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Items: 1 to 50 of 56

1.

Long-lived metabolic enzymes in the Crystallin lens identified by pulse-labeling of mice and mass spectrometry.

Liu P, Edassery SL, Ali L, Thomson BR, Savas JN, Jin J.

Elife. 2019 Dec 10;8. pii: e50170. doi: 10.7554/eLife.50170. [Epub ahead of print]

2.

Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways.

Ruhl DA, Bomba-Warczak E, Watson ET, Bradberry MM, Peterson TA, Basu T, Frelka A, Evans CS, Briguglio JS, Basta T, Stowell MHB, Savas JN, Roopra A, Pearce RA, Piper RC, Chapman ER.

Nat Commun. 2019 Aug 6;10(1):3532. doi: 10.1038/s41467-019-11459-4.

3.

CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.

Piunti A, Smith ER, Morgan MAJ, Ugarenko M, Khaltyan N, Helmin KA, Ryan CA, Murray DC, Rickels RA, Yilmaz BD, Rendleman EJ, Savas JN, Singer BD, Bulun SE, Shilatifard A.

Sci Adv. 2019 Jul 3;5(7):eaax2887. doi: 10.1126/sciadv.aax2887. eCollection 2019 Jul.

4.

Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function.

Kim JJ, Savas JN, Miller MT, Hu X, Carromeu C, Lavallée-Adam M, Freitas BCG, Muotri AR, Yates JR 3rd, Ghosh A.

PLoS One. 2019 Feb 21;14(2):e0212553. doi: 10.1371/journal.pone.0212553. eCollection 2019.

5.

Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission.

Rice HC, de Malmazet D, Schreurs A, Frere S, Van Molle I, Volkov AN, Creemers E, Vertkin I, Nys J, Ranaivoson FM, Comoletti D, Savas JN, Remaut H, Balschun D, Wierda KD, Slutsky I, Farrow K, De Strooper B, de Wit J.

Science. 2019 Jan 11;363(6423). pii: eaao4827. doi: 10.1126/science.aao4827.

6.

Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function.

Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy AN, Yates JR 3rd, Metallo CM, Sander M.

Cell Rep. 2018 Dec 4;25(10):2904-2918.e8. doi: 10.1016/j.celrep.2018.11.031.

7.

An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses.

Condomitti G, Wierda KD, Schroeder A, Rubio SE, Vennekens KM, Orlandi C, Martemyanov KA, Gounko NV, Savas JN, de Wit J.

Neuron. 2018 Oct 10;100(1):201-215.e9. doi: 10.1016/j.neuron.2018.08.038. Epub 2018 Oct 2.

8.

Selective permeability of mouse blood-aqueous barrier as determined by 15N-heavy isotope tracing and mass spectrometry.

Liu P, Thomson BR, Khalatyan N, Feng L, Liu X, Savas JN, Quaggin SE, Jin J.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):9032-9037. doi: 10.1073/pnas.1807982115. Epub 2018 Aug 20.

9.

Uncovering Discrete Synaptic Proteomes to Understand Neurological Disorders.

Wang YZ, Savas JN.

Proteomes. 2018 Jul 19;6(3). pii: E30. doi: 10.3390/proteomes6030030. Review.

10.

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.

Wang L, Zhao Z, Ozark PA, Fantini D, Marshall SA, Rendleman EJ, Cozzolino KA, Louis N, He X, Morgan MA, Takahashi YH, Collings CK, Smith ER, Ntziachristos P, Savas JN, Zou L, Hashizume R, Meeks JJ, Shilatifard A.

Nat Med. 2018 Jun;24(6):758-769. doi: 10.1038/s41591-018-0034-6. Epub 2018 May 21.

11.

Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice.

He Q, Arroyo ED, Smukowski SN, Xu J, Piochon C, Savas JN, Portera-Cailliau C, Contractor A.

Mol Psychiatry. 2019 Nov;24(11):1732-1747. doi: 10.1038/s41380-018-0048-y. Epub 2018 Apr 27.

12.

Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology.

Savas JN, Wang YZ, DeNardo LA, Martinez-Bartolome S, McClatchy DB, Hark TJ, Shanks NF, Cozzolino KA, Lavallée-Adam M, Smukowski SN, Park SK, Kelly JW, Koo EH, Nakagawa T, Masliah E, Ghosh A, Yates JR 3rd.

Cell Rep. 2017 Nov 28;21(9):2614-2627. doi: 10.1016/j.celrep.2017.11.009.

13.

A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism.

Wang L, Collings CK, Zhao Z, Cozzolino KA, Ma Q, Liang K, Marshall SA, Sze CC, Hashizume R, Savas JN, Shilatifard A.

Genes Dev. 2017 Oct 15;31(20):2056-2066. doi: 10.1101/gad.306092.117. Epub 2017 Nov 14.

14.

A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation.

Morgan MAJ, Rickels RA, Collings CK, He X, Cao K, Herz HM, Cozzolino KA, Abshiru NA, Marshall SA, Rendleman EJ, Sze CC, Piunti A, Kelleher NL, Savas JN, Shilatifard A.

Genes Dev. 2017 Oct 1;31(19):2003-2014. doi: 10.1101/gad.305201.117.

15.

Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins.

Elegheert J, Cvetkovska V, Clayton AJ, Heroven C, Vennekens KM, Smukowski SN, Regan MC, Jia W, Smith AC, Furukawa H, Savas JN, de Wit J, Begbie J, Craig AM, Aricescu AR.

Neuron. 2017 Sep 27;96(1):242-244. doi: 10.1016/j.neuron.2017.09.011. No abstract available.

16.

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.

Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Krüger R, Surmeier DJ, Krainc D.

Science. 2017 Sep 22;357(6357):1255-1261. doi: 10.1126/science.aam9080. Epub 2017 Sep 7.

17.

Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification.

Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, Bui JD, Chang AN, Yates JR 3rd, Goldrath AW, Overkleeft HS, Ovaa H, Chang JT.

J Clin Invest. 2017 Oct 2;127(10):3609-3623. doi: 10.1172/JCI90895. Epub 2017 Aug 28.

18.

Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins.

Elegheert J, Cvetkovska V, Clayton AJ, Heroven C, Vennekens KM, Smukowski SN, Regan MC, Jia W, Smith AC, Furukawa H, Savas JN, de Wit J, Begbie J, Craig AM, Aricescu AR.

Neuron. 2017 Aug 16;95(4):896-913.e10. doi: 10.1016/j.neuron.2017.07.040. Erratum in: Neuron. 2017 Sep 27;96(1):242-244.

19.

Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E).

Park J, Yang J, Wenzel AT, Ramachandran A, Lee WJ, Daniels JC, Kim J, Martinez-Escala E, Amankulor N, Pro B, Guitart J, Mendillo ML, Savas JN, Boggon TJ, Choi J.

Blood. 2017 Sep 21;130(12):1430-1440. doi: 10.1182/blood-2017-02-768234. Epub 2017 Jul 10.

20.

Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase.

Jha S, Rollins MG, Fuchs G, Procter DJ, Hall EA, Cozzolino K, Sarnow P, Savas JN, Walsh D.

Nature. 2017 Jun 29;546(7660):651-655. doi: 10.1038/nature22814. Epub 2017 Jun 21.

21.

Global Analysis of Protein Expression of Inner Ear Hair Cells.

Hickox AE, Wong AC, Pak K, Strojny C, Ramirez M, Yates JR 3rd, Ryan AF, Savas JN.

J Neurosci. 2017 Feb 1;37(5):1320-1339. doi: 10.1523/JNEUROSCI.2267-16.2016. Epub 2016 Dec 30.

22.

Synapse biology in the 'circuit-age'-paths toward molecular connectomics.

Schreiner D, Savas JN, Herzog E, Brose N, de Wit J.

Curr Opin Neurobiol. 2017 Feb;42:102-110. doi: 10.1016/j.conb.2016.12.004. Epub 2016 Dec 26. Review.

23.

URI Regulates KAP1 Phosphorylation and Transcriptional Repression via PP2A Phosphatase in Prostate Cancer Cells.

Mita P, Savas JN, Briggs EM, Ha S, Gnanakkan V, Yates JR 3rd, Robins DM, David G, Boeke JD, Garabedian MJ, Logan SK.

J Biol Chem. 2016 Dec 2;291(49):25516-25528. Epub 2016 Oct 25.

24.

Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.

Shrestha E, Hussein MA, Savas JN, Ouimet M, Barrett TJ, Leone S, Yates JR 3rd, Moore KJ, Fisher EA, Garabedian MJ.

J Biol Chem. 2016 May 20;291(21):11172-84. doi: 10.1074/jbc.M116.726729. Epub 2016 Mar 29.

25.

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation.

Yonashiro R, Tahara EB, Bengtson MH, Khokhrina M, Lorenz H, Chen KC, Kigoshi-Tansho Y, Savas JN, Yates JR, Kay SA, Craig EA, Mogk A, Bukau B, Joazeiro CA.

Elife. 2016 Mar 4;5:e11794. doi: 10.7554/eLife.11794.

26.

Proteomic Analysis of Protein Turnover by Metabolic Whole Rodent Pulse-Chase Isotopic Labeling and Shotgun Mass Spectrometry Analysis.

Savas JN, Park SK, Yates JR 3rd.

Methods Mol Biol. 2016;1410:293-304. doi: 10.1007/978-1-4939-3524-6_18.

PMID:
26867752
27.

Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients.

Topol A, English JA, Flaherty E, Rajarajan P, Hartley BJ, Gupta S, Desland F, Zhu S, Goff T, Friedman L, Rapoport J, Felsenfeld D, Cagney G, Mackay-Sim A, Savas JN, Aronow B, Fang G, Zhang B, Cotter D, Brennand KJ.

Transl Psychiatry. 2015 Oct 20;5:e662. doi: 10.1038/tp.2015.118.

28.

The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors.

Savas JN, Ribeiro LF, Wierda KD, Wright R, DeNardo-Wilke LA, Rice HC, Chamma I, Wang YZ, Zemla R, Lavallée-Adam M, Vennekens KM, O'Sullivan ML, Antonios JK, Hall EA, Thoumine O, Attie AD, Yates JR 3rd, Ghosh A, de Wit J.

Neuron. 2015 Aug 19;87(4):764-80. doi: 10.1016/j.neuron.2015.08.007.

29.

Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex.

McClatchy DB, Savas JN, Martínez-Bartolomé S, Park SK, Maher P, Powell SB, Yates JR 3rd.

Mol Psychiatry. 2016 Feb;21(2):205-15. doi: 10.1038/mp.2015.41. Epub 2015 Apr 14.

30.

Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3.

Shanks NF, Cais O, Maruo T, Savas JN, Zaika EI, Azumaya CM, Yates JR 3rd, Greger I, Nakagawa T.

J Neurosci. 2014 Sep 3;34(36):12104-20. doi: 10.1523/JNEUROSCI.0595-14.2014.

31.

Ecto-Fc MS identifies ligand-receptor interactions through extracellular domain Fc fusion protein baits and shotgun proteomic analysis.

Savas JN, De Wit J, Comoletti D, Zemla R, Ghosh A, Yates JR 3rd.

Nat Protoc. 2014 Sep;9(9):2061-74. doi: 10.1038/nprot.2014.140. Epub 2014 Aug 7.

32.

Co-opting the Fanconi anemia genomic stability pathway enables herpesvirus DNA synthesis and productive growth.

Karttunen H, Savas JN, McKinney C, Chen YH, Yates JR 3rd, Hukkanen V, Huang TT, Mohr I.

Mol Cell. 2014 Jul 3;55(1):111-22. doi: 10.1016/j.molcel.2014.05.020. Epub 2014 Jun 19.

33.

Reelin induces Erk1/2 signaling in cortical neurons through a non-canonical pathway.

Lee GH, Chhangawala Z, von Daake S, Savas JN, Yates JR 3rd, Comoletti D, D'Arcangelo G.

J Biol Chem. 2014 Jul 18;289(29):20307-17. doi: 10.1074/jbc.M114.576249. Epub 2014 May 29.

34.

Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia.

Brennand K, Savas JN, Kim Y, Tran N, Simone A, Hashimoto-Torii K, Beaumont KG, Kim HJ, Topol A, Ladran I, Abdelrahim M, Matikainen-Ankney B, Chao SH, Mrksich M, Rakic P, Fang G, Zhang B, Yates JR 3rd, Gage FH.

Mol Psychiatry. 2015 Mar;20(3):361-8. doi: 10.1038/mp.2014.22. Epub 2014 Apr 1.

35.

Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR 3rd, Lafaille JJ, Hempstead BL, Littman DR, Gan WB.

Cell. 2013 Dec 19;155(7):1596-609. doi: 10.1016/j.cell.2013.11.030.

36.

Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.

Wan J, Savas JN, Roth AF, Sanders SS, Singaraja RR, Hayden MR, Yates JR 3rd, Davis NG.

Chem Biol. 2013 Nov 21;20(11):1421-34. doi: 10.1016/j.chembiol.2013.09.018. Epub 2013 Nov 7.

37.

Identification of long-lived proteins reveals exceptional stability of essential cellular structures.

Toyama BH, Savas JN, Park SK, Harris MS, Ingolia NT, Yates JR 3rd, Hetzer MW.

Cell. 2013 Aug 29;154(5):971-982. doi: 10.1016/j.cell.2013.07.037.

38.

Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development.

de Wit J, O'Sullivan ML, Savas JN, Condomitti G, Caccese MC, Vennekens KM, Yates JR 3rd, Ghosh A.

Neuron. 2013 Aug 21;79(4):696-711. doi: 10.1016/j.neuron.2013.06.049. Epub 2013 Aug 1.

39.

Analysis of URI nuclear interaction with RPB5 and components of the R2TP/prefoldin-like complex.

Mita P, Savas JN, Ha S, Djouder N, Yates JR 3rd, Logan SK.

PLoS One. 2013 May 8;8(5):e63879. doi: 10.1371/journal.pone.0063879. Print 2013.

40.

In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation.

Butko MT, Savas JN, Friedman B, Delahunty C, Ebner F, Yates JR 3rd, Tsien RY.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E726-35. doi: 10.1073/pnas.1300424110. Epub 2013 Feb 4.

41.

Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L.

Shanks NF, Savas JN, Maruo T, Cais O, Hirao A, Oe S, Ghosh A, Noda Y, Greger IH, Yates JR 3rd, Nakagawa T.

Cell Rep. 2012 Jun 28;1(6):590-8. doi: 10.1016/j.celrep.2012.05.004. Epub 2012 May 23.

42.

Quantitative analysis of BDNF/TrkB protein and mRNA in cortical and striatal neurons using α-tubulin as a normalization factor.

Ma B, Savas JN, Chao MV, Tanese N.

Cytometry A. 2012 Aug;81(8):704-17. doi: 10.1002/cyto.a.22073. Epub 2012 May 30.

43.

Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis.

Culver BP, Savas JN, Park SK, Choi JH, Zheng S, Zeitlin SO, Yates JR 3rd, Tanese N.

J Biol Chem. 2012 Jun 22;287(26):21599-614. doi: 10.1074/jbc.M112.359307. Epub 2012 May 3.

44.

Toward objective evaluation of proteomic algorithms.

Yates JR 3rd, Park SK, Delahunty CM, Xu T, Savas JN, Cociorva D, Carvalho PC.

Nat Methods. 2012 Apr 27;9(5):455-6. doi: 10.1038/nmeth.1983. No abstract available.

45.

FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development.

O'Sullivan ML, de Wit J, Savas JN, Comoletti D, Otto-Hitt S, Yates JR 3rd, Ghosh A.

Neuron. 2012 Mar 8;73(5):903-10. doi: 10.1016/j.neuron.2012.01.018.

46.

Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons.

Ma B, Savas JN, Yu MS, Culver BP, Chao MV, Tanese N.

Sci Rep. 2011;1:140. doi: 10.1038/srep00140. Epub 2011 Nov 3.

47.

Extremely long-lived nuclear pore proteins in the rat brain.

Savas JN, Toyama BH, Xu T, Yates JR 3rd, Hetzer MW.

Science. 2012 Feb 24;335(6071):942. doi: 10.1126/science.1217421. Epub 2012 Feb 2.

48.

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway.

Jeong H, Cohen DE, Cui L, Supinski A, Savas JN, Mazzulli JR, Yates JR 3rd, Bordone L, Guarente L, Krainc D.

Nat Med. 2011 Dec 18;18(1):159-65. doi: 10.1038/nm.2559.

49.

Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP.

Mita P, Savas JN, Djouder N, Yates JR 3rd, Ha S, Ruoff R, Schafler ED, Nwachukwu JC, Tanese N, Cowan NJ, Zavadil J, Garabedian MJ, Logan SK.

Mol Cell Biol. 2011 Sep;31(17):3639-52. doi: 10.1128/MCB.05429-11. Epub 2011 Jul 5.

50.

Mass spectrometry accelerates membrane protein analysis.

Savas JN, Stein BD, Wu CC, Yates JR 3rd.

Trends Biochem Sci. 2011 Jul;36(7):388-96. doi: 10.1016/j.tibs.2011.04.005. Epub 2011 May 26. Review.

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