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Items: 23


Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage.

Hingorani DV, Lippert CN, Crisp JL, Savariar EN, Hasselmann JPC, Kuo C, Nguyen QT, Tsien RY, Whitney MA, Ellies LG.

PLoS One. 2018 Sep 24;13(9):e0198464. doi: 10.1371/journal.pone.0198464. eCollection 2018.


Detection of Subclinical Arthritis in Mice by a Thrombin Receptor-Derived Imaging Agent.

Friedman B, Whitney MA, Savariar EN, Caneda C, Steinbach P, Xiong Q, Hingorani DV, Crisp J, Adams SR, Kenner M, Lippert CN, Nguyen QT, Guma M, Tsien RY, Corr M.

Arthritis Rheumatol. 2018 Jan;70(1):69-79. doi: 10.1002/art.40316. Epub 2017 Nov 29.


Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize.

Adams SR, Yang HC, Savariar EN, Aguilera J, Crisp JL, Jones KA, Whitney MA, Lippman SM, Cohen EE, Tsien RY, Advani SJ.

Nat Commun. 2016 Oct 4;7:13019. doi: 10.1038/ncomms13019.


Molecular targeting of papillary thyroid carcinoma with fluorescently labeled ratiometric activatable cell penetrating peptides in a transgenic murine model.

Orosco RK, Savariar EN, Weissbrod PA, Diaz-Perez JA, Bouvet M, Tsien RY, Nguyen QT.

J Surg Oncol. 2016 Feb;113(2):138-43. doi: 10.1002/jso.24129. Epub 2016 Jan 12.


Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery.

Buckel L, Savariar EN, Crisp JL, Jones KA, Hicks AM, Scanderbeg DJ, Nguyen QT, Sicklick JK, Lowy AM, Tsien RY, Advani SJ.

Cancer Res. 2015 Apr 1;75(7):1376-1387. doi: 10.1158/0008-5472.CAN-14-1931. Epub 2015 Feb 13.


Surgical molecular navigation with ratiometric activatable cell penetrating peptide for intraoperative identification and resection of small salivary gland cancers.

Hussain T, Savariar EN, Diaz-Perez JA, Messer K, Pu M, Tsien RY, Nguyen QT.

Head Neck. 2016 May;38(5):715-23. doi: 10.1002/hed.23946. Epub 2015 Jun 22.


Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models.

Metildi CA, Felsen CN, Savariar EN, Nguyen QT, Kaushal S, Hoffman RM, Tsien RY, Bouvet M.

Ann Surg Oncol. 2015;22(6):2082-7. doi: 10.1245/s10434-014-4144-1. Epub 2014 Oct 16.


Dual targeting of integrin αvβ3 and matrix metalloproteinase-2 for optical imaging of tumors and chemotherapeutic delivery.

Crisp JL, Savariar EN, Glasgow HL, Ellies LG, Whitney MA, Tsien RY.

Mol Cancer Ther. 2014 Jun;13(6):1514-25. doi: 10.1158/1535-7163.MCT-13-1067. Epub 2014 Apr 15.


Detection and monitoring of localized matrix metalloproteinase upregulation in a murine model of asthma.

Felsen CN, Savariar EN, Whitney M, Tsien RY.

Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15;306(8):L764-74. doi: 10.1152/ajplung.00371.2013. Epub 2014 Feb 7.


In vivo targeting of hydrogen peroxide by activatable cell-penetrating peptides.

Weinstain R, Savariar EN, Felsen CN, Tsien RY.

J Am Chem Soc. 2014 Jan 22;136(3):874-7. doi: 10.1021/ja411547j. Epub 2014 Jan 8.


Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides.

Savariar EN, Felsen CN, Nashi N, Jiang T, Ellies LG, Steinbach P, Tsien RY, Nguyen QT.

Cancer Res. 2013 Jan 15;73(2):855-64. doi: 10.1158/0008-5472.CAN-12-2969. Epub 2012 Nov 27.


Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation.

Whitney M, Savariar EN, Friedman B, Levin RA, Crisp JL, Glasgow HL, Lefkowitz R, Adams SR, Steinbach P, Nashi N, Nguyen QT, Tsien RY.

Angew Chem Int Ed Engl. 2013 Jan 2;52(1):325-30. doi: 10.1002/anie.201205721. Epub 2012 Oct 18.


Redox, Ionic Strength, and pH Sensitive Supramolecular Polymer Assemblies.

Ghosh S, Yesilyurt V, Savariar EN, Irvin K, Thayumanavan S.

J Polym Sci A Polym Chem. 2009 Jan 8;47(4):1052-1060.


Generating peptide titration-type curves using polymeric reverse micelles as selective extraction agents along with matrix-assisted laser desorption ionization-mass spectrometry detection.

Rodthongkum N, Washington JD, Savariar EN, Thayumanavan S, Vachet RW.

Anal Chem. 2009 Jun 15;81(12):5046-53. doi: 10.1021/ac900661e.


Fluorescence patterns from supramolecular polymer assembly and disassembly for sensing metallo- and nonmetalloproteins.

González DC, Savariar EN, Thayumanavan S.

J Am Chem Soc. 2009 Jun 10;131(22):7708-16. doi: 10.1021/ja900579g.


Functional group density and recognition in polymer nanotubes.

Savariar EN, Sochat MM, Klaikherd A, Thayumanavan S.

Angew Chem Int Ed Engl. 2009;48(1):110-4. doi: 10.1002/anie.200804136. No abstract available.


Molecular discrimination inside polymer nanotubules.

Savariar EN, Krishnamoorthy K, Thayumanavan S.

Nat Nanotechnol. 2008 Feb;3(2):112-7. doi: 10.1038/nnano.2008.6. Epub 2008 Feb 3.


Disassembly of noncovalent amphiphilic polymers with proteins and utility in pattern sensing.

Savariar EN, Ghosh S, González DC, Thayumanavan S.

J Am Chem Soc. 2008 Apr 23;130(16):5416-7. doi: 10.1021/ja800164z. Epub 2008 Apr 2.


Polymeric inverse micelles as selective peptide extraction agents for MALDI-MS analysis.

Combariza MY, Savariar EN, Vutukuri DR, Thayumanavan S, Vachet RW.

Anal Chem. 2007 Sep 15;79(18):7124-30. Epub 2007 Aug 11.


Supramolecular assemblies from amphiphilic homopolymers: Testing the scope.

Savariar EN, Aathimanikandan SV, Thayumanavan S.

J Am Chem Soc. 2006 Dec 20;128(50):16224-30.


Selective sensing of metalloproteins from nonselective binding using a fluorogenic amphiphilic polymer.

Sandanaraj BS, Demont R, Aathimanikandan SV, Savariar EN, Thayumanavan S.

J Am Chem Soc. 2006 Aug 23;128(33):10686-7.


Temperature-sensitive dendritic micelles.

Aathimanikandan SV, Savariar EN, Thayumanavan S.

J Am Chem Soc. 2005 Oct 26;127(42):14922-9.


Dendrimeric micelles for controlled drug release and targeted delivery.

Ambade AV, Savariar EN, Thayumanavan S.

Mol Pharm. 2005 Jul-Aug;2(4):264-72.

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