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Items: 1 to 50 of 66

1.

Depletion of Bone Marrow-Derived Fibrocytes Attenuates TAA-Induced Liver Fibrosis in Mice.

Hempel F, Roderfeld M, Savai R, Sydykov A, Irungbam K, Schermuly R, Voswinckel R, Köhler K, Churin Y, Kiss L, Bier J, Pons-Kühnemann J, Roeb E.

Cells. 2019 Oct 7;8(10). pii: E1210. doi: 10.3390/cells8101210.

2.

Phenotypic Plasticity of Fibroblasts during Mammary Carcinoma Development.

Elwakeel E, Brüggemann M, Fink AF, Schulz MH, Schmid T, Savai R, Brüne B, Zarnack K, Weigert A.

Int J Mol Sci. 2019 Sep 9;20(18). pii: E4438. doi: 10.3390/ijms20184438.

3.

Therapeutic Targeting of Th17/Tc17 Cells Leads to Clinical Improvement of Lichen Planus.

Solimani F, Pollmann R, Schmidt T, Schmidt A, Zheng X, Savai R, Mühlenbein S, Pickert J, Eubel V, Möbs C, Eming R, Hertl M.

Front Immunol. 2019 Jul 31;10:1808. doi: 10.3389/fimmu.2019.01808. eCollection 2019.

4.

Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis.

Rubio K, Singh I, Dobersch S, Sarvari P, Günther S, Cordero J, Mehta A, Wujak L, Cabrera-Fuentes H, Chao CM, Braubach P, Bellusci S, Seeger W, Günther A, Preissner KT, Wygrecka M, Savai R, Papy-Garcia D, Dobreva G, Heikenwalder M, Savai-Pullamsetti S, Braun T, Barreto G.

Nat Commun. 2019 May 20;10(1):2229. doi: 10.1038/s41467-019-10066-7.

5.

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension.

Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza GL, Meister M, Muley T, Seeger-Nukpezah T, Samakovlis C, Weissmann N, Grimminger F, Seeger W, Savai R, Pullamsetti SS.

Nat Commun. 2019 May 13;10(1):2130. doi: 10.1038/s41467-019-10044-z.

6.

Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET.

Jia Y, Vong JS, Asafova A, Garvalov BK, Caputo L, Cordero J, Singh A, Boettger T, Günther S, Fink L, Acker T, Barreto G, Seeger W, Braun T, Savai R, Dobreva G.

J Exp Med. 2019 Jun 3;216(6):1377-1395. doi: 10.1084/jem.20181394. Epub 2019 Apr 23.

7.

miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction.

Saul MJ, Baumann I, Bruno A, Emmerich AC, Wellstein J, Ottinger SM, Contursi A, Dovizio M, Donnini S, Tacconelli S, Raouf J, Idborg H, Stein S, Korotkova M, Savai R, Terzuoli E, Sala G, Seeger W, Jakobsson PJ, Patrignani P, Suess B, Steinhilber D.

FASEB J. 2019 Jun;33(6):6933-6947. doi: 10.1096/fj.201802547R. Epub 2019 Mar 28.

PMID:
30922080
8.

Polypharmacology or Promiscuity? Structural Interactions of Resveratrol With Its Bandwagon of Targets.

Saqib U, Kelley TT, Panguluri SK, Liu D, Savai R, Baig MS, Schürer SC.

Front Pharmacol. 2018 Oct 24;9:1201. doi: 10.3389/fphar.2018.01201. eCollection 2018. Review.

9.

Drug repositioning as an effective therapy for protease-activated receptor 2 inhibition.

Saqib U, Savai R, Liu D, Banerjee S, Baig MS.

J Cell Biochem. 2018 Oct 29. doi: 10.1002/jcb.27334. [Epub ahead of print]

PMID:
30370939
10.

Repurposing Thioridazine (TDZ) as an anti-inflammatory agent.

Baig MS, Roy A, Saqib U, Rajpoot S, Srivastava M, Naim A, Liu D, Saluja R, Faisal SM, Pan Q, Turkowski K, Darwhekar GN, Savai R.

Sci Rep. 2018 Aug 20;8(1):12471. doi: 10.1038/s41598-018-30763-5.

11.

Phytochemicals as modulators of M1-M2 macrophages in inflammation.

Saqib U, Sarkar S, Suk K, Mohammad O, Baig MS, Savai R.

Oncotarget. 2018 Apr 3;9(25):17937-17950. doi: 10.18632/oncotarget.24788. eCollection 2018 Apr 3. Review.

12.

Classical IL-6 signaling: a promising therapeutic target for pulmonary arterial hypertension.

Pullamsetti SS, Seeger W, Savai R.

J Clin Invest. 2018 May 1;128(5):1720-1723. doi: 10.1172/JCI120415. Epub 2018 Apr 9.

13.

FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis.

Al-Tamari HM, Dabral S, Schmall A, Sarvari P, Ruppert C, Paik J, DePinho RA, Grimminger F, Eickelberg O, Guenther A, Seeger W, Savai R, Pullamsetti SS.

EMBO Mol Med. 2018 Feb;10(2):276-293. doi: 10.15252/emmm.201606261.

14.

Lung cancer-associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell-immune cell cross-talk.

Pullamsetti SS, Kojonazarov B, Storn S, Gall H, Salazar Y, Wolf J, Weigert A, El-Nikhely N, Ghofrani HA, Krombach GA, Fink L, Gattenlöhner S, Rapp UR, Schermuly RT, Grimminger F, Seeger W, Savai R.

Sci Transl Med. 2017 Nov 15;9(416). pii: eaai9048. doi: 10.1126/scitranslmed.aai9048.

PMID:
29141888
15.

S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β.

Weichand B, Popp R, Dziumbla S, Mora J, Strack E, Elwakeel E, Frank AC, Scholich K, Pierre S, Syed SN, Olesch C, Ringleb J, Ören B, Döring C, Savai R, Jung M, von Knethen A, Levkau B, Fleming I, Weigert A, Brüne B.

J Exp Med. 2017 Sep 4;214(9):2695-2713. doi: 10.1084/jem.20160392. Epub 2017 Jul 24.

16.

Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer.

Kiehl S, Zimmermann T, Savai R, Pullamsetti SS, Seeger W, Bartkuhn M, Dammann RH.

Sci Rep. 2017 Jun 20;7(1):3896. doi: 10.1038/s41598-017-04248-w.

17.

Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy.

Zheng X, Turkowski K, Mora J, Brüne B, Seeger W, Weigert A, Savai R.

Oncotarget. 2017 Jul 18;8(29):48436-48452. doi: 10.18632/oncotarget.17061. Review.

18.

Macrophage Regulation during Vascular Remodeling: Implications for Pulmonary Hypertension Therapy.

Pullamsetti SS, Savai R.

Am J Respir Cell Mol Biol. 2017 May;56(5):556-558. doi: 10.1165/rcmb.2017-0033ED. No abstract available.

PMID:
28459385
19.

Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate.

Mehta A, Cordero J, Dobersch S, Romero-Olmedo AJ, Savai R, Bodner J, Chao CM, Fink L, Guzmán-Díaz E, Singh I, Dobreva G, Rapp UR, Günther S, Ilinskaya ON, Bellusci S, Dammann RH, Braun T, Seeger W, Gattenlöhner S, Tresch A, Günther A, Barreto G.

EMBO Mol Med. 2016 Dec 1;8(12):1380-1389. doi: 10.15252/emmm.201606382. Print 2016 Dec.

20.

Translational Advances in the Field of Pulmonary Hypertension. From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting Cell Growth and Proliferation Signaling Hubs.

Pullamsetti SS, Savai R, Seeger W, Goncharova EA.

Am J Respir Crit Care Med. 2017 Feb 15;195(4):425-437. doi: 10.1164/rccm.201606-1226PP. Review. No abstract available.

21.

Notch1 signalling regulates endothelial proliferation and apoptosis in pulmonary arterial hypertension.

Dabral S, Tian X, Kojonazarov B, Savai R, Ghofrani HA, Weissmann N, Florio M, Sun J, Jonigk D, Maegel L, Grimminger F, Seeger W, Savai Pullamsetti S, Schermuly RT.

Eur Respir J. 2016 Oct;48(4):1137-1149. doi: 10.1183/13993003.00773-2015. Epub 2016 Jul 28.

22.

CRISPR-Cas9-based target validation for p53-reactivating model compounds.

Wanzel M, Vischedyk JB, Gittler MP, Gremke N, Seiz JR, Hefter M, Noack M, Savai R, Mernberger M, Charles JP, Schneikert J, Bretz AC, Nist A, Stiewe T.

Nat Chem Biol. 2016 Jan;12(1):22-8. doi: 10.1038/nchembio.1965. Epub 2015 Nov 23.

23.

Immune and Inflammatory Cell Composition of Human Lung Cancer Stroma.

Banat GA, Tretyn A, Pullamsetti SS, Wilhelm J, Weigert A, Olesch C, Ebel K, Stiewe T, Grimminger F, Seeger W, Fink L, Savai R.

PLoS One. 2015 Sep 28;10(9):e0139073. doi: 10.1371/journal.pone.0139073. eCollection 2015.

24.

Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer.

Schmall A, Al-Tamari HM, Herold S, Kampschulte M, Weigert A, Wietelmann A, Vipotnik N, Grimminger F, Seeger W, Pullamsetti SS, Savai R.

Am J Respir Crit Care Med. 2015 Feb 15;191(4):437-47. doi: 10.1164/rccm.201406-1137OC.

PMID:
25536148
25.

Sequential Salinomycin Treatment Results in Resistance Formation through Clonal Selection of Epithelial-Like Tumor Cells.

Kopp F, Hermawan A, Oak PS, Ulaganathan VK, Herrmann A, Elnikhely N, Thakur C, Xiao Z, Knyazev P, Ataseven B, Savai R, Wagner E, Roidl A.

Transl Oncol. 2014 Dec;7(6):702-11. doi: 10.1016/j.tranon.2014.09.002.

26.

ABCB4 is frequently epigenetically silenced in human cancers and inhibits tumor growth.

Kiehl S, Herkt SC, Richter AM, Fuhrmann L, El-Nikhely N, Seeger W, Savai R, Dammann RH.

Sci Rep. 2014 Nov 4;4:6899. doi: 10.1038/srep06899.

27.

Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension.

Savai R, Al-Tamari HM, Sedding D, Kojonazarov B, Muecke C, Teske R, Capecchi MR, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS.

Nat Med. 2014 Nov;20(11):1289-300. doi: 10.1038/nm.3695. Epub 2014 Oct 26.

PMID:
25344740
28.

Interactions between neutrophils and non-small cell lung cancer cells: enhancement of tumor proliferation and inflammatory mediator synthesis.

Hattar K, Franz K, Ludwig M, Sibelius U, Wilhelm J, Lohmeyer J, Savai R, Subtil FS, Dahlem G, Eul B, Seeger W, Grimminger F, Grandel U.

Cancer Immunol Immunother. 2014 Dec;63(12):1297-306. doi: 10.1007/s00262-014-1606-z. Epub 2014 Sep 4.

29.

Elimination of B-RAF in oncogenic C-RAF-expressing alveolar epithelial type II cells reduces MAPK signal intensity and lung tumor growth.

Zanucco E, El-Nikhely N, Götz R, Weidmann K, Pfeiffer V, Savai R, Seeger W, Ullrich A, Rapp UR.

J Biol Chem. 2014 Sep 26;289(39):26804-16. doi: 10.1074/jbc.M114.558999. Epub 2014 Aug 5.

30.

Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension.

El Kasmi KC, Pugliese SC, Riddle SR, Poth JM, Anderson AL, Frid MG, Li M, Pullamsetti SS, Savai R, Nagel MA, Fini MA, Graham BB, Tuder RM, Friedman JE, Eltzschig HK, Sokol RJ, Stenmark KR.

J Immunol. 2014 Jul 15;193(2):597-609. doi: 10.4049/jimmunol.1303048. Epub 2014 Jun 13.

31.

Differential effects of drugs targeting cancer stem cell (CSC) and non-CSC populations on lung primary tumors and metastasis.

Larzabal L, El-Nikhely N, Redrado M, Seeger W, Savai R, Calvo A.

PLoS One. 2013 Nov 20;8(11):e79798. doi: 10.1371/journal.pone.0079798. eCollection 2013.

32.

Mistletoe lectin has a shiga toxin-like structure and should be combined with other Toll-like receptor ligands in cancer therapy.

Maletzki C, Linnebacher M, Savai R, Hobohm U.

Cancer Immunol Immunother. 2013 Aug;62(8):1283-92. doi: 10.1007/s00262-013-1455-1. Epub 2013 Jul 6.

PMID:
23832140
33.

E-cadherin controls bronchiolar progenitor cells and onset of preneoplastic lesions in mice.

Ceteci F, Ceteci S, Zanucco E, Thakur C, Becker M, El-Nikhely N, Fink L, Seeger W, Savai R, Rapp UR.

Neoplasia. 2012 Dec;14(12):1164-77.

34.

Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension.

Savai R, Pullamsetti SS, Kolbe J, Bieniek E, Voswinckel R, Fink L, Scheed A, Ritter C, Dahal BK, Vater A, Klussmann S, Ghofrani HA, Weissmann N, Klepetko W, Banat GA, Seeger W, Grimminger F, Schermuly RT.

Am J Respir Crit Care Med. 2012 Nov 1;186(9):897-908. doi: 10.1164/rccm.201202-0335OC. Epub 2012 Sep 6.

PMID:
22955318
35.

Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation.

Hattar K, Savai R, Subtil FS, Wilhelm J, Schmall A, Lang DS, Goldmann T, Eul B, Dahlem G, Fink L, Schermuly RT, Banat GA, Sibelius U, Grimminger F, Vollmer E, Seeger W, Grandel U.

Cancer Immunol Immunother. 2013 Feb;62(2):309-20. doi: 10.1007/s00262-012-1341-2. Epub 2012 Aug 26.

36.

Zyxin is a transforming growth factor-β (TGF-β)/Smad3 target gene that regulates lung cancer cell motility via integrin α5β1.

Mise N, Savai R, Yu H, Schwarz J, Kaminski N, Eickelberg O.

J Biol Chem. 2012 Sep 7;287(37):31393-405. doi: 10.1074/jbc.M112.357624. Epub 2012 Jul 9.

37.

Tumor-stromal interactions in lung cancer: novel candidate targets for therapeutic intervention.

El-Nikhely N, Larzabal L, Seeger W, Calvo A, Savai R.

Expert Opin Investig Drugs. 2012 Aug;21(8):1107-22. doi: 10.1517/13543784.2012.693478. Epub 2012 Jun 6. Review.

PMID:
22667993
38.

Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF.

Pullamsetti SS, Banat GA, Schmall A, Szibor M, Pomagruk D, Hänze J, Kolosionek E, Wilhelm J, Braun T, Grimminger F, Seeger W, Schermuly RT, Savai R.

Oncogene. 2013 Feb 28;32(9):1121-34. doi: 10.1038/onc.2012.136. Epub 2012 Apr 23.

PMID:
22525277
39.

Role of Src tyrosine kinases in experimental pulmonary hypertension.

Pullamsetti SS, Berghausen EM, Dabral S, Tretyn A, Butrous E, Savai R, Butrous G, Dahal BK, Brandes RP, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Rosenkranz S, Schermuly RT.

Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):1354-65. doi: 10.1161/ATVBAHA.112.248500. Epub 2012 Apr 19.

PMID:
22516066
40.

Expression of B-RAF V600E in type II pneumocytes causes abnormalities in alveolar formation, airspace enlargement and tumor formation in mice.

Zanucco E, Götz R, Potapenko T, Carraretto I, Ceteci S, Ceteci F, Seeger W, Savai R, Rapp UR.

PLoS One. 2011;6(12):e29093. doi: 10.1371/journal.pone.0029093. Epub 2011 Dec 14.

41.

Inhibition of microRNA-17 improves lung and heart function in experimental pulmonary hypertension.

Pullamsetti SS, Doebele C, Fischer A, Savai R, Kojonazarov B, Dahal BK, Ghofrani HA, Weissmann N, Grimminger F, Bonauer A, Seeger W, Zeiher AM, Dimmeler S, Schermuly RT.

Am J Respir Crit Care Med. 2012 Feb 15;185(4):409-19. doi: 10.1164/rccm.201106-1093OC. Epub 2011 Dec 8.

PMID:
22161164
42.

The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis.

Pullamsetti SS, Savai R, Dumitrascu R, Dahal BK, Wilhelm J, Konigshoff M, Zakrzewicz D, Ghofrani HA, Weissmann N, Eickelberg O, Guenther A, Leiper J, Seeger W, Grimminger F, Schermuly RT.

Sci Transl Med. 2011 Jun 15;3(87):87ra53. doi: 10.1126/scitranslmed.3001725.

43.

Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats.

Dahal BK, Kosanovic D, Kaulen C, Cornitescu T, Savai R, Hoffmann J, Reiss I, Ghofrani HA, Weissmann N, Kuebler WM, Seeger W, Grimminger F, Schermuly RT.

Respir Res. 2011 May 2;12:60. doi: 10.1186/1465-9921-12-60.

44.

cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.

Pullamsetti SS, Savai R, Schaefer MB, Wilhelm J, Ghofrani HA, Weissmann N, Schudt C, Fleming I, Mayer K, Leiper J, Seeger W, Grimminger F, Schermuly RT.

Circulation. 2011 Mar 22;123(11):1194-204. doi: 10.1161/CIRCULATIONAHA.110.941484. Epub 2011 Mar 7.

PMID:
21382892
45.

Tyrosine kinase inhibitors with antiangiogenic properties for the treatment of non-small cell lung cancer.

Nguewa PA, Calvo A, Pullamsetti SS, Banat GA, Grimminger F, Savai R.

Expert Opin Investig Drugs. 2011 Jan;20(1):61-74. doi: 10.1517/13543784.2011.541153. Epub 2010 Dec 11. Review.

PMID:
21142806
46.

Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis.

Nikolova S, Guenther A, Savai R, Weissmann N, Ghofrani HA, Konigshoff M, Eickelberg O, Klepetko W, Voswinckel R, Seeger W, Grimminger F, Schermuly RT, Pullamsetti SS.

Respir Res. 2010 Oct 27;11:146. doi: 10.1186/1465-9921-11-146.

47.

Inflammation, immunological reaction and role of infection in pulmonary hypertension.

Pullamsetti SS, Savai R, Janssen W, Dahal BK, Seeger W, Grimminger F, Ghofrani HA, Weissmann N, Schermuly RT.

Clin Microbiol Infect. 2011 Jan;17(1):7-14. doi: 10.1111/j.1469-0691.2010.03285.x. Review.

48.

Inhibition of urokinase activity reduces primary tumor growth and metastasis formation in a murine lung carcinoma model.

Henneke I, Greschus S, Savai R, Korfei M, Markart P, Mahavadi P, Schermuly RT, Wygrecka M, Stürzebecher J, Seeger W, Günther A, Ruppert C.

Am J Respir Crit Care Med. 2010 Mar 15;181(6):611-9. doi: 10.1164/rccm.200903-0342OC. Epub 2010 Jan 7.

PMID:
20056905
49.

Targeting cancer with phosphodiesterase inhibitors.

Savai R, Pullamsetti SS, Banat GA, Weissmann N, Ghofrani HA, Grimminger F, Schermuly RT.

Expert Opin Investig Drugs. 2010 Jan;19(1):117-31. doi: 10.1517/13543780903485642. Review.

PMID:
20001559
50.

Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4.

Kolosionek E, Savai R, Ghofrani HA, Weissmann N, Guenther A, Grimminger F, Seeger W, Banat GA, Schermuly RT, Pullamsetti SS.

Mol Biol Cell. 2009 Nov;20(22):4751-65. doi: 10.1091/mbc.E09-01-0019. Epub 2009 Sep 16.

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