LC, Ernst M, Mihovilovic MD, Savić MM, Sieghart W, Cook JM.

J Med Chem. 2018 Mar 22;61(6):2422-2446. doi: 10.1021/acs.jmedchem.7b01664. Epub 2018 Mar 6.


Elucidation of the profound antagonism of contractile action of phenylephrine in rat aorta effected by an atypical sympathomimetic decongestant.

Rizvić E, Janković G, Savić MM.

Korean J Physiol Pharmacol. 2017 Jul;21(4):385-395. doi: 10.4196/kjpp.2017.21.4.385. Epub 2017 Jun 26.


Atypical sympathomimetic drug lerimazoline mediates contractile effects in rat aorta predominantly by 5-HT2A receptors.

Rizvić E, Janković G, Kostić-Rajačić S, Savić MM.

Bosn J Basic Med Sci. 2017 Aug 20;17(3):194-202. doi: 10.17305/bjbms.2017.2071.


Positive modulation of α5 GABAA receptors in preadolescence prevents reduced locomotor response to amphetamine in adult female but not male rats prenatally exposed to lipopolysaccharide.

Batinić B, Santrač A, Jančić I, Li G, Vidojević A, Marković B, Cook JM, Savić MM.

Int J Dev Neurosci. 2017 Oct;61:31-39. doi: 10.1016/j.ijdevneu.2017.06.001. Epub 2017 Jun 10.


Parenteral nanoemulsions of risperidone for enhanced brain delivery in acute psychosis: Physicochemical and in vivo performances.

Đorđević SM, Santrač A, Cekić ND, Marković BD, Divović B, Ilić TM, Savić MM, Savić SD.

Int J Pharm. 2017 Nov 30;533(2):421-430. doi: 10.1016/j.ijpharm.2017.05.051. Epub 2017 May 25.


Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator.

Piantadosi SC, French BJ, Poe MM, Timić T, Marković BD, Pabba M, Seney ML, Oh H, Orser BA, Savić MM, Cook JM, Sibille E.

Front Pharmacol. 2016 Nov 22;7:446. eCollection 2016.


Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABAA receptors containing the α5 subunit.

Stamenić TT, Poe MM, Rehman S, Santrač A, Divović B, Scholze P, Ernst M, Cook JM, Savić MM.

Eur J Pharmacol. 2016 Nov 15;791:433-443. doi: 10.1016/j.ejphar.2016.09.016. Epub 2016 Sep 14.


A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model.

Clayton T, Poe MM, Rallapalli S, Biawat P, Savić MM, Rowlett JK, Gallos G, Emala CW, Kaczorowski CC, Stafford DC, Arnold LA, Cook JM.

Int J Med Chem. 2015;2015:430248. doi: 10.1155/2015/430248. Epub 2015 Nov 10. Review.


Lipopolysaccharide exposure during late embryogenesis results in diminished locomotor activity and amphetamine response in females and spatial cognition impairment in males in adult, but not adolescent rat offspring.

Batinić B, Santrač A, Divović B, Timić T, Stanković T, Obradović ALj, Joksimović S, Savić MM.

Behav Brain Res. 2016 Feb 15;299:72-80. doi: 10.1016/j.bbr.2015.11.025. Epub 2015 Nov 24.


Biocompatible microemulsions of a model NSAID for skin delivery: A decisive role of surfactants in skin penetration/irritation profiles and pharmacokinetic performance.

Todosijević MN, Savić MM, Batinić BB, Marković BD, Gašperlin M, Ranđelović DV, Lukić MŽ, Savić SD.

Int J Pharm. 2015 Dec 30;496(2):931-41. doi: 10.1016/j.ijpharm.2015.10.048. Epub 2015 Oct 20.


Parenteral nanoemulsions as promising carriers for brain delivery of risperidone: Design, characterization and in vivo pharmacokinetic evaluation.

Đorđević SM, Cekić ND, Savić MM, Isailović TM, Ranđelović DV, Marković BD, Savić SR, Timić Stamenić T, Daniels R, Savić SD.

Int J Pharm. 2015 Sep 30;493(1-2):40-54. doi: 10.1016/j.ijpharm.2015.07.007. Epub 2015 Jul 21.


Negative modulation of α₅ GABAA receptors in rats may partially prevent memory impairment induced by MK-801, but not amphetamine- or MK-801-elicited hyperlocomotion.

Timić Stamenić T, Joksimović S, Biawat P, Stanković T, Marković B, Cook JM, Savić MM.

J Psychopharmacol. 2015 Sep;29(9):1013-24. doi: 10.1177/0269881115590601. Epub 2015 Jun 23.


Duration of treatment and activation of α1-containing GABAA receptors variably affect the level of anxiety and seizure susceptibility after diazepam withdrawal in rats.

Kovačević J, Timić T, Tiruveedhula VV, Batinić B, Namjoshi OA, Milić M, Joksimović S, Cook JM, Savić MM.

Brain Res Bull. 2014 May;104:1-6. doi: 10.1016/j.brainresbull.2014.03.002. Epub 2014 Mar 30.


Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects.

Obradović ALj, Joksimović S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth BL, Sieghart W, Cook JM, Savić MM.

Brain Res. 2014 Mar 20;1554:36-48. doi: 10.1016/j.brainres.2014.01.036. Epub 2014 Jan 25.


Experimental design in formulation of diazepam nanoemulsions: physicochemical and pharmacokinetic performances.

Đorđević SM, Radulović TS, Cekić ND, Ranđelović DV, Savić MM, Krajišnik DR, Milić JR, Savić SD.

J Pharm Sci. 2013 Nov;102(11):4159-72. doi: 10.1002/jps.23734. Epub 2013 Sep 23.


Insights into functional pharmacology of α₁ GABA(A) receptors: how much does partial activation at the benzodiazepine site matter?

Joksimović S, Varagic Z, Kovačević J, Van Linn M, Milić M, Rallapalli S, Timić T, Sieghart W, Cook JM, Savić MM.

Psychopharmacology (Berl). 2013 Nov;230(1):113-23. doi: 10.1007/s00213-013-3143-4. Epub 2013 May 18.


PWZ-029, an inverse agonist selective for α₅ GABAA receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats.

Milić M, Timić T, Joksimović S, Biawat P, Rallapalli S, Divljaković J, Radulović T, Cook JM, Savić MM.

Behav Brain Res. 2013 Mar 15;241:206-13. doi: 10.1016/j.bbr.2012.12.016. Epub 2012 Dec 20.


Midazolam impairs acquisition and retrieval, but not consolidation of reference memory in the Morris water maze.

Timić T, Joksimović S, Milić M, Divljaković J, Batinić B, Savić MM.

Behav Brain Res. 2013 Mar 15;241:198-205. doi: 10.1016/j.bbr.2012.12.014. Epub 2012 Dec 19.


Tolerance liability of diazepam is dependent on the dose used for protracted treatment.

Divljaković J, Milić M, Timić T, Savić MM.

Pharmacol Rep. 2012;64(5):1116-25.


βCCT, an antagonist selective for α(1)GABA(A) receptors, reverses diazepam withdrawal-induced anxiety in rats.

Divljaković J, Milić M, Namjoshi OA, Tiruveedhula VV, Timić T, Cook JM, Savić MM.

Brain Res Bull. 2013 Feb;91:1-7. doi: 10.1016/j.brainresbull.2012.10.011. Epub 2012 Nov 10.


Benzodiazepine-induced spatial learning deficits in rats are regulated by the degree of modulation of α1 GABA(A) receptors.

Joksimović S, Divljaković J, Van Linn ML, Varagic Z, Brajković G, Milinković MM, Yin W, Timić T, Sieghart W, Cook JM, Savić MM.

Eur Neuropsychopharmacol. 2013 May;23(5):390-9. doi: 10.1016/j.euroneuro.2012.05.003. Epub 2012 May 26.


The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats.

Milić M, Divljaković J, Rallapalli S, van Linn ML, Timić T, Cook JM, Savić MM.

Behav Pharmacol. 2012 Apr;23(2):191-7. doi: 10.1097/FBP.0b013e3283512c85.


From conventional towards new - natural surfactants in drug delivery systems design: current status and perspectives.

Savić S, Tamburić S, Savić MM.

Expert Opin Drug Deliv. 2010 Mar;7(3):353-69. doi: 10.1517/17425240903535833. Review.


Behavioural characterization of four endemic Stachys taxa.

Savić MM, Kukić JM, Grayer RJ, Milinković MM, Marin PD, Divljaković J, Van Linn M, Cook JM, Petrović SD.

Phytother Res. 2010 Sep;24(9):1309-16. doi: 10.1002/ptr.3106.


Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats?

Savić MM, Majumder S, Huang S, Edwankar RV, Furtmüller R, Joksimović S, Clayton T Sr, Ramerstorfer J, Milinković MM, Roth BL, Sieghart W, Cook JM.

Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17;34(2):376-86. doi: 10.1016/j.pnpbp.2010.01.004. Epub 2010 Jan 13.


Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance.

Savić S, Weber C, Savić MM, Müller-Goymann C.

Int J Pharm. 2009 Nov 3;381(2):220-30. doi: 10.1016/j.ijpharm.2009.07.007. Epub 2009 Jul 16.


Influence of the preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles.

Cekić ND, Milić JR, Savić SD, Savić MM, Jović Z, Daniels R.

Drug Dev Ind Pharm. 2009 Sep;35(9):1092-102. doi: 10.1080/03639040902774164.


The differential role of alpha1- and alpha5-containing GABA(A) receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats.

Savić MM, Milinković MM, Rallapalli S, Clayton T Sr, Joksimović S, Van Linn M, Cook JM.

Int J Neuropsychopharmacol. 2009 Oct;12(9):1179-93. doi: 10.1017/S1461145709000108. Epub 2009 Mar 6.


PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats.

Savić MM, Clayton T, Furtmüller R, Gavrilović I, Samardzić J, Savić S, Huck S, Sieghart W, Cook JM.

Brain Res. 2008 May 7;1208:150-9. doi: 10.1016/j.brainres.2008.02.020. Epub 2008 Feb 19.


Preparation and characterisation of phenytoin-loaded alginate and alginate-chitosan microparticles.

Cekić ND, Savić SD, Milić J, Savić MM, Jović Z, Malesević M.

Drug Deliv. 2007 Nov;14(8):483-90.


[Transthoracic ultrasonography in diagnosis and treatment of acute pleural empyema].

Stević RS, Ercegovac MM, Jaković RM, Moskovljević DD, Bascarević SM, Savić MM, Jovanović DM.

Acta Chir Iugosl. 2007;54(3):129-36. Serbian.


Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists?

Savić MM, Huang S, Furtmüller R, Clayton T, Huck S, Obradović DI, Ugresić ND, Sieghart W, Bokonjić DR, Cook JM.

Neuropsychopharmacology. 2008 Jan;33(2):332-9. Epub 2007 Mar 28.


Vehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeation.

Savić SD, Savić MM, Vesić SA, Vuleta GM, Müller-Goymann CC.

Int J Pharm. 2006 Aug 31;320(1-2):86-95. Epub 2006 May 5.


Benzodiazepine site inverse agonists and locomotor activity in rats: bimodal and biphasic influence.

Savić MM, Obradović DI, Ugresić ND, Cook JM, Yin W, Van Linn M, Bokonjić DR.

Pharmacol Biochem Behav. 2006 May;84(1):35-42. Epub 2006 May 24.


Memory effects of benzodiazepines: memory stages and types versus binding-site subtypes.

Savić MM, Obradović DI, Ugresić ND, Bokonjić DR.

Neural Plast. 2005;12(4):289-98. Review.


The lack of bicuculline and picrotoxin influence on midazolam depressant action on brain oxygen consumption.

Obradović DI, Savić MM, Obradović MM, Ugresić ND, Bokonjić DR.

Neurosci Lett. 2006 Apr 24;397(3):201-4. Epub 2006 Jan 18.


Bidirectional effects of benzodiazepine binding site ligands on active avoidance acquisition and retention: differential antagonism by flumazenil and beta-CCt.

Savić MM, Obradović DI, Ugresić ND, Cook JM, Sarma PV, Bokonjić DR.

Psychopharmacology (Berl). 2005 Jul;180(3):455-65. Epub 2005 Feb 18.


Bidirectional effects of benzodiazepine binding site ligands in the passive avoidance task: differential antagonism by flumazenil and beta-CCt.

Savić MM, Obradović DI, Ugresić ND, Cook JM, Yin W, Bokonjić DR.

Behav Brain Res. 2005 Mar 30;158(2):293-300.


Bidirectional effects of benzodiazepine binding site ligands in the elevated plus-maze: differential antagonism by flumazenil and beta-CCt.

Savić MM, Obradović DI, Ugresić ND, Cook JM, Yin W, Bokonjić DR.

Pharmacol Biochem Behav. 2004 Oct;79(2):279-90.


The influence of midazolam on active avoidance retrieval and acquisition rate in rats.

Obradović DI, Savić MM, Andjelković DS, Ugresić ND, Bokonjić DR.

Pharmacol Biochem Behav. 2004 Jan;77(1):77-83.


The influence of diazepam on atropine reversal of behavioural impairment in dichlorvos-treated rats.

Savić MM, Obradović DI, Ugresić ND, Bokonjić DR.

Pharmacol Toxicol. 2003 Nov;93(5):211-8.


The influence of midazolam and flumazenil on rat brain slices oxygen consumption.

Obradović DI, Savić MM, Andjelković DS, Ugresić ND, Bokonjić DR.

Pharmacol Res. 2003 Feb;47(2):127-31.


Gaba-benzodiazepine receptor complex in brain oxidative metabolism regulation.

Obradović DI, Bokonjić DR, Savić MM, Andjelković DS, Ugresić ND, Stojilković MP.

Pharmacol Res. 2002 Aug;46(2):149-54.


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