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Items: 1 to 50 of 72

1.

Evaluation of transcutaneous immunization as a delivery route for an enterotoxigenic E. coli adhesin-based vaccine with CfaE, the colonization factor antigen 1 (CFA/I) tip adhesin.

Rollenhagen JE, Woods CM, O'Dowd A, Poole ST, Tian JH, Guebre-Xabier M, Ellingsworth L, Prouty MG, Glenn G, Savarino SJ.

Vaccine. 2019 Sep 30;37(42):6134-6138. doi: 10.1016/j.vaccine.2019.08.057. Epub 2019 Sep 3.

2.

Intradermal or sublingual delivery and heat-labile enterotoxin (LT) proteins shape immunologic outcomes to CFA/I fimbriae-derived subunit antigen vaccine against enterotoxigenic E. coli.

Maciel M Jr, Bauer D, Baudier RL, Bitoun J, Clements JD, Poole ST, Smith MA, Kaminski RW, Savarino SJ, Norton EB.

Infect Immun. 2019 Aug 19. pii: IAI.00460-19. doi: 10.1128/IAI.00460-19. [Epub ahead of print]

PMID:
31427449
3.

Hyperimmune bovine colostral anti-CS17 antibodies protect against enterotoxigenic Escherichia coli diarrhea in a randomized, doubled-blind, placebo-controlled human infection model.

Savarino SJ, McKenzie R, Tribble DR, Porter CK, O'Dowd A, Sincock SA, Poole ST, DeNearing B, Woods CM, Kim H, Grahek SL, Brinkley C, Crabb JH, Bourgeois AL.

J Infect Dis. 2019 Mar 21. pii: jiz135. doi: 10.1093/infdis/jiz135. [Epub ahead of print]

PMID:
30897198
4.

Biochemical and Immunological Evaluation of Recombinant CS6-Derived Subunit Enterotoxigenic Escherichia coli Vaccine Candidates.

Poole ST, Maciel M Jr, Dinadayala P, Dori KE, McVeigh AL, Liu Y, Barry E, Grassel C, Prouty MG, Renauld-Mongénie G, Savarino SJ.

Infect Immun. 2019 Feb 21;87(3). pii: e00788-18. doi: 10.1128/IAI.00788-18. Print 2019 Mar.

5.

Establishment, Validation, and Application of a New World Primate Model of Enterotoxigenic Escherichia coli Disease for Vaccine Development.

Rollenhagen JE, Jones F, Hall E, Maves R, Nunez G, Espinoza N, O'Dowd A, Prouty MG, Savarino SJ.

Infect Immun. 2019 Jan 24;87(2). pii: e00634-18. doi: 10.1128/IAI.00634-18. Print 2019 Feb.

6.

Evaluation of a conjugate vaccine platform against enterotoxigenic Escherichia coli (ETEC), Campylobacter jejuni and Shigella.

Laird RM, Ma Z, Dorabawila N, Pequegnat B, Omari E, Liu Y, Maue AC, Poole ST, Maciel M, Satish K, Gariepy CL, Schumack NM, McVeigh AL, Poly F, Ewing CP, Prouty MG, Monteiro MA, Savarino SJ, Guerry P.

Vaccine. 2018 Oct 29;36(45):6695-6702. doi: 10.1016/j.vaccine.2018.09.052. Epub 2018 Sep 27.

7.

Enterotoxigenic E. coli virulence gene regulation in human infections.

Crofts AA, Giovanetti SM, Rubin EJ, Poly FM, Gutiérrez RL, Talaat KR, Porter CK, Riddle MS, DeNearing B, Brubaker J, Maciel M Jr, Alcala AN, Chakraborty S, Prouty MG, Savarino SJ, Davies BW, Trent MS.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8968-E8976. doi: 10.1073/pnas.1808982115. Epub 2018 Aug 20.

8.

Prophylactic Efficacy of Hyperimmune Bovine Colostral Antiadhesin Antibodies Against Enterotoxigenic Escherichia coli Diarrhea: A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial.

Savarino SJ, McKenzie R, Tribble DR, Porter CK, O'Dowd A, Cantrell JA, Sincock SA, Poole ST, DeNearing B, Woods CM, Kim H, Grahek SL, Brinkley C, Crabb JH, Bourgeois AL.

J Infect Dis. 2017 Jul 1;216(1):7-13. doi: 10.1093/infdis/jix144.

PMID:
28541500
9.

Multiplex real time PCR panels to identify fourteen colonization factors of enterotoxigenic Escherichia coli (ETEC).

Liu J, Silapong S, Jeanwattanalert P, Lertsehtakarn P, Bodhidatta L, Swierczewski B, Mason C, McVeigh AL, Savarino SJ, Nshama R, Mduma E, Maro A, Zhang J, Gratz J, Houpt ER.

PLoS One. 2017 May 5;12(5):e0176882. doi: 10.1371/journal.pone.0176882. eCollection 2017.

10.

Antibodies Damage the Resilience of Fimbriae, Causing Them To Be Stiff and Tangled.

Singh B, Mortezaei N, Savarino SJ, Uhlin BE, Bullitt E, Andersson M.

J Bacteriol. 2016 Dec 13;199(1). pii: e00665-16. doi: 10.1128/JB.00665-16. Print 2017 Jan 1.

11.

Off-pathway assembly of fimbria subunits is prevented by chaperone CfaA of CFA/I fimbriae from enterotoxigenic E. coli.

Bao R, Liu Y, Savarino SJ, Xia D.

Mol Microbiol. 2016 Dec;102(6):975-991. doi: 10.1111/mmi.13530. Epub 2016 Oct 7.

12.

An Evidenced-Based Scale of Disease Severity following Human Challenge with Enteroxigenic Escherichia coli.

Porter CK, Riddle MS, Alcala AN, Sack DA, Harro C, Chakraborty S, Gutierrez RL, Savarino SJ, Darsley M, McKenzie R, DeNearing B, Steinsland H, Tribble DR, Bourgeois AL.

PLoS One. 2016 Mar 3;11(3):e0149358. doi: 10.1371/journal.pone.0149358. eCollection 2016.

13.

Immunogenicity of a prototype enterotoxigenic Escherichia coli adhesin vaccine in mice and nonhuman primates.

Sincock SA, Hall ER, Woods CM, O'Dowd A, Poole ST, McVeigh AL, Nunez G, Espinoza N, Miller M, Savarino SJ.

Vaccine. 2016 Jan 4;34(2):284-291. doi: 10.1016/j.vaccine.2015.11.017. Epub 2015 Nov 18.

PMID:
26597148
14.

Antibody-mediated disruption of the mechanics of CS20 fimbriae of enterotoxigenic Escherichia coli.

Singh B, Mortezaei N, Uhlin BE, Savarino SJ, Bullitt E, Andersson M.

Sci Rep. 2015 Sep 28;5:13678. doi: 10.1038/srep13678.

15.

Maternal vaccination with a fimbrial tip adhesin and passive protection of neonatal mice against lethal human enterotoxigenic Escherichia coli challenge.

Luiz WB, Rodrigues JF, Crabb JH, Savarino SJ, Ferreira LC.

Infect Immun. 2015 Dec;83(12):4555-64. doi: 10.1128/IAI.00858-15. Epub 2015 Sep 14.

16.

Gastrointestinal Infections in Deployed Forces in the Middle East Theater: An Historical 60 Year Perspective.

Riddle MS, Savarino SJ, Sanders JW.

Am J Trop Med Hyg. 2015 Nov;93(5):912-917. doi: 10.4269/ajtmh.15-0200. Epub 2015 Sep 8. Review.

17.

Structure and function of enterotoxigenic Escherichia coli fimbriae from differing assembly pathways.

Mortezaei N, Epler CR, Shao PP, Shirdel M, Singh B, McVeigh A, Uhlin BE, Savarino SJ, Andersson M, Bullitt E.

Mol Microbiol. 2015 Jan;95(1):116-26. doi: 10.1111/mmi.12847. Epub 2014 Nov 27.

18.

Structure of CfaA suggests a new family of chaperones essential for assembly of class 5 fimbriae.

Bao R, Fordyce A, Chen YX, McVeigh A, Savarino SJ, Xia D.

PLoS Pathog. 2014 Aug 14;10(8):e1004316. doi: 10.1371/journal.ppat.1004316. eCollection 2014 Aug.

19.

Preliminary X-ray diffraction analysis of CfaA, a molecular chaperone essential for the assembly of CFA/I fimbriae of human enterotoxigenic Escherichia coli.

Bao R, Esser L, Poole S, McVeigh A, Chen YX, Savarino SJ, Xia D.

Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):196-9. doi: 10.1107/S2053230X13033967. Epub 2014 Jan 21.

20.

Moving beyond a heat-labile enterotoxin-based vaccine against enterotoxigenic Escherichia coli.

Riddle MS, Savarino SJ.

Lancet Infect Dis. 2014 Mar;14(3):174-5. doi: 10.1016/S1473-3099(13)70355-4. Epub 2013 Nov 29. No abstract available.

PMID:
24291167
21.

Tight conformational coupling between the domains of the enterotoxigenic Escherichia coli fimbrial adhesin CfaE regulates binding state transition.

Liu Y, Esser L, Interlandi G, Kisiela DI, Tchesnokova V, Thomas WE, Sokurenko E, Xia D, Savarino SJ.

J Biol Chem. 2013 Apr 5;288(14):9993-10001. doi: 10.1074/jbc.M112.413534. Epub 2013 Feb 7.

22.

Adaptive evolution of class 5 fimbrial genes in enterotoxigenic Escherichia coli and its functional consequences.

Chattopadhyay S, Tchesnokova V, McVeigh A, Kisiela DI, Dori K, Navarro A, Sokurenko EV, Savarino SJ.

J Biol Chem. 2012 Feb 24;287(9):6150-8. doi: 10.1074/jbc.M111.303735. Epub 2012 Jan 3.

23.

A systematic review of ETEC epidemiology focusing on colonization factor and toxin expression.

Isidean SD, Riddle MS, Savarino SJ, Porter CK.

Vaccine. 2011 Aug 26;29(37):6167-78. doi: 10.1016/j.vaccine.2011.06.084. Epub 2011 Jul 1. Review.

PMID:
21723899
24.

Volunteer challenge with enterotoxigenic Escherichia coli that express intestinal colonization factor fimbriae CS17 and CS19.

McKenzie R, Porter CK, Cantrell JA, Denearing B, O'Dowd A, Grahek SL, Sincock SA, Woods C, Sebeny P, Sack DA, Tribble DR, Bourgeois AL, Savarino SJ.

J Infect Dis. 2011 Jul 1;204(1):60-4. doi: 10.1093/infdis/jir220.

25.

A systematic review of experimental infections with enterotoxigenic Escherichia coli (ETEC).

Porter CK, Riddle MS, Tribble DR, Louis Bougeois A, McKenzie R, Isidean SD, Sebeny P, Savarino SJ.

Vaccine. 2011 Aug 11;29(35):5869-85. doi: 10.1016/j.vaccine.2011.05.021. Epub 2011 May 25. Review.

PMID:
21616116
26.

A commensal gone bad: complete genome sequence of the prototypical enterotoxigenic Escherichia coli strain H10407.

Crossman LC, Chaudhuri RR, Beatson SA, Wells TJ, Desvaux M, Cunningham AF, Petty NK, Mahon V, Brinkley C, Hobman JL, Savarino SJ, Turner SM, Pallen MJ, Penn CW, Parkhill J, Turner AK, Johnson TJ, Thomson NR, Smith SG, Henderson IR.

J Bacteriol. 2010 Nov;192(21):5822-31. doi: 10.1128/JB.00710-10. Epub 2010 Aug 27.

27.

Shear-enhanced binding of intestinal colonization factor antigen I of enterotoxigenic Escherichia coli.

Tchesnokova V, McVeigh AL, Kidd B, Yakovenko O, Thomas WE, Sokurenko EV, Savarino SJ.

Mol Microbiol. 2010 Apr;76(2):489-502. doi: 10.1111/j.1365-2958.2010.07116.x. Epub 2010 Mar 25.

28.

Structure of CFA/I fimbriae from enterotoxigenic Escherichia coli.

Li YF, Poole S, Nishio K, Jang K, Rasulova F, McVeigh A, Savarino SJ, Xia D, Bullitt E.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10793-8. doi: 10.1073/pnas.0812843106. Epub 2009 Jun 10.

29.

Crystallization and preliminary X-ray diffraction analyses of several forms of the CfaB major subunit of enterotoxigenic Escherichia coli CFA/I fimbriae.

Li YF, Poole S, Rasulova F, McVeigh AL, Savarino SJ, Xia D.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Mar 1;65(Pt 3):242-7. doi: 10.1107/S1744309109001584. Epub 2009 Feb 14.

30.

The three-dimensional structure of CFA/I adhesion pili: traveler's diarrhea bacteria hang on by a spring.

Mu XQ, Savarino SJ, Bullitt E.

J Mol Biol. 2008 Feb 22;376(3):614-20. doi: 10.1016/j.jmb.2007.10.067. Epub 2007 Nov 1.

31.

Comparative analyses of phenotypic and genotypic methods for detection of enterotoxigenic Escherichia coli toxins and colonization factors.

Sjöling A, Wiklund G, Savarino SJ, Cohen DI, Svennerholm AM.

J Clin Microbiol. 2007 Oct;45(10):3295-301. Epub 2007 Aug 8.

32.

A receptor-binding site as revealed by the crystal structure of CfaE, the colonization factor antigen I fimbrial adhesin of enterotoxigenic Escherichia coli.

Li YF, Poole S, Rasulova F, McVeigh AL, Savarino SJ, Xia D.

J Biol Chem. 2007 Aug 17;282(33):23970-80. Epub 2007 Jun 14.

33.

Donor strand complementation governs intersubunit interaction of fimbriae of the alternate chaperone pathway.

Poole ST, McVeigh AL, Anantha RP, Lee LH, Akay YM, Pontzer EA, Scott DA, Bullitt E, Savarino SJ.

Mol Microbiol. 2007 Mar;63(5):1372-84.

35.

Enterotoxigenic Escherichia coli colonization factor types collected from 1997 to 2001 in US military personnel during operation Bright Star in northern Egypt.

Rockabrand DM, Shaheen HI, Khalil SB, Peruski LF Jr, Rozmajzl PJ, Savarino SJ, Monteville MR, Frenck RW, Svennerholm AM, Putnam SD, Sanders JW.

Diagn Microbiol Infect Dis. 2006 May;55(1):9-12. Epub 2006 Mar 20.

PMID:
16542813
36.

Crystallization and preliminary X-ray diffraction analysis of CfaE, the adhesive subunit of the CFA/I fimbriae from human enterotoxigenic Escherichia coli.

Li YF, Poole S, Rasulova F, Esser L, Savarino SJ, Xia D.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Feb 1;62(Pt 2):121-4. Epub 2006 Jan 27.

37.

The New World primate, Aotus nancymae, as a model for examining the immunogenicity of a prototype enterotoxigenic Escherichia coli subunit vaccine.

Jones FR, Hall ER, Tribble D, Savarino SJ, Cassels FJ, Porter C, Meza R, Nunez G, Espinoza N, Salazar M, Luckett R, Scott D.

Vaccine. 2006 May 1;24(18):3786-92. Epub 2005 Aug 30.

PMID:
16343702
38.

Serologic correlates of protection against enterotoxigenic Escherichia coli diarrhea.

Rao MR, Wierzba TF, Savarino SJ, Abu-Elyazeed R, El-Ghoreb N, Hall ER, Naficy A, Abdel-Messih I, Frenck RW Jr, Svennerholm AM, Clemens JD.

J Infect Dis. 2005 Feb 15;191(4):562-70. Epub 2005 Jan 14.

PMID:
15655780
39.

Phenotypic profiles of enterotoxigenic Escherichia coli associated with early childhood diarrhea in rural Egypt.

Shaheen HI, Khalil SB, Rao MR, Abu Elyazeed R, Wierzba TF, Peruski LF Jr, Putnam S, Navarro A, Morsy BZ, Cravioto A, Clemens JD, Svennerholm AM, Savarino SJ.

J Clin Microbiol. 2004 Dec;42(12):5588-95.

40.

Evolutionary and functional relationships of colonization factor antigen i and other class 5 adhesive fimbriae of enterotoxigenic Escherichia coli.

Anantha RP, McVeigh AL, Lee LH, Agnew MK, Cassels FJ, Scott DA, Whittam TS, Savarino SJ.

Infect Immun. 2004 Dec;72(12):7190-201.

41.

Epidemiology of Shigella-associated diarrhea in rural Egyptian children.

Abu-Elyazeed RR, Wierzba TF, Frenck RW, Putnam SD, Rao MR, Savarino SJ, Kamal KA, Peruski LF Jr, Abd-El Messih IA, El-Alkamy SA, Naficy AB, Clemens JD.

Am J Trop Med Hyg. 2004 Sep;71(3):367-72.

PMID:
15381821
42.

Antimicrobial susceptibility trends in Campylobacter jejuni and Campylobacter coli isolated from a rural Egyptian pediatric population with diarrhea.

Putnam SD, Frenck RW, Riddle MS, El-Gendy A, Taha NN, Pittner BT, Abu-Elyazeed R, Wierzba TF, Rao MR, Savarino SJ, Clemens JD.

Diagn Microbiol Infect Dis. 2003 Dec;47(4):601-8.

PMID:
14711482
43.

High disease burden of diarrhea due to enterotoxigenic Escherichia coli among rural Egyptian infants and young children.

Rao MR, Abu-Elyazeed R, Savarino SJ, Naficy AB, Wierzba TF, Abdel-Messih I, Shaheen H, Frenck RW Jr, Svennerholm AM, Clemens JD.

J Clin Microbiol. 2003 Oct;41(10):4862-4.

44.

A legacy in 20th-century medicine: Robert Allan Phillips and the taming of cholera.

Savarino SJ.

Clin Infect Dis. 2002 Sep 15;35(6):713-20. Epub 2002 Aug 23.

PMID:
12203169
45.

Introductory evaluation of an oral, killed whole cell enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine in Egyptian infants.

Savarino SJ, Hall ER, Bassily S, Wierzba TF, Youssef FG, Peruski LF Jr, Abu-Elyazeed R, Rao M, Francis WM, El Mohamady H, Safwat M, Naficy AB, Svennerholm AM, Jertborn M, Lee YJ, Clemens JD; Pride Study Group.

Pediatr Infect Dis J. 2002 Apr;21(4):322-30.

PMID:
12075764
46.

Pathogenicity and convalescent excretion of Campylobacter in rural Egyptian children.

Rao MR, Naficy AB, Savarino SJ, Abu-Elyazeed R, Wierzba TF, Peruski LF, Abdel-Messih I, Frenck R, Clemens JD.

Am J Epidemiol. 2001 Jul 15;154(2):166-73.

PMID:
11447051
47.

The interrelationship of malnutrition and diarrhea in a periurban area outside Alexandria, Egypt.

Wierzba TF, El-Yazeed RA, Savarino SJ, Mourad AS, Rao M, Baddour M, El-Deen AN, Naficy AB, Clemens JD.

J Pediatr Gastroenterol Nutr. 2001 Feb;32(2):189-96.

PMID:
11321391
48.

Induction of systemic antifimbria and antitoxin antibody responses in Egyptian children and adults by an oral, killed enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine.

Hall ER, Wierzba TF, Ahrén C, Rao MR, Bassily S, Francis W, Girgis FY, Safwat M, Lee YJ, Svennerholm AM, Clemens JD, Savarino SJ.

Infect Immun. 2001 May;69(5):2853-7.

49.

Seroepidemiology of Helicobacter pylori infection in a population of Egyptian children.

Naficy AB, Frenck RW, Abu-Elyazeed R, Kim Y, Rao MR, Savarino SJ, Wierzba TF, Hall E, Clemens JD.

Int J Epidemiol. 2000 Oct;29(5):928-32.

PMID:
11034980
50.

IS1414, an Escherichia coli insertion sequence with a heat-stable enterotoxin gene embedded in a transposase-like gene.

McVeigh A, Fasano A, Scott DA, Jelacic S, Moseley SL, Robertson DC, Savarino SJ.

Infect Immun. 2000 Oct;68(10):5710-5.

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