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A Machine Learning Approach to Identify a Circulating MicroRNA Signature for Alzheimer Disease.

Zhao X, Kang J, Svetnik V, Warden D, Wilcock G, David Smith A, Savage MJ, Laterza OF.

J Appl Lab Med. 2019 Dec 6. pii: jalm.2019.029595. doi: 10.1373/jalm.2019.029595. [Epub ahead of print]


Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.

Selnick HG, Hess JF, Tang C, Liu K, Schachter JB, Ballard JE, Marcus J, Klein DJ, Wang X, Pearson M, Savage MJ, Kaul R, Li TS, Vocadlo DJ, Zhou Y, Zhu Y, Mu C, Wang Y, Wei Z, Bai C, Duffy JL, McEachern EJ.

J Med Chem. 2019 Nov 27;62(22):10062-10097. doi: 10.1021/acs.jmedchem.9b01090. Epub 2019 Sep 29.


Entanglement Suppression and Emergent Symmetries of Strong Interactions.

Beane SR, Kaplan DB, Klco N, Savage MJ.

Phys Rev Lett. 2019 Mar 15;122(10):102001. doi: 10.1103/PhysRevLett.122.102001.


Pembrolizumab alone or in combination with chemotherapy as first-line therapy for patients with advanced gastric or gastroesophageal junction adenocarcinoma: results from the phase II nonrandomized KEYNOTE-059 study.

Bang YJ, Kang YK, Catenacci DV, Muro K, Fuchs CS, Geva R, Hara H, Golan T, Garrido M, Jalal SI, Borg C, Doi T, Yoon HH, Savage MJ, Wang J, Dalal RP, Shah S, Wainberg ZA, Chung HC.

Gastric Cancer. 2019 Jul;22(4):828-837. doi: 10.1007/s10120-018-00909-5. Epub 2019 Mar 25.


Clinical Utility of the Combined Positive Score for Programmed Death Ligand-1 Expression and the Approval of Pembrolizumab for Treatment of Gastric Cancer.

Kulangara K, Zhang N, Corigliano E, Guerrero L, Waldroup S, Jaiswal D, Ms MJ, Shah S, Hanks D, Wang J, Lunceford J, Savage MJ, Juco J, Emancipator K.

Arch Pathol Lab Med. 2019 Mar;143(3):330-337. doi: 10.5858/arpa.2018-0043-OA. Epub 2018 Jul 20.


Scalar, Axial, and Tensor Interactions of Light Nuclei from Lattice QCD.

Chang E, Davoudi Z, Detmold W, Gambhir AS, Orginos K, Savage MJ, Shanahan PE, Wagman ML, Winter F; NPLQCD Collaboration.

Phys Rev Lett. 2018 Apr 13;120(15):152002. doi: 10.1103/PhysRevLett.120.152002.


Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy.

Wang X, Smith K, Pearson M, Hughes A, Cosden ML, Marcus J, Hess JF, Savage MJ, Rosahl T, Smith SM, Schachter JB, Uslaner JM.

PLoS One. 2018 Apr 6;13(4):e0195486. doi: 10.1371/journal.pone.0195486. eCollection 2018.


Extending a Systems Model of the APP Pathway: Separation of β- and γ-Secretase Sequential Cleavage Steps of APP.

van Maanen EMT, van Steeg TJ, Ahsman MJ, Michener MS, Savage MJ, Kennedy ME, Kleijn HJ, Stone J, Danhof M.

J Pharmacol Exp Ther. 2018 Jun;365(3):507-518. doi: 10.1124/jpet.117.244699. Epub 2018 Mar 21.


First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 study.

Balar AV, Castellano D, O'Donnell PH, Grivas P, Vuky J, Powles T, Plimack ER, Hahn NM, de Wit R, Pang L, Savage MJ, Perini RF, Keefe SM, Bajorin D, Bellmunt J.

Lancet Oncol. 2017 Nov;18(11):1483-1492. doi: 10.1016/S1470-2045(17)30616-2. Epub 2017 Sep 26.


Isotensor Axial Polarizability and Lattice QCD Input for Nuclear Double-β Decay Phenomenology.

Shanahan PE, Tiburzi BC, Wagman ML, Winter F, Chang E, Davoudi Z, Detmold W, Orginos K, Savage MJ; NPLQCD Collaboration.

Phys Rev Lett. 2017 Aug 11;119(6):062003. doi: 10.1103/PhysRevLett.119.062003. Epub 2017 Aug 10.


Proton-Proton Fusion and Tritium β Decay from Lattice Quantum Chromodynamics.

Savage MJ, Shanahan PE, Tiburzi BC, Wagman ML, Winter F, Beane SR, Chang E, Davoudi Z, Detmold W, Orginos K; NPLQCD Collaboration.

Phys Rev Lett. 2017 Aug 11;119(6):062002. doi: 10.1103/PhysRevLett.119.062002. Epub 2017 Aug 10.


A multinational study distinguishing Alzheimer's and healthy patients using cerebrospinal fluid tau/Aβ42 cutoff with concordance to amyloid positron emission tomography imaging.

Mo Y, Stromswold J, Wilson K, Holder D, Sur C, Laterza O, Savage MJ, Struyk A, Scheltens P, Teunissen CE, Burke J, Macaulay SL, Bråthen G, Sando SB, White LR, Weiss C, Cowes A, Bush MM, DeSilva G, Darby DG, Rainey-Smith SR, Surls J, Sagini E, Tanen M, Altman A, Luthman J, Egan MF.

Alzheimers Dement (Amst). 2017 Mar 6;6:201-209. doi: 10.1016/j.dadm.2017.02.004. eCollection 2017.


The Relevance of Hereditary Cancer Risks to Precision Oncology: What Should Providers Consider When Conducting Tumor Genomic Profiling?

Jain R, Savage MJ, Forman AD, Mukherji R, Hall MJ.

J Natl Compr Canc Netw. 2016 Jun;14(6):795-806. Review.


Unitary Limit of Two-Nucleon Interactions in Strong Magnetic Fields.

Detmold W, Orginos K, Parreño A, Savage MJ, Tiburzi BC, Beane SR, Chang E; NPLQCD Collaboration.

Phys Rev Lett. 2016 Mar 18;116(11):112301. doi: 10.1103/PhysRevLett.116.112301. Epub 2016 Mar 14.


Systems Pharmacology Analysis of the Amyloid Cascade after β-Secretase Inhibition Enables the Identification of an Aβ42 Oligomer Pool.

van Maanen EM, van Steeg TJ, Michener MS, Savage MJ, Kennedy ME, Kleijn HJ, Stone JA, Danhof M.

J Pharmacol Exp Ther. 2016 Apr;357(1):205-16. doi: 10.1124/jpet.115.230565. Epub 2016 Jan 29.


Pharmacological Inhibition of O-GlcNAcase Does Not Increase Sensitivity of Glucocorticoid Receptor-Mediated Transrepression.

Stivers PJ, Harmonay L, Hicks A, Mehmet H, Morris M, Robinson GM, Strack PR, Savage MJ, Zaller DM, Zwierzynski I, Brandish PE.

PLoS One. 2015 Dec 15;10(12):e0145151. doi: 10.1371/journal.pone.0145151. eCollection 2015.


Effect of Tween-20 on Core Biomarkers Measured in Cerebrospinal Fluid from Patients with Alzheimer's Disease, Mild Cognitive Impairment, or Healthy Control Individuals.

Berge G, Lauridsen C, Sando SB, Holder DJ, Møller I, Aasly JO, Bråthen G, Savage MJ, White LR.

J Alzheimers Dis. 2016;49(2):493-502. doi: 10.3233/JAD-150234.


Ab initio Calculation of the np→dγ Radiative Capture Process.

Beane SR, Chang E, Detmold W, Orginos K, Parreño A, Savage MJ, Tiburzi BC; NPLQCD Collaboration.

Phys Rev Lett. 2015 Sep 25;115(13):132001. doi: 10.1103/PhysRevLett.115.132001. Epub 2015 Sep 24.


An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter.

Lucey BP, Gonzales C, Das U, Li J, Siemers ER, Slemmon JR, Bateman RJ, Huang Y, Fox GB, Claassen JA, Slats D, Verbeek MM, Tong G, Soares H, Savage MJ, Kennedy M, Forman M, Sjögren M, Margolin R, Chen X, Farlow MR, Dean RA, Waring JF.

Alzheimers Res Ther. 2015 Jul 29;7(1):53. doi: 10.1186/s13195-015-0136-z. eCollection 2015.


Nowcasting daily minimum air and grass temperature.

Savage MJ.

Int J Biometeorol. 2016 Feb;60(2):183-94. doi: 10.1007/s00484-015-1017-7. Epub 2015 Jun 30.


Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.

Chu X, Shih SJ, Shaw R, Hentze H, Chan GH, Owens K, Wang S, Cai X, Newton D, Castro-Perez J, Salituro G, Palamanda J, Fernandis A, Ng CK, Liaw A, Savage MJ, Evers R.

Drug Metab Dispos. 2015 Jun;43(6):851-63. doi: 10.1124/dmd.115.063347. Epub 2015 Mar 26.


Soluble BACE-1 Activity and sAβPPβ Concentrations in Alzheimer's Disease and Age-Matched Healthy Control Cerebrospinal Fluid from the Alzheimer's Disease Neuroimaging Initiative-1 Baseline Cohort.

Savage MJ, Holder DJ, Wu G, Kaplow J, Siuciak JA, Potter WZ; Foundation for National Institutes of Health (FNIH) Biomarkers Consortium CSF Proteomics Project Team for Alzheimer's Disease Neuroimaging Initiative.

J Alzheimers Dis. 2015;46(2):431-40. doi: 10.3233/JAD-142778.


Magnetic moments of light nuclei from lattice quantum chromodynamics.

Beane SR, Chang E, Cohen S, Detmold W, Lin HW, Orginos K, Parreño A, Savage MJ, Tiburzi BC; (NPLQCD Collaboration).

Phys Rev Lett. 2014 Dec 19;113(25):252001. Epub 2014 Dec 16.


Cerebrospinal fluid biomarkers distinguish postmortem-confirmed Alzheimer's disease from other dementias and healthy controls in the OPTIMA cohort.

Seeburger JL, Holder DJ, Combrinck M, Joachim C, Laterza O, Tanen M, Dallob A, Chappell D, Snyder K, Flynn M, Simon A, Modur V, Potter WZ, Wilcock G, Savage MJ, Smith AD.

J Alzheimers Dis. 2015;44(2):525-39. doi: 10.3233/JAD-141725.


CNS amyloid-β, soluble APP-α and -β kinetics during BACE inhibition.

Dobrowolska JA, Michener MS, Wu G, Patterson BW, Chott R, Ovod V, Pyatkivskyy Y, Wildsmith KR, Kasten T, Mathers P, Dancho M, Lennox C, Smith BE, Gilberto D, McLoughlin D, Holder DJ, Stamford AW, Yarasheski KE, Kennedy ME, Savage MJ, Bateman RJ.

J Neurosci. 2014 Jun 11;34(24):8336-46. doi: 10.1523/JNEUROSCI.0540-14.2014.


Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase.

Converso A, Hartingh T, Fraley ME, Garbaccio RM, Hartman GD, Huang SY, Majercak JM, McCampbell A, Na SJ, Ray WJ, Savage MJ, Wolffe C, Yeh S, Yu Y, White R, Zhang R.

Bioorg Med Chem Lett. 2014 Jun 15;24(12):2737-40. doi: 10.1016/j.bmcl.2014.04.034. Epub 2014 Apr 18.


A sensitive aβ oligomer assay discriminates Alzheimer's and aged control cerebrospinal fluid.

Savage MJ, Kalinina J, Wolfe A, Tugusheva K, Korn R, Cash-Mason T, Maxwell JW, Hatcher NG, Haugabook SJ, Wu G, Howell BJ, Renger JJ, Shughrue PJ, McCampbell A.

J Neurosci. 2014 Feb 19;34(8):2884-97. doi: 10.1523/JNEUROSCI.1675-13.2014.


Pyroglutamate-modified amyloid-β protein demonstrates similar properties in an Alzheimer's disease familial mutant knock-in mouse and Alzheimer's disease brain.

Wu G, Miller RA, Connolly B, Marcus J, Renger J, Savage MJ.

Neurodegener Dis. 2014;14(2):53-66. doi: 10.1159/000353634. Epub 2013 Oct 23.


Hyperon-nucleon interactions from quantum chromodynamics and the composition of dense nuclear matter.

Beane SR, Chang E, Cohen SD, Detmold W, Lin HW, Luu TC, Orginos K, Parreño A, Savage MJ, Walker-Loud A; NPLQCD Collaboration.

Phys Rev Lett. 2012 Oct 26;109(17):172001. Epub 2012 Oct 23.


Characterization of plasma β-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease.

Wu G, Sankaranarayanan S, Wong J, Tugusheva K, Michener MS, Shi X, Cook JJ, Simon AJ, Savage MJ.

J Neurosci Res. 2012 Dec;90(12):2247-58. doi: 10.1002/jnr.23122. Epub 2012 Sep 18.


Pharmacological applications of a novel neoepitope antibody to a modified amyloid precursor protein-derived beta-secretase product.

Wu G, Sankaranarayanan S, Montgomery DL, Simon AJ, An Z, Savage MJ.

Protein Cell. 2011 Jul;2(7):573-84. doi: 10.1007/s13238-011-1076-4. Epub 2011 Aug 6.


Evidence for a bound H dibaryon from lattice QCD.

Beane SR, Chang E, Detmold W, Joo B, Lin HW, Luu TC, Orginos K, Parreño A, Savage MJ, Torok A, Walker-Loud A; NPLQCD Collaboration.

Phys Rev Lett. 2011 Apr 22;106(16):162001. Epub 2011 Apr 20.


Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.

Wu G, Sankaranarayanan S, Hsieh SH, Simon AJ, Savage MJ.

J Neurosci Res. 2011 Jun;89(6):822-32. doi: 10.1002/jnr.22618. Epub 2011 Mar 23.


Field evaluation of polymer capacitive humidity sensors for Bowen ratio energy balance flux measurements.

Savage MJ.

Sensors (Basel). 2010;10(8):7748-71. doi: 10.3390/s100807748. Epub 2010 Aug 20.


Color screening by pions.

Detmold W, Savage MJ; NPLQCD Collaboration.

Phys Rev Lett. 2009 Jan 23;102(3):032004. Epub 2009 Jan 23.


Multipion systems in lattice QCD and the three-pion interaction.

Beane SR, Detmold W, Luu TC, Orginos K, Savage MJ, Torok A; NPLQCD Collaboration.

Phys Rev Lett. 2008 Feb 29;100(8):082004. Epub 2008 Feb 29.


A transgenic rat model of Alzheimer's disease with extracellular Abeta deposition.

Flood DG, Lin YG, Lang DM, Trusko SP, Hirsch JD, Savage MJ, Scott RW, Howland DS.

Neurobiol Aging. 2009 Jul;30(7):1078-90. Epub 2007 Nov 28.


Nucleon-nucleon scattering from fully dynamical lattice QCD.

Beane SR, Bedaque PF, Orginos K, Savage MJ.

Phys Rev Lett. 2006 Jul 7;97(1):012001. Epub 2006 Jul 5.


AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice.

Chang EH, Savage MJ, Flood DG, Thomas JM, Levy RB, Mahadomrongkul V, Shirao T, Aoki C, Huerta PT.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3410-5. Epub 2006 Feb 21.


Comparative analysis of cortical gene expression in mouse models of Alzheimer's disease.

Wu ZL, Ciallella JR, Flood DG, O'Kane TM, Bozyczko-Coyne D, Savage MJ.

Neurobiol Aging. 2006 Mar;27(3):377-86. Epub 2005 May 31.


Cardiorespiratory fitness, physical activity, and arterial stiffness: the Northern Ireland Young Hearts Project.

Boreham CA, Ferreira I, Twisk JW, Gallagher AM, Savage MJ, Murray LJ.

Hypertension. 2004 Nov;44(5):721-6. Epub 2004 Sep 27.


Fruit and vegetable consumption and bone mineral density: the Northern Ireland Young Hearts Project.

McGartland CP, Robson PJ, Murray LJ, Cran GW, Savage MJ, Watkins DC, Rooney MM, Boreham CA.

Am J Clin Nutr. 2004 Oct;80(4):1019-23.


Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis.

Rea IM, McKeown PP, McMaster D, Young IS, Patterson C, Savage MJ, Belton C, Marchegiani F, Olivieri F, Bonafe M, Franceschi C.

Exp Gerontol. 2004 Apr;39(4):629-35.


Carbonated soft drink consumption and bone mineral density in adolescence: the Northern Ireland Young Hearts project.

McGartland C, Robson PJ, Murray L, Cran G, Savage MJ, Watkins D, Rooney M, Boreham C.

J Bone Miner Res. 2003 Sep;18(9):1563-9.


Protein tyrosine phosphatases are up-regulated and participate in cell death induced by polyglutamine expansion.

Wu ZL, O'Kane TM, Scott RW, Savage MJ, Bozyczko-Coyne D.

J Biol Chem. 2002 Nov 15;277(46):44208-13. Epub 2002 Sep 10.


Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.

Savage MJ, Lin YG, Ciallella JR, Flood DG, Scott RW.

J Neurosci. 2002 May 1;22(9):3376-85.


FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction.

Flood DG, Reaume AG, Dorfman KS, Lin YG, Lang DM, Trusko SP, Savage MJ, Annaert WG, De Strooper B, Siman R, Scott RW.

Neurobiol Aging. 2002 May-Jun;23(3):335-48.


What determines drop out in prospective studies of coronary heart disease risk factors between youth and young adulthood: the Young Hearts Study.

van Lenthe FJ, Boreham CA, Twisk JW, Savage MJ, Murray L, Smith GD.

J Epidemiol Community Health. 2001 Sep;55(9):681-2. No abstract available.


Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.

Maroney AC, Finn JP, Connors TJ, Durkin JT, Angeles T, Gessner G, Xu Z, Meyer SL, Savage MJ, Greene LA, Scott RW, Vaught JL.

J Biol Chem. 2001 Jul 6;276(27):25302-8. Epub 2001 Apr 26.


Parental recall of birthweight: a good proxy for recorded birthweight?

Walton KA, Murray LJ, Gallagher AM, Cran GW, Savage MJ, Boreham C.

Eur J Epidemiol. 2000;16(9):793-6.


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