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Infect Immun. 2007 Aug;75(8):3859-67. Epub 2007 May 21.

Heterogeneity of a Campylobacter jejuni protein that is secreted through the flagellar filament.

Author information

1
Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.

Abstract

Cj0859c, or FspA, is a small, acidic protein of Campylobacter jejuni that is expressed by a sigma(28) promoter. Analysis of the fspA gene in 41 isolates of C. jejuni revealed two overall variants of the predicted protein, FspA1 and FspA2. Secretion of FspA occurs in broth-grown bacteria and requires a minimum flagellar structure. The addition of recombinant FspA2, but not FspA1, to INT407 cells in vitro resulted in a rapid induction of apoptosis. These data define a novel C. jejuni virulence factor, and the observed heterogeneity among fspA alleles suggests alternate virulence potential among different strains.

PMID:
17517862
PMCID:
PMC1951984
DOI:
10.1128/IAI.00159-07
[Indexed for MEDLINE]
Free PMC Article

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