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Dihydronicotinamide riboside is a potent NAD+ concentration enhancer in vitro and in vivo.

Yang Y, Mohammed FS, Zhang N, Sauve AA.

J Biol Chem. 2019 Jun 7;294(23):9295-9307. doi: 10.1074/jbc.RA118.005772. Epub 2019 Apr 4.


Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R.

Cell Metab. 2018 Mar 6;27(3):667-676.e4. doi: 10.1016/j.cmet.2018.02.001.


Regulatory Effects of NAD+ Metabolic Pathways on Sirtuin Activity.

Zhang N, Sauve AA.

Prog Mol Biol Transl Sci. 2018;154:71-104. doi: 10.1016/bs.pmbts.2017.11.012. Review.


Synthesis of β-Nicotinamide Riboside Using an Efficient Two-Step Methodology.

Zhang N, Sauve AA.

Curr Protoc Nucleic Acid Chem. 2017 Dec 24;71:14.14.1-14.14.9. doi: 10.1002/cpnc.43.


NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.

Ryu D, Zhang H, Ropelle ER, Sorrentino V, Mázala DA, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM, Bellemin S, Iyer SR, Wang X, Gariani K, Sauve AA, Cantó C, Conley KE, Walter L, Lovering RM, Chin ER, Jasmin BJ, Marcinek DJ, Menzies KJ, Auwerx J.

Sci Transl Med. 2016 Oct 19;8(361):361ra139.


NAD(+) metabolism: Bioenergetics, signaling and manipulation for therapy.

Yang Y, Sauve AA.

Biochim Biophys Acta. 2016 Dec;1864(12):1787-1800. doi: 10.1016/j.bbapap.2016.06.014. Epub 2016 Jun 29. Review.


Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects.

Traba J, Kwarteng-Siaw M, Okoli TC, Li J, Huffstutler RD, Bray A, Waclawiw MA, Han K, Pelletier M, Sauve AA, Siegel RM, Sack MN.

J Clin Invest. 2015 Nov 3;125(12):4592-600. doi: 10.1172/JCI83260.


Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart.

Xu W, Barrientos T, Mao L, Rockman HA, Sauve AA, Andrews NC.

Cell Rep. 2015 Oct 20;13(3):533-545. doi: 10.1016/j.celrep.2015.09.023. Epub 2015 Oct 8.


Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice.

Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku CS, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J.

Hepatology. 2016 Apr;63(4):1190-204. doi: 10.1002/hep.28245. Epub 2015 Dec 16.


NAD⁺ content and its role in mitochondria.

Li W, Sauve AA.

Methods Mol Biol. 2015;1241:39-48. doi: 10.1007/978-1-4939-1875-1_4.


Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells.

Tian L, Wang C, Hagen FK, Gormley M, Addya S, Soccio R, Casimiro MC, Zhou J, Powell MJ, Xu P, Deng H, Sauve AA, Pestell RG.

Oncotarget. 2014 Sep 15;5(17):7303-15.


Multifunctionalization of cetuximab with bioorthogonal chemistries and parallel EGFR profiling of cell-lines using imaging, FACS and immunoprecipitation approaches.

Reschke ML, Uprety R, Bodhinayake I, Banu M, Boockvar JA, Sauve AA.

Biochim Biophys Acta. 2014 Dec;1844(12):2182-92. doi: 10.1016/j.bbapap.2014.07.017. Epub 2014 Aug 1.


Mangiferin stimulates carbohydrate oxidation and protects against metabolic disorders induced by high-fat diets.

Apontes P, Liu Z, Su K, Benard O, Youn DY, Li X, Li W, Mirza RH, Bastie CC, Jelicks LA, Pessin JE, Muzumdar RH, Sauve AA, Chi Y.

Diabetes. 2014 Nov;63(11):3626-36. doi: 10.2337/db14-0006. Epub 2014 May 21.


SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.

North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA.

EMBO J. 2014 Jul 1;33(13):1438-53. doi: 10.15252/embj.201386907. Epub 2014 May 12.


NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease.

Cerutti R, Pirinen E, Lamperti C, Marchet S, Sauve AA, Li W, Leoni V, Schon EA, Dantzer F, Auwerx J, Viscomi C, Zeviani M.

Cell Metab. 2014 Jun 3;19(6):1042-9. doi: 10.1016/j.cmet.2014.04.001. Epub 2014 May 8.


Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle.

Pirinen E, Cantó C, Jo YS, Morato L, Zhang H, Menzies KJ, Williams EG, Mouchiroud L, Moullan N, Hagberg C, Li W, Timmers S, Imhof R, Verbeek J, Pujol A, van Loon B, Viscomi C, Zeviani M, Schrauwen P, Sauve AA, Schoonjans K, Auwerx J.

Cell Metab. 2014 Jun 3;19(6):1034-41. doi: 10.1016/j.cmet.2014.04.002. Epub 2014 May 8.


Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB.

Nature. 2014 Apr 10;508(7495):258-62. doi: 10.1038/nature13198.


Dual mode action of mangiferin in mouse liver under high fat diet.

Lim J, Liu Z, Apontes P, Feng D, Pessin JE, Sauve AA, Angeletti RH, Chi Y.

PLoS One. 2014 Mar 5;9(3):e90137. doi: 10.1371/journal.pone.0090137. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e100170.


Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection.

Chi Y, Sauve AA.

Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):657-61. doi: 10.1097/MCO.0b013e32836510c0. Review.


SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation.

Laurent G, de Boer VC, Finley LW, Sweeney M, Lu H, Schug TT, Cen Y, Jeong SM, Li X, Sauve AA, Haigis MC.

Mol Cell Biol. 2013 Nov;33(22):4552-61. doi: 10.1128/MCB.00087-13. Epub 2013 Sep 16.


Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes.

Cantó C, Sauve AA, Bai P.

Mol Aspects Med. 2013 Dec;34(6):1168-201. doi: 10.1016/j.mam.2013.01.004. Epub 2013 Jan 25. Review.


Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models.

Gong B, Pan Y, Vempati P, Zhao W, Knable L, Ho L, Wang J, Sastre M, Ono K, Sauve AA, Pasinetti GM.

Neurobiol Aging. 2013 Jun;34(6):1581-8. doi: 10.1016/j.neurobiolaging.2012.12.005. Epub 2013 Jan 9.


Sirtuins: NAD(+)-dependent deacetylase mechanism and regulation.

Sauve AA, Youn DY.

Curr Opin Chem Biol. 2012 Dec;16(5-6):535-43. doi: 10.1016/j.cbpa.2012.10.003. Epub 2012 Oct 23. Review.


The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.

Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J.

Cell Metab. 2012 Jun 6;15(6):838-47. doi: 10.1016/j.cmet.2012.04.022.


Advances in characterization of human sirtuin isoforms: chemistries, targets and therapeutic applications.

Cen Y, Youn DY, Sauve AA.

Curr Med Chem. 2011;18(13):1919-35. Review.


PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.

Bai P, Cantó C, Oudart H, Brunyánszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper RH, Schoonjans K, Schreiber V, Sauve AA, Menissier-de Murcia J, Auwerx J.

Cell Metab. 2011 Apr 6;13(4):461-468. doi: 10.1016/j.cmet.2011.03.004.


PARP-2 regulates SIRT1 expression and whole-body energy expenditure.

Bai P, Canto C, Brunyánszki A, Huber A, Szántó M, Cen Y, Yamamoto H, Houten SM, Kiss B, Oudart H, Gergely P, Menissier-de Murcia J, Schreiber V, Sauve AA, Auwerx J.

Cell Metab. 2011 Apr 6;13(4):450-460. doi: 10.1016/j.cmet.2011.03.013.


Mechanism-based affinity capture of sirtuins.

Cen Y, Falco JN, Xu P, Youn DY, Sauve AA.

Org Biomol Chem. 2011 Feb 21;9(4):987-93. doi: 10.1039/c0ob00774a. Epub 2010 Dec 24.


Characterization of nicotinamidases: steady state kinetic parameters, classwide inhibition by nicotinaldehydes, and catalytic mechanism.

French JB, Cen Y, Vrablik TL, Xu P, Allen E, Hanna-Rose W, Sauve AA.

Biochemistry. 2010 Dec 14;49(49):10421-39. doi: 10.1021/bi1012518. Epub 2010 Nov 15.


Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect.

Diani-Moore S, Ram P, Li X, Mondal P, Youn DY, Sauve AA, Rifkind AB.

J Biol Chem. 2010 Dec 10;285(50):38801-10. doi: 10.1074/jbc.M110.131573. Epub 2010 Sep 28.



Sauve AA.

Biochim Biophys Acta. 2010 Aug;1804(8):1565-6. doi: 10.1016/j.bbapap.2010.06.001. No abstract available.


Efficient syntheses of clofarabine and gemcitabine from 2-deoxyribonolactone.

Cen Y, Sauve AA.

Nucleosides Nucleotides Nucleic Acids. 2010 Feb;29(2):113-22. doi: 10.1080/15257771003597758.


Vitamin B3, the nicotinamide adenine dinucleotides and aging.

Xu P, Sauve AA.

Mech Ageing Dev. 2010 Apr;131(4):287-98. doi: 10.1016/j.mad.2010.03.006. Epub 2010 Mar 20. Review.


Sirtuin chemical mechanisms.

Sauve AA.

Biochim Biophys Acta. 2010 Aug;1804(8):1591-603. doi: 10.1016/j.bbapap.2010.01.021. Epub 2010 Feb 2. Review.


Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells.

Frizzell KM, Gamble MJ, Berrocal JG, Zhang T, Krishnakumar R, Cen Y, Sauve AA, Kraus WL.

J Biol Chem. 2009 Dec 4;284(49):33926-38. doi: 10.1074/jbc.M109.023879. Epub 2009 Oct 7.


Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters.

Zhang T, Berrocal JG, Frizzell KM, Gamble MJ, DuMond ME, Krishnakumar R, Yang T, Sauve AA, Kraus WL.

J Biol Chem. 2009 Jul 24;284(30):20408-17. doi: 10.1074/jbc.M109.016469. Epub 2009 May 28.


Pharmaceutical strategies for activating sirtuins.

Sauve AA.

Curr Pharm Des. 2009;15(1):45-56. Review.


A SIR-tain acetyl complex is caught by a sulfur trap.

Sauve AA.

Structure. 2008 Sep 10;16(9):1289-92. doi: 10.1016/j.str.2008.08.004. No abstract available.


Plasmodium falciparum Sir2 is an NAD+-dependent deacetylase and an acetyllysine-dependent and acetyllysine-independent NAD+ glycohydrolase.

French JB, Cen Y, Sauve AA.

Biochemistry. 2008 Sep 23;47(38):10227-39. doi: 10.1021/bi800767t. Epub 2008 Aug 26.


Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt.

Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA, Sartorelli V.

Dev Cell. 2008 May;14(5):661-73. doi: 10.1016/j.devcel.2008.02.004.


NAD+ and vitamin B3: from metabolism to therapies.

Sauve AA.

J Pharmacol Exp Ther. 2008 Mar;324(3):883-93. doi: 10.1124/jpet.107.120758. Epub 2007 Dec 28. Review.


Nicotinamide riboside kinase structures reveal new pathways to NAD+.

Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C.

PLoS Biol. 2007 Oct 2;5(10):e263.


Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.

Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA.

Cell. 2007 Sep 21;130(6):1095-107.


Hormonal control of androgen receptor function through SIRT1.

Fu M, Liu M, Sauve AA, Jiao X, Zhang X, Wu X, Powell MJ, Yang T, Gu W, Avantaggiati ML, Pattabiraman N, Pestell TG, Wang F, Quong AA, Wang C, Pestell RG.

Mol Cell Biol. 2006 Nov;26(21):8122-35. Epub 2006 Aug 21.


The biochemistry of sirtuins.

Sauve AA, Wolberger C, Schramm VL, Boeke JD.

Annu Rev Biochem. 2006;75:435-65. Review.


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