Sort by
Items per page

Send to

Choose Destination

Search results

Items: 46


Adiponectin resistance and proinflammatory changes in the visceral adipose tissue induced by fructose consumption via ketohexokinase-dependent pathway.

Marek G, Pannu V, Shanmugham P, Pancione B, Mascia D, Crosson S, Ishimoto T, Sautin YY.

Diabetes. 2015 Feb;64(2):508-18. doi: 10.2337/db14-0411. Epub 2014 Sep 3.


Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy.

Lanaspa MA, Ishimoto T, Cicerchi C, Tamura Y, Roncal-Jimenez CA, Chen W, Tanabe K, Andres-Hernando A, Orlicky DJ, Finol E, Inaba S, Li N, Rivard CJ, Kosugi T, Sanchez-Lozada LG, Petrash JM, Sautin YY, Ejaz AA, Kitagawa W, Garcia GE, Bonthron DT, Asipu A, Diggle CP, Rodriguez-Iturbe B, Nakagawa T, Johnson RJ.

J Am Soc Nephrol. 2014 Nov;25(11):2526-38. doi: 10.1681/ASN.2013080901. Epub 2014 May 29.


Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids.

Cicerchi C, Li N, Kratzer J, Garcia G, Roncal-Jimenez CA, Tanabe K, Hunter B, Rivard CJ, Sautin YY, Gaucher EA, Johnson RJ, Lanaspa MA.

FASEB J. 2014 Aug;28(8):3339-50. doi: 10.1096/fj.13-243634. Epub 2014 Apr 22.


Sugar, uric acid, and the etiology of diabetes and obesity.

Johnson RJ, Nakagawa T, Sanchez-Lozada LG, Shafiu M, Sundaram S, Le M, Ishimoto T, Sautin YY, Lanaspa MA.

Diabetes. 2013 Oct;62(10):3307-15. doi: 10.2337/db12-1814. Review.


Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome.

Lanaspa MA, Ishimoto T, Li N, Cicerchi C, Orlicky DJ, Ruzycki P, Rivard C, Inaba S, Roncal-Jimenez CA, Bales ES, Diggle CP, Asipu A, Petrash JM, Kosugi T, Maruyama S, Sanchez-Lozada LG, McManaman JL, Bonthron DT, Sautin YY, Johnson RJ.

Nat Commun. 2013;4:2434. doi: 10.1038/ncomms3434. Erratum in: Nat Commun. 2013;4:2929. Ruzicky, Philip [corrected to Ruzycki, Philip].


High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase.

Ishimoto T, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Orlicky DJ, Cicerchi C, McMahan RH, Abdelmalek MF, Rosen HR, Jackman MR, MacLean PS, Diggle CP, Asipu A, Inaba S, Kosugi T, Sato W, Maruyama S, Sánchez-Lozada LG, Sautin YY, Hill JO, Bonthron DT, Johnson RJ.

Hepatology. 2013 Nov;58(5):1632-43. doi: 10.1002/hep.26594. Epub 2013 Oct 8.


What are the key arguments against uric acid as a true risk factor for hypertension?

Johnson RJ, Sánchez-Lozada LG, Mazzali M, Feig DI, Kanbay M, Sautin YY.

Hypertension. 2013 May;61(5):948-51. doi: 10.1161/HYPERTENSIONAHA.111.00650. Epub 2013 Mar 4. No abstract available.


What can asymptomatic hyperuricaemia and systemic inflammation in the absence of gout tell us?

Inaba S, Sautin Y, Garcia GE, Johnson RJ.

Rheumatology (Oxford). 2013 Jun;52(6):963-5. doi: 10.1093/rheumatology/ket001. Epub 2013 Feb 13. No abstract available.


Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver.

Lanaspa MA, Sanchez-Lozada LG, Cicerchi C, Li N, Roncal-Jimenez CA, Ishimoto T, Le M, Garcia GE, Thomas JB, Rivard CJ, Andres-Hernando A, Hunter B, Schreiner G, Rodriguez-Iturbe B, Sautin YY, Johnson RJ.

PLoS One. 2012;7(10):e47948. doi: 10.1371/journal.pone.0047948. Epub 2012 Oct 24.


Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver.

Lanaspa MA, Sanchez-Lozada LG, Choi YJ, Cicerchi C, Kanbay M, Roncal-Jimenez CA, Ishimoto T, Li N, Marek G, Duranay M, Schreiner G, Rodriguez-Iturbe B, Nakagawa T, Kang DH, Sautin YY, Johnson RJ.

J Biol Chem. 2012 Nov 23;287(48):40732-44. doi: 10.1074/jbc.M112.399899. Epub 2012 Oct 3.


Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice.

Ishimoto T, Lanaspa MA, Le MT, Garcia GE, Diggle CP, Maclean PS, Jackman MR, Asipu A, Roncal-Jimenez CA, Kosugi T, Rivard CJ, Maruyama S, Rodriguez-Iturbe B, Sánchez-Lozada LG, Bonthron DT, Sautin YY, Johnson RJ.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4320-5. doi: 10.1073/pnas.1119908109. Epub 2012 Feb 27.


Uric acid and fructose: potential biological mechanisms.

Lanaspa MA, Tapia E, Soto V, Sautin Y, Sánchez-Lozada LG.

Semin Nephrol. 2011 Sep;31(5):426-32. doi: 10.1016/j.semnephrol.2011.08.006. Review.


Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake.

Roncal-Jimenez CA, Lanaspa MA, Rivard CJ, Nakagawa T, Sanchez-Lozada LG, Jalal D, Andres-Hernando A, Tanabe K, Madero M, Li N, Cicerchi C, Mc Fann K, Sautin YY, Johnson RJ.

Metabolism. 2011 Sep;60(9):1259-70. doi: 10.1016/j.metabol.2011.01.008. Epub 2011 Apr 12.


Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome.

Baldwin W, McRae S, Marek G, Wymer D, Pannu V, Baylis C, Johnson RJ, Sautin YY.

Diabetes. 2011 Apr;60(4):1258-69. doi: 10.2337/db10-0916. Epub 2011 Feb 23.


Induction of nitric oxide by erythropoietin is mediated by the {beta} common receptor and requires interaction with VEGF receptor 2.

Sautina L, Sautin Y, Beem E, Zhou Z, Schuler A, Brennan J, Zharikov SI, Diao Y, Bungert J, Segal MS.

Blood. 2010 Jan 28;115(4):896-905. doi: 10.1182/blood-2009-04-216432. Epub 2009 Nov 20.


Uric acid: more to learn, more experiments to do.

Johnson RJ, Rivard C, Nakagawa T, Sautin YY, Sanchez-Lozada LG.

Am J Hypertens. 2009 Sep;22(9):952-3. doi: 10.1038/ajh.2009.117. No abstract available.


Combination of captopril and allopurinol retards fructose-induced metabolic syndrome.

Roncal CA, Reungjui S, Sánchez-Lozada LG, Mu W, Sautin YY, Nakagawa T, Johnson RJ.

Am J Nephrol. 2009;30(5):399-404. doi: 10.1159/000235731. Epub 2009 Aug 21.


Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver.

Sánchez-Lozada LG, Mu W, Roncal C, Sautin YY, Abdelmalek M, Reungjui S, Le M, Nakagawa T, Lan HY, Yu X, Johnson RJ.

Eur J Nutr. 2010 Feb;49(1):1-9. doi: 10.1007/s00394-009-0042-x. Epub 2009 Jul 22.


A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid.

Kim KM, Henderson GN, Ouyang X, Frye RF, Sautin YY, Feig DI, Johnson RJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jul 15;877(22):2032-8. doi: 10.1016/j.jchromb.2009.05.037. Epub 2009 May 27.


Systemic inflammation, metabolic syndrome and progressive renal disease.

Cirillo P, Sautin YY, Kanellis J, Kang DH, Gesualdo L, Nakagawa T, Johnson RJ.

Nephrol Dial Transplant. 2009 May;24(5):1384-7. doi: 10.1093/ndt/gfp038. Epub 2009 Feb 10. Review. No abstract available.


Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells.

Cirillo P, Gersch MS, Mu W, Scherer PM, Kim KM, Gesualdo L, Henderson GN, Johnson RJ, Sautin YY.

J Am Soc Nephrol. 2009 Mar;20(3):545-53. doi: 10.1681/ASN.2008060576. Epub 2009 Jan 21.


Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?

Johnson RJ, Perez-Pozo SE, Sautin YY, Manitius J, Sanchez-Lozada LG, Feig DI, Shafiu M, Segal M, Glassock RJ, Shimada M, Roncal C, Nakagawa T.

Endocr Rev. 2009 Feb;30(1):96-116. doi: 10.1210/er.2008-0033. Epub 2009 Jan 16. Review.


Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia.

Sánchez-Lozada LG, Soto V, Tapia E, Avila-Casado C, Sautin YY, Nakagawa T, Franco M, Rodríguez-Iturbe B, Johnson RJ.

Am J Physiol Renal Physiol. 2008 Oct;295(4):F1134-41. doi: 10.1152/ajprenal.00104.2008. Epub 2008 Aug 13.


Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?

Johnson RJ, Sautin YY, Oliver WJ, Roncal C, Mu W, Gabriela Sanchez-Lozada L, Rodriguez-Iturbe B, Nakagawa T, Benner SA.

J Comp Physiol B. 2009 Jan;179(1):67-76. doi: 10.1007/s00360-008-0291-7. Epub 2008 Jul 23. Review.


Uric acid: the oxidant-antioxidant paradox.

Sautin YY, Johnson RJ.

Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):608-19. doi: 10.1080/15257770802138558.


Fructose consumption as a risk factor for non-alcoholic fatty liver disease.

Ouyang X, Cirillo P, Sautin Y, McCall S, Bruchette JL, Diehl AM, Johnson RJ, Abdelmalek MF.

J Hepatol. 2008 Jun;48(6):993-9. doi: 10.1016/j.jhep.2008.02.011. Epub 2008 Mar 10.


The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease.

Johnson RJ, Gaucher EA, Sautin YY, Henderson GN, Angerhofer AJ, Benner SA.

Med Hypotheses. 2008;71(1):22-31. doi: 10.1016/j.mehy.2008.01.017. Epub 2008 Mar 10. Review.


The conundrum of hyperuricemia, metabolic syndrome, and renal disease.

Nakagawa T, Cirillo P, Sato W, Gersch M, Sautin Y, Roncal C, Mu W, Sánchez-Lozada LG, Johnson RJ.

Intern Emerg Med. 2008 Dec;3(4):313-8. doi: 10.1007/s11739-008-0141-3. Epub 2008 Mar 5. Review.


Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.

Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, Gersch MS, Benner S, Sánchez-Lozada LG.

Am J Clin Nutr. 2007 Oct;86(4):899-906. Review.


Could uric acid have a role in acute renal failure?

Ejaz AA, Mu W, Kang DH, Roncal C, Sautin YY, Henderson G, Tabah-Fisch I, Keller B, Beaver TM, Nakagawa T, Johnson RJ.

Clin J Am Soc Nephrol. 2007 Jan;2(1):16-21. Epub 2006 Dec 6. Review.


Fructose, but not dextrose, accelerates the progression of chronic kidney disease.

Gersch MS, Mu W, Cirillo P, Reungjui S, Zhang L, Roncal C, Sautin YY, Johnson RJ, Nakagawa T.

Am J Physiol Renal Physiol. 2007 Oct;293(4):F1256-61. Epub 2007 Aug 1.


Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress.

Sautin YY, Nakagawa T, Zharikov S, Johnson RJ.

Am J Physiol Cell Physiol. 2007 Aug;293(2):C584-96. Epub 2007 Apr 11. Erratum in: Am J Physiol Cell Physiol. 2010 Sep;299(3):C726.


Uric acid, the metabolic syndrome, and renal disease.

Cirillo P, Sato W, Reungjui S, Heinig M, Gersch M, Sautin Y, Nakagawa T, Johnson RJ.

J Am Soc Nephrol. 2006 Dec;17(12 Suppl 3):S165-8. Review.


Does Tamm-Horsfall protein-uric acid binding play a significant role in urate homeostasis?

Gersch MS, Sautin YY, Gersch CM, Henderson G, Bankir L, Johnson RJ.

Nephrol Dial Transplant. 2006 Oct;21(10):2938-42. Epub 2006 Jul 21.


Human vascular smooth muscle cells express a urate transporter.

Price KL, Sautin YY, Long DA, Zhang L, Miyazaki H, Mu W, Endou H, Johnson RJ.

J Am Soc Nephrol. 2006 Jul;17(7):1791-5. Epub 2006 Jun 14.


Unearthing uric acid: an ancient factor with recently found significance in renal and cardiovascular disease.

Nakagawa T, Kang DH, Feig D, Sanchez-Lozada LG, Srinivas TR, Sautin Y, Ejaz AA, Segal M, Johnson RJ.

Kidney Int. 2006 May;69(10):1722-5. Review.


Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathy.

Nakagawa T, Sato W, Sautin YY, Glushakova O, Croker B, Atkinson MA, Tisher CC, Johnson RJ.

J Am Soc Nephrol. 2006 Mar;17(3):736-45. Epub 2006 Jan 25.


Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts.

Nakagawa T, Lan HY, Glushakova O, Zhu HJ, Kang DH, Schreiner GF, Böttinger EP, Johnson RJ, Sautin YY.

J Am Soc Nephrol. 2005 Apr;16(4):899-904. Epub 2005 Feb 16.


The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPase.

Lu M, Sautin YY, Holliday LS, Gluck SL.

J Biol Chem. 2004 Mar 5;279(10):8732-9. Epub 2003 Dec 12.


Hepatic oval (stem) cell expression of endothelial differentiation gene receptors for lysophosphatidic acid in mouse chronic liver injury.

Sautin YY, Jorgensen M, Petersen BE, Saulnier-Blache JS, Crawford JM, Svetlov SI.

J Hematother Stem Cell Res. 2002 Aug;11(4):643-9. Review.


EDG receptors and hepatic pathophysiology of LPA and S1P: EDG-ology of liver injury.

Svetlov SI, Sautin YY, Crawford JM.

Biochim Biophys Acta. 2002 May 23;1582(1-3):251-6. Review.


Involvement of wild-type p53 in radiation-induced c-Jun N-terminal kinase activation in human thyroid cells.

Shklyaev SS, Namba H, Sautin Y, Mitsutake N, Nagayama Y, Ishikawa N, Ito K, Zeki K, Yamashita S.

Anticancer Res. 2001 Jul-Aug;21(4A):2569-75.


Enhancement of survival by LPA via Erk1/Erk2 and PI 3-kinase/Akt pathways in a murine hepatocyte cell line.

Sautin YY, Crawford JM, Svetlov SI.

Am J Physiol Cell Physiol. 2001 Dec;281(6):C2010-9.


Ceramide-induced apoptosis of human thyroid cancer cells resistant to apoptosis by irradiation.

Sautin Y, Takamura N, Shklyaev S, Nagayama Y, Ohtsuru A, Namba H, Yamashita S.

Thyroid. 2000 Sep;10(9):733-40.


Supplemental Content

Loading ...
Support Center